Figure 6From: Contrast-enhanced small-animal PET/CT in cancer research: strong improvement of diagnostic accuracy without significant alteration of quantitative accuracy and NEMA NU 4–2008 image quality parameters Impact of intraperitoneal and intravenous contrast media enhancement on tumor localization on SA-CT images: mice. Representative coronal slices for unenhanced CT (a), contrast-enhanced SA-PET/CT (b and c), and necropsy photograph of a mouse with multiple abdominal lesions and hemorrhagic ascites (d). The animal first underwent SA-CT acquisition, was subsequently injected with a mixture of 18F-FDG and Fenestra VC, and received an intraperitoneal injection of iohexol immediately before the SA-PET/CT acquisition began. Tumors are well defined on the contrast-enhanced CT slice (yellow arrows), including a necrotic lesion located near the bladder harboring a low 18F-FDG uptake and a central photopenic area on an SA-PET slice. Also visible is a tumor at the site of tumor cell injection.Back to article page