EJNMMI Research

Table 1 Comparison of sigma-1 receptor ligand binding affinities to S1R, S2R, and VAChT

From: Further validation to support clinical translation of [¹⁸F]FTC-146 for imaging sigma-1 receptors


	FTC-146	(−)-Vesamicol	SN-56	SA4503	FPS	Fluspidine
S1R K ₁ (nM)	0.0025	74 [24]	0.56	4.6	4.3 [17]	0.59 [18]
S2R K ₁ (nM)	364	364 [24]	>1000	63	142 [17]	708 [18]
VAChT K ₁ (nM)	450	20	140	50	N/A	1400 [18]

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