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  1. There is a growing body of nuclear contrast agents that are repurposed for fluorescence-guided surgery. New contrast agents are obtained by substituting the radioactive tag with, or adding a fluorescent cyanin...

    Authors: Marcus C. M. Stroet, Bianca M. Dijkstra, Sebastiaan E. Dulfer, Schelto Kruijff, Wilfred F. A. den Dunnen, Frank A. E. Kruyt, Rob J. M. Groen, Yann Seimbille, Kranthi M. Panth, Laura Mezzanotte, Clemens W. G. M. Lowik and Marion de Jong
    Citation: EJNMMI Research 2021 11:47
    Content type: Original research Published on:

  2. Animal brain functions evaluated by in vivo imaging under anesthesia can be affected by anesthetic agents, resulting in incorrect assessment of physiological brain function. We therefore performed dynamic posi...

    Authors: Chie Suzuki, Mutsumi Kosugi and Yasuhiro Magata
    Citation: EJNMMI Research 2021 11:46
    Content type: Original research Published on:

  3. Inflammatory vascular disease of the arteries, such as inflamed atheromatous plaques or arteritis, may cause aneurysms or ischemic strokes. In this context, using positron emission tomography (PET) to image in...

    Authors: Romain Schollhammer, Sébastien Lepreux, Nicole Barthe, Delphine Vimont, Anne Rullier, Igor Sibon, Xavier Berard, Andrea Zhang, Yasuyuki Kimura, Masahiro Fujita, Robert B. Innis, Paolo Zanotti-Fregonara and Clément Morgat
    Citation: EJNMMI Research 2021 11:45
    Content type: Original research Published on:

  4. High-performance time-of-flight (TOF) positron emission tomography (PET) systems have the capability for rapid data acquisition while preserving diagnostic image quality. However, determining a reliable and cl...

    Authors: Julia Pilz, Lukas Hehenwarter, Georg Zimmermann, Gundula Rendl, Gregor Schweighofer-Zwink, Mohsen Beheshti and Christian Pirich
    Citation: EJNMMI Research 2021 11:44
    Content type: Original research Published on:

  5. 99mTc-tricarbonyl-nitrilotriacetic acid, [99mTc]Tc(CO)3(NTA), is a new 99mTc-renal radiopharmaceutical with a clearance equal to that of 131I-ortho-iodohippuran, [131I]I-OIH. Our purpose was to compare the perfor...

    Authors: Andrew T. Taylor, Malgorzata Lipowska and Raghuveer K. Halkar
    Citation: EJNMMI Research 2021 11:43
    Content type: Original research Published on:

  6. To elucidate the biological association between tumor proliferation, tumor infiltration and neovascularization, we analyzed the association between volumetric information of 4′-[methyl-11C]thiothymidine (4DST) po...

    Authors: Takashi Norikane, Katsuya Mitamura, Yuka Yamamoto, Yukito Maeda, Kenichi Tanaka, Tetsuhiro Hatakeyama, Keisuke Miyake, Jun Toyohara and Yoshihiro Nishiyama
    Citation: EJNMMI Research 2021 11:42
    Content type: Original research Published on:

  7. Detection of the site of recurrence using PSMA-PET/CT is important to guide treatment in patients with biochemical recurrence of prostate cancer (PCa). The aim of this study was to evaluate the positivity rate...

    Authors: Niloefar Ahmadi Bidakhvidi, Annouschka Laenen, Sander Jentjens, Christophe M. Deroose, Koen Van Laere, Liesbeth De Wever, Cindy Mai, Charlien Berghen, Gert De Meerleer, Karin Haustermans, Steven Joniau, Wouter Everaerts and Karolien Goffin
    Citation: EJNMMI Research 2021 11:41
    Content type: Original research Published on:

  8. When Alzheimer’s disease (AD) is occurring at an early onset before 65 years old, its clinical course is generally more aggressive than in the case of a late onset. We aim at identifying [ ...

    Authors: Jing Li, Emanuele Antonecchia, Marco Camerlenghi, Agostino Chiaravalloti, Qian Chu, Alfonso Di Costanzo, Zhen Li, Lin Wan, Xiangsong Zhang, Nicola D’Ascenzo, Orazio Schillaci and Qingguo Xie
    Citation: EJNMMI Research 2021 11:40
    Content type: Original research Published on:

  10. Glycolysis is increased by hypoxia, suggesting a possible correlation between the accumulation of 2-[18F]fluoro-2-deoxy-D-glucose (FDG) in malignant tumors and regional hypoxia defined by 1H-1-(3-[18F]fluoro-2-hy...

    Authors: Sadek A. Nehmeh, Mohamed B. Moussa, Nancy Lee, Pat Zanzonico, Mithat Gönen, John L. Humm and Heiko Schöder
    Citation: EJNMMI Research 2021 11:38
    Content type: Original research Published on:

  11. Our aim was to measure the impact of two cycles of standard chemotherapy on tumoural neoangiogenesis by [18F] fluorine arginine-glycine-aspartic (RGD-K5) positron emission tomography–computed tomography (PET) on ...

    Authors: David Tonnelet, M. D. Pierre Bohn, Stephanie Becker, Pierre Decazes, Vincent Camus, Sebastien Thureau, Hervé Tilly, Fabrice Jardin and Pierre Vera
    Citation: EJNMMI Research 2021 11:37
    Content type: Original research Published on:

  12. Positron Emission Tomography (PET) imaging of the Synaptic Vesicle glycoprotein (SV) 2A is a new tool to quantify synaptic density. [18F]UCB-H was one of the first promising SV2A-ligands to be labelled and used i...

    Authors: Sébastien Goutal, Martine Guillermier, Guillaume Becker, Mylène Gaudin, Yann Bramoullé, André Luxen, Christian Lemaire, Alain Plenevaux, Eric Salmon, Philippe Hantraye, Olivier Barret and Nadja Van Camp
    Citation: EJNMMI Research 2021 11:36
    Content type: Original research Published on:

  13. Previous studies found that the positron emission tomography (PET) radioligand [18F]LSN3316612 accurately quantified O-GlcNAcase in human brain using a two-tissue compartment model (2TCM). This study sought to as...

    Authors: Jae-Hoon Lee, Mattia Veronese, Jeih-San Liow, Cheryl L. Morse, Jose A. Montero Santamaria, Mohammad B. Haskali, Sami S. Zoghbi, Victor W. Pike, Robert B. Innis and Paolo Zanotti-Fregonara
    Citation: EJNMMI Research 2021 11:35
    Content type: Original research Published on:

  14. The tubarial glands (TGs) are recently reported as newly found salivary gland structures that can be organs at risk predominantly localized in the tori tubarius in the nasopharynx using prostate-specific membr...

    Authors: Yohji Matsusaka, Tomohiko Yamane, Kenji Fukushima, Akira Seto, Ichiro Matsunari and Ichiei Kuji
    Citation: EJNMMI Research 2021 11:34
    Content type: Original research Published on:

  15. The aim of this prospective study was to evaluate a data-driven gating software’s performance, in terms of identifying the respiratory signal, comparing [68Ga]Ga-DOTATOC and [18F]FDG examinations. In addition, fo...

    Authors: Jonathan Sigfridsson, Elin Lindström, Victor Iyer, Maria Holstensson, Irina Velikyan, Anders Sundin and Mark Lubberink
    Citation: EJNMMI Research 2021 11:33
    Content type: Original research Published on:

  16. Identifying the correct location of a parathyroid adenoma in patients with primary hyperparathyroidism (pHPT) is crucial as it can guide surgical treatment. This study aimed to determine the diagnostic perform...

    Authors: M. E. Noltes, S. Kruijff, L. Jansen, H. E. Westerlaan, W. T. Zandee, R. A. J. O. Dierckx and A. H. Brouwers
    Citation: EJNMMI Research 2021 11:32
    Content type: Original research Published on:

  17. The objective of the study is to define the most appropriate region for intensity normalization in brain 18FDG PET semi-quantitative analysis. The best option could be based on previous absolute quantification st...

    Authors: A. Verger, M. Doyen, J. Y. Campion and Eric Guedj
    Citation: EJNMMI Research 2021 11:31
    Content type: Short communication Published on:

  18. Atherosclerotic plaque vulnerability is comprised by plaque composition driven by inflammatory activity and these features can be depicted with 3D ultrasound and 2-[18F]FDG-PET, respectively. The study investi...

    Authors: Laerke Urbak, Rasmus S. Ripa, Benjamin V. Sandholt, Andreas Kjaer, Henrik Sillesen and Martin Graebe
    Citation: EJNMMI Research 2021 11:30
    Content type: Original research Published on:

  19. Post-transplant lymphoproliferative disorders (PTLDs) are a spectrum of hematological malignancies occurring after solid organ and hematopoietic stem cell transplantation. [18F]FDG PET/CT is routinely performed a...

    Authors: F. Montes de Jesus, D. Dierickx, V. Vergote, W. Noordzij, R. A. J. O. Dierckx, C. M. Deroose, A. W. J. M. Glaudemans, O. Gheysens and T. C. Kwee
    Citation: EJNMMI Research 2021 11:29
    Content type: Original research Published on:

  20. In women undergoing breast-conserving surgery (BCS), 20–25% require a re-operation as a result of incomplete tumour resection. An intra-operative technique to assess tumour margins accurately would be a major ...

    Authors: Patriek A. G. T. Jurrius, Maarten R. Grootendorst, Marika Krotewicz, Massimiliano Cariati, Ashutosh Kothari, Neill Patani, Paulina Karcz, Monika Nagadowska, Kunal N. Vyas, Arnie Purushotham and Maria Turska-d’Amico
    Citation: EJNMMI Research 2021 11:28
    Content type: Original research Published on:

  21. Many radioligands have been developed for the visualization of atherosclerosis by targeting inflammation. However, interpretation of in vivo signals is often limited to plaque identification. We evaluated bind...

    Authors: Eric J. Meester, Erik de Blois, Boudewijn J. Krenning, Antonius F. W. van der Steen, Jeff P. Norenberg, Kim van Gaalen, Monique R. Bernsen, Marion de Jong and Kim van der Heiden
    Citation: EJNMMI Research 2021 11:27
    Content type: Original research Published on:

  22. Expression of translocator protein (TSPO) on the outer mitochondrial membrane of activated microglia is strongly associated with neuroinflammation. The second-generation PET ligand [18F]FEPPA specifically binds T...

    Authors: Chi-Wei Chang, Chuang-Hsin Chiu, Ming-Hsien Lin, Hung-Ming Wu, Tsung-Hsun Yu, Pao-Yeh Wang, Yu-Yeh Kuo, Ya-Yao Huang, Chyng-Yann Shiue, Wen-Sheng Huang and Skye Hsin-Hsien Yeh
    Citation: EJNMMI Research 2021 11:26
    Content type: Original research Published on:

  23. Salivary glands are highly perfused and express the prostate-specific membrane antigen (PSMA) receptor as well as the sodium—iodide symporter. As a consequence, treatment with 177Lu/225Ac-PSMA for prostate cancer...

    Authors: V. Mohan, N. M. Bruin, M. E. T. Tesselaar, J. P. de Boer, E. Vegt, J. J. M. A. Hendrikx, A. Al-Mamgani, J. B. van de Kamer, J.-J. Sonke and W. V. Vogel
    Citation: EJNMMI Research 2021 11:25
    Content type: Original research Published on:

  24. The aim of this study was to evaluate the impact of the contouring methods on dose metrics and their predictive value on tumor control and survival, in both situations of pre-treatment and post-treatment dosim...

    Authors: Guillaume Nodari, Romain Popoff, Jean Marc Riedinger, Olivier Lopez, Julie Pellegrinelli, Inna Dygai-Cochet, Claire Tabouret-Viaud, Benoit Presles, Olivier Chevallier, Sophie Gehin, Matthieu Gallet, Marianne Latournerie, Sylvain Manfredi, Romaric Loffroy, Jean Marc Vrigneaud and Alexandre Cochet
    Citation: EJNMMI Research 2021 11:24
    Content type: Original research Published on:

  25. To determine which imaging method used during radioembolization (RE) work-up: contrast-enhanced computed tomography (CECT), 99mTc-MAA-SPECT/CT or cone beam-CT (CBCT), more accurately predicts the final target vol...

    Authors: Macarena Rodríguez-Fraile, Ana Ezponda, Fabiana Grisanti, Verónica Morán, Marta Calvo, Pablo Berián, Antonio Martínez de la Cuesta, Lidia Sancho, Mercedes Iñarrairaegui, Bruno Sangro and José Ignacio Bilbao
    Citation: EJNMMI Research 2021 11:23
    Content type: Original research Published on:

  26. Intraoperative identification of prostate cancer (PCa) lymph node (LN) metastases (LNM) detected by preoperative PSMA PET/CT may be facilitated by PSMA radio-guided surgery (RGS) with use of a γ-probe. Earlier...

    Authors: Michael Mix, Wolfgang Schultze-Seemann, Moritz von Büren, August Sigle, Mohamed A. Omrane, Markus T. Grabbert, Martin Werner, Christian Gratzke, Philipp T. Meyer and Cordula A. Jilg
    Citation: EJNMMI Research 2021 11:22
    Content type: Original research Published on:

  27. [68Ga]Ga-PSMA-11 PET/CT allows for a superior detection of prostate cancer tissue, especially in the context of a low tumor burden. Digital PET/CT bears the potential of reducing scan time duration/administered t...

    Authors: Manuel Weber, Walter Jentzen, Regina Hofferber, Ken Herrmann, Wolfgang Peter Fendler, Maurizio Conti, Axel Wetter, David Kersting, Christoph Rischpler and Pedro Fragoso Costa
    Citation: EJNMMI Research 2021 11:21
    Content type: Original research Published on:

  28. A major challenge to the long-term success of neuroblastoma therapy is widespread metastases that survive initial therapy as minimal residual disease (MRD). The SSTR2 receptor is expressed by most neuroblastom...

    Authors: Jason L. J. Dearling, Ellen M. van Dam, Matthew J. Harris and Alan B. Packard
    Citation: EJNMMI Research 2021 11:20
    Content type: Original research Published on:

  29. To develop and validate a machine learning model based on radiomic features derived from 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) images to preoperatively predict...

    Authors: Haiqun Xing, Zhixin Hao, Wenjia Zhu, Dehui Sun, Jie Ding, Hui Zhang, Yu Liu and Li Huo
    Citation: EJNMMI Research 2021 11:19
    Content type: Original research Published on:

  30. Small molecules targeting fibroblast activation protein (FAP) have emerged as a new group of tracers for positron emission tomography (PET) in 2018. While most of the existing literature has been focussed on t...

    Authors: Paul Windisch, Daniel R. Zwahlen, Frederik L. Giesel, Eberhard Scholz, Patrick Lugenbiel, Jürgen Debus, Uwe Haberkorn and Sebastian Adeberg
    Citation: EJNMMI Research 2021 11:18
    Content type: Review Published on:

  31. Adrenocortical carcinoma (ACC) is an uncommon malignancy with an estimated 15,400 new cases annually across the globe. The prognosis is generally poor as the disease is often already advanced at initial diagno...

    Authors: Sen Lu, Jasreman Dhillon, Julie Hallanger Johnson and Ghassan El-Haddad
    Citation: EJNMMI Research 2021 11:17
    Content type: Case report Published on:

  32. The functional 6-[18F]FDOPA positron emission tomography (PET) can be a helpful tool in differentiating parkinsonism with dopaminergic deficiency from clinically similar differential diagnoses. Furthermore, in T2...

    Authors: Enrico Michler, Daniel Kaiser, Kiriaki Eleftheriadou, Björn Falkenburger, Jörg Kotzerke and Sebastian Hoberück
    Citation: EJNMMI Research 2021 11:16
    Content type: Original research Published on:

  33. The aim of this study was to assess the reader variability in quantitatively assessing pre- and post-treatment 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography ([18F]FDG PET/CT) sc...

    Authors: Joo Hyun O, Su Jin Lim, Hao Wang, Jeffrey P. Leal, Hui-Kuo G. Shu and Richard L. Wahl
    Citation: EJNMMI Research 2021 11:15
    Content type: Original research Published on:

  34. RNA-based vaccination strategies tailoring immune response to specific reactions have become an important pillar for a broad range of applications. Recently, the use of lipid-based nanoparticles opened the pos...

    Authors: Matthias Miederer, Stefanie Pektor, Isabelle Miederer, Nicole Bausbacher, Isabell Sofia Keil, Hossam Hefesha, Heinrich Haas, Ugur Sahin and Mustafa Diken
    Citation: EJNMMI Research 2021 11:14
    Content type: Original research Published on:

  35. We investigated the potential of interim 4′-[methyl-11C]thiothymidine ([11C]4DST) PET for predicting the chemoradiotherapeutic response for head and neck squamous cell carcinoma (HNSCC), in comparison with 2-deox...

    Authors: Katsuya Mitamura, Takashi Norikane, Yuka Yamamoto, Kengo Fujimoto, Yasukage Takami, Hiroshi Hoshikawa, Jun Toyohara and Yoshihiro Nishiyama
    Citation: EJNMMI Research 2021 11:13
    Content type: Original research Published on:

  36. Both prostate-specific membrane antigen (PSMA) uptake and tumour blood flow (TBF) correlate with International Society of Urological Pathology (ISUP) Grade Group (GG) and hence prostate cancer (PCa) aggressive...

    Authors: Mads Ryø Jochumsen, Jens Sörensen, Lars Poulsen Tolbod, Bodil Ginnerup Pedersen, Jørgen Frøkiær, Michael Borre and Kirsten Bouchelouche
    Citation: EJNMMI Research 2021 11:12
    Content type: Original research Published on:

  37. Until now, results evaluating the expression of PSMA in ovarian cancer were sparse and contradictory. The aim was to reinvestigate the feasibility of a PSMA targeted theranostic approach in epithelial ovarian ...

    Authors: Nicolas Aide, Laurent Poulain, Nicolas Elie, Mélanie Briand, Florence Giffard, Cécile Blanc-Fournier, Florence Joly and Charline Lasnon
    Citation: EJNMMI Research 2021 11:11
    Content type: Short communication Published on:

  38. To improve the diagnostic accuracy of axillary lymph node (LN) metastasis in breast cancer patients using 2-[18F]FDG-PET/CT, we constructed an artificial intelligence (AI)-assisted diagnosis system that uses deep...

    Authors: Zongyao Li, Kazuhiro Kitajima, Kenji Hirata, Ren Togo, Junki Takenaka, Yasuo Miyoshi, Kohsuke Kudo, Takahiro Ogawa and Miki Haseyama
    Citation: EJNMMI Research 2021 11:10
    Content type: Original research Published on:

  39. [18F]Fluoromisonidazole ([18F]FMISO) is a PET imaging probe widely used for the detection of hypoxia. We previously reported that [18F]FMISO is metabolized to the glutathione conjugate of the reduced form in hypo...

    Authors: Yoichi Shimizu, Yukihiro Nakai, Hiroyuki Watanabe, Shimpei Iikuni, Masahiro Ono, Hideo Saji, Yuji Kuge, Tsuneo Saga and Yuji Nakamoto
    Citation: EJNMMI Research 2021 11:9
    Content type: Preliminary research Published on:

  40. The purpose of this study was to evaluate both the biodistribution and safety of 64Cu-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA)-Trastuzumab, a novel 64Cu-labeled positron emission tomography (PET) trace...

    Authors: Inki Lee, Ilhan Lim, Byung Hyun Byun, Byung Il Kim, Chang Woon Choi, Sang-Keun Woo, Kwang Il Kim, Kyo Chul Lee, Joo Hyun Kang, Min-Ki Seong, Hyun-Ah Kim, Woo Chul Noh and Sang Moo Lim
    Citation: EJNMMI Research 2021 11:8
    Content type: Original research Published on:

  41. In this descriptive study of male and female mice at different weeks of age, we use serial non-invasive cardiac 18F-FDG-PET scans to follow up on metabolic alterations, heart function parameters, and the ECG o...

    Authors: Maximilian Fischer, Mathias J. Zacherl, Tobias Weinberger, Ludwig Weckbach, Bruno Huber, Christian Schulz, Steffen Massberg, Peter Bartenstein, Sebastian Lehner and Andrei Todica
    Citation: EJNMMI Research 2021 11:7
    Content type: Original research Published on:

  43. [68 Ga]Ga-DOTATATE PET/CT is now recognised as the most sensitive functional imaging modality for the diagnosis of well-differentiated neuroendocrine tumours (NET) and can inform treatment with peptide receptor r...

    Authors: Luigi Aloj, Olivier Giger, Iosif A. Mendichovszky, Ben G. Challis, Meytar Ronel, Ines Harper, Heok Cheow, Rogier ten Hoopen, Deborah Pitfield, Ferdia A. Gallagher, Bala Attili, Mary McLean, Robin L. Jones, Palma Dileo, Venkata Ramesh Bulusu, Eamonn R. Maher…
    Citation: EJNMMI Research 2021 11:5
    Content type: Original research Published on:

  44. Positron emission tomography (PET) is routinely used for cancer staging and treatment follow-up. Metabolic active tumor volume (MATV) as well as total MATV (TMATV—including primary tumor, lymph nodes and metas...

    Authors: Elisabeth Pfaehler, Liesbet Mesotten, Gem Kramer, Michiel Thomeer, Karolien Vanhove, Johan de Jong, Peter Adriaensens, Otto S. Hoekstra and Ronald Boellaard
    Citation: EJNMMI Research 2021 11:4
    Content type: Original research Published on:

  45. Assessing the extent of disease in newly diagnosed prostate cancer (PC) patients is crucial for tailoring an appropriate treatment approach. Prostate-specific membrane antigen (PSMA)–targeted positron emission...

    Authors: Jonathan Kuten, Snir Dekalo, Ishai Mintz, Ofer Yossepowitch, Roy Mano and Einat Even-Sapir
    Citation: EJNMMI Research 2021 11:3
    Content type: Original research Published on:

  46. Identification of the dominant intraprostatic lesion(s) (DILs) can facilitate diagnosis and treatment by targeting biologically significant intra-prostatic foci. A PSMA ligand, [18F]DCFPyL (2-(3-{1-carboxy-5-[(6-...

    Authors: Dae-Myoung Yang, Fiona Li, Glenn Bauman, Joseph Chin, Stephen Pautler, Madeleine Moussa, Irina Rachinsky, John Valliant and Ting-Yim Lee
    Citation: EJNMMI Research 2021 11:2
    Content type: Original research Published on:

  47. The aim of this study was to compare a commercial dosimetry workstation (PLANET® Dose) and the dosimetry approach (GE Dosimetry Toolkit® and OLINDA/EXM® V1.0) currently used in our department for quantificatio...

    Authors: Lore Santoro, L. Pitalot, D. Trauchessec, E. Mora-Ramirez, P. O. Kotzki, M. Bardiès and E. Deshayes
    Citation: EJNMMI Research 2021 11:1
    Content type: Original research Published on:

  48. We investigated the image quality of 11C, 68Ga, 18F and 89Zr, which have different positron fractions, physical half-lifes and positron ranges. Three small animal positron emission tomography/computed tomography ...

    Authors: Jarmo Teuho, Leon Riehakainen, Aake Honkaniemi, Olli Moisio, Chunlei Han, Marko Tirri, Shihao Liu, Tove J. Grönroos, Jie Liu, Lin Wan, Xiao Liang, Yiqing Ling, Yuexuan Hua, Anne Roivainen, Juhani Knuuti, Qingguo Xie…
    Citation: EJNMMI Research 2020 10:155
    Content type: Original research Published on:

  49. 2-deoxy-2-[18F]fluoro-d-glucose’s (FDG) biodistribution limits the evaluation of cardiac sarcoidosis (CS) and neurosarcoidosis (NS). While protocols for cardiac suppression exist, they can be inconvenient for pat...

    Authors: Patrick Martineau, Matthieu Pelletier-Galarneau, Daniel Juneau, Eugene Leung, Pablo Nery, Rob deKemp, Rob Beanlands and David Birnie
    Citation: EJNMMI Research 2020 10:154
    Content type: Original research Published on:

  50. Deriving links between imaging and genomic markers is an evolving field. 2-[18F]FDG PET/CT (18F-fluorodeoxyglucose positron emission tomography–computed tomography) is commonly used for cancer imaging, with maxim...

    Authors: Amin Haghighat Jahromi, Donald A. Barkauskas, Matthew Zabel, Aaron M. Goodman, Garret Frampton, Mina Nikanjam, Carl K. Hoh and Razelle Kurzrock
    Citation: EJNMMI Research 2020 10:150
    Content type: Original research Published on:

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