[111In]AT2S (%ID/g tissue ± SD) | |||||||||
---|---|---|---|---|---|---|---|---|---|
Organs | AR4-2J | HEK293-hsst 2A + | HEK293-hsst 3 + | HEK293-hsst 5 + | |||||
1 h | 4 h | 4 h + Tate a | 4 h | 4 h + DP2 b | 4 h | 4 h + AT2S c | 4 h | 4 h + AT2S c | |
Blood | 1.34 ± 0.21 | 0.19 ± 0.02 | 0.26 ± 0.03 | 0.23 ± 0.07 | 0.66 ± 0.35 | 0.19 ± 0.03 | 0.2 ± 0.10 | 0.1 ± 0.04 | 0.23 ± 0.03 |
Liver | 1.27 ± 0.09 | 0.95 ± 0.21 | 1.02 ± 0.11 | 1.31 ± 0.36 | 0.963 ± 0.67 | 1.02 ± 0.19 | 1.09 ± 0.2 | 1.1 ± 0.08 | 1.25 ± 0.09 |
Heart | 0.67 ± 0.12 | 0.18 ± 0.05 | 0.17 ± 0.04 | 0.22 ± 0.05 | 0.38 ± 0.10 | 0.15 ± 0.04 | 0.15 ± 0.01 | 0.15 ± 0.02 | 0.18 ± 0.03 |
Kidneys | 23.83 ± 4.28 | 21.10 ± 4.43 | 24.41 ± 9.15 | 23.20 ± 7.04 | 25.51 ± 3.70 | 23.42 ± 4.69 | 23.55 ± 8.96 | 24.12 ± 1.21 | 24.68 ± 2.20 |
Stomach | 3.23 ± 0.77 | 1.81 ± 0.47 | 0.18 ± 0.07*** | 1.96 ± 0.53 | 1.29 ± 0.36 | 3.41 ± 0.97 | 0.19 ± 0.05*** | 3.06 ± 0.73 | 0.17 ± 0.2*** |
Intestines | 1.98 ± 0.29 | 1.92 ± 0.25 | 0.77 ± 0.58* | 2.00 ± 0.48 | 1.74 ± 1.02 | 2.39 ± 0.43 | 0.54 ± 0.2*** | 1.54 ± 0.09 | 0.57 ± 0.20*** |
Spleen | 0.84 ± 0.21 | 1.10 ± 0.63 | 0.61 ± 0.18 | 0.46 ± 0.11 | 0.50 ± 0.36 | 0.82 ± 0.11 | 0.98 ± 0.23 | 0.78 ± 0.07 | 1.08 ± 0.16 |
Muscle | 0.22 ± 0.02 | 0.06 ± 0.01 | 0.07 ± 0.01 | 0.07 ± 0.02 | 0.07 ± 0.03 | 0.06 ± 0.01 | 0.07 ± 0.02 | 0.06 ± 0.01 | 0.06 ± 0.02 |
Lung | 2.05 ± 0.52 | 1.43 ± 1.36 | 3.30 ± 4.93 | 1.37 ± 0.55 | 0.47 ± 0.08 | 0.68 ± 0.29 | 0.73 ± 0.14 | 0.56 ± 0.28 | 0.83 ± 0.13 |
Femur | 0.49 ± 0.12 | 0.40 ± 0.24 | 0.19 ± 0.02 | 0.24 ± 0.09 | 0.21 ± 0.11 | 0.23 ± 0.03 | 0.23 ± 0.04 | - | - |
Pancreas | 7.35 ± 0.74 | 5.13 ± 0.75 | 0.15 ± 0.05** | 5.73 ± 1.28 | 0.16 ± 0.10*** | 3.33 ± 0.4 | 0.11 ± 0.01*** | 2.79 ± 0.4 | 0.43 ± 0.54*** |
Tumor | 3.05 ± 0.51 | 1.82 ± 0.36 | 0.21 ± 0.17*** | 1.49 ± 0.2 | 0.27 ± 0.20*** | 1.24 ± 0.27 | 0.32 ± 0.06*** | 0.41 ± 0.12 | 0.22 ± 0.006* |