Name | Nature | Molecular weight (kDa) | Targeted area | Tumor model | Tumor uptake | T/C | Imaging technique | Time point | Clin |
---|---|---|---|---|---|---|---|---|---|
64Cu-NOTA-rh-HGF | rh-ligand | ~90 | Extracellular | U87MG | 6.8 ± 1.8%ID/g | T/M =13.5 ± 6.1 | PET | 9 h p.i. | No |
125I-mAb | mAb | ~150 | Extracellular | S114 | – | T/TB = 0.37 | Gamma camera | 3 days p.i. | No |
125I-Met3 | mAb | ~150 | Extracellular | S114, SK-LMS-1/HGF | 18.6 ± 2.1%EIA, 7.2 ± 2.2%EIA | T/TB = 0.32 ± 0.13, T/TB = 0.168 ± 0.076 | Gamma camera | 3 days p.i., 6 days p.i. | No |
125I-Met5 | mAb | ~150 | Extracellular | SK-LMS-1/HGF | 13.3 ± 7.6%EIA, | T/TB = 0.146 ± 0.097 | Gamma camera | 1 day p.i. | No |
125I-hFab-Met-1 | Fab fragment | ~60 | Extracellular | SK-LMS-1/HGF | 6%EIA | – | Gamma camera | 5 h p.i. | No |
125I-MET4 | mAb | ~150 | Extracellular | SK-LMS-1/HGF | – | – | Gamma camera | 3 days p.i. | No |
89Zr-DN30 | mAb | ~150 | Extracellular | GTL-16 | 19.6 ± 3.3%ID/g | T/M = 17.5 | PET | 3 days p.i | No |
89Zr-df-onartuzumab | mAb | ~99 | Extracellular | MKN-45 | 23%ID/g | T/M = 27 | PET | 3 days p.i | No |
89Zr-DFO-H2cys-diabody | scFv | ~55 | Extracellular | Hcc827-GR6 | 3.4 ± 0.3%ID/g | T/M =27 ± 14 | PET | 44 h p.i. | No |
Ms20-QD | scFv | ~25 | Extracellular | H1993 | – | T/Tn = 4.3 | NIRfluorescence | 24 h p.i. | No |
anti-MET-Gd-DTPA-albumin | mAb | ~150 | Extracellular | C6 | – | SIC(T/Tn) ≈ 5 | MRI | 3 h p.i. | No |
SPIO-anti-c-MET | PcAb | ~150 | Extracellular | CDAA-HCC | – | SIC(T/Tn) ≈ 2 | MRI | 1.5 h p.i. | No |
125I-Met-pep1 | Peptide | ~1.5 | Extracellular | SK-LMS-1/HGF | 5%EIA, | – | Gamma camera | 4 h p.i. | No |
125I-cMBP-GGG | Peptide | ~1.9 | Extracellular | U87MG | 7.05 ± 1.2%ID/g | T/Bl = 2.94 | SPECT | 4 h p.i. | No |
cMBP-AOC-Cy5.5 | Peptide | ~2.8 | Extracellular | U87MG | – | T/M =33.711 ± 3.34 | NIRfluorescence | 5 h p.i. | No |
GE-137 | Peptide | ~4.2 | Extracellular | SKOv3 | – | T/Ba = 1.6 | NIRfluorescence | 3 h p.i. | Yes |
18F-AH113804 | Peptide | ~3.2 | Extracellular | HCC1954 | 1.5 ± 0.2%ID/ml | T/M ≈ 2 | PET | 1 h p.i. | No |
99mTc-AH113018 | Peptide | ~3.2 | Extracellular | MKN-45 | 10.1 ± 1.5%ID/g | T/M =55.2 ± 13.4 | SPECT | 1.5 h p.i. | No |
89Zr-PRS-110 | s-protein | 57 | Extracellular | H441 | 7.5 ± 3.4%ID/g | T:M = 29 | PET | 48 h p.i. | No |
11C- SU11274 | smTKI | ~0.6 | Intracellular | H1975 | SUV = 0.45 | T/TN = 2.6 | PET | 1.3 h p.i. | No |