Optimization of diagnostic performance for differentiation of recurrence from radiation necrosis in patients with metastatic brain tumors using tumor volume-corrected 11C-methionine uptake

EJNMMI Research

Table 2 Different cutoff values for tumor to normal tissue ratio according to metabolic tumor volume

MTV (cm³)	AUC	Optimal cutoff value	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Accuracy (%)
≤ 0.5 (n = 15)	0.840	1.23	70.0	80.0	87.5	57.1	73.3
> 0.5, ≤ 4.0 (n = 35)	0.817	1.54	77.8	76.5	77.8	76.5	77.1
> 4.0 (n = 27)	0.924	1.85	82.6	100	100	50	85.2

MTV metabolic tumor volume, AUC area under the ROC curve, PPV positive predictive value, NPV negative predictive value