Accuracy and uncertainty analysis of reduced time point imaging effect on time-integrated activity for 177Lu-DOTATATE PRRT in patients and clinically realistic simulations

EJNMMI Research

Table 2 Optimal sampling schedules (lowest RMSE across all sampling schedules) for each structure and reduced time point method (Hänscheid, Madsen, 2TP, and 3TP) using measured clinical patient data with RMSE, MPE (SD), and MAPE for that sampling schedule

Struct	Method	Optimal TP	RMSE (MBq-h)	MPE (SD) [range] (%)	MAPE (%)
Kidney	Hänscheid	t_D3-5	561	− 3.1 (8.4) [− 26.4–10.7]	6.6
Kidney	Madsen	t_D3-5	603	− 4.1 (7.4) [− 23.4–16.7]	6.3
Kidney	2TP	t_D1-2,t_D3-5	254	1.0 (3.7) [− 7.2–19.3]	2.3
Kidney	3TP	t_D1-2,t_D3-5,t_D6-8	219	2.2 (1.8) [− 4.8–5.9]	2.4
Liver	Hänscheid	t_D3-5	5168	4.0 (3.4) [− 4.8–8.2]	4.8
Liver	Madsen	t_D3-5	3122	− 1.3 (2.8) [− 9.3–2.2]	2.2
Liver	2TP	t_D3-5,t_D6-8	1482	0.6 (2.2) [− 8.0–4.0]	1.7
Liver	3TP	t_D1-2,t_D3-5,t_D6-8	1367	1.2 (1.5) [− 4.3–4.3]	1.6
Spleen	Hänscheid	t_D6-8	820	− 3.7 (7.6) [− 25.2–11.6]	6.2
Spleen	Madsen	t_D3-5	270	− 0.3 (2.8) [− 7.2–3.4]	2.1
Spleen	2TP	t_D1-2,t_D3-5	333	1.2 (2.8) [− 3.5–10.5]	2.0
Spleen	3TP	t_D1-2,t_D3-5,t_D6-8	487	2.5 (1.6) [0.2–7.2]	2.5
Tumor	Hänscheid	t_D3-5	1629	0.2 (6.9) [− 22.9–18.4]	5.5
Tumor	Madsen	t_D3-5	1061	− 1.1 (7.3) [− 23.5–17.1]	5.9
Tumor	2TP	t_D1-2,t_D3-5	558	0.9 (5.8) [− 17.7–20.6]	4.0
Tumor	3TP	t_D1-2,t_D3-5,t_D6-8	424	2.1 (2.1) [− 6.6–14.2]	2.2