An exploratory study of volumetric analysis for assessing tumor response with 18F-FAZA PET/CT in patients with advanced non-small-cell lung cancer (NSCLC)

EJNMMI Research

Table 1 Comparison of the effect of chemotherapy on the primary tumor measured with ¹⁸F-FAZA and ¹⁸F-FDG PET including tumor response in non-small-cell lung cancer

Patient	Age	Sex	¹⁸F-FAZA (T/Bg ratio)^a		¹⁸F-FDG (SUV_max)^b		Fractional hypoxic volume		CT scan
			Baseline	2 cycles	Baseline	2 cycles	Baseline	2 cycles
1	56	F	7.1	5.0	32.5	24.2	96 %	100 %	PD
2	43	M	3.0	2.0	15.4	2.1	98 %	9 %	SD
3	45	F	4.4	3.3	27.3	18.2	95 %	95 %	PD
4	52	F	7.7	7.7	5.8	^c	100 %	97 %	SD
5	48	F	2.9	2.6	7.2	5.9	63 %	30 %	SD
6	61	M	6.7	4.7	15.8	4.4	100 %	100 %	SD
7	62	F	3.3	5.4	8.9	6.0	58 %	100 %	PR

PR partial response, SD stabile disease, PD progressive disease
^aUptake for the whole primary tumor was corrected for partial volume effect. It was then divided by the mean of the background activity and this is tumor to background (T/Bg) value
^bUptake for the whole primary tumor, expressed in SUV, were corrected for partial volume effect
^cDue to a dosimeter error, not usable for qualitative comparison