Figure 5

Proposed interaction of AMPK on insulin signaling and GLUT4 translocation. Potential targets of AMPK to alter insulin signaling of GLUT4 translocation through a direct inhibition of AS160 or via the mTOR pathway to inhibit Akt. The role that excessive glycogen levels play in the PRKAG2 mutation may also contribute to myocardial insulin resistance. PI3K, phosphatidylinositol 3-kinase; PIP3, phosphatidylinositol (3,4,5)-triphosphate; GLUT4, glucose transporter 4; PDK-1, phosphoinositide-dependent kinase-1; IRS, insulin receptor subunit.