From: Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood–brain barriers studied with (R)-[11C]verapamil positron emission tomography
Healthy volunteers and 2 mg/kg tariquidar treated
Number
5
Body weight (kg)
74±5
Baseline (R)-[11C]verapamil (MBq)
379±11
I.V. injection time (sec)
51±10
Post-inhibition (R)-[11C]verapamil (MBq)
389±15
43±11