Fig. 4

Time-activity curves from the frontal cortex and hippocampus during different anesthesia conditions, isoflurane anesthesia (a, b), ket/dex anesthesia (c, d) dex-treated awake mice (e, f), and awake (g, h). The gray circles represent the actual measured activity in the ROI, the red circles the image-derived input function or the ex vivo-derived input function from whole blood samples, and corresponding lines represents the fitted input curves