From: [11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors
Brain region | Xanomeline | Xanomeline | Pirenzepine | Trihexyphenidyl | Darifenacin | Mean | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
 | (5 mg kg −1SC) | (30 mg kg −1SC) | (30 mg kg −1SC) | (3 mg kg −1SC) | (3 mg kg −1IV) | (n= 20) | |||||
 | Baseline | Pre-treated | Baseline | Pre-treated | Baseline | Pre-treated | Baseline | Pre-treated | Baseline | Pre-treated | Baseline |
Left striatum | 0.25 ± 0.05 | 0.30 ± 0.04* | 0.22 ± 0.07 | 0.22 ± 0.05 | 0.25 ± 0.04 | 0.21 ± 0.05* | 0.24 ± 0.02 | 0.21 ± 0.01 | 0.29 ± 0.03 | 0.28 ± 0.04 | 0.25 ± 0.05a |
Right striatum | 0.24 ± 0.04 | 0.27 ± 0.01 | 0.23 ± 0.08 | 0.25 ± 0.06 | 0.25 ± 0.06 | 0.23 ± 0.03 | 0.22 ± 0.01 | 0.22 ± 0.01 | 0.26 ± 0.05 | 0.26 ± 0.03 | 0.24 ± 0.05b |
Hippocampus | 0.20 ± 0.03 | 0.24 ± 0.01* | 0.19 ± 0.04 | 0.19 ± 0.06 | 0.20 ± 0.03 | 0.18 ± 0.02 | 0.19 ± 0.01 | 0.16 ± 0.01** | 0.24 ± 0.02 | 0.22 ± 0.04 | 0.20 ± 0.03c |
Frontal cortical area | 0.12 ± 0.07 | 0.10 ± 0.04 | 0.17 ± 0.06 | 0.14 ± 0.04 | 0.16 ± 0.05 | 0.10 ± 0.04** | 0.11 ± 0.03 | 0.05 ± 0.03* | 0.22 ± 0.02 | 0.20 ± 0.06 | 0.16 ± 0.06d |
Posterior cortical area | 0.12 ± 0.06 | 0.10 ± 0.04 | 0.15 ± 0.06 | 0.13 ± 0.04 | 0.13 ± 0.03 | 0.09 ± 0.03** | 0.11 ± 0.05 | 0.05 ± 0.03* | 0.23 ± 0.01 | 0.18 ± 0.05 | 0.15 ± 0.06e |