Fig. 1

Imaging microglial depletion and activation with [¹¹C]PBR28 PET. a Parametric images of [¹¹C]PBR28 V _T at baseline (left), acutely post-PLX3397 (microglial depletion, center), and 12 days post-PLX3397 (recovery, right). b Parametric images of [¹¹C]PBR28 V _T in a different animal at baseline (left), 2.5 h post-LPS (microglial activation, center), and 14 days post-LPS (recovery, right). All V _T parametric images are in units of milliliters per cubic centimeter