Table 1 Compound-specific and system-specific parameters that were fixed or fitted to describe [⁶⁸Ga]Ga-PSMA-11 biodistribution using the PBPK model

Molecular weight [⁶⁸Ga]Ga-PSMA-11

1011.9 g/mol

[24]

Lipophilicity [⁶⁸Ga]Ga-PSMA-11

− 3.8

[23]

Fraction unbound

0.43

[25]

K_D

0.06 nmol/L

[28]

k_off

0.015 min⁻¹

[28]

k_int tumor

0.001 min⁻¹

[17]

k_int other tissue

0.035 min⁻¹

[28]

k_deg tumor

0.00014 min⁻¹

[17]

k_deg other tissue

0.00037 min⁻¹

[17]

PSMA amount tumor

0.437 nmol

[17]

PSMA amount salivary gland

0.162 nmol*

[17]

PSMA amount liver

4.00 nmol*

[17]

PSMA amount kidney

4.64 nmol*

[17]

Blood flow tumor

16.4 mL/min/100 g*

[17, 21]