Accuracy and uncertainty analysis of reduced time point imaging effect on time-integrated activity for 177Lu-DOTATATE PRRT in patients and clinically realistic simulations

EJNMMI Research

Table 3 Optimal sampling schedules (lowest RMSE across all sampling schedules) for each structure and reduced time point method (Hänscheid, Madsen, 2TP, and 3TP) using simulated data with RMSE, MPE, and MAPE for that sampling schedule

Struct	Method	Optimal TP (h)	RMSE (MBq-h)	MPE (SD) [range] (%)	MAPE (%)
Kidney	Hänscheid	63	445	4.9 (4.4) [− 14.0–12.4]	6.0
Kidney	Madsen	79	228	0.3 (3.4) [− 18.1–6.2]	2.4
Kidney	2TP	8, 172	98	0.6 (1.4) [− 6.4–3.5]	1.3
Kidney	3TP	8, 148, 220	96	0.7 (1.3) [− 4.5–3.4]	1.2
Liver	Hänscheid	97	4035	3.7 (4.3) [− 23.5–8.7]	5.1
Liver	Madsen	109	3028	− 2.4 (5.1) [− 36.7–2.4]	3.0
Liver	2TP	8, 212	524	0.5 (0.6) [− 0.8–2.0]	0.6
Liver	3TP	8, 200, 224	525	0.4 (0.6) [− 0.9–2.1]	0.5
Spleen	Hänscheid	70	569	1.7 (4.0) [− 10.8–9.8]	3.7
Spleen	Madsen	107	302	1.6 (1.8) [− 5.5–5.9]	2.0
Spleen	2TP	8, 168	161	0.2 (1.3) [− 4.1–2.8]	1.0
Spleen	3TP	8, 144, 220	142	0.2 (1.2) [− 3.4–2.6]	1.0
Tumor	Hänscheid	133	1362	4.4 (5.6) [− 29.2–12.7]	6.2
Tumor	Madsen	140	646	− 1.8 (6.1) [− 36.3–7.4]	3.9
Tumor	2TP	12, 240	317	0.7 (2.4) [− 15.3–8.7]	1.8
Tumor	3TP	24, 224, 240	495	1.9 (1.6) [− 6.6–8.6]	2.1