Pilot study of 89Zr-bevacizumab positron emission tomography in patients with advanced non-small cell lung cancer

EJNMMI Research

Table 1 Patient characteristics

Number	Sex	Age (years)	Primary tumor	Evaluable metastasis	Histology	Bevacizumab maintenance therapy	Best response	Site of progression	PFS (weeks)	OS (weeks)
1	F	56	RLL	-	AC	Yes	PR	LLL	56	79
2	M	51	RUL	Peritoneum	AC	Yes	PR	PC	13	17
3	M	59	RLL	Bone	AC	Yes	PR	RUL^a	27	48
4	M	61	RLL	Bone	LCC	Yes	CR	RA	35	63
5	F	54	RLL	Bone	AC	Yes	PR	Brain	54	74
6	F	69	RH	Pericardium	AC	Yes	PR	MC	34	60
7	M	51	LH	Bone	AC	No	PD	Liver^a	3	3

Evaluable metastases are non-primary lesions, located within the PET field of view. All patients received bevacizumab maintenance therapy, except for one patient, who died before bevacizumab maintenance therapy could be administered. The best tumor response to chemotherapy is shown. Progressive disease was seen in all patients. ^aTwo patients developed clinical disease progression before radiological progression. One patient developed progression due to brain metastasis. Sites of radiological progression are shown. PFS and OS were calculated in weeks, between start of chemotherapy and date of progression and death, respectively. AC, adenocarcinoma; CR, complete response; F, female; LCC, large cell carcinoma; LH, left hilum; LLL, left lower lobe; M, male; MC, meningitis carcinomatosa; OS, overall survival; PC, peritonitis carcinomatosa; PD, progressive disease; PFS, progression-free survival; PR, partial response; RA right adrenal gland; RH, right hilum; RLL, right lower lobe; RUL, right upper lobe; SDC, salivary duct carcinoma.