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  1. The implementation of imaging technologies has dramatically increased the efficiency of preclinical studies, enabling a powerful, non-invasive and clinically translatable way for monitoring disease progression...

    Authors: Jordi L Tremoleda, Angela Kerton and Willy Gsell
    Citation: EJNMMI Research 2012 2:44
    Content type: Review Published on:

  2. We performed an initial evaluation of non-invasive ECG-gated [18 F]FDG-positron emission tomography (FDG-PET) for serial measurements of left ventricular volumes and function in murine models of dilated (DCM) and...

    Authors: Stefan Brunner, Andrei Todica, Guido Böning, Stefan G Nekolla, Moritz Wildgruber, Sebastian Lehner, Martina Sauter, Christopher Übleis, Karin Klingel, Paul Cumming, Wolfgang Michael Franz and Marcus Hacker
    Citation: EJNMMI Research 2012 2:43
    Content type: Original research Published on:

  3. Posterior lumbar interbody fusion (PLIF) is a method that allows decompression of the spinal canal and nerve roots by laminectomy combined with fusion by means of intervertebral cages filled with bone graft an...

    Authors: Boudewijn Brans, Rene Weijers, Serve Halders, Roel Wierts, Marloes Peters, Ilona Punt and Paul Willems
    Citation: EJNMMI Research 2012 2:42
    Content type: Preliminary research Published on:

  4. 18F-FDG-PET imaging has emerged as a promising method in the diagnosis of chronic osteomyelitis commonly due to Staphylococcus aureus. The inaccuracy of 18 F-FDG-PET in the detection of periprosthetic joint infe...

    Authors: Petteri Lankinen, Kaisa Lehtimäki, Antti J Hakanen, Anne Roivainen and Hannu T Aro
    Citation: EJNMMI Research 2012 2:41
    Content type: Original research Published on:

  6. Nanomedicine is emerging as a promising approach for diagnostic applications. Nanoparticles are structures in the nanometer size range, which can present different shapes, compositions, charges, surface modifi...

    Authors: AndréLuís Branco de Barros, Andrew Tsourkas, Babak Saboury, Valbert Nascimento Cardoso and Abass Alavi
    Citation: EJNMMI Research 2012 2:39
    Content type: Review Published on:

  7. This study compares the frequency and distribution of increased activity on 18 F-fluoride PET/CT with the presence of bone marrow edema on whole-body MR imaging in the spine and sacroiliac joints (SIJ) of pati...

    Authors: Dorothee R Fischer, Christian W A Pfirrmann, Veronika Zubler, Katrin D M Stumpe, Burkhardt Seifert, Klaus Strobel, Giorgio Tamborrini, Gustav K von Schulthess, Beat A Michel and Adrian Ciurea
    Citation: EJNMMI Research 2012 2:38
    Content type: Original research Published on:

  8. Dysfunction of the glycine transporter 1 (GlyT1) has been suggested to be involved in psychiatric disorders such as schizophrenia. GlyT1 inhibitors have therefore been considered to have antipsychotic therapeu...

    Authors: Takeshi Fuchigami, Akihiro Takano, Balázs Gulyás, Zhisheng Jia, Sjoerd J Finnema, Jan D Andersson, Ryuji Nakao, Yasuhiro Magata, Mamoru Haratake, Morio Nakayama and Christer Halldin
    Citation: EJNMMI Research 2012 2:37
    Content type: Original research Published on:

  9. At present, several positron emission tomography (PET) tracers are in use for imaging P-glycoprotein (P-gp) function in man. At baseline, substrate tracers such as R-[11C]verapamil display low brain concentration...

    Authors: Joost Verbeek, Jonas Eriksson, Stina Syvänen, Maaike Labots, Elizabeth C M de Lange, Rob A Voskuyl, Martinus P J Mooijer, Marissa Rongen, Adriaan A Lammertsma and Albert D Windhorst
    Citation: EJNMMI Research 2012 2:36
    Content type: Original research Published on:

  10. We recently showed improved between-subject variability in our [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) experiments using a Michaelis-Menten transport model to calculate the metabolic tumor ...

    Authors: Simon-Peter Williams, Judith E Flores-Mercado, Andreas R Baudy, Ruediger E Port and Thomas Bengtsson
    Citation: EJNMMI Research 2012 2:35
    Content type: Original research Published on:

  11. In breast cancer endocrine therapy, post-therapy Ki-67 assay of biopsy material predicts recurrence-free survival but is invasive and prone to sampling error. [18F]Fluorodeoxyglucose (FDG) positron emission tomog...

    Authors: Brenda F Kurland, Vijayakrishna K Gadi, Jennifer M Specht, Kimberly H Allison, Robert B Livingston, Eve T Rodler, Lanell M Peterson, Erin K Schubert, Xiaoyu Chai, David A Mankoff and Hannah M Linden
    Citation: EJNMMI Research 2012 2:34
    Content type: Original research Published on:

  12. Attenuation correction of a single photon emission computed tomography (SPECT) image is possible using computed tomography (CT)-based attenuation maps with hybrid SPECT/CT. CT attenuation maps acquired during ...

    Authors: Kazuhiro Koshino, Kazuhito Fukushima, Masaji Fukumoto, Kazunari Sasaki, Tetsuaki Moriguchi, Yuki Hori, Tsutomu Zeniya, Yoshihiro Nishimura, Keisuke Kiso and Hidehiro Iida
    Citation: EJNMMI Research 2012 2:33
    Content type: Original research Published on:

  13. Astatine-211 (211At) is an alpha particle emitting halogen with almost optimal linear energy transfer for creating DNA double-strand breaks and is thus proposed for radionuclide therapy when bound to tumor-seekin...

    Authors: Nils Rudqvist, Toshima Z Parris, Emil Schüler, Khalil Helou and Eva Forssell-Aronsson
    Citation: EJNMMI Research 2012 2:32
    Content type: Original research Published on:

  14. We evaluated pharmacodynamic changes in tumour perfusion using positron emission tomography (PET) imaging with 15O-water to assess biological response to sunitinib, a multitargeted tyrosine kinase inhibitor.

    Authors: Andrew M Scott, Paul L Mitchell, Graeme O'Keefe, Timothy Saunder, Rodney J Hicks, Aurora Poon, Charles Baum, Nicoletta Brega, Timothy J McCarthy and Guy C Toner
    Citation: EJNMMI Research 2012 2:31
    Content type: Original research Published on:

  15. Transcranial Doppler (TCD) CO2-reactivity and oxygen-15 positron emission tomography (PET) have both been used to measure the cerebral haemodynamic state in patients who may have a compromised blood flow. Our pur...

    Authors: Suzanne Persoon, L Jaap Kappelle, Bart N M van Berckel, Ronald Boellaard, Cyrille H Ferrier, Adriaan A Lammertsma and Catharina J M Klijn
    Citation: EJNMMI Research 2012 2:30
    Content type: Original research Published on:

  17. Currently, 68Ga-labeled 1,4,7,10-tetraazacyclododecane-tetraacetic acid (DOTA)-peptides are the most widely used class of 68Ga radiotracers for PET, although DOTA is not optimal for 68Ga complexation. More recent...

    Authors: Johannes Notni, Karolin Pohle and Hans-Jürgen Wester
    Citation: EJNMMI Research 2012 2:28
    Content type: Short communication Published on:

  18. It is important that referring physicians and other treating clinicians properly understand the final reports from diagnostic tests. The aim of the study was to investigate whether referring physicians interpr...

    Authors: Elin Trägårdh, Peter Höglund, Mattias Ohlsson, Mattias Wieloch and Lars Edenbrandt
    Citation: EJNMMI Research 2012 2:27
    Content type: Original research Published on:

  19. Noninvasive preclinical imaging methodologies such as small animal positron emission tomography (PET) allow the repeated measurement of the same subject which is generally assumed to reduce the variability of ...

    Authors: Marianne Isabelle Martic-Kehl, Simon Mensah Ametamey, Malte Frederick Alf, Pius August Schubiger and Michael Honer
    Citation: EJNMMI Research 2012 2:26
    Content type: Original research Published on:

  20. In this study, we report on the synthesis, radiolabeling, and biological evaluation of two new somatostatin-14 (SS14) analogs, modified with the universal chelator DOTA. We were interested to investigate if an...

    Authors: Aikaterini Tatsi, Theodosia Maina, Renzo Cescato, Beatrice Waser, Eric P Krenning, Marion de Jong, Paul Cordopatis, Jean Claude Reubi and Berthold A Nock
    Citation: EJNMMI Research 2012 2:25
    Content type: Original research Published on:

  21. Radiolabelled bombesin (BN) conjugates are promising radiotracers for imaging and therapy of breast and prostate tumours, in which BN2/gastrin-releasing peptide receptors are overexpressed. We describe the influe...

    Authors: Simone Däpp, Cristina Müller, Elisa García Garayoa, Peter Bläuenstein, Veronique Maes, Luc Brans, Dirk A Tourwé and Roger Schibli
    Citation: EJNMMI Research 2012 2:24
    Content type: Original research Published on:

  22. Alternative positron-emission tomography (PET) probes like labeled inhibitors of the prostate-specific membrane antigen (PSMA) are of emerging clinical impact as they show the ability to image small lesions of...

    Authors: Martin Schäfer, Ulrike Bauder-Wüst, Karin Leotta, Frederic Zoller, Walter Mier, Uwe Haberkorn, Michael Eisenhut and Matthias Eder
    Citation: EJNMMI Research 2012 2:23
    Content type: Original research Published on:

  23. The BRAF inhibitor, vemurafenib, has recently been approved for the treatment of metastatic melanoma in patients harboring BRAFV600 mutations. Currently, dual BRAF and MEK inhibition are ongoing in clinical trial...

    Authors: Andreas R Baudy, Taner Dogan, Judith E Flores-Mercado, Klaus P Hoeflich, Fei Su, Nicholas van Bruggen and Simon-Peter Williams
    Citation: EJNMMI Research 2012 2:22
    Content type: Original research Published on:

  24. The “back-translation” of clinically available protocols to measure myocardial perfusion to preclinical imaging in mouse models of human disease is attractive for basic biomedical research. With respect to sin...

    Authors: Alexis Vrachimis, Sven Hermann, Domokos Máthé, Otmar Schober and Michael Schäfers
    Citation: EJNMMI Research 2012 2:21
    Content type: Original research Published on:

  25. Anemia is usually not taken into account in internal radiotherapy. We investigated whether the hemoglobin (Hb) level could have an impact on the tumor response, as observed in external beam radiotherapy (EBRT).

    Authors: Stephan Walrand, Renaud Lhommel, Pierre Goffette, Marc Van den Eynde, Stanislas Pauwels and FranÇois Jamar
    Citation: EJNMMI Research 2012 2:20
    Content type: Original research Published on:

  26. Bimodal molecular imaging with fluorescence diffuse optical tomography (fDOT) and positron emission tomography (PET) has the capacity to provide multiple molecular information of mouse tumors. The objective of...

    Authors: Xiao Tong, Anikitos Garofalakis, Albertine Dubois, Raphaël Boisgard, Frédéric Ducongé, Régine Trébossen and Bertrand Tavitian
    Citation: EJNMMI Research 2012 2:19
    Content type: Original research Published on:

  29. As is well known, limited spatial resolution leads to partial volume effects (PVE) and consequently to limited signal recovery. Determination of the mean activity concentration of a target structure is thus co...

    Authors: Frank Hofheinz, Jens Langner, Jan Petr, Bettina Beuthien-Baumann, Liane Oehme, Jörg Steinbach, Jörg Kotzerke and Jörg van den Hoff
    Citation: EJNMMI Research 2012 2:16
    Content type: Original research Published on:

  30. Positron-emission tomography and the radioligand [11C](R)-PK11195 have been used for the imaging of the translocator protein (TSPO) and applied to map microglia cells in the brain in neuropsychiatric disorders. [

    Authors: Aurelija Jučaite, Zsolt Cselényi, Annie Arvidsson, Gabrielle Åhlberg, Per Julin, Katarina Varnäs, Per Stenkrona, Jan Andersson, Christer Halldin and Lars Farde
    Citation: EJNMMI Research 2012 2:15
    Content type: Original research Published on:

  31. Tumor targeting is of high clinical and biological relevance, and major efforts have been made to develop molecular imaging technologies for visualization of the disease markers in tissue. Of particular intere...

    Authors: Andreas Buehler, Eva Herzog, Angelica Ale, Bradley D Smith, Vasilis Ntziachristos and Daniel Razansky
    Citation: EJNMMI Research 2012 2:14
    Content type: Preliminary research Published on:

  32. Bisphosphonates possess strong affinity to bone. 99mTc bisphosphonate complexes are widely used for bone scintigraphy. For positron emission tomography (PET) bone imaging, Ga-68-based PET tracers based on bisphos...

    Authors: Johannes Notni, Jan Plutnar and Hans-Jürgen Wester
    Citation: EJNMMI Research 2012 2:13
    Content type: Short communication Published on:

  33. [11C]Flumazenil and positron emission tomography (PET) are used clinically to assess gamma-aminobutyric acid (GABA)-ergic function and to localize epileptic foci prior to resective surgery. Enhanced P-glycoprotei...

    Authors: Femke E Froklage, Stina Syvänen, N Harry Hendrikse, Marc C Huisman, Carla FM Molthoff, Yoshihiko Tagawa, Jaap C Reijneveld, Jan J Heimans, Adriaan A Lammertsma, Jonas Eriksson, Elizabeth CM de Lange and Rob A Voskuyl
    Citation: EJNMMI Research 2012 2:12
    Content type: Original research Published on:

  34. Quantification of kinetic parameters of positron emission tomography (PET) imaging agents normally requires collecting arterial blood samples which is inconvenient for patients and difficult to implement in ro...

    Authors: Kaiyumars B Contractor, Laura M Kenny, Charles R Coombes, Federico E Turkheimer, Eric O Aboagye and Lula Rosso
    Citation: EJNMMI Research 2012 2:11
    Content type: Original research Published on:

  35. [18F]fluoro-2-deoxy-D-glucose ([18F]FDG) positron emission tomography (PET) is a valuable tool for monitoring response to therapy in oncology. In longitudinal studies, however, patients are not scanned in exactly...

    Authors: Floris HP van Velden, Paul van Beers, Johan Nuyts, Linda M Velasquez, Wendy Hayes, Adriaan A Lammertsma, Ronald Boellaard and Dirk Loeckx
    Citation: EJNMMI Research 2012 2:10
    Content type: Original research Published on:

  36. The F3 peptide (KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK), a fragment of the human high mobility group protein 2, binds nucleolin. Nucleolin is expressed in the nuclei of normal cells but is also expressed on the membr...

    Authors: Bart Cornelissen, Andrew Waller, Carol Target, Veerle Kersemans, Sean Smart and Katherine A Vallis
    Citation: EJNMMI Research 2012 2:9
    Content type: Original research Published on:

  37. Gastrin-releasing peptide receptors [GRPR] are highly over-expressed in multiple cancers and have been studied as a diagnostic target. Multimeric gastrin-releasing peptides are expected to have enhanced tumor ...

    Authors: Patrick Fournier, Véronique Dumulon-Perreault, Samia Ait-Mohand, Réjean Langlois, François Bénard, Roger Lecomte and Brigitte Guérin
    Citation: EJNMMI Research 2012 2:8
    Content type: Original research Published on:

  38. Noninvasive multimodality imaging is essential for preclinical evaluation of the biodistribution and pharmacokinetics of radionuclide therapy and for monitoring tumor response. Imaging with nonstandard positro...

    Authors: Nadège Anizan, Thomas Carlier, Cecilia Hindorf, Jacques Barbet and Manuel Bardiès
    Citation: EJNMMI Research 2012 2:7
    Content type: Original research Published on:

  39. A retrospective analysis of estimates of tumor glucose uptake from 1,192 dynamic 2-deoxy-2-(18F)fluoro-D-glucose-positron-emission tomography [ FDG-PET] scans showed strong correlations between blood glucose and ...

    Authors: Simon-Peter Williams, Judith E Flores-Mercado, Ruediger E Port and Thomas Bengtsson
    Citation: EJNMMI Research 2012 2:6
    Content type: Original research Published on:

  40. In this study, pretargeted immuno-positron-emission tomography [PET] with a bispecific monoclonal anti-carcinoembryonic antigen [CEA] (CEACAM5) × anti-hapten antibody (bispecific monoclonal antibody [bsmAb]) a...

    Authors: Rafke Schoffelen, Winette TA van der Graaf, Robert M Sharkey, Gerben M Franssen, William J McBride, Chien-Hsing Chang, Peter Laverman, David M Goldenberg, Wim JG Oyen and Otto C Boerman
    Citation: EJNMMI Research 2012 2:5
    Content type: Original research Published on:

  41. In single photon emission computed tomography [SPECT], high specific activity of 111In-labelled tracers will allow administration of low amounts of tracer to prevent receptor saturation and/or side effects. To in...

    Authors: Maarten Brom, Lieke Joosten, Wim JG Oyen, Martin Gotthardt and Otto C Boerman
    Citation: EJNMMI Research 2012 2:4
    Content type: Original research Published on:

  42. We present the electrophilic synthesis of [18F]2β-carbomethoxy-3β-(4-fluoro)tropane [[18F]CFT] and the pharmacological specificity and selectivity of [18F]CFT for monoamine transporters in the brain and periphera...

    Authors: Sarita Forsback, Päivi Marjamäki, Olli Eskola, Jörgen Bergman, Johanna Rokka, Tove Grönroos, Merja Haaparanta and Olof Solin
    Citation: EJNMMI Research 2012 2:3
    Content type: Original research Published on:

  43. Experimental models are essential tools in the development and evaluation of novel treatment options, but the preclinical model of renal ischemia-reperfusion injury is limited to the retrieval of (very) early ...

    Authors: Tanja Herrler, Hao Wang, Anne Tischer, Peter Bartenstein, Karl-Walter Jauch, Markus Guba, Markus Diemling, Cyril Nimmon and Marcus Hacker
    Citation: EJNMMI Research 2012 2:2
    Content type: Original research Published on:

  44. P-glycoprotein [Pgp] dysfunction may be involved in neurodegenerative diseases, such as Alzheimer's disease, and in drug resistant epilepsy. Positron emission tomography using the Pgp substrate tracer (R)-[11C]ve...

    Authors: Daniëlle ME van Assema, Mark Lubberink, Ronald Boellaard, Robert C Schuit, Albert D Windhorst, Philip Scheltens, Bart NM van Berckel and Adriaan A Lammertsma
    Citation: EJNMMI Research 2012 2:1
    Content type: Original research Published on:

  45. Obesity is a result of a relative excess in energy intake over energy expenditure. These processes are controlled by genetic, environmental, psychological and biological factors. One of the factors involved in...

    Authors: Barbara A de Weijer, Elsmarieke van de Giessen, Thérèse A van Amelsvoort, Erik Boot, Breg Braak, Ignace M Janssen, Arnold van de Laar, Eric Fliers, Mireille J Serlie and Jan Booij
    Citation: EJNMMI Research 2011 1:37
    Content type: Short communication Published on:

  47. Metabolic tumor volume assessment using positron-emission tomography [PET] may be of interest for both target volume definition in radiotherapy and monitoring response to therapy. It has been reported, however...

    Authors: Patsuree Cheebsumon, Floris HP van Velden, Maqsood Yaqub, Corneline J Hoekstra, Linda M Velasquez, Wendy Hayes, Otto S Hoekstra, Adriaan A Lammertsma and Ronald Boellaard
    Citation: EJNMMI Research 2011 1:35
    Content type: Original research Published on:

  48. Receptor scintigraphy gains more interest for diagnosis and treatment of tumors, in particular for neuroendocrine tumors (NET). We used a pan-Bombesin analog, the peptide DOTA-PEG2-[D-tyr6, β-Ala11, Thi13, Nle14]...

    Authors: Caixia Cheng, Leyun Pan, Antonia Dimitrakopoulou-Strauss, Martin Schäfer, Carmen Wängler, Björn Wängler, Uwe Haberkorn and Ludwig G Strauss
    Citation: EJNMMI Research 2011 1:34
    Content type: Original research Published on:

  49. Fluorine-18 dihydrotetrabenazine [DTBZ] analogues, which selectively target the vesicular monoamine transporter 2 [VMAT2], have been extensively studied for in vivo quantification of beta cell mass by positron-em...

    Authors: Mahabuba Jahan, Olof Eriksson, Peter Johnström, Olle Korsgren, Anders Sundin, Lars Johansson and Christer Halldin
    Citation: EJNMMI Research 2011 1:33
    Content type: Original research Published on:

  50. The purpose of the study is to evaluate whether a pinhole collimator is better adapted to bremsstrahlung single photon emission computed tomography [SPECT] than parallel-hole collimators and in the affirmative, t...

    Authors: Stephan Walrand, Michel Hesse, Georges Demonceau, Stanislas Pauwels and François Jamar
    Citation: EJNMMI Research 2011 1:32
    Content type: Original research Published on:
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