Compound | logP | IC50 (nM) | Total cellular activity 1 h (%) | Internalized activity 1 h (%) |
---|---|---|---|---|
NOTA-pentixafor | – | 253 ± 49 | – | – |
[68Ga]NOTA-pentixafor | −2.36 | 17.8 ± 7.7 | 2.45 ± 0.02 | 0.43 ± 0.07 |
Pentixafor | – | 102 ± 17 | – | – |
[68Ga]pentixafor | −2.90 | 24.8 ± 2.5 | 6.36 ± 0.46 | 3.39 ± 0.16 |