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  1. The autonomic nervous system is frequently affected in some neurodegenerative diseases, including Parkinson’s disease and Dementia with Lewy bodies. In vivo imaging methods to visualize and quantify the periph...

    Authors: Jacob Horsager, Niels Okkels, Nathalie Van Den Berge, Jan Jacobsen, Anna Schact, Ole Lajord Munk, Kim Vang, Dirk Bender, David J. Brooks and Per Borghammer
    Citation: EJNMMI Research 2022 12:17
    Content type: Original research Published on:

  2. This study examines the clinical feasibility and impact of implementing a fully automated whole-body PET protocol with data-driven respiratory gating in patients with a broad range of oncological and non-oncol...

    Authors: André H. Dias, Paul Schleyer, Mikkel H. Vendelbo, Karin Hjorthaug, Lars C. Gormsen and Ole L. Munk
    Citation: EJNMMI Research 2022 12:16
    Content type: Original research Published on:

  3. Dynamic whole-body (D-WB) FDG PET/CT is a recently developed technique that allows direct reconstruction of multiparametric images of metabolic rate of FDG uptake (MRFDG) and “free” FDG (DVFDG). Multiparametric i...

    Authors: André H. Dias, Allan K. Hansen, Ole L. Munk and Lars C. Gormsen
    Citation: EJNMMI Research 2022 12:15
    Content type: Original research Published on:

  4. With the rise of prostate-specific membrane antigen (PSMA) radioguided surgery, which is performed using a microdosing regime, demand for visual target confirmation via fluorescence guidance is growing. While ...

    Authors: Paolo Dell’Oglio, Danny M. van Willigen, Matthias N. van Oosterom, Kevin Bauwens, Fabian Hensbergen, Mick M. Welling, Huijbert van der Stadt, Elise Bekers, Martin Pool, Pim van Leeuwen, Tobias Maurer, Fijs W. B. van Leeuwen and Tessa Buckle
    Citation: EJNMMI Research 2022 12:14
    Content type: Original research Published on:

  5. Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [11C]...

    Authors: Ryosuke Arakawa, Akihiro Takano, Sangram Nag, Zhisheng Jia, Nahid Amini, Kevin P. Maresca, Lei Zhang, Edmund J. Keliher, Christopher R. Butler, Justin R. Piro, Tarek A. Samad, Deborah Smith, Deane Nason, Steve O’Neil, Patrick Trapa, Kari R. Fonseca…
    Citation: EJNMMI Research 2022 12:13
    Content type: Original research Published on:

  6. To assess the diagnostic value of an additional late-phase PET/CT scan after urination as part of 68 Ga-PSMA-11 PET/CT for the restaging of patients with biochemically recurrent prostate cancer (BCR).

    Authors: Janna Morawitz, Julian Kirchner, Johannes Hertelendy, Christina Loberg, Lars Schimmöller, Mardjan Dabir, Lena Häberle, Eduards Mamlins, Christina Antke, Christian Arsov, Gerald Antoch and Lino M. Sawicki
    Citation: EJNMMI Research 2022 12:12
    Content type: Original research Published on:

  7. Q.Clear is a Bayesian penalised likelihood (BPL) reconstruction algorithm available on General Electric (GE) Positron Emission Tomography (PET)-Computed Tomography (CT) and PET-Magnetic Resonance (MR) scanners...

    Authors: Daniela Ribeiro, William Hallett, Oliver Howes, Robert McCutcheon, Matthew M. Nour and Adriana A. S. Tavares
    Citation: EJNMMI Research 2022 12:11
    Content type: Original research Published on:

  8. To assess 68Ga-PSMA PET/CT for detection of low- and intermediate-risk prostate cancer (PCa), high-risk PCa in comparison with mpMRI, respectively, and to determine which of low- and intermediate-risk PCa are mor...

    Authors: Chuanchi Zhou, Yongxiang Tang, Zhihe Deng, Jinhui Yang, Ming Zhou, Long Wang and Shuo Hu
    Citation: EJNMMI Research 2022 12:10
    Content type: Original research Published on:

  9. Post-therapy [90Y] PET/CT-based dosimetry is currently recommended to validate treatment planning as [99mTc] MAA SPECT/CT is often a poor predictor of subsequent actual [90Y] absorbed dose. Treatment planning sof...

    Authors: Emile B. Veenstra, Simeon J. S. Ruiter, Robbert J. de Haas, Reinoud P. H. Bokkers, Koert P. de Jong and Walter Noordzij
    Citation: EJNMMI Research 2022 12:9
    Content type: Original research Published on:

  10. Radiohybrid prostate-specific membrane antigen (rhPSMA) ligands such as 18F-rhPSMA-7 are a new class of theranostic agents in clinical development for prostate cancer. We compared preclinical dosimetry and human ...

    Authors: Karina Knorr, So Won Oh, Markus Krönke, Alexander Wurzer, Calogero D’Alessandria, Michael Herz, Wolfgang Weber, Hans-Jürgen Wester, Matthias Eiber, Nahid Yusufi and Stephan Nekolla
    Citation: EJNMMI Research 2022 12:8
    Content type: Original research Published on:

  11. In patients with neuroendocrine tumor liver metastases, additional tumor reduction can be achieved by sequential treatment with [166Ho]-radioembolization after peptide receptor radionuclide therapy (PRRT). The ai...

    Authors: Sander C. Ebbers, Tessa Brabander, Margot E. T. Tesselaar, Johannes Hofland, Manon N. G. J. A. Braat, Frank J. Wessels, Maarten W. Barentsz, Marnix G. E. H. Lam and Arthur J. A. T. Braat
    Citation: EJNMMI Research 2022 12:7
    Content type: Original research Published on:

  12. Dimethyl fumarate (DMF) is an oral immunomodulatory drug used in the treatment of autoimmune diseases. Here, we sought to study whether the effect of DMF can be detected using positron emission tomography (PET...

    Authors: S. K. Vainio, A. M. Dickens, M. Matilainen, F. R. López-Picón, R. Aarnio, O. Eskola, O. Solin, D. C. Anthony, J. O. Rinne, L. Airas and M. Haaparanta-Solin
    Citation: EJNMMI Research 2022 12:6
    Content type: Original research Published on:

  13. In the last decades, our understanding of the role of the immune system in cancer has significantly improved and led to the discovery of new immunotherapeutic targets and tools, which boosted the advances in c...

    Authors: Dario Gosmann, Lisa Russelli, Wolfgang A. Weber, Markus Schwaiger, Angela M. Krackhardt and Calogero D’Alessandria
    Citation: EJNMMI Research 2022 12:5
    Content type: Review Published on:

  14. Multiple myeloma (MM) cells synthesize large amounts of paraproteins, making radiolabeled amino acids promising candidates for PET imaging of MM patients.

    Authors: Volker Morath, Michael Heider, Markus Mittelhäuser, Hannes Rolbieski, Jacob Stroh, Jérémie Calais, Matthias Eiber, Florian Bassermann and Wolfgang A. Weber
    Citation: EJNMMI Research 2022 12:4
    Content type: Short communication Published on:

  15. [11C]UCB-J is a PET radioligand that binds to the presynaptic vesicle glycoprotein 2A. Therefore, [11C]UCB-J PET may serve as an in vivo marker of synaptic integrity. The main objective of this study was to evalu...

    Authors: Hayel Tuncel, Ronald Boellaard, Emma M. Coomans, Marijke den Hollander-Meeuwsen, Erik F. J. de Vries, Andor W. J. M. Glaudemans, Paula Kopschina Feltes, David Vállez García, Sander C. J. Verfaillie, Emma E. Wolters, Steven P. Sweeney, J. Michael Ryan, Magnus Ivarsson, Berkley A. Lynch, Patrick Schober, Philip Scheltens…
    Citation: EJNMMI Research 2022 12:3
    Content type: Original research Published on:

  16. Near-infrared (NIR) fluorescence imaging has been emerging as a promising strategy to overcome the high number of early esophageal adenocarcinomas missed by white light endoscopy and random biopsy collection. ...

    Authors: Sabrina Marcazzan, Marcos J. Braz Carvalho, Matthias Konrad, Julia Strangmann, Anna Tenditnaya, Theresa Baumeister, Roland M. Schmid, Hans-Jürgen Wester, Vasilis Ntziachristos, Dimitris Gorpas, Timothy C. Wang, Margret Schottelius and Michael Quante
    Citation: EJNMMI Research 2022 12:2
    Content type: Preliminary research Published on:

  17. [18F]PR04.MZ is a new PET imaging agent for dopamine transporters, providing excellent image quality and allowing for the evaluation of patients with movement disorders such as Parkinson’s disease. The objective ...

    Authors: Wencke Lehnert, Patrick J. Riss, Ana Hurtado de Mendoza, Sandra Lopez, Gonzalo Fernandez, Marcelo Ilheu, Horacio Amaral and Vasko Kramer
    Citation: EJNMMI Research 2022 12:1
    Content type: Original research Published on:

  18. Tumour hypoxia promotes an aggressive tumour phenotype and enhances resistance to anticancer treatments. Following the recent observation that the mitochondrial inhibitor atovaquone increases tumour oxygenatio...

    Authors: Pauline Bourigault, Michael Skwarski, Ruth E. Macpherson, Geoff S. Higgins and Daniel R. McGowan
    Citation: EJNMMI Research 2021 11:130
    Content type: Original research Published on:

  19. Cardiac sarcoidosis (CS) diagnosis is usually based on advanced imaging techniques and multidisciplinary evaluation. Diagnosis is classified as definite, probable, possible or unlikely. If diagnostic confidenc...

    Authors: H. Mathijssen, T. W. H. Tjoeng, R. G. M. Keijsers, A. L. M. Bakker, F. Akdim, H. W. van Es, F. T. van Beek, M. V. Veltkamp, J. C. Grutters and M. C. Post
    Citation: EJNMMI Research 2021 11:129
    Content type: Original research Published on:

  20. Accurate prostate cancer imaging is critical for patient management. Multiple studies have demonstrated superior diagnostic accuracy of [68Ga]-PSMA-11 PET/CT over conventional imaging for disease detection, with ...

    Authors: Venkata Avinash Chikatamarla, Satomi Okano, Peter Jenvey, Alexander Ansaldo, Matthew J. Roberts, Stuart C. Ramsay, Paul A. Thomas and David A. Pattison
    Citation: EJNMMI Research 2021 11:128
    Content type: Original research Published on:

  21. Malignant melanoma is an aggressive tumor with a tendency to metastasize early and with an increasing incidence worldwide. Although in early stage, melanoma is well treatable by excision, the chances of cure a...

    Authors: Maxim Shevtsov, Susanne Kaesler, Christian Posch, Gabriele Multhoff and Tilo Biedermann
    Citation: EJNMMI Research 2021 11:127
    Content type: Review Published on:

  22. Advanced salivary gland cancers become difficult to treat when they are technically irresectable and radiotherapy limits are exceeded. There is also an unmet need to improve palliative systemic therapy. Saliva...

    Authors: Thomas J. W. Klein Nulent, Robert J. J. van Es, Stefan M. Willems, Arthur. J. A. T. Braat, Lot A. Devriese, Remco de Bree and Bart de Keizer
    Citation: EJNMMI Research 2021 11:126
    Content type: Original research Published on:

  23. Centiloid (CL) scaling has become a standardized quantitative measure in amyloid PET because it facilitates the direct comparison of results across institutions, even when different analytical methods or trace...

    Authors: Hiroshi Matsuda, Tensho Yamao, Mitsuru Shakado, Yoko Shigemoto, Kyoji Okita and Noriko Sato
    Citation: EJNMMI Research 2021 11:125
    Content type: Short communication Published on:

  24. O-(2-[18F]-fluoroethyl)-L-tyrosine (18F-FET) is a highly sensitive PET tracer for glioma imaging, and its uptake is suggested to be driven by an overexpression of the L-type amino-acid transporter 1 (LAT1). Howev...

    Authors: Franziska J. Vettermann, Caroline Diekmann, Lorraine Weidner, Marcus Unterrainer, Bogdana Suchorska, Viktoria Ruf, Mario Dorostkar, Vera Wenter, Jochen Herms, Jörg-Christian Tonn, Peter Bartenstein, Markus J. Riemenschneider and Nathalie L. Albert
    Citation: EJNMMI Research 2021 11:124
    Content type: Original research Published on:

  25. Indocyanine green (ICG) is frequently used for the detection of the sentinel lymph node (SLN) in gynecology, but it carries the loss of the presurgical SLN mapping provided by [99mTc]-based colloids. Hybrid trace...

    Authors: Nuria Sánchez-Izquierdo, Sergi Vidal-Sicart, Francisco Campos, Aureli Torné, Martina Aida Angeles, Federico Migliorelli, Meritxell Munmany, Adela Saco, Berta Diaz-Feijoo, Ariel Glickman, Jaume Ordi, Andrés Perissinotti, Marta del Pino and Pilar Paredes
    Citation: EJNMMI Research 2021 11:123
    Content type: Original research Published on:

  26. Using two static scans for 123I-meta-iodobenzyl-guanidine (123I-MIBG) myocardial scintigraphy ignores the dynamic response from vesicular trapping in nerve terminals. Moreover, the long pause between scans is imp...

    Authors: Yoshitaka Kumakura, Yuji Shimizu, Masatsugu Hariu, Ken-ichi Ichikawa, Norihito Yoshida, Masato Suzuki, Satoru Oji, Shinya Narukawa, Haruo Yoshimasu and Kyoichi Nomura
    Citation: EJNMMI Research 2021 11:122
    Content type: Original research Published on:

  27. Pheochromocytomas (PCCs) and paragangliomas (PGLs), together referred to as PPGLs, are rare chromaffin cell-derived tumors. They require timely diagnosis as this is the only way to achieve a cure through surge...

    Authors: Hermine Mohr, Alessia Foscarini, Katja Steiger, Simone Ballke, Christoph Rischpler, Franz Schilling and Natalia S. Pellegata
    Citation: EJNMMI Research 2021 11:121
    Content type: Review Published on:

  28. Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies to date. The impressively developed stroma that surrounds and modulates the behavior of cancer cells is one of the main factors...

    Authors: Na Sun, Marija Trajkovic-Arsic, Fengxia Li, Yin Wu, Corinna Münch, Thomas Kunzke, Annette Feuchtinger, Katja Steiger, Anna Melissa Schlitter, Wilko Weichert, Irene Esposito, Jens T. Siveke and Axel Walch
    Citation: EJNMMI Research 2021 11:120
    Content type: Original research Published on:

  29. The role of image-derived biomarkers in recurrent oligometastatic Prostate Cancer (PCa) is unexplored. This paper aimed to evaluate [18F]FMCH PET/CT radiomic analysis in patients with recurrent PCa after primary ...

    Authors: Martina Sollini, Francesco Bartoli, Lara Cavinato, Francesca Ieva, Alessandra Ragni, Andrea Marciano, Roberta Zanca, Luca Galli, Fabiola Paiar, Francesco Pasqualetti and Paola Anna Erba
    Citation: EJNMMI Research 2021 11:119
    Content type: Original research Published on:

  30. Low-grade neuroendocrine tumors (NETs) are characterized by an abundance of somatostatin receptors (SSTR) that can be targeted with somatostatin analogs (SSA). When activated with a single dose of SSA, the rec...

    Authors: Ulrika Jahn, Ezgi Ilan, Irina Velikyan, Katarzyna Fröss-Baron, Mark Lubberink and Anders Sundin
    Citation: EJNMMI Research 2021 11:118
    Content type: Original research Published on:

  31. The purpose of this study is to compare dynamic and static whole-body (WB) [18F]NaF PET/CT scan methods used for analysis of bone plasma clearance in patients with chronic kidney disease-mineral and bone disorder...

    Authors: M. H. Vrist, J. N. Bech, T. G. Lauridsen, C. A. Fynbo and J. Theil
    Citation: EJNMMI Research 2021 11:117
    Content type: Original research Published on:

  32. Neoadjuvant systemic therapy (NST) is a widely accepted initial treatment modality that can lead to pathologic downstaging of the axillary disease burden in breast cancer patients. Axillary response as well as...

    Authors: Cornelis M. de Mooij, Cristina Mitea, Felix M. Mottaghy, Marjolein L. Smidt and Thiemo J. A. van Nijnatten
    Citation: EJNMMI Research 2021 11:116
    Content type: Original research Published on:

  33. Recent advancements in the field of immune-oncology have led to a significant increase in life expectancy of patients with diverse forms of cancer, such as hematologic malignancies, melanoma and lung cancer. U...

    Authors: Q. Lecocq, P. Debie, J. Puttemans, R. M. Awad, L. De Beck, T. Ertveldt, Y. De Vlaeminck, C. Goyvaerts, G. Raes, M. Keyaerts, K. Breckpot and N. Devoogdt
    Citation: EJNMMI Research 2021 11:115
    Content type: Original research Published on:

  34. Imaging diagnosis of inflammation has been challenging for many years. Inflammation imaging agents commonly used in nuclear medicine, such as [67Ga]Ga-citrate and 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) showed...

    Authors: Shigufa Kahn Ali, Samia Ait-Mohand, Véronique Dumulon-Perreault and Brigitte Guérin
    Citation: EJNMMI Research 2021 11:114
    Content type: Original research Published on:

  35. Immunotherapy is a valuable option for cancer treatment, and the curative effect of anti-PD-1/PD-L1 therapy correlates closely with PD-L1 expression levels. Positron emission tomography (PET) imaging of PD-L1 ...

    Authors: Yanling Yang, Chao Wang, Yan Wang, Yan Sun, Xing Huang, Minzhou Huang, Hui Xu, Huaying Fan, Daquan Chen and Feng Zhao
    Citation: EJNMMI Research 2021 11:113
    Content type: Original research Published on:

  38. 68Ga-pentixafor PET/CT was reported to have a high sensitivity in detecting tumor involvement of Waldenström macroglobulinemia/lymphoplasmacytic lymphoma (WM/LPL) in our previous study. We aimed to further inves....

    Authors: Qingqing Pan, Xinxin Cao, Yaping Luo, Jian Li and Fang Li
    Citation: EJNMMI Research 2021 11:110
    Content type: Original research Published on:

  39. The analysis aimed to compare the radiotracers [68Ga]-Ga-PSMA-11 and [18F]-F-PSMA-1007 intraindividually in terms of malignant lesions, mi(molecular-imaging)TNM staging and presumable unspecific lesions retrospec...

    Authors: Sebastian Hoberück, Steffen Löck, Angelika Borkowetz, Ulrich Sommer, Robert Winzer, Klaus Zöphel, Dieter Fedders, Enrico Michler, Jörg Kotzerke, Klaus Kopka, Tobias Hölscher and Anja Braune
    Citation: EJNMMI Research 2021 11:109
    Content type: Original research Published on:

  41. Localized prostate cancer (PCa) in patients is characterized by a dominant focus in the gland (dominant intraprostatic lesion, DIL). Accurate DIL identification may enable more accurate diagnosis and therapy t...

    Authors: Dae-Myoung Yang, Ryan Alfano, Glenn Bauman, Jonathan D. Thiessen, Joseph Chin, Stephen Pautler, Madeleine Moussa, Jose A. Gomez, Irina Rachinsky, Mena Gaed, Kevin J. Chung, Aaron Ward and Ting-Yim Lee
    Citation: EJNMMI Research 2021 11:107
    Content type: Original research Published on:

  42. In the context of nuclear medicine and theranostics, integrin-related research and development was, for most of the time, focused predominantly on 'RGD peptides' and the subtype αvβ3-integrin. However, there a...

    Authors: Katja Steiger, Neil Gerard Quigley, Tanja Groll, Frauke Richter, Maximilian Alexander Zierke, Ambros Johannes Beer, Wilko Weichert, Markus Schwaiger, Susanne Kossatz and Johannes Notni
    Citation: EJNMMI Research 2021 11:106
    Content type: Review Published on:

  43. Since three-dimensional segmentation of cardiac region in 123I-metaiodobenzylguanidine (MIBG) study has not been established, this study aimed to achieve organ segmentation using a convolutional neural network (C...

    Authors: Shintaro Saito, Kenichi Nakajima, Lars Edenbrandt, Olof Enqvist, Johannes Ulén and Seigo Kinuya
    Citation: EJNMMI Research 2021 11:105
    Content type: Original research Published on:

  44. The incidence and lethality of pancreatic ductal adenocarcinoma (PDAC) will continue to increase in the next decade. For most patients, chemotherapeutic combination therapies remain the standard of care. The d...

    Authors: Günter Schneider, Matthias Wirth, Ulrich Keller and Dieter Saur
    Citation: EJNMMI Research 2021 11:104
    Content type: Review Published on:

  45. Accumulating evidence indicates that neuroinflammation (NI) significantly contributes to drug addiction, but the conversion of NI after drug withdrawal is not clear. Here, we conducted 18F-flutriciclamide (GE180)...

    Authors: Junpeng Li, Da Shao, Donglang Jiang, Qi Huang, Yihui Guan, Bin Lai, Jun Zhao, Fengchun Hua and Fang Xie
    Citation: EJNMMI Research 2021 11:103
    Content type: Original research Published on:

  48. [18F]FDG PET/CT is the elective imaging modality for treatment monitoring in multiple myeloma (MM). However, MM is a heterogeneous disease from an imaging point of view, raising challenges in interpretation of PE...

    Authors: Christos Sachpekidis, Maximilian Merz, Marc-Steffen Raab, Uta Bertsch, Vivienn Weru, Annette Kopp-Schneider, Anna Jauch, Hartmut Goldschmidt and Antonia Dimitrakopoulou-Strauss
    Citation: EJNMMI Research 2021 11:100
    Content type: Original research Published on:

  49. Our study aimed to elucidate the intracellular processes associated with quinolinic acid (QA)-induced brain injury by acquiring semiquantitative fluorescent images of reactive oxygen species (ROS) generation a...

    Authors: Rie Hosoi, Yuka Fujii, Ohba Hiroyuki, Miho Shukuri, Shingo Nishiyama, Masakatsu Kanazawa, Kenichiro Todoroki, Yasushi Arano, Toshihiro Sakai, Hideo Tsukada and Osamu Inoue
    Citation: EJNMMI Research 2021 11:99
    Content type: Original research Published on:

  50. Gastroenteropancreatic neuroendocrine tumors most commonly metastasize to the liver; however, high normal background 68Ga-DOTATATE activity and high image noise make metastatic lesions difficult to detect. The pu...

    Authors: Jonathan Wehrend, Michael Silosky, Fuyong Xing and Bennett B. Chin
    Citation: EJNMMI Research 2021 11:98
    Content type: Original research Published on:

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