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EJNMMI Research

Table 3 Biodistribution of 123 I-CMICE-013 in healthy Sprague–Dawley rats

From: Biodistribution and radiodosimetry of a novel myocardial perfusion tracer 123I-CMICE-013 in healthy rats

Organ

%ID/organ (mean ± SD)

2 min

23 min

43 min

62 min

82 min

102 min

24 h

Thyroid

0.47 ± 0.20

0.48 ± 0.19

0.48 ± 0.17

0.48 ± 0.17

0.49 ± 0.15

0.49 ± 0.14

0.69 ± 0.23

Stomach

6.70 ± 2.25

7.84 ± 1.68

8.71 ± 1.24

10.10 ± 0.98

11.60 ± 1.10

13.09 ± 1.58

1.30 ± 0.34

Liver

17.96 ± 4.46

13.84 ± 4.63

11.39 ± 4.21

9.61 ± 3.59

8.30 ± 3.19

7.39 ± 2.95

n/a

Heart

4.18 ± 0.99

3.69 ± 0.77

3.24 ± 0.70

2.81 ± 0.62

2.43 ± 0.56

2.16 ± 0.48

n/a

Bladder

0.15 ± 0.19

0.42 ± 0.40

0.52 ± 0.49

0.56 ± 0.52

0.61 ± 0.56

0.64 ± 0.57

0.16 ± 0.07

Intestine

4.69 ± 2.78

5.81 ± 2.91

7.63 ± 3.24

8.28 ± 3.18

8.06 ± 3.07

7.91 ± 3.02

0.58 ± 0.33

Sal. gland

2.97 ± 1.12

3.04 ± 1.16

3.06 ± 1.16

3.05 ± 1.16

3.00 ± 1.13

2.95 ± 1.11

n/a

  1. Fourteen animals were divided into two groups. Group no. 1 (n = 6) was used in 0- to 2-h imaging and group no. 2 (n = 8) was used in 24-h imaging. At 24 h post-injection, no activity was observed in the microSPECT images of the liver, heart, and salivary gland.
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