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Table 5 Biodistribution at 48 h post injection of 177Lu-CHX-A″ DTPA-labelled hu3S193 wild type and I253A/H310A in tumour-bearing mice

From: Engineering anti-Lewis-Y hu3S193 antibodies with improved therapeutic ratio for radioimmunotherapy of epithelial cancers

Tissue

Hu3S193 wild type

Hu3S193 I253A/H310A

HuA33

Tumour

44.81 ± 3.35

16.95 ± 3.60

10.35 ± 0.54

Blood

15.67 ± 2.47

1.05 ± 0.27

20.88 ± 1.25

Liver

5.99 ± 1.43

14.16 ± 1.28

6.37 ± 0.62

Spleen

9.32 ± 1.33

13.77 ± 2.57

9.60 ± 0.88

Kidney

8.27 ± 4.36

3.91 ± 0.41

7.98 ± 0.51

Lung

9.79 ± 1.55

1.95 ± 0.25

12.06 ± 0.99

Heart

5.72 ± 1.09

2.66 ± 0.16

6.03 ± 0.49

Muscle

2.01 ± 0.44

1.03 ± 0.08

2.34 ± 0.44