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EJNMMI Research
Figure 1 | EJNMMI Research

Figure 1

From: Strategy to develop a MAO-A-resistant 5-hydroxy-l-[β-11C]tryptophan isotopologue based on deuterium kinetic isotope effects

Figure 1

Uptake and retention in beta cells of [11C]DHTP (left panel) and [11C]HTP (right panel). [11C]DHTP had increased retention in the neuroendocrine cell line INS-1 compared to [11C]HTP as measured by the slope of linear regression. Inhibition of MAO-A increased the retention of [11C]HTP at all time points, but only at a single time point for [11C]DHTP. Stars indicate increase of tracer uptake after MAO-A inhibition as compared to baseline.

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