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  1. Systematic evaluations of the diagnostic accuracy of positron emission tomography (PET) imaging have been widely conducted in many countries. Although Japan’s total number of PET units is the second highest in...

    Authors: Shuhei Nomura, Akinori Hisashige, Daisuke Yoneoka, Mikiko Kanda, Karin Miyamoto, Miwako Segawa, Erika Ota and Kenji Shibuya
    Citation: EJNMMI Research 2015 5:6
    Content type: Original research Published on:

  2. Non-small cell lung carcinoma (NSCLC) represents approximately 80% of lung cancer cases, and over 60% of these tumors express the epidermal growth factor receptor (EGFR). Activating mutations in the tyrosine k...

    Authors: Galith Abourbeh, Batel Itamar, Olga Salnikov, Sergey Beltsov and Eyal Mishani
    Citation: EJNMMI Research 2015 5:4
    Content type: Original research Published on:

  3. CD8-positive cells might play a crucial role in the therapeutic response to radiation, which has however not been investigated in radioimmunotherapy (RIT). The aim of this study was to evaluate whether cytotox...

    Authors: Erika Elgström, Sophie E Eriksson, Tomas G Ohlsson, Rune Nilsson and Jan Tennvall
    Citation: EJNMMI Research 2015 5:3
    Content type: Original research Published on:

  4. CD13 is selectively upregulated in angiogenic active endothelium and can serve as a target for molecular imaging tracers to non-invasively visualise angiogenesis in vivo. Non-invasive determination of CD13 expres...

    Authors: Geert Hendrikx, Marijke De Saint-Hubert, Ingrid Dijkgraaf, Matthias Bauwens, Kim Douma, Roel Wierts, Ivo Pooters, Nynke MS Van den Akker, Tilman M Hackeng, Mark J Post and Felix M Mottaghy
    Citation: EJNMMI Research 2015 5:2
    Content type: Original research Published on:

  5. In cancer radiotherapy, knowledge of normal tissue responses and toxicity risks is essential in order to deliver the highest possible absorbed dose to the tumor while maintaining normal tissue exposure at non-...

    Authors: Britta Langen, Nils Rudqvist, Toshima Z Parris, Emil Schüler, Johan Spetz, Khalil Helou and Eva Forssell-Aronsson
    Citation: EJNMMI Research 2015 5:1
    Content type: Original research Published on:

  6. The goal of the present study was to evaluate the reproducibility of cerebral adenosine A2A receptor (A2AR) quantification using 11C-TMSX and PET in a test-retest study.

    Authors: Mika Naganawa, Masahiro Mishina, Muneyuki Sakata, Keiichi Oda, Mikio Hiura, Kenji Ishii and Kiichi Ishiwata
    Citation: EJNMMI Research 2014 4:76
    Content type: Original research Published on:

  7. [18 F]AFM is a potent and promising PET imaging agent for the serotonin transporter. We carried out an acute toxicity study in rats and radiation dosimetry in monkeys before the translation of the tracer to human...

    Authors: Ya-Yao Huang, Chen-Yi Cheng, Wen-Sheng Huang, Kuo-Hsing Ma, Ta-Wei Tseng, Ta-Kai Chou, Yiyun Huang and Chyng-Yann Shiue
    Citation: EJNMMI Research 2014 4:71
    Content type: Original research Published on:

    The Erratum to this article has been published in EJNMMI Research 2016 6:66

  8. Peptide receptor radionuclide therapy (PRRT) is applied in patients with advanced neuroendocrine tumors. Co-infused amino acids (AA) should prevent nephrotoxicity. The aims of this study were to correlate the ...

    Authors: Constantin Lapa, Rudolf A Werner, Christina Bluemel, Katharina Lueckerath, Dirk O Muegge, Alexander Strate, Heribert Haenscheid, Andreas Schirbel, Martin S Allen-Auerbach, Ralph A Bundschuh, Andreas K Buck and Ken Herrmann
    Citation: EJNMMI Research 2014 4:74
    Content type: Original research Published on:

  9. Boron neutron capture therapy (BNCT) is a molecular radiation treatment based on the 10B (n, α) 7Li nuclear reaction in cancer cells, in which delivery of 10B by 4-borono-phenylalanine conjugated with fructose (B...

    Authors: Kohei Hanaoka, Tadashi Watabe, Sadahiro Naka, Yasukazu Kanai, Hayato Ikeda, Genki Horitsugi, Hiroki Kato, Kayako Isohashi, Eku Shimosegawa and Jun Hatazawa
    Citation: EJNMMI Research 2014 4:70
    Content type: Original research Published on:

  10. Hepatobiliary scintigraphy using 99mTc-mebrofenin has been used as an investigation to study liver function after liver transplantation (LTx). Hepatic extraction fraction (HEF) is a measurement of the hepatic ext...

    Authors: Anastasios Kaxiras, Shinji Yamamoto, Gunnar Söderdahl, Annika Wernerson, Rimma Axelsson and Bo-Göran Ericzon
    Citation: EJNMMI Research 2014 4:73
    Content type: Original research Published on:

  11. Endothelial dysfunction is associated with vascular risk factors such as dyslipidemia, hypertension, and diabetes, leading to coronary atherosclerosis. Sympathetic stress using cold-pressor testing (CPT) has b...

    Authors: Etienne Croteau, Jennifer M Renaud, Christine Archer, Ran Klein, Jean N DaSilva, Terrence D Ruddy, Rob SB Beanlands and Robert A deKemp
    Citation: EJNMMI Research 2014 4:68
    Content type: Original research Published on:

  12. Absolute quantitative single-photon emission computed tomography (SPECT) has several important applications including monitoring tumor response after treatment and dose estimation for targeted radionuclide the...

    Authors: Nadège Anizan, Hao Wang, Xian C Zhou, Robert F Hobbs, Richard L Wahl and Eric C Frey
    Citation: EJNMMI Research 2014 4:67
    Content type: Original research Published on:

  13. Tumor hypoxia is linked to invasion and metastasis but whether this associates with tumor growth rate is not well understood. We aimed to study the relationship between hypoxia evaluated with the positron emis...

    Authors: Antti Silvoniemi, Jonna Silén, Sarita Forsback, Eliisa Löyttyniemi, Aleksi R Schrey, Olof Solin, Reidar Grénman, Heikki Minn and Tove J Grönroos
    Citation: EJNMMI Research 2014 4:65
    Content type: Original research Published on:

  14. Galectin-3 is a ß-galactoside-binding lectin expressed in most of tissues in normal conditions and overexpressed in myocardium from early stages of heart failure (HF). It is an established biomarker associated...

    Authors: Teresa Arias, Artiom Petrov, Jiqiu Chen, Hans de Haas, Carlos Pérez-Medina, Gustav J Strijkers, Roger J Hajjar, Zahi A Fayad, Valentín Fuster and Jagat Narula
    Citation: EJNMMI Research 2014 4:75
    Content type: Original research Published on:

  15. At fluorodeoxyglucose/positron emission tomography (FDG/PET) examinations, a generally increased uptake of the skeletal muscles is sometimes encountered. As the tracer distribution constitutes a ‘zero-sum-game...

    Authors: Henry Lindholm, Fredrik Brolin, Cathrine Jonsson and Hans Jacobsson
    Citation: EJNMMI Research 2014 4:72
    Content type: Original research Published on:

  16. Defining tumour volume for treatment response and radiotherapy planning is challenging and prone to inter- and intra-observer variability. Various automated tumour delineation methods have been proposed in the...

    Authors: Azadeh Firouzian, Matthew D Kelly and Jérôme M Declerck
    Citation: EJNMMI Research 2014 4:69
    Content type: Original research Published on:

  17. The ability to quantify the capacity of a central nervous system (CNS) drug to cross the human blood-brain barrier (BBB) provides valuable information for de-risking drug development of new molecules. Here, we...

    Authors: Khanum Ridler, Vincent Cunningham, Mickael Huiban, Laurent Martarello, Sabina Pampols-Maso, Jan Passchier, Roger N Gunn, Graham Searle, Anissa Abi-Dargham, Mark Slifstein, Jeanette Watson, Marc Laruelle and Eugenii A Rabiner
    Citation: EJNMMI Research 2014 4:66
    Content type: Original research Published on:

  18. We have explored the possibility that the serotonin 1B receptor radioligand [11C]AZ10419369 is a substrate for adenosine triphosphate (ATP)-binding cassette (ABC) transporters, such as P-glycoprotein (P-gp), Mrp4...

    Authors: Miklós Tóth, Jenny Häggkvist, Andrea Varrone, Sjoerd J Finnema, Janine Doorduin, Masaki Tokunaga, Makoto Higuchi, Balázs Gulyás and Christer Halldin
    Citation: EJNMMI Research 2014 4:64
    Content type: Original research Published on:

  19. The serotonin precursor 5-hydroxy-l-[β-11C]tryptophan ([11C]HTP) is in clinical use for localization of neuroendocrine tumors and has been suggested as a proxy marker for pancreatic islet cells. However, degradat...

    Authors: Jonas Eriksson, Ola Ã…berg, Ram Kumar Selvaraju, Gunnar Antoni, Lars Johansson and Olof Eriksson
    Citation: EJNMMI Research 2014 4:62
    Content type: Original research Published on:

  20. Due to its high expression in prostate cancer, PSMA (prostate-specific membrane antigen) represents an ideal target for both diagnostic imaging and endoradiotherapeutic approaches. Based on a previously publis...

    Authors: Martina Weineisen, Jakub Simecek, Margret Schottelius, Markus Schwaiger and Hans-Jürgen Wester
    Citation: EJNMMI Research 2014 4:63
    Content type: Original research Published on:

  21. Three-dimensional (3D) hydrogel-based stem cell therapies contribute to enhanced therapeutic efficacy in treating diseases, and determining the optimal mechanical strength of the hydrogel in vivo is important for...

    Authors: Do Won Hwang, Kyung Min Park, Hye-kyung Shim, Yeona Jin, Hyun Jeong Oh, So Won Oh, Song Lee, Hyewon Youn, Yoon Ki Joung, Hong J Lee, Seung U Kim, Ki Dong Park and Dong Soo Lee
    Citation: EJNMMI Research 2014 4:61
    Content type: Original research Published on:

  22. Epithelial ovarian cancer (EOC) is characterized by the overexpression of cancer antigen 125 (CA125), a mucinous glycoprotein that serves as a tumor biomarker. Early diagnosis of EOC is plagued by its asymptom...

    Authors: Sai Kiran Sharma, Melinda Wuest, Monica Wang, Darryl Glubrecht, Bonnie Andrais, Suzanne E Lapi and Frank Wuest
    Citation: EJNMMI Research 2014 4:60
    Content type: Original research Published on:

  23. The kidneys are regarded as one of the main dose-limiting organs in the treatment of neuroendocrine tumours with 177Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate), despite the successful use of kidney uptake bloc...

    Authors: Johanna Dalmo, Emelie Westberg, Lars Barregard, Lisa Svedbom, Martin Johansson, Margareta Törnqvist and Eva Forssell-Aronsson
    Citation: EJNMMI Research 2014 4:59
    Content type: Original research Published on:

  24. Bone Scan Index (BSI) is a quantitative measurement of tumour burden in the skeleton calculated from bone scan images. When analysed at the time of diagnosis,it has been shown to provide prognostic information...

    Authors: Mariana Reza, Anders Bjartell, Mattias Ohlsson, Reza Kaboteh, Per Wollmer, Lars Edenbrandt and Elin Trägårdh
    Citation: EJNMMI Research 2014 4:58
    Content type: Original research Published on:

  25. In vivo bioluminescence, fluorescence, and single-photon emission computed tomography (SPECT) imaging provide complementary information about biological processes. However, to date these signatures are evaluated ...

    Authors: Matthias N van Oosterom, Rob Kreuger, Tessa Buckle, Wendy A Mahn, Anton Bunschoten, Lee Josephson, Fijs WB van Leeuwen and Freek J Beekman
    Citation: EJNMMI Research 2014 4:56
    Content type: Original research Published on:

  26. Hepatic mitochondrial dysfunction has been implicated in pathological conditions leading to non-alcoholic steatohepatitis (NASH). Technetium-99 m-2-methoxyisobutyl-isonitrile (99mTc-MIBI), a lipophilic cationic m...

    Authors: Takemi Rokugawa, Tomoya Uehara, Yusuke Higaki, Shuuichi Matsushima, Atsushi Obata, Yasushi Arano and Kohji Abe
    Citation: EJNMMI Research 2014 4:57
    Content type: Original research Published on:

  27. Radiation treatment with simultaneous integrated boost against suspected lymph node metastases may be a curative therapeutic option in patients with high-risk prostate cancer (>15% estimated risk of pelvic lym...

    Authors: Sara Strandberg, Camilla Thellenberg Karlsson, Torbjörn Sundström, Mattias Ögren, Margareta Ögren, Jan Axelsson and Katrine Riklund
    Citation: EJNMMI Research 2014 4:55
    Content type: Original research Published on:

  28. Dopamine D2/3 receptor (D2/3R) agonist radiopharmaceuticals are considered superior to antagonists to detect dopamine release, e.g. induced by amphetamines. Agonists bind preferentially to the high-affinity state...

    Authors: Jan-Peter van Wieringen, Martin C Michel, Henk M Janssen, Anton G Janssen, Philip H Elsinga and Jan Booij
    Citation: EJNMMI Research 2014 4:53
    Content type: Original research Published on:

  29. Today's standard treatment of advanced-stage ovarian cancer, including surgery followed by a paclitaxel-platinum-based chemotherapy, is limited in efficacy. Recently, we could show that radioimmunotherapy (RIT...

    Authors: Dennis Lindenblatt, Eliane Fischer, Susan Cohrs, Roger Schibli and Jürgen Grünberg
    Citation: EJNMMI Research 2014 4:54
    Content type: Original research Published on:

  30. The aims of this study were to determine the optimal tracer kinetic model for [11C]-meta- hydroxyephedrine ([11C]HED) and to evaluate the performance of several simplified methods.

    Authors: Hendrik J Harms, Stefan de Haan, Paul Knaapen, Cornelis P Allaart, Mischa T Rijnierse, Robert C Schuit, Albert D Windhorst, Adriaan A Lammertsma, Marc C Huisman and Mark Lubberink
    Citation: EJNMMI Research 2014 4:52
    Content type: Original research Published on:

  31. Development of tracers for imaging with positron emission tomography (PET) is often a time-consuming process associated with considerable attrition. In an effort to simplify this process, we herein propose a m...

    Authors: Markus Fridén, Marie Wennerberg, Madeleine Antonsson, Maria Sandberg-Ställ, Lars Farde and Magnus Schou
    Citation: EJNMMI Research 2014 4:50
    Content type: Original research Published on:

  32. Prostate cancer is a leading cause of death in the male population of the western world. Human kallikrein-related peptidase 2 (hK2) is abundantly expressed in malignant prostatic tissue, and its gene, KLK2, is re...

    Authors: Oskar Vilhelmsson Timmermand, David Ulmert, Susan Evans-Axelsson, Kim Pettersson, Anders Bjartell, Hans Lilja, Sven-Erik Strand and Thuy A Tran
    Citation: EJNMMI Research 2014 4:51
    Content type: Original research Published on:

  33. 2-deoxy-2-[18F]fluoro-D-glucose-positron emission tomography (18F-FDG-PET) is applied in the clinic for infection assessment and is under consideration for investigating the inflammatory/immune response in lympho...

    Authors: Svetlana Chefer, Richard C Reba, Christopher Z Leyson, Jurgen Seidel, Reed F Johnson, Joseph E Blaney, Peter B Jahrling and Julie Dyall
    Citation: EJNMMI Research 2014 4:49
    Content type: Preliminary research Published on:

  34. Selective arterial radioembolisation of liver tumours has increased, because of encouraging efficacy reports; however, therapeutic parameters used in external beam therapy are not applicable for understanding ...

    Authors: Jonas Högberg, Magnus Rizell, Ragnar Hultborn, Johanna Svensson, Olof Henrikson, Johan Mölne, Peter Gjertsson and Peter Bernhardt
    Citation: EJNMMI Research 2014 4:48
    Content type: Original research Published on:

  35. Peptide receptor radionuclide therapy (PRRT) is an effective form of treatment for patients with metastatic neuroendocrine tumors (NETs). However, delivering sufficient radiation dose to the tumor to result in...

    Authors: David L Bushnell, Mark T. Madsen, Thomas O'cdorisio, Yusuf Menda, Saima Muzahir, Randi Ryan and M. Sue O'dorisio
    Citation: EJNMMI Research 2014 4:38
    Content type: Original research Published on:

  36. The multitargeting tyrosine kinase inhibitor (TKI) sunitinib is currently the first-line drug therapy for metastasizing renal cell carcinoma (RCC). TKIs have profound effects on tumor angiogenesis, leading to ...

    Authors: David W Chapman, Hans-Sonke Jans, Ivy Ma, John R Mercer, Leonard I Wiebe, Melinda Wuest and Ronald B Moore
    Citation: EJNMMI Research 2014 4:27
    Content type: Original research Published on:

  37. Glioblastoma, the most frequent and aggressive of all astrocytomas, presents a clear predominance in male humans, but the assessment of sexual differences in its tumourigenesis and growth has received little a...

    Authors: Rocío Pérez-Carro, Omar Cauli and Pilar López-Larrubia
    Citation: EJNMMI Research 2014 4:44
    Content type: Original research Published on:

  38. Inhibition of mitogen-activated protein kinase (MEK, also known as MAPK2, MAPKK), a key molecule of the Ras/MAPK (mitogen-activated protein kinase) pathway, has shown promising effects on B-raf-mutated and some R...

    Authors: Tetyana Tegnebratt, Elisabeth Ruge, Sabine Bader, Nobuya Ishii, Satoshi Aida, Yasushi Yoshimura, Chia-Huey Ooi, Li Lu, Nicholas Mitsios, Valerie Meresse, Jan Mulder, Michael Pawlak, Miro Venturi, Jean Tessier and Sharon Stone-Elander
    Citation: EJNMMI Research 2014 4:34
    Content type: Original research Published on:

  39. Targeted radionuclide therapy with high-energy beta-emitters is generally considered suboptimal to cure small tumours (<300 mg). Tumour targeting of the CCK2 receptor-binding minigastrin analogue PP-F11 was de...

    Authors: Mark W. Konijnenberg, Wout A. P. Breeman, Erik de Blois, Ho Sze Chan, Otto C. Boerman, Peter Laverman, Petra Kolenc-Peitl, Marleen Melis and Marion de Jong
    Citation: EJNMMI Research 2014 4:47
    Content type: Original research Published on:

  40. Peptide receptor radionuclide therapy (PRRT) is routinely used for advanced or metastasized neuroendocrine tumours (NET). To prevent nephrotoxicity, positively charged amino acids (AA) are co-infused. The aim ...

    Authors: Constantin Lapa, Rudolf A Werner, Christina Bluemel, Katharina Lückerath, Andreas Schirbel, Alexander Strate, Andreas K Buck and Ken Herrmann
    Citation: EJNMMI Research 2014 4:46
    Content type: Original research Published on:

  41. Staphylococcus epidermidis (S. epidermidis) has emerged as one of the leading pathogens of biomaterial-related infections. Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible endothelial molecule con...

    Authors: Helena Ahtinen, Julia Kulkova, Laura Lindholm, Erkki Eerola, Antti J Hakanen, Niko Moritz, Mirva Söderström, Tiina Saanijoki, Sirpa Jalkanen, Anne Roivainen and Hannu T Aro
    Citation: EJNMMI Research 2014 4:45
    Content type: Original research Published on:

  42. [18F]fluciclatide, a peptide ligand with high affinity for αvβ3/αvβ5 integrins, is a proposed biomarker of tumor angiogenesis. The study rationale was to perform a preliminary evaluation of the relationship betwe...

    Authors: Laura M Kenny, Giampaolo Tomasi, Federico Turkheimer, James Larkin, Martin Gore, Cathryn S Brock, Stephen Mangar and Eric O Aboagye
    Citation: EJNMMI Research 2014 4:30
    Content type: Preliminary research Published on:

  43. The α7 nicotinic acetylcholine receptor (nAChR) is an important molecular target in neuropsychiatry and oncology. Development of applicable highly specific radiotracers has been challenging due to comparably l...

    Authors: Sven Rötering, Winnie Deuther-Conrad, Paul Cumming, Cornelius K Donat, Matthias Scheunemann, Steffen Fischer, Guoming Xiong, Jörg Steinbach, Dan Peters, Osama Sabri, Jan Bucerius and Peter Brust
    Citation: EJNMMI Research 2014 4:43
    Content type: Original research Published on:

  44. The aim of this pilot study was to evaluate whether the uptake of 89Zr-bevacizumab in non-small cell lung cancer (NSCLC) tumors could be visualized and quantified. The correlation between tumor 89Zr-bevacizumab u...

    Authors: Idris Bahce, Marc C Huisman, Eline E Verwer, Rogier Ooijevaar, Firdaouss Boutkourt, Danielle J Vugts, Guus AMS van Dongen, Ronald Boellaard and Egbert F Smit
    Citation: EJNMMI Research 2014 4:35
    Content type: Original research Published on:

  46. The biology of the vulnerable plaque includes increased inflammation and rapid growth of vasa vasorum, processes that are associated with enhanced vascular endothelial growth factor (VEGF)/ imaging receptors f...

    Authors: Yared Tekabe, Maria Kollaros, Adam Zerihoun, Geping Zhang, Marina V Backer, Joseph M Backer and Lynne L Johnson
    Citation: EJNMMI Research 2014 4:41
    Content type: Original research Published on:

  47. The trapping mechanisms of the PET hypoxia imaging agent copper(II)-diacetyl-bis(N4-methylthiosemicarbazone) (64Cu(ATSM)) remain unresolved, although its reduction prior to dissociation may be mediated by intrace...

    Authors: Fiona Shaughnessy, Erika Mariotti, Karen P Shaw, Thomas R Eykyn, Philip J Blower, Richard Siow and Richard Southworth
    Citation: EJNMMI Research 2014 4:40
    Content type: Original research Published on:

  48. Heterogeneous ventilation in lungs of individuals with allergies, cigarette smokers, asthmatics and chronic obstructive pulmonary disease (COPD) patients has been demonstrated using imaging modalities such as ...

    Authors: Pernilla Norberg, Hans Lennart Persson, Birgitta Schmekel, Gudrun Alm Carlsson, Karl Wahlin, Michael Sandborg and Agnetha Gustafsson
    Citation: EJNMMI Research 2014 4:39
    Content type: Original research Published on:

  49. The purpose of the study was to evaluate the applicability of 18 F-labelled amyloid imaging positron emission tomography (PET) agent [ 18 ...

    Authors: Anniina Snellman, Johanna Rokka, Francisco R López-Picón, Olli Eskola, Mario Salmona, Gianluigi Forloni, Mika Scheinin, Olof Solin, Juha O Rinne and Merja Haaparanta-Solin
    Citation: EJNMMI Research 2014 4:37
    Content type: Original research Published on:

  50. With the increasing utilization of 68Ge-68Ga radionuclide generators, 68Ga labelled peptides like DOTATATE are receiving more attention in nuclear medicine. On the one hand, the long half-life of the parent nucli...

    Authors: Ferdinand Sudbrock, Thomas Fischer, Beate Zimmermanns, Mehrab Guliyev, Markus Dietlein, Alexander Drzezga and Klaus Schomäcker
    Citation: EJNMMI Research 2014 4:36
    Content type: Original research Published on:

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