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  1. The ability of recombinant antibodies to adequately penetrate into tumours is a key factor in achieving therapeutic effect; however, the behaviour of antibodies at a cellular level in tumours is poorly underst...

    Authors: Marika Ciprotti, Geoffrey Chong, Hui K Gan, Anthony Chan, Carmel Murone, Duncan MacGregor, Fook-Thean Lee, Terrance G Johns, Joan K Heath, Matthias Ernst, Antony W Burgess and Andrew M Scott

    Citation: EJNMMI Research 2014 4:22

    Content type: Original research

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  2. Previously, we reported on the unexpected development of distant metastases in the subcutaneous rat pancreas CA20948 tumor model after 4.5 weeks of treatment with RAD001-only or in combination with [177Lu-DOTA0,T...

    Authors: Sander M Bison, Stefan E Pool, Stuart J Koelewijn, Linda M van der Graaf, Harald C Groen, Marleen Melis and Marion de Jong

    Citation: EJNMMI Research 2014 4:21

    Content type: Original research

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  3. The utility of 18 F-FDG and 11C-PBR28 to identify aortic wall inflammation associated with abdominal aortic aneurysm (AAA) development was assessed.

    Authors: Sean J English, Jose A Diaz, Xia Shao, David Gordon, Melissa Bevard, Gang Su, Peter K Henke, Virginia E Rogers, Gilbert R Upchurch and Morand Piert

    Citation: EJNMMI Research 2014 4:20

    Content type: Original Research

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  4. This study was designed to explore the feasibility of replacing the conventional peri-/intratumoural ultrasound (US)-guided technetium-99m albumin nanocolloid (99mTc-nanocolloid) administration by an injection of...

    Authors: Bas Pouw, Linda J de Wit-van der Veen, Daan Hellingman, Oscar R Brouwer, Marie-Jeanne TFD Vrancken Peeters, Marcel PM Stokkel and Renato A Valdés Olmos

    Citation: EJNMMI Research 2014 4:19

    Content type: Original research

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  5. Standard uptake values (SUV) as well as tumor-to-blood standard uptake ratios (SUR) measured with [ 18F-]fluorodeoxyglucose (FDG) PET are time dependent. This poses a serious problem for reliable quantification s...

    Authors: Jörg van den Hoff, Alexandr Lougovski, Georg Schramm, Jens Maus, Liane Oehme, Jan Petr, Bettina Beuthien-Baumann, Jörg Kotzerke and Frank Hofheinz

    Citation: EJNMMI Research 2014 4:18

    Content type: Original research

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  6. Vascular endothelial growth factor receptor 2 (VEGFR2) is a crucial mediator of tumour angiogenesis. High expression levels of the receptor have been correlated to poor prognosis in cancer patients. Reliable i...

    Authors: Erik Samén, Li Lu, Jan Mulder, Jan-Olov Thorell, Peter Damberg, Tetyana Tegnebratt, Lars Holmgren, Helene Rundqvist and Sharon Stone-Elander

    Citation: EJNMMI Research 2014 4:17

    Content type: Original research

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  7. 123I-CMICE-013 is a novel radiotracer previously reported to have promising characteristics for single-photon emission computed tomography (SPECT) myocardial perfusion imaging. We evaluated the biokinetics and ra...

    Authors: Yin Duan, Julia Lockwood, Lihui Wei, Chad Hunter, Karen Soueidan, Corinne Bensimon, Pasan Fernando, R Glenn Wells and Terrence D Ruddy

    Citation: EJNMMI Research 2014 4:16

    Content type: Original research

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  8. Cerenkov luminescence imaging (CLI) is an emerging imaging technique where visible light emitted from injected beta-emitting radionuclides is detected with an optical imaging device. CLI research has mostly be...

    Authors: Jeffrey D Steinberg, Anandhkumar Raju, Prashant Chandrasekharan, Chang-Tong Yang, Karen Khoo, Jean-Pierre Abastado, Edward G Robins and David W Townsend

    Citation: EJNMMI Research 2014 4:15

    Content type: Preliminary research

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  9. To date, the majority of protein-based radiopharmaceuticals have been radiolabelled using non-site-specific conjugation methods, with little or no control to ensure retained protein function post-labelling. Th...

    Authors: Adam Badar, Jennifer Williams, Rafael TM de Rosales, Richard Tavaré, Florian Kampmeier, Philip J Blower and Gregory ED Mullen

    Citation: EJNMMI Research 2014 4:14

    Content type: Original research

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  10. Sensitive and specific detection of nodal status, sites of metastases and low-volume recurrent disease could greatly improve management of patients with advanced prostate cancer. Prostate-specific membrane ant...

    Authors: Florian Kampmeier, Jennifer D Williams, John Maher, Gregory E Mullen and Philip J Blower

    Citation: EJNMMI Research 2014 4:13

    Content type: Original research

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  11. The objective of this study is to investigate the feasibility and the additional interest of a parametric imaging (PI) method to monitor the early tumour metabolic response in a prospective series of oesophage...

    Authors: Pierre Vera, Bernard Dubray, Odré Palie, Irène Buvat, Sébastien Hapdey, Romain Modzelewski, Ahmed Benyoucef, Caroline Rousseau, Marc-Etienne Meyer, Stéphane Bardet, Isabelle Gardin, Frederic Di Fiore and Pierre Michel

    Citation: EJNMMI Research 2014 4:12

    Content type: Original research

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  12. Patients with squamous cell carcinoma in the head and neck region (HNSCC) offer a diagnostic challenge due to difficulties to detect small tumours and metastases. Imaging methods available are not sufficient, ...

    Authors: Anna-Karin Haylock, Diana Spiegelberg, Johan Nilvebrant, Karl Sandström and Marika Nestor

    Citation: EJNMMI Research 2014 4:11

    Content type: Original research

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  13. 4′-[methyl-11C]-thiothymidine (4DST) is a novel positron emission tomography (PET) tracer to assess proliferation of malignancy. The diagnostic abilities of 4DST and 2-deoxy-2-18 F-fluoro-d-glucose (FDG) for dete...

    Authors: Ryogo Minamimoto, Jun Toyohara, Hideyuki Ito, Ayako Seike, Yoko Miyata, Miyako Morooka, Momoko Okasaki, Kazuhiko Nakajima, Kimiteru Ito, Kiichi Ishiwata and Kazuo Kubota

    Citation: EJNMMI Research 2014 4:10

    Content type: Original research

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  14. Neuroendocrine tumors are well vascularized and express specific cell surface markers, such as somatostatin receptors and the glucagon-like peptide-1 receptor (GLP-1R). Using the Rip1Tag2 transgenic mouse mode...

    Authors: Andreas Wicki, Damian Wild, Vincent Prêtre, Rosalba Mansi, Annette Orleth, Jean-Claude Reubi, Christoph Rochlitz, Christoph Mamot, Helmut R Mäcke and Gerhard Christofori

    Citation: EJNMMI Research 2014 4:9

    Content type: Original research

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  15. Positron emission tomography (PET) scanning with [18 F]fluorodeoxyglucose (18 F-FDG) is a useful diagnostic and prediction tool in brain tumors, but its value in childhood diffuse intrinsic pontine glioma (DIPG) ...

    Authors: Marc H A Jansen, Reina W Kloet, Dannis G van Vuurden, Sophie EM Veldhuijzen van Zanten, Birgit I Witte, Serge Goldman, W Peter Vandertop, Emile FI Comans, Otto S Hoekstra, Ronald Boellaard and Gert-Jan JL Kaspers

    Citation: EJNMMI Research 2014 4:8

    Content type: Original research

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  16. Quantitative measures of 11C-raclopride receptor binding can be used as a correlate of postsynaptic D2 receptor density in the striatum, allowing 11C-raclopride positron emission tomography (PET) to be used for t...

    Authors: Felix P Kuhn, Geoffrey I Warnock, Cyrill Burger, Katharina Ledermann, Chantal Martin-Soelch and Alfred Buck

    Citation: EJNMMI Research 2014 4:7

    Content type: Original research

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  17. The purpose of this study was to assess the relationship of CT-perfusion (CTP), 18F-FDG-PET/CT and histological parameters, and the possible added value of CTP to FDG-PET/CT in the initial staging of lung cancer.

    Authors: Martin W Huellner, Timothy D Collen, Philipp Gut, Ralph Winterhalder, Chantal Pauli, Joachim Diebold, Burkhardt Seifert, Klaus Strobel and Patrick Veit-Haibach

    Citation: EJNMMI Research 2014 4:6

    Content type: Original research

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  18. In an effort to reduce necessary acquisition time to perform molecular breast imaging (MBI), we compared diagnostic performance of MBI performed with standard 10-min-per-view acquisitions and half-time 5-min-p...

    Authors: Carrie B Hruska, Amy Lynn Conners, Katie N Jones, Amanda L Weinmann, Ravi K Lingineni, Rickey E Carter, Deborah J Rhodes and Michael K O’Connor

    Citation: EJNMMI Research 2014 4:5

    Content type: Original research

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  19. Florbetapir is one of several 18F-labeled amyloid plaque imaging tracers for positron emission tomography (PET). As the bio-distribution and radiation dose of PET tracers in human research are important for estim...

    Authors: Abhinay D Joshi, Michael J Pontecorvo, Lee Adler, Michael G Stabin, Daniel M Skovronsky, Alan P Carpenter and Mark A Mintun

    Citation: EJNMMI Research 2014 4:4

    Content type: Preliminary research

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  20. We observed a disproportional 18 F-fluorothymidine (F-FLT) uptake in follicular lymphoma (FL) relative to its low cell proliferation. We tested the hypothesis that the ‘excess’ uptake of 18 F-FLT in FL is rela...

    Authors: Marielle J Wondergem, Ken Herrmann, Sergei Syrbu, Josée M Zijlstra, Nikie Hoetjes, Otto S Hoekstra, Saskia AGM Cillessen, Laura M Moesbergen, Andreas K Buck, Julie M Vose and Malik E Juweid

    Citation: EJNMMI Research 2014 4:3

    Content type: Original research

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  21. The lupus-associated (La)-specific murine monoclonal antibody DAB4 (APOMAB®) specifically binds dead cancer cells. Using DAB4, we examined La expression in human lung cancer samples to assess its suitability a...

    Authors: Alexander H Staudacher, Fares Al-Ejeh, Cara K Fraser, Jocelyn M Darby, David M Roder, Andrew Ruszkiewicz, Jim Manavis and Michael P Brown

    Citation: EJNMMI Research 2014 4:2

    Content type: Original research

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  22. F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising modality for detecting active lesions of cardiac sarcoidosis (CS). However, determining whether 18F-FDG uptake in the myocardium is phy...

    Authors: Miyako Morooka, Masao Moroi, Kimiichi Uno, Kimiteru Ito, Jin Wu, Takashi Nakagawa, Kazuo Kubota, Ryogo Minamimoto, Yoko Miyata, Momoko Okasaki, Osamu Okazaki, Yoshihito Yamada, Tetsuo Yamaguchi and Michiaki Hiroe

    Citation: EJNMMI Research 2014 4:1

    Content type: Original research

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  23. While non-rigid fusion is by definition expected to alter the information of positron emission tomography (PET) data, we assessed whether rigid transformation also influences metabolic tumor volume (MTV) deter...

    Authors: Ingo G Steffen, Frank Hofheinz, Julian MM Rogasch, Christian Furth, Holger Amthauer and Juri Ruf

    Citation: EJNMMI Research 2013 3:85

    Content type: Original research

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  24. We present a method for extracting arterial input functions from dynamic [18F]FLT PET images of the head and neck, directly accounting for the partial volume effect. The method uses two blood samples, for which t...

    Authors: Sara L Hackett, Dan Liu, Anastasia Chalkidou, Paul Marsden, David Landau and John D Fenwick

    Citation: EJNMMI Research 2013 3:84

    Content type: Original research

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  25. Artificial neural network (ANN)-based bone scan index (BSI), a marker of the amount of bone metastasis, has been shown to enhance diagnostic accuracy and reproducibility but is potentially affected by training...

    Authors: Kenichi Nakajima, Yasuo Nakajima, Hiroyuki Horikoshi, Munehisa Ueno, Hiroshi Wakabayashi, Tohru Shiga, Mana Yoshimura, Eiji Ohtake, Yoshifumi Sugawara, Hideyasu Matsuyama and Lars Edenbrandt

    Citation: EJNMMI Research 2013 3:83

    Content type: Original research

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  26. Peptide receptor radionuclide therapy (PRRT) with 177Lu-[DOTA0,Tyr3]octreotate (177Lu-octreotate) is generally performed using a fixed activity of 7.4 GBq (200 mCi) per course bound to 180 to 300 μg of the peptid...

    Authors: Amir Sabet, James Nagarajah, Ahmet Semih Dogan, Hans-Jürgen Biersack, Amin Sabet, Stefan Guhlke and Samer Ezziddin

    Citation: EJNMMI Research 2013 3:82

    Content type: Original research

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  27. Circumferential pulmonary vein isolation (PVI) is the cornerstone of the current state-of-the-art management of atrial fibrillation (AF). However, the precise mechanisms behind AF relapses post PVI are still u...

    Authors: Christian Wenning, Philipp S Lange, Christoph Schülke, Alexis Vrachimis, Gerold Mönnig, Otmar Schober, Lars Eckardt and Michael Schäfers

    Citation: EJNMMI Research 2013 3:81

    Content type: Original research

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  28. Sigma2 (σ2) receptors are highly expressed in cancer cell lines and in tumours. Two novel selective 18F-phthalimido σ2 ligands, 18F-SIG343 and 18F-SIG353, were prepared and characterised for their potential tumou...

    Authors: Vu H Nguyen, Tien Pham, Chris Fookes, Paula Berghofer, Ivan Greguric, Andrew Arthur, Filomena Mattner, Gita Rahardjo, Emma Davis, Nicholas Howell, Marie-Claude Gregoire, Andrew Katsifis and Rachael Shepherd

    Citation: EJNMMI Research 2013 3:80

    Content type: Original research

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  29. The aim of this randomised pilot study was to investigate the haemodynamic effects measured by oxygen-15 positron emission tomography (PET) of interventional treatment consisting of either endarterectomy or en...

    Authors: Suzanne Persoon, Bart NM van Berckel, Jochem P Bremmer, Ronald Boellaard, Ale Algra, Gert Jan de Borst, Adriaan A Lammertsma, L Jaap Kappelle and Catharina JM Klijn

    Citation: EJNMMI Research 2013 3:79

    Content type: Original research

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  30. [11C]Befloxatone measures the density of the enzyme monoamine oxidase A (MAO-A) in the brain. MAO-A is responsible for the degradation of different neurotransmitters and is implicated in several neurologic and ps...

    Authors: Paolo Zanotti-Fregonara, Claire Leroy, Dimitri Roumenov, Christian Trichard, Jean-Luc Martinot and Michel Bottlaender

    Citation: EJNMMI Research 2013 3:78

    Content type: Original research

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  31. The standard uptake value (SUV) approach in oncological positron emission tomography has known shortcomings, all of which affect the reliability of the SUV as a surrogate of the targeted quantity, the metaboli...

    Authors: Jörg van den Hoff, Liane Oehme, Georg Schramm, Jens Maus, Alexandr Lougovski, Jan Petr, Bettina Beuthien-Baumann and Frank Hofheinz

    Citation: EJNMMI Research 2013 3:77

    Content type: Original research

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  32. Recently, we reported an information density theory and an analysis of three-parameter plus shorter scan than conventional method (3P+) for the amyloid-binding ligand [11C]Pittsburgh compound B (PIB) as an exampl...

    Authors: Koichi Sato, Kiyoshi Fukushi, Hitoshi Shinotoh, Hitoshi Shimada, Shigeki Hirano, Noriko Tanaka, Tetsuya Suhara, Toshiaki Irie and Hiroshi Ito

    Citation: EJNMMI Research 2013 3:76

    Content type: Original research

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  33. Image-based diagnosis of tumours can be advanced and improved by targeted strategies addressing malignant molecular structures. A promising molecular target is the cholecystokinin-2-receptor (CCK2R) which can ...

    Authors: Susanne Kossatz, Rosalba Mansi, Martin Béhé, Peter Czerney and Ingrid Hilger

    Citation: EJNMMI Research 2013 3:75

    Content type: Original research

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  34. The Langendorff perfused heart is a physiologically relevant and controllable model with potential for assessing the pharmacokinetics of new radiotracers under a range of pathophysiological conditions.. We ass...

    Authors: Erika Mariotti, Mattia Veronese, Joel T Dunn, Rodolfo A Medina, Philip J Blower, Richard Southworth and Thomas R Eykyn

    Citation: EJNMMI Research 2013 3:74

    Content type: Original research

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  35. The radiopharmaceutical 131I-metaiodobenzylguanidine (131I-MIBG) is used for the targeted radiotherapy of noradrenaline transporter (NAT)-expressing neuroblastoma. Enhancement of 131I-MIBG's efficacy is achieved ...

    Authors: Colin Rae, Mathias Tesson, John W Babich, Marie Boyd and Robert J Mairs

    Citation: EJNMMI Research 2013 3:73

    Content type: Original research

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  36. Stem cell therapy has a promising potential for the curing of various degenerative diseases, including congestive heart failure (CHF). In this study, we determined the efficacy of different delivery methods fo...

    Authors: Esmat Elhami, Bryson Dietz, Bo Xiang, Jixian Deng, Fei Wang, Chao Chi, Andrew L Goertzen, Shadreck Mzengeza, Darren Freed, Rakesh C Arora and Ganghong Tian

    Citation: EJNMMI Research 2013 3:72

    Content type: Original research

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  37. This study is to evaluate the predictive value of FDG-PET (PET) in pediatric and adolescent patients suffering from non-Hodgkin lymphoma (pNHL) in comparison to information provided by conventional imaging met...

    Authors: Christian Furth, Ingo G Steffen, Anne S Erdrich, Patrick Hundsdoerfer, Juri Ruf, Günter Henze, Stefan Schönberger, Holger Amthauer and Hubertus Hautzel

    Citation: EJNMMI Research 2013 3:71

    Content type: Original research

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  38. Fluorine-18 fluoroethoxybenzovesamicol ([18F]FEOBV) is a radioligand for the selective imaging of the vesicular acetylcholine transporter with positron emission tomography (PET). The current study demonstrates th...

    Authors: Maxime J Parent, Marilyn Cyr, Antonio Aliaga, Alexey Kostikov, Esther Schirrmacher, Jean-Paul Soucy, Naguib Mechawar, Pedro Rosa-Neto and Marc-Andre Bedard

    Citation: EJNMMI Research 2013 3:70

    Content type: Original research

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  39. [18 F]fluorodopa (FDOPA) positron emission tomography (PET) allows assessment of levodopa (LDOPA) metabolism and is widely used to study Parkinson's disease. We examined how [18 F]FDOPA PET-derived kinetic parame...

    Authors: Matthew D Walker, Katherine Dinelle, Rick Kornelsen, Anna Lee, Matthew J Farrer, A Jon Stoessl and Vesna Sossi

    Citation: EJNMMI Research 2013 3:69

    Content type: Original research

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  40. The folate receptor (FR) is a well-established target for tumor imaging and therapy. To date, only a few 18 F-folate conjugates via 18 F-prosthetic group labeling for positron emission tomography (PET) imaging ha...

    Authors: Hanno Schieferstein, Thomas Betzel, Cindy R Fischer and Tobias L Ross

    Citation: EJNMMI Research 2013 3:68

    Content type: Original research

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  41. Positron emission tomography (PET) with [2-18 F]-2-fluoro-2-deoxy-D-glucose ([18 F]FDG-PET) was acquired at multiple time-points a) to monitor the early response to RO5126766 (CH5126766) in xenograft models b) to...

    Authors: Tetyana Tegnebratt, Li Lu, Lucy Lee, Valerie Meresse, Jean Tessier, Nobuya Ishii, Naoki Harada, Pavel Pisa and Sharon Stone-Elander

    Citation: EJNMMI Research 2013 3:67

    Content type: Original research

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  42. Until now, no kinetic model was described for the oncologic tracer [18F]fluoromethylcholine ([18F]FCho), so it was aimed to validate a proper model, which is easy to implement and allows tracer quantification in ...

    Authors: Dominique Slaets and Filip De Vos

    Citation: EJNMMI Research 2013 3:66

    Content type: Original research

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  43. Adenosine may have beneficial effects on left ventricular function after myocardial infarction (MI), but the magnitude of this effect on remote and MI areas is controversial. We assessed the long-term effects ...

    Authors: Mélanie Bousquenaud, Fatiha Maskali, Sylvain Poussier, Jennifer Zangrando, Pierre-Yves Marie, Henri Boutley, Renaud Fay, Gilles Karcher, Daniel R Wagner and Yvan Devaux

    Citation: EJNMMI Research 2013 3:65

    Content type: Original research

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  44. The objective of this study was firstly to develop and evaluate an automated method for the detection of new lesions and changes in bone scan index (BSI) in serial bone scans and secondly to evaluate the progn...

    Authors: Reza Kaboteh, Peter Gjertsson, Håkan Leek, Milan Lomsky, Mattias Ohlsson, Karl Sjöstrand and Lars Edenbrandt

    Citation: EJNMMI Research 2013 3:64

    Content type: Original research

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  45. The European Association of Nuclear Medicine procedure guidelines for whole-body fluorodeoxyglucose positron-emission tomography (FDG-PET) scanning prescribe a dose proportional to the patient’s body mass. How...

    Authors: Eleonore H de Groot, Nieky Post, Ronald Boellaard, Nils RL Wagenaar, Antoon TM Willemsen and Jorn A van Dalen

    Citation: EJNMMI Research 2013 3:63

    Content type: Original research

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  46. The purpose of the present study was to quantify renal cell injury after ischemia and reperfusion in a pig model using 99mTc-lactadherin as a marker of apoptosis and 99mTc-sestamibi as a marker of mitochondrial d...

    Authors: Stine S Pedersen, Anna K Keller, Marie K Nielsen, Bente Jespersen, Lise Falborg, Jan T Rasmussen, Christian W Heegaard and Michael Rehling

    Citation: EJNMMI Research 2013 3:62

    Content type: Original research

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  47. Kinetic modeling of brain glucose metabolism in small rodents from positron emission tomography (PET) data using 2-deoxy-2-[18 F]fluoro-d-glucose (FDG) has been highly inconsistent, due to different modeling para...

    Authors: Malte F Alf, Marianne I Martić-Kehl, Roger Schibli and Stefanie D Krämer

    Citation: EJNMMI Research 2013 3:61

    Content type: Original research

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  48. Gastrointestinal (GI) disorders are commonly associated with chronic conditions such as diabetes, obesity, and hypertension. Direct consequences are obstipation or diarrhea as opposite aspects of the irritable...

    Authors: Parasuraman Padmanabhan, Johannes Grosse, Abu Bakar Md Ali Asad, George K Radda and Xavier Golay

    Citation: EJNMMI Research 2013 3:60

    Content type: Original research

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  49. Preclinical and histological data show overexpression of the type 1 cannabinoid receptor (CB1R) in prostate carcinoma (PCa). In a prospective study, the feasibility of 18F-MK-9470 positron emission tomography (PE...

    Authors: Kimy M Emonds, Michel Koole, Cindy Casteels, Laura Van den Bergh, Guy M Bormans, Filip Claus, Liesbeth De Wever, Evelyne Lerut, Hendrik Van Poppel, Steven Joniau, Herlinde Dumez, Karin Haustermans, Luc Mortelmans, Karolien Goffin, Koen Van Laere, Christophe M Deroose…

    Citation: EJNMMI Research 2013 3:59

    Content type: Original research

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  50. Stress myocardial perfusion scintigraphy (MPS) is widely regarded as a useful imaging modality for diagnosing patients with suspected ischemic heart disease. Current European guidelines recommend stress study ...

    Authors: Lars Edenbrandt, Mattias Ohlsson and Elin Trägårdh

    Citation: EJNMMI Research 2013 3:58

    Content type: Original research

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