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  1. Content type: Original research

    Anemia is usually not taken into account in internal radiotherapy. We investigated whether the hemoglobin (Hb) level could have an impact on the tumor response, as observed in external beam radiotherapy (EBRT).

    Authors: Stephan Walrand, Renaud Lhommel, Pierre Goffette, Marc Van den Eynde, Stanislas Pauwels and FranÇois Jamar

    Citation: EJNMMI Research 2012 2:20

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  2. Content type: Original research

    Bimodal molecular imaging with fluorescence diffuse optical tomography (fDOT) and positron emission tomography (PET) has the capacity to provide multiple molecular information of mouse tumors. The objective of...

    Authors: Xiao Tong, Anikitos Garofalakis, Albertine Dubois, Raphaël Boisgard, Frédéric Ducongé, Régine Trébossen and Bertrand Tavitian

    Citation: EJNMMI Research 2012 2:19

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  3. Content type: Original research

    As is well known, limited spatial resolution leads to partial volume effects (PVE) and consequently to limited signal recovery. Determination of the mean activity concentration of a target structure is thus co...

    Authors: Frank Hofheinz, Jens Langner, Jan Petr, Bettina Beuthien-Baumann, Liane Oehme, Jörg Steinbach, Jörg Kotzerke and Jörg van den Hoff

    Citation: EJNMMI Research 2012 2:16

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  4. Content type: Original research

    Positron-emission tomography and the radioligand [11C](R)-PK11195 have been used for the imaging of the translocator protein (TSPO) and applied to map microglia cells in the brain in neuropsychiatric disorders. [

    Authors: Aurelija Jučaite, Zsolt Cselényi, Annie Arvidsson, Gabrielle Åhlberg, Per Julin, Katarina Varnäs, Per Stenkrona, Jan Andersson, Christer Halldin and Lars Farde

    Citation: EJNMMI Research 2012 2:15

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  5. Content type: Preliminary research

    Tumor targeting is of high clinical and biological relevance, and major efforts have been made to develop molecular imaging technologies for visualization of the disease markers in tissue. Of particular intere...

    Authors: Andreas Buehler, Eva Herzog, Angelica Ale, Bradley D Smith, Vasilis Ntziachristos and Daniel Razansky

    Citation: EJNMMI Research 2012 2:14

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  6. Content type: Short communication

    Bisphosphonates possess strong affinity to bone. 99mTc bisphosphonate complexes are widely used for bone scintigraphy. For positron emission tomography (PET) bone imaging, Ga-68-based PET tracers based on bisphos...

    Authors: Johannes Notni, Jan Plutnar and Hans-Jürgen Wester

    Citation: EJNMMI Research 2012 2:13

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  7. Content type: Original research

    [11C]Flumazenil and positron emission tomography (PET) are used clinically to assess gamma-aminobutyric acid (GABA)-ergic function and to localize epileptic foci prior to resective surgery. Enhanced P-glycoprotei...

    Authors: Femke E Froklage, Stina Syvänen, N Harry Hendrikse, Marc C Huisman, Carla FM Molthoff, Yoshihiko Tagawa, Jaap C Reijneveld, Jan J Heimans, Adriaan A Lammertsma, Jonas Eriksson, Elizabeth CM de Lange and Rob A Voskuyl

    Citation: EJNMMI Research 2012 2:12

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  8. Content type: Original research

    Quantification of kinetic parameters of positron emission tomography (PET) imaging agents normally requires collecting arterial blood samples which is inconvenient for patients and difficult to implement in ro...

    Authors: Kaiyumars B Contractor, Laura M Kenny, Charles R Coombes, Federico E Turkheimer, Eric O Aboagye and Lula Rosso

    Citation: EJNMMI Research 2012 2:11

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  9. Content type: Original research

    [18F]fluoro-2-deoxy-D-glucose ([18F]FDG) positron emission tomography (PET) is a valuable tool for monitoring response to therapy in oncology. In longitudinal studies, however, patients are not scanned in exactly...

    Authors: Floris HP van Velden, Paul van Beers, Johan Nuyts, Linda M Velasquez, Wendy Hayes, Adriaan A Lammertsma, Ronald Boellaard and Dirk Loeckx

    Citation: EJNMMI Research 2012 2:10

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  10. Content type: Original research

    The F3 peptide (KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK), a fragment of the human high mobility group protein 2, binds nucleolin. Nucleolin is expressed in the nuclei of normal cells but is also expressed on the membr...

    Authors: Bart Cornelissen, Andrew Waller, Carol Target, Veerle Kersemans, Sean Smart and Katherine A Vallis

    Citation: EJNMMI Research 2012 2:9

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  11. Content type: Original research

    Gastrin-releasing peptide receptors [GRPR] are highly over-expressed in multiple cancers and have been studied as a diagnostic target. Multimeric gastrin-releasing peptides are expected to have enhanced tumor ...

    Authors: Patrick Fournier, Véronique Dumulon-Perreault, Samia Ait-Mohand, Réjean Langlois, François Bénard, Roger Lecomte and Brigitte Guérin

    Citation: EJNMMI Research 2012 2:8

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  12. Content type: Original research

    Noninvasive multimodality imaging is essential for preclinical evaluation of the biodistribution and pharmacokinetics of radionuclide therapy and for monitoring tumor response. Imaging with nonstandard positro...

    Authors: Nadège Anizan, Thomas Carlier, Cecilia Hindorf, Jacques Barbet and Manuel Bardiès

    Citation: EJNMMI Research 2012 2:7

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  13. Content type: Original research

    A retrospective analysis of estimates of tumor glucose uptake from 1,192 dynamic 2-deoxy-2-(18F)fluoro-D-glucose-positron-emission tomography [ FDG-PET] scans showed strong correlations between blood glucose and ...

    Authors: Simon-Peter Williams, Judith E Flores-Mercado, Ruediger E Port and Thomas Bengtsson

    Citation: EJNMMI Research 2012 2:6

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  14. Content type: Original research

    In this study, pretargeted immuno-positron-emission tomography [PET] with a bispecific monoclonal anti-carcinoembryonic antigen [CEA] (CEACAM5) × anti-hapten antibody (bispecific monoclonal antibody [bsmAb]) a...

    Authors: Rafke Schoffelen, Winette TA van der Graaf, Robert M Sharkey, Gerben M Franssen, William J McBride, Chien-Hsing Chang, Peter Laverman, David M Goldenberg, Wim JG Oyen and Otto C Boerman

    Citation: EJNMMI Research 2012 2:5

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  15. Content type: Original research

    In single photon emission computed tomography [SPECT], high specific activity of 111In-labelled tracers will allow administration of low amounts of tracer to prevent receptor saturation and/or side effects. To in...

    Authors: Maarten Brom, Lieke Joosten, Wim JG Oyen, Martin Gotthardt and Otto C Boerman

    Citation: EJNMMI Research 2012 2:4

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  16. Content type: Original research

    We present the electrophilic synthesis of [18F]2β-carbomethoxy-3β-(4-fluoro)tropane [[18F]CFT] and the pharmacological specificity and selectivity of [18F]CFT for monoamine transporters in the brain and periphera...

    Authors: Sarita Forsback, Päivi Marjamäki, Olli Eskola, Jörgen Bergman, Johanna Rokka, Tove Grönroos, Merja Haaparanta and Olof Solin

    Citation: EJNMMI Research 2012 2:3

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  17. Content type: Original research

    Experimental models are essential tools in the development and evaluation of novel treatment options, but the preclinical model of renal ischemia-reperfusion injury is limited to the retrieval of (very) early ...

    Authors: Tanja Herrler, Hao Wang, Anne Tischer, Peter Bartenstein, Karl-Walter Jauch, Markus Guba, Markus Diemling, Cyril Nimmon and Marcus Hacker

    Citation: EJNMMI Research 2012 2:2

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  18. Content type: Original research

    P-glycoprotein [Pgp] dysfunction may be involved in neurodegenerative diseases, such as Alzheimer's disease, and in drug resistant epilepsy. Positron emission tomography using the Pgp substrate tracer (R)-[11C]ve...

    Authors: Daniëlle ME van Assema, Mark Lubberink, Ronald Boellaard, Robert C Schuit, Albert D Windhorst, Philip Scheltens, Bart NM van Berckel and Adriaan A Lammertsma

    Citation: EJNMMI Research 2012 2:1

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  19. Content type: Short communication

    Obesity is a result of a relative excess in energy intake over energy expenditure. These processes are controlled by genetic, environmental, psychological and biological factors. One of the factors involved in...

    Authors: Barbara A de Weijer, Elsmarieke van de Giessen, Thérèse A van Amelsvoort, Erik Boot, Breg Braak, Ignace M Janssen, Arnold van de Laar, Eric Fliers, Mireille J Serlie and Jan Booij

    Citation: EJNMMI Research 2011 1:37

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  20. Content type: Original research

    Metabolic tumor volume assessment using positron-emission tomography [PET] may be of interest for both target volume definition in radiotherapy and monitoring response to therapy. It has been reported, however...

    Authors: Patsuree Cheebsumon, Floris HP van Velden, Maqsood Yaqub, Corneline J Hoekstra, Linda M Velasquez, Wendy Hayes, Otto S Hoekstra, Adriaan A Lammertsma and Ronald Boellaard

    Citation: EJNMMI Research 2011 1:35

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  21. Content type: Original research

    Receptor scintigraphy gains more interest for diagnosis and treatment of tumors, in particular for neuroendocrine tumors (NET). We used a pan-Bombesin analog, the peptide DOTA-PEG2-[D-tyr6, β-Ala11, Thi13, Nle14]...

    Authors: Caixia Cheng, Leyun Pan, Antonia Dimitrakopoulou-Strauss, Martin Schäfer, Carmen Wängler, Björn Wängler, Uwe Haberkorn and Ludwig G Strauss

    Citation: EJNMMI Research 2011 1:34

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  22. Content type: Original research

    Fluorine-18 dihydrotetrabenazine [DTBZ] analogues, which selectively target the vesicular monoamine transporter 2 [VMAT2], have been extensively studied for in vivo quantification of beta cell mass by positron-em...

    Authors: Mahabuba Jahan, Olof Eriksson, Peter Johnström, Olle Korsgren, Anders Sundin, Lars Johansson and Christer Halldin

    Citation: EJNMMI Research 2011 1:33

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  23. Content type: Original research

    The purpose of the study is to evaluate whether a pinhole collimator is better adapted to bremsstrahlung single photon emission computed tomography [SPECT] than parallel-hole collimators and in the affirmative, t...

    Authors: Stephan Walrand, Michel Hesse, Georges Demonceau, Stanislas Pauwels and François Jamar

    Citation: EJNMMI Research 2011 1:32

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  24. Content type: Original research

    Photoimmunodetection, in which monoclonal antibodies [mAbs] are labeled with fluorescent dyes, might have clinical potential for early detection and characterization of cancer. For this purpose, the dye should...

    Authors: Ruth Cohen, Marieke A Stammes, Inge HC de Roos, Marijke Stigter-van Walsum, Gerard WM Visser and Guus AMS van Dongen

    Citation: EJNMMI Research 2011 1:31

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  25. Content type: Original research

    Brown adipose tissue [BAT] metabolism in vivo is vital for the development of novel strategies in combating obesity and diabetes. Currently, BAT is activated at low temperatures and measured using 2-deoxy-2-18F-f...

    Authors: M Reza Mirbolooki, Cristian C Constantinescu, Min-Liang Pan and Jogeshwar Mukherjee

    Citation: EJNMMI Research 2011 1:30

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  26. Content type: Original research

    Regional cerebral blood flow [rCBF] measurements are valuable for identifying angiogenically active tumours, and perfusion computed tomography [CT] has been suggested for that purpose. This study aimed to vali...

    Authors: Julie Marie Grüner, Rune Paamand, Liselotte Højgaard and Ian Law

    Citation: EJNMMI Research 2011 1:28

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  27. Content type: Original research

    Paraoxonase 1 [PON1] is recognized as a protective enzyme against LDL oxidation, and PON1 polymorphism has been described as a factor influencing coronary heart disease [CHD] free survival. As coronary vasorea...

    Authors: Vincent Dunet, Juan Ruiz, Gilles Allenbach, Paola Izzo, Richard W James and John O Prior

    Citation: EJNMMI Research 2011 1:27

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  28. Content type: Original research

    Molecular apoptosis imaging is frequently discussed to be useful for monitoring cancer therapy. We demonstrate that the sole assessment of therapy effects by apoptosis imaging can be misleading, depending on t...

    Authors: Wiltrud Lederle, Susanne Arns, Anne Rix, Felix Gremse, Dennis Doleschel, Jörn Schmaljohann, Felix M Mottaghy, Fabian Kiessling and Moritz Palmowski

    Citation: EJNMMI Research 2011 1:26

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  29. Content type: Original research

    We evaluated the utility of L-3,4-dihydroxy-6-[18F]fluoro-phenylalanine ([18F]FDOPA) positron emission tomography (PET) as a method for assessing the severity of dopaminergic dysfunction in unilaterally 6-hydroxy...

    Authors: Kiyoshi Kyono, Tadayuki Takashima, Yumiko Katayama, Toshiyuki Kawasaki, Riyo Zochi, Maki Gouda, Yasuhiro Kuwahara, Kazuhiro Takahashi, Yasuhiro Wada, Hirotaka Onoe and Yasuyoshi Watanabe

    Citation: EJNMMI Research 2011 1:25

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  30. Content type: Original research

    Sensitive antibody-based tumor targeting has the potential not only to image metastatic and micrometastatic disease, but also to be the basis of targeted therapy. The vast majority of pancreas cancers express ...

    Authors: Mark D Girgis, Tove Olafsen, Vania Kenanova, Katelyn E McCabe, Anna M Wu and James S Tomlinson

    Citation: EJNMMI Research 2011 1:24

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  31. Content type: Original research

    To achieve an acceptable signal-to-noise ratio (SNR) in PET images, smoothing filters (SF) are usually employed during or after image reconstruction preventing utilisation of the full intrinsic resolution of t...

    Authors: Frank Hofheinz, Jens Langner, Bettina Beuthien-Baumann, Liane Oehme, Jörg Steinbach, Jörg Kotzerke and Jörg van den Hoff

    Citation: EJNMMI Research 2011 1:23

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  32. Content type: Original research

    The aim of this study was to compare the diagnostic performance of the three software packages 4DMSPECT (4DM), Emory Cardiac Toolbox (ECTb), and Cedars Quantitative Perfusion SPECT (QPS) for quantification of ...

    Authors: Lena Johansson, Milan Lomsky, Jens Marving, Mattias Ohlsson, Sven-Eric Svensson and Lars Edenbrandt

    Citation: EJNMMI Research 2011 1:22

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  33. Content type: Original research

    Several peptide hormone receptors were identified that are specifically over-expressed on the cell surface of certain human tumors. For example, high incidence and density of the Y1 subtype of neuropeptide Y (NPY...

    Authors: David Chatenet, Renzo Cescato, Beatrice Waser, Judit Erchegyi, Jean E Rivier and Jean Claude Reubi

    Citation: EJNMMI Research 2011 1:21

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  34. Content type: Original research

    Overexpression of syndecan-1 (CD138) in breast carcinoma correlates with a poor prognosis and an aggressive phenotype. The objective of this study was to evaluate the potential of targeting CD138 by immuno-PET...

    Authors: Caroline Rousseau, Anne Lise Ruellan, Karine Bernardeau, Françoise Kraeber-Bodéré, Sebastien Gouard, Delphine Loussouarn, Catherine Saï-Maurel, Alain Faivre-Chauvet, John Wijdenes, Jacques Barbet, Joëlle Gaschet, Michel Chérel and François Davodeau

    Citation: EJNMMI Research 2011 1:20

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  35. Content type: Original research

    Small-cell lung carcinoma (SCLC) is an aggressive malignancy characterised by an early relapse, a tendency towards drug resistance, and a high incidence of metastasis. SCLC cells are of neuroendocrine origin a...

    Authors: Ann Erlandsson, Eva Forssell-Aronsson, Tomas Seidal and Peter Bernhardt

    Citation: EJNMMI Research 2011 1:19

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  36. Content type: Original research

    The aim of the present study was to explore the biodistribution, normal tissue toxicity, and therapeutic efficacy of the internalizing low-dose rate alpha-particle-emitting radioimmunoconjugate 227Th-trastuzumab ...

    Authors: Nasir Abbas, Helen Heyerdahl, Øyvind S Bruland, Jørgen Borrebæk, Jahn Nesland and Jostein Dahle

    Citation: EJNMMI Research 2011 1:18

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  37. Content type: Review

    Nuclear medicine has become a key part of molecular imaging. In the present review article, we focus on the transbilayer phospholipids as exquisite targets for radiolabelled probes in molecular imaging. Asymme...

    Authors: Tarik Z Belhocine and Frank S Prato

    Citation: EJNMMI Research 2011 1:17

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  38. Content type: Original research

    We propose a new methodology, reference Standardised Uptake Value (SUVref), for reducing the quantitative variation resulting from differences in reconstruction protocol. Such variation that is not directly addre...

    Authors: Matthew D Kelly and Jerome M Declerck

    Citation: EJNMMI Research 2011 1:16

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  39. Content type: Original research

    Our objective was to compare 111In- or 64Cu-DOTA-trastuzumab Fab fragments for imaging small or large s.c. tumor xenografts in athymic mice that display a wide range of human epidermal growth factor receptor-2 (H...

    Authors: Conrad Chan, Deborah A Scollard, Kristin McLarty, Serena Smith and Raymond M Reilly

    Citation: EJNMMI Research 2011 1:15

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  40. Content type: Original research

    Atherosclerosis is a chronic inflammatory disease of artery wall characterized by infiltration of monocytes into subendothelial space and their differentiation into macrophages. Since rupture-prone plaques com...

    Authors: Johanna MU Silvola, Iina Laitinen, Henri J Sipilä, V Jukka O Laine, Pia Leppänen, Seppo Ylä-Herttuala, Juhani Knuuti and Anne Roivainen

    Citation: EJNMMI Research 2011 1:14

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  41. Content type: Original research

    Kinetic modeling of physiological function using imaging techniques requires the accurate measurement of the time-activity curve of the tracer in plasma, known as the arterial input function (IF). The measurem...

    Authors: Geoff Warnock, Mohamed-Ali Bahri, David Goblet, Fabrice Giacomelli, Christian Lemaire, Joel Aerts, Alain Seret, Xavier Langlois, Andre Luxen and Alain Plenevaux

    Citation: EJNMMI Research 2011 1:13

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  42. Content type: Preliminary research

    The objective of this study is the implementation of a kinetic model for 11C-desmethylloperamide (11C-dLop) and the determination of a typical parameter for P-glycoprotein (P-gp) functionality in mice. Since arte...

    Authors: Lieselotte Moerman, Dieter De Naeyer, Paul Boon and Filip De Vos

    Citation: EJNMMI Research 2011 1:12

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  43. Content type: Review

    Preclinical models for musculoskeletal disorders are critical for understanding the pathogenesis of bone and joint disorders in humans and the development of effective therapies. The assessment of these models...

    Authors: Jordi L Tremoleda, Magdy Khalil, Luke L Gompels, Marzena Wylezinska-Arridge, Tonia Vincent and Willy Gsell

    Citation: EJNMMI Research 2011 1:11

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  44. Content type: Original research

    Vascular adhesion protein-1 (VAP-1) is an adhesion molecule that plays a key role in recruiting leucocytes into sites of inflammation. We have previously shown that 68Gallium-labelled VAP-1-targeting peptide (68G...

    Authors: Anu Autio, Tiina Henttinen, Henri J Sipilä, Sirpa Jalkanen and Anne Roivainen

    Citation: EJNMMI Research 2011 1:10

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  45. Content type: Review

    The classical attitude of Nuclear Medicine practitioners on matters of peptide-receptor interactions has maintained an intrinsic monogamic character since many years. New advances in the field of biochemistry ...

    Authors: Roy Moncayo

    Citation: EJNMMI Research 2011 1:9

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  46. Content type: Original research

    We evaluated the effect of insulin stimulation and dietary changes on myocardial, skeletal muscle and brain [18F]-fluorodeoxyglucose (FDG) kinetics and uptake in vivo in intact mice.

    Authors: Michael C Kreissl, David B Stout, Koon-Pong Wong, Hsiao-Ming Wu, Evren Caglayan, Waldemar Ladno, Xiaoli Zhang, John O Prior, Christoph Reiners, Sung-Cheng Huang and Heinrich R Schelbert

    Citation: EJNMMI Research 2011 1:8

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