Table 3 Biodistribution of ¹⁸ F-SIG343 and ¹⁸ F-SIG353 in representative tissues (decay corrected)

¹⁸F-SIG343

15

9.6 ± 0.2^***

16.0 ± 0.9^**

14.6 ± 1.2

26.1 ± 0.6

4.5 ± 0.4

30.3 ± 1.2^***

5.5 ± 0.4

0.9 ± 0.1

42.9 ± 2.8^*

10.8 ± 1.8

3.1 ± 0.5

30

8.8 ± 0.6^***

21.9 ± 0.8^***

15.2 ± 1.1^*

19.8 ± 0.9^***

4.3 ± 0.2

17.4 ± 0.7^***

3.5 ± 0.2^**

0.7 ± 0.04

50.2 ± 2.0^***

14.0 ± 2.2

3.0 ± 0.1^*

60

7.1 ± 0.4^***

15.2 ± 1.1^***

12.8 ± 0.9^***

12.0 ± 0.6^**

3.8 ± 0.1

9.9 ± 0.3^***

1.9 ± 0.04^**

0.6 ± 0.1

64.4 ± 3.5^***

13.5 ± 2.2

3.5 ± 0.3^*

120

5.2 ± 0.7^***

19.8 ± 0.9^*

8.5 ± 0.2^***

7.5 ± 0.4

3.2 ± 0.1

5.0 ± 0.3

1.1 ± 0.1

0.4 ± 0.01

61.7 ± 3.4^***

11.5 ± 1.4

3.9 ± 0.2

¹⁸F-SIG353

15

4.4 ± 0.2

23.5 ± 2.0

15.7 ± 1.1

23.4 ± 2.0

5.3 ± 0.3

17.4 ± 0.5

4.5 ± 0.2

1.2 ± 0.03

56.4 ± 4.7

10.0 ± 0.9

3.8 ± 0.3

30

2.3 ± 0.1

33.0 ± 1.8

12.0 ± 0.6

13.3 ± 0.8

4.7 ± 0.2

8.6 ± 0.4

2.5 ± 0.1

1.0 ± 0.1

72.8 ± 2.4

11.8 ± 1.5

3.8 ± 0.3

60

1.3 ± 0.01

32.6 ± 1.0

7.7 ± 0.4

8.7 ± 0.3

3.8 ± 0.2

6.1 ± 0.1

1.7 ± 0.02

0.7 ± 0.02

94.3 ± 4.2

9.6 ± 1.5

4.6 ± 0.2

120

0.8 ± 0.02

24.1 ± 1.4

5.5 ± 0.2

7.1 ± 0.2

3.9 ± 0.1

4.7 ± 0.2

1.3 ± 0.1

0.7 ± 0.03

119.2 ± 1.6

12.2 ± 3.1

4.8 ± 0.4