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Table 2 18F-florbetapir SUVRs in the healthy controls (HCs) and patients with major depressive disorder (MDD) with differing levels of treatment resistance in seven cortical VOIs and the global cortex

From: Beta-amyloid deposition in patients with major depressive disorder with differing levels of treatment resistance: a pilot study

Region

HCs

MDD patients

P value

Mild treatment resistance

Moderate-to-severe treatment resistance

Frontal

   

0.365

 Mean ± SD

1.09 ± 0.09

1.12 ± 0.11

1.11 ± 0.15

 

 Median (IQR)

1.07 (1.04–1.16)

1.09 (1.06–1.15)

1.07 (1.03–1.15)

 

Anterior cingulate

   

0.606

 Mean ± SD

1.21 ± 0.11

1.24 ± 0.12

1.21 ± 0.15

 

 Median (IQR)

1.18 (1.13–1.30)

1.24 (1.16–1.33)

1.22 (1.11–1.29)

 

Posterior cingulate

   

0.251

 Mean ± SD

1.31 ± 0.12

1.31 ± 0.16

1.36 ± 0.16

 

 Median (IQR)

1.28 (1.21–1.43)

1.29 (1.24–1.41)

1.35 (1.27–1.44)

 

Occipital

   

0.284

 Mean ± SD

1.15 ± 0.08

1.18 ± 0.08

1.21 ± 0.13

 

 Median (IQR)

1.16 (1.09–1.21)

1.17 (1.14–1.23)

1.19 (1.12–1.24)

 

Parietal

   

0.032*

 Mean ± SD

1.01 ± 0.08

1.08 ± 0.11

1.11 ± 0.15a*

 

 Median (IQR)

1.03 (0.94–1.06)

1.06 (1.00–1.17)

1.08 (1.02–1.14)

 

Precuneous

   

0.201

 Mean ± SD

1.02 ± 0.08

1.06 ± 0.1

1.10 ± 0.17

 

 Median (IQR)

1.02 (0.95–1.09)

1.04 (1.00–1.10)

1.06 (0.99–1.13)

 

Temporal

   

0.693

 Mean ± SD

1.03 ± 0.06

1.02 ± 0.07

1.03 ± 0.12

 

 Median (IQR)

1.02 (1.00–1.07)

1.01 (0.99–1.04)

1.00 (0.95–1.08)

 

Global

   

0.52

 Mean ± SD

1.13 ± 0.07

1.15 ± 0.09

1.16 ± 0.13

 

 Median (IQR)

1.11 (1.07–1.16)

1.13 (1.11–1.19)

1.14 (1.09–1.18)

 
  1. aSignificant difference as compared with HCs: *P < 0.05