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  1. This study evaluated the absorption, distribution, and excretion of Gallium-68 (68Ga) radionuclide after a single intravenous (i.v.) injection of 68Ge/68Ga generator eluate in healthy rats. Additionally, human ra...

    Authors: Anu Autio, Helena Virtanen, Tuula Tolvanen, Heidi Liljenbäck, Vesa Oikonen, Tiina Saanijoki, Riikka Siitonen, Meeri Käkelä, Andrea Schüssele, Mika Teräs and Anne Roivainen

    Citation: EJNMMI Research 2015 5:40

    Content type: Original research

    Published on:

    The Erratum to this article has been published in EJNMMI Research 2016 6:51

  2. We aimed to evaluate and define the general clinical applicability and impact of pulmonary radioaerosol mucociliary clearance (PRMC) on the work up of patients suspected of having primary ciliary dyskinesia (P...

    Authors: Mathias Munkholm, Kim Gjerum Nielsen and Jann Mortensen

    Citation: EJNMMI Research 2015 5:39

    Content type: Original research

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  3. Reactive oxygen species (ROS) have been implicated in cisplatin-induced nephrotoxicity. The aim of this study was to investigate the potential of using [3H]-labeled N-methyl-2,3-diamino-6-phenyl-dihydrophenanthri...

    Authors: Nozomi Takai, Kohji Abe, Misato Tonomura, Natsumi Imamoto, Kazumi Fukumoto, Miwa Ito, Sotaro Momosaki, Kae Fujisawa, Kenji Morimoto, Nobuo Takasu and Osamu Inoue

    Citation: EJNMMI Research 2015 5:38

    Content type: Research Article

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  4. Reactive oxygen species (ROS) have been implicated in the pathophysiology of the brain after ischemic stroke. In this study, we investigate the generation of brain ROS after transient focal ischemia in mice us...

    Authors: Kohji Abe, Misato Tonomura, Miwa Ito, Nozomi Takai, Natsumi Imamoto, Takemi Rokugawa, Sotaro Momosaki, Kazumi Fukumoto, Kenji Morimoto and Osamu Inoue

    Citation: EJNMMI Research 2015 5:37

    Content type: Original research

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  5. Radioligand therapy (RLT) with 177Lu-DKFZ-617 PSMA (Lu-PSMA) (prostate-specific membrane antigen) is a novel targeted therapy of metastatic prostate cancer. We analysed retrospectively the early side effects and ...

    Authors: Hojjat Ahmadzadehfar, Kambiz Rahbar, Stefan Kürpig, Martin Bögemann, Michael Claesener, Elisabeth Eppard, Florian Gärtner, Sebastian Rogenhofer, Michael Schäfers and Markus Essler

    Citation: EJNMMI Research 2015 5:36

    Content type: Research Article

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  6. Compartmental analysis is a standard method to quantify metabolic processes using fluorodeoxyglucose-positron emission tomography (FDG-PET). For liver studies, this analysis is complex due to the hepatocyte ca...

    Authors: Sara Garbarino, Valentina Vivaldi, Fabrice Delbary, Giacomo Caviglia, Michele Piana, Cecilia Marini, Selene Capitanio, Iolanda Calamia, Ambra Buschiazzo and Gianmario Sambuceti

    Citation: EJNMMI Research 2015 5:35

    Content type: Original research

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  7. The norepinephrine transporter (NET) has been demonstrated to be relevant to a multitude of neurological, psychiatric and cardiovascular pathologies. Due to the wide range of possible applications for PET imag...

    Authors: Christina Rami-Mark, Neydher Berroterán-Infante, Cecile Philippe, Stefanie Foltin, Chrysoula Vraka, Alexander Hoepping, Rupert Lanzenberger, Marcus Hacker, Markus Mitterhauser and Wolfgang Wadsak

    Citation: EJNMMI Research 2015 5:34

    Content type: Original research

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  8. PET radiopharmaceuticals capable of imaging β-amyloid (Aβ) plaque burden in the brain could offer highly valuable diagnostic tools for clinical studies of Alzheimer’s disease. To further supplement existing ar...

    Authors: Guruswami SM Sundaram, Dhruva Dhavale, Julie L Prior, Jothilingam Sivapackiam, Richard Laforest, Paul Kotzbauer and Vijay Sharma

    Citation: EJNMMI Research 2015 5:33

    Content type: Original research

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  9. The maximum standardized uptake value (SUVmax) is a common clinical parameter for quantification in F18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT), but it is influenced by...

    Authors: Julian MM Rogasch, Ingo G Steffen, Frank Hofheinz, Oliver S Großer, Christian Furth, Konrad Mohnike, Peter Hass, Mathias Walke, Ivayla Apostolova and Holger Amthauer

    Citation: EJNMMI Research 2015 5:31

    Content type: Original research

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  10. Brain metastases are common in human epidermal growth factor receptor (Her)-2-positive breast cancer. Drug access to brain metastases and normal brain is key to management of cranial disease. In this study, po...

    Authors: Azeem Saleem, Graham E Searle, Laura M Kenny, Mickael Huiban, Kasia Kozlowski, Adam D Waldman, Laura Woodley, Carlo Palmieri, Charles Lowdell, Tomomi Kaneko, Philip S Murphy, Mike R Lau, Eric O Aboagye and Raoul C Coombes

    Citation: EJNMMI Research 2015 5:30

    Content type: Original research

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    The Erratum to this article has been published in EJNMMI Research 2017 7:74

    A Erratum has been published.

  11. Previous clinical studies have revealed the potential of [18F]-fluoro-L-α-methyltyrosine (18F-FAMT) for the differential diagnosis of malignant tumours from sarcoidosis. However, one concern regarding the differe...

    Authors: Aiko Yamaguchi, Hirofumi Hanaoka, Yutaka Fujisawa, Songji Zhao, Kazutomo Suzue, Akihiro Morita, Hideyuki Tominaga, Tetsuya Higuchi, Hajime Hisaeda, Yoshito Tsushima, Yuji Kuge and Yasuhiko Iida

    Citation: EJNMMI Research 2015 5:29

    Content type: Original research

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  12. J591 is a monoclonal antibody that targets the external domain of the prostate-specific membrane antigen (PSMA). Besides prostate cancer cells, it also targets the neovasculature of non-prostate solid tumors. ...

    Authors: Neeta Pandit-Taskar, Joseph A O’Donoghue, Chaitanya R Divgi, Eze A Wills, Lawrence Schwartz, Mithat Gönen, Peter Smith-Jones, Neil H Bander, Howard I Scher, Steven M Larson and Michael J Morris

    Citation: EJNMMI Research 2015 5:28

    Content type: Original research

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  13. The number of routine care patient examinations with 68Ga radiopharmaceuticals is still relatively limited, probably caused by the presumed need for large investments in hot cells, automated synthesis modules, la...

    Authors: Roeland Vis, Jules Lavalaye and Ewoudt MW van de Garde

    Citation: EJNMMI Research 2015 5:27

    Content type: Original research

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  14. Positron emission tomography (PET) with 18F-3′-deoxy-3′-fluorothymidine ([18F]FLT) can be used to assess tumour proliferation. A kinetic-filtering (KF) classification algorithm has been suggested for segmentation...

    Authors: Lieke L Hoyng, Virginie Frings, Otto S Hoekstra, Laura M Kenny, Eric O Aboagye and Ronald Boellaard

    Citation: EJNMMI Research 2015 5:26

    Content type: Research article

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  15. High-grade gliomas (HGGs) express somatostatin receptors (SSTR), rendering them candidates for peptide receptor radionuclide therapy (PRRT). Our purpose was to evaluate the potential of 68Ga-DOTA-1-Nal3-octreotid...

    Authors: Aida Kiviniemi, Maria Gardberg, Janek Frantzén, Marko Pesola, Ville Vuorinen, Riitta Parkkola, Tuula Tolvanen, Sami Suilamo, Jarkko Johansson, Pauliina Luoto, Jukka Kemppainen, Anne Roivainen and Heikki Minn

    Citation: EJNMMI Research 2015 5:25

    Content type: Original research

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  16. Features of the tumor microenvironment influence the efficacy of cancer nanotherapeutics. The ability to directly radiolabel nanotherapeutics offers a valuable translational tool to obtain biodistribution and ...

    Authors: Daniel F Gaddy, Helen Lee, Jinzi Zheng, David A Jaffray, Thomas J Wickham and Bart S Hendriks

    Citation: EJNMMI Research 2015 5:24

    Content type: Original research

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  17. [18F]Fludarabine is a novel positron emission tomography (PET) radiotracer for imaging lymphoma. The purpose of this preclinical study was to evaluate the robustness of [18F]fludarabine during rituximab therapy. ...

    Authors: Narinée Hovhannisyan, Stéphane Guillouet, Fabien Fillesoye, Martine Dhilly, Delphine Patin, Françoise Galateau, Michel Leporrier and Louisa Barré

    Citation: EJNMMI Research 2015 5:23

    Content type: Original research

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  18. Recently, an intra-patient comparison demonstrated that the somatostatin (sst) ligand [68Ga]HA-DOTATATE ([68Ga]DOTA-3-iodo-Tyr3-octreotate) provides PET images comparable to or superior to those obtained with [68

    Authors: Margret Schottelius, Jakub Šimeček, Frauke Hoffmann, Marina Willibald, Markus Schwaiger and Hans-Jürgen Wester

    Citation: EJNMMI Research 2015 5:22

    Content type: Original research

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  19. Tenascin-C (TNC), an extracellular matrix glycoprotein, is expressed transiently in distinct areas in association with active tissue remodeling. This study aimed to explore how ischemic postconditioning (PC) a...

    Authors: Junichi Taki, Anri Inaki, Hiroshi Wakabayashi, Ichiro Matsunari, Kyoko Imanaka-Yoshida, Kazuma Ogawa, Michiaki Hiroe, Kazuhiro Shiba, Toshimichi Yoshida and Seigo Kinuya

    Citation: EJNMMI Research 2015 5:21

    Content type: Original research

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  20. Over the last decade, an increasing number of studies have been published on the use of amyloid-β (Aβ) PET imaging with different 18F-radiopharmaceuticals for clinical characterization of Alzheimer’s disease (AD)...

    Authors: Behrooz H Yousefi, Boris von Reutern, Daniela Scherübl, André Manook, Markus Schwaiger, Timo Grimmer, Gjermund Henriksen, Stefan Förster, Alexander Drzezga and Hans-Jürgen Wester

    Citation: EJNMMI Research 2015 5:20

    Content type: Original research

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  21. With the recent growth of interest in cell-based therapies and radiolabeled cell products, there is a need to develop more robust cell labeling and imaging methods for in vivo tracking of living cells. This study...

    Authors: Aditya Bansal, Mukesh K Pandey, Yunus E Demirhan, Jonathan J Nesbitt, Ruben J Crespo-Diaz, Andre Terzic, Atta Behfar and Timothy R DeGrado

    Citation: EJNMMI Research 2015 5:19

    Content type: Original research

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  22. In vivo imaging using genetic reporters is a central supporting tool in the development of cell and gene therapies affording us the ability to selectively track the therapeutic indefinitely. Pr...

    Authors: Adam Badar, Louise Kiru, Tammy L Kalber, Amit Jathoul, Karin Straathof, Erik Årstad, Mark F Lythgoe and Martin Pule

    Citation: EJNMMI Research 2015 5:18

    Content type: Original research

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  23. The frequent expression of neurotensin receptors (NT-R) in primaries of pancreatic ductal carcinomas has triggered the development of radioactive neurotensin analogs for possible in vivo targeting of these tumors...

    Authors: Meike Körner, Beatrice Waser, Oliver Strobel, Markus Büchler and Jean Claude Reubi

    Citation: EJNMMI Research 2015 5:17

    Content type: Original research

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  24. The amount of inhomogeneities in a 99mTc Technegas single-photon emission computed tomography (SPECT) lung image, caused by reduced ventilation in lung regions affected by chronic obstructive pulmonary disease (C...

    Authors: Pernilla Norberg, Anna Olsson, Gudrun Alm Carlsson, Michael Sandborg and Agnetha Gustafsson

    Citation: EJNMMI Research 2015 5:16

    Content type: Original research

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  25. Deformable image registration allows volume of interest (VOI)- and voxel-based analysis of longitudinal changes in fluorodeoxyglucose (FDG) tumor uptake in patients with non-small cell lung cancer (NSCLC). Thi...

    Authors: Gerald SMA Kerner, Alexander Fischer, Michel JB Koole, Jan Pruim and Harry JM Groen

    Citation: EJNMMI Research 2015 5:15

    Content type: Original research

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  26. Tyrosine kinase inhibitors (TKIs) have experienced a tremendous boost in the last decade, where more than 15 small molecule TKIs have been approved by the FDA. Unfortunately, despite their promising clinical s...

    Authors: Paul Slobbe, Albert D Windhorst, Marijke Stigter-van Walsum, Egbert F Smit, Heiko G Niessen, Flavio Solca, Gerd Stehle, Guus A M S van Dongen and Alex J Poot

    Citation: EJNMMI Research 2015 5:14

    Content type: Original research

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  27. Management of infection is a major clinical problem. Staphylococcus aureus is a Gram-positive bacterium which colonises approximately one third of the adult human population. Staphylococcal infections can be life...

    Authors: Bethany Mills, Ramla O Awais, Jeni Luckett, Dave Turton, Paul Williams, Alan C Perkins and Philip J Hill

    Citation: EJNMMI Research 2015 5:13

    Content type: Original research

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  28. In specialized movement disorder centers, Parkinson’s disease (PD) is wrongly diagnosed in 6 to 25% of cases. To improve the accuracy of the clinical diagnosis, it is necessary to have a reliable and practical...

    Authors: Sven R Suwijn, Caroline JM van Boheemen, Rob J de Haan, Gerrit Tissingh, Jan Booij and Rob MA de Bie

    Citation: EJNMMI Research 2015 5:12

    Content type: Review

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  29. Technetium-99m methoxyisobutylisonitrile (Tc MIBI) is a substrate with the same uptake kinetics as doxorubicin. Multidrug resistance (MDR) is a mechanism that impedes chemotherapy of non-small cell lung cancer...

    Authors: Shohei Kanno, Keita Utsunomiya, Yumiko Kono, Noboru Tanigawa and Satoshi Sawada

    Citation: EJNMMI Research 2015 5:11

    Content type: Original research

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  30. The purpose of this study was to quantitatively evaluate the tumor accumulation and heterogeneity of 111In-ibritumomab tiuxetan (Zevalin®) and tumor accumulation of 18F-fluoro-deoxyglucose (FDG) and compare them ...

    Authors: Kohei Hanaoka, Makoto Hosono, Yoichi Tatsumi, Kazunari Ishii, Sung-Woon Im, Norio Tsuchiya, Kenta Sakaguchi and Itaru Matsumura

    Citation: EJNMMI Research 2015 5:10

    Content type: Original research

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  31. Recent research has demonstrated the potential of 18-kDa translocator protein (TSPO) to serve as a target for nuclear imaging of gliomas. The aim of this study was to evaluate SPECT imaging of GL26 mouse gliom...

    Authors: Stergios Tsartsalis, Noé Dumas, Benjamin B Tournier, Tien Pham, Marcelle Moulin-Sallanon, Marie-Claude Grégoire, Yves Charnay and Philippe Millet

    Citation: EJNMMI Research 2015 5:9

    Content type: Preliminary research

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  32. The purpose of this study was to determine whether brain metastases from HER2-positive breast cancer could be detected noninvasively using positron emission tomography (PET) with 64Cu-1,4,7,10-tetraazacyclododeca...

    Authors: Hiroaki Kurihara, Akinobu Hamada, Masayuki Yoshida, Schuichi Shimma, Jun Hashimoto, Kan Yonemori, Hitomi Tani, Yasuji Miyakita, Yousuke Kanayama, Yasuhiro Wada, Makoto Kodaira, Mayu Yunokawa, Harukaze Yamamoto, Chikako Shimizu, Kazuhiro Takahashi, Yasuyoshi Watanabe…

    Citation: EJNMMI Research 2015 5:8

    Content type: Original research

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  33. 3′-deoxy-3′-[18F]fluorothymidine (18F-FLT) has been used to evaluate tumor malignancy and cell proliferation in human brain gliomas. However, 18F-FLT has several limitations in clinical use. Recently, 11C-labeled...

    Authors: Yasunori Toyota, Keisuke Miyake, Nobuyuki Kawai, Tetsuhiro Hatakeyama, Yuka Yamamoto, Jun Toyohara, Yoshihiro Nishiyama and Takashi Tamiya

    Citation: EJNMMI Research 2015 5:7

    Content type: Original research

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  34. Systematic evaluations of the diagnostic accuracy of positron emission tomography (PET) imaging have been widely conducted in many countries. Although Japan’s total number of PET units is the second highest in...

    Authors: Shuhei Nomura, Akinori Hisashige, Daisuke Yoneoka, Mikiko Kanda, Karin Miyamoto, Miwako Segawa, Erika Ota and Kenji Shibuya

    Citation: EJNMMI Research 2015 5:6

    Content type: Original research

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  35. Botulinum neurotoxin A (BoNT-A) is a highly neurotoxic drug and frequently used in patients. Knowledge on the optimal way of administration of BoNT-A and its subsequent distribution is still rather limited. An...

    Authors: Janneke IM van Uhm, Gerard WM Visser, Marcel J van der Schans, Albert A Geldof, Eric JH Meuleman and Jakko A Nieuwenhuijzen

    Citation: EJNMMI Research 2015 5:5

    Content type: Original research

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    The Erratum to this article has been published in EJNMMI Research 2016 6:8

  36. Non-small cell lung carcinoma (NSCLC) represents approximately 80% of lung cancer cases, and over 60% of these tumors express the epidermal growth factor receptor (EGFR). Activating mutations in the tyrosine k...

    Authors: Galith Abourbeh, Batel Itamar, Olga Salnikov, Sergey Beltsov and Eyal Mishani

    Citation: EJNMMI Research 2015 5:4

    Content type: Original research

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  37. CD8-positive cells might play a crucial role in the therapeutic response to radiation, which has however not been investigated in radioimmunotherapy (RIT). The aim of this study was to evaluate whether cytotox...

    Authors: Erika Elgström, Sophie E Eriksson, Tomas G Ohlsson, Rune Nilsson and Jan Tennvall

    Citation: EJNMMI Research 2015 5:3

    Content type: Original research

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  38. CD13 is selectively upregulated in angiogenic active endothelium and can serve as a target for molecular imaging tracers to non-invasively visualise angiogenesis in vivo. Non-invasive determination of CD13 expres...

    Authors: Geert Hendrikx, Marijke De Saint-Hubert, Ingrid Dijkgraaf, Matthias Bauwens, Kim Douma, Roel Wierts, Ivo Pooters, Nynke MS Van den Akker, Tilman M Hackeng, Mark J Post and Felix M Mottaghy

    Citation: EJNMMI Research 2015 5:2

    Content type: Original research

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  39. In cancer radiotherapy, knowledge of normal tissue responses and toxicity risks is essential in order to deliver the highest possible absorbed dose to the tumor while maintaining normal tissue exposure at non-...

    Authors: Britta Langen, Nils Rudqvist, Toshima Z Parris, Emil Schüler, Johan Spetz, Khalil Helou and Eva Forssell-Aronsson

    Citation: EJNMMI Research 2015 5:1

    Content type: Original research

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  40. The goal of the present study was to evaluate the reproducibility of cerebral adenosine A2A receptor (A2AR) quantification using 11C-TMSX and PET in a test-retest study.

    Authors: Mika Naganawa, Masahiro Mishina, Muneyuki Sakata, Keiichi Oda, Mikio Hiura, Kenji Ishii and Kiichi Ishiwata

    Citation: EJNMMI Research 2014 4:76

    Content type: Original research

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  41. [18 F]AFM is a potent and promising PET imaging agent for the serotonin transporter. We carried out an acute toxicity study in rats and radiation dosimetry in monkeys before the translation of the tracer to human...

    Authors: Ya-Yao Huang, Chen-Yi Cheng, Wen-Sheng Huang, Kuo-Hsing Ma, Ta-Wei Tseng, Ta-Kai Chou, Yiyun Huang and Chyng-Yann Shiue

    Citation: EJNMMI Research 2014 4:71

    Content type: Original research

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    The Erratum to this article has been published in EJNMMI Research 2016 6:66

  42. Peptide receptor radionuclide therapy (PRRT) is applied in patients with advanced neuroendocrine tumors. Co-infused amino acids (AA) should prevent nephrotoxicity. The aims of this study were to correlate the ...

    Authors: Constantin Lapa, Rudolf A Werner, Christina Bluemel, Katharina Lueckerath, Dirk O Muegge, Alexander Strate, Heribert Haenscheid, Andreas Schirbel, Martin S Allen-Auerbach, Ralph A Bundschuh, Andreas K Buck and Ken Herrmann

    Citation: EJNMMI Research 2014 4:74

    Content type: Original research

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  43. Boron neutron capture therapy (BNCT) is a molecular radiation treatment based on the 10B (n, α) 7Li nuclear reaction in cancer cells, in which delivery of 10B by 4-borono-phenylalanine conjugated with fructose (B...

    Authors: Kohei Hanaoka, Tadashi Watabe, Sadahiro Naka, Yasukazu Kanai, Hayato Ikeda, Genki Horitsugi, Hiroki Kato, Kayako Isohashi, Eku Shimosegawa and Jun Hatazawa

    Citation: EJNMMI Research 2014 4:70

    Content type: Original research

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  44. Hepatobiliary scintigraphy using 99mTc-mebrofenin has been used as an investigation to study liver function after liver transplantation (LTx). Hepatic extraction fraction (HEF) is a measurement of the hepatic ext...

    Authors: Anastasios Kaxiras, Shinji Yamamoto, Gunnar Söderdahl, Annika Wernerson, Rimma Axelsson and Bo-Göran Ericzon

    Citation: EJNMMI Research 2014 4:73

    Content type: Original research

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  45. Endothelial dysfunction is associated with vascular risk factors such as dyslipidemia, hypertension, and diabetes, leading to coronary atherosclerosis. Sympathetic stress using cold-pressor testing (CPT) has b...

    Authors: Etienne Croteau, Jennifer M Renaud, Christine Archer, Ran Klein, Jean N DaSilva, Terrence D Ruddy, Rob SB Beanlands and Robert A deKemp

    Citation: EJNMMI Research 2014 4:68

    Content type: Original research

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  46. Absolute quantitative single-photon emission computed tomography (SPECT) has several important applications including monitoring tumor response after treatment and dose estimation for targeted radionuclide the...

    Authors: Nadège Anizan, Hao Wang, Xian C Zhou, Robert F Hobbs, Richard L Wahl and Eric C Frey

    Citation: EJNMMI Research 2014 4:67

    Content type: Original research

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  47. Tumor hypoxia is linked to invasion and metastasis but whether this associates with tumor growth rate is not well understood. We aimed to study the relationship between hypoxia evaluated with the positron emis...

    Authors: Antti Silvoniemi, Jonna Silén, Sarita Forsback, Eliisa Löyttyniemi, Aleksi R Schrey, Olof Solin, Reidar Grénman, Heikki Minn and Tove J Grönroos

    Citation: EJNMMI Research 2014 4:65

    Content type: Original research

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  48. At fluorodeoxyglucose/positron emission tomography (FDG/PET) examinations, a generally increased uptake of the skeletal muscles is sometimes encountered. As the tracer distribution constitutes a ‘zero-sum-game...

    Authors: Henry Lindholm, Fredrik Brolin, Cathrine Jonsson and Hans Jacobsson

    Citation: EJNMMI Research 2014 4:72

    Content type: Original research

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  49. Defining tumour volume for treatment response and radiotherapy planning is challenging and prone to inter- and intra-observer variability. Various automated tumour delineation methods have been proposed in the...

    Authors: Azadeh Firouzian, Matthew D Kelly and Jérôme M Declerck

    Citation: EJNMMI Research 2014 4:69

    Content type: Original research

    Published on: