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EJNMMI Research
Fig. 1 | EJNMMI Research

Fig. 1

From: A physiologically based pharmacokinetic model for [68Ga]Ga-(HA-)DOTATATE to predict whole-body distribution and tumor sink effects in GEP-NET patients

Fig. 1

Structural overview of the multi-compartment PBPK model for GEP-NET patients, where somatostatin receptor expression fractions (related to spleen) are depicted as SSTRfr. *Intestinal compartment consists of small intestine (SSTR2 fraction = 0.09) and large intestine (SSTR2 fraction = 0.11). CLrenal: renal clearance; SSTRfr: somatostatin receptor fraction

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