Animal | Dose (mg/kg) | Plasma concentration at 1 min (ng/mL) | AUC (1 to 60 min) (ng/mL × min) | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Oseltamivir | Ro 64-0802 | Oseltamivir | Ro 64-0802 | |||||||
Baseline | Poly I:C | Baseline | Poly I:C | Baseline | Poly I:C | Baseline | Poly I:C | Baseline | Poly I:C | |
M176 | 3.4 | 3.3 | 590 | 281 | 622 | 494 | 14,437 | 10,237 | 43,252 | 38,523 |
F175 | 3.0 | 3.0 | 282 | 222 | 749 | 727 | 9,291 | 7,782 | 48,849 | 45,976 |
F174 | 3.2 | 3.3 | 343 | 190 | 1,004 | 1,093 | 10,667 | 5,238 | 65,966 | 48,924 |
Mean | 3.2 | 3.2 | 405 | 231 | 792 | 772 | 11,465 | 7,752 | 52,689 | 44,474 |
SD | 0.2 | 0.1 | 163 | 46 | 195 | 302 | 2,664 | 2,500 | 11,834 | 5,361 |