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  1. Focal therapies or focally escalated therapies of primary prostate cancer are becoming more and more important. This increases the need to identify the exact extension of the intraprostatic tumor and possible ...

    Authors: Thomas Franz Fassbender, Florian Schiller, Constantinos Zamboglou, Vanessa Drendel, Selina Kiefer, Cordula A. Jilg, Anca-Ligia Grosu and Michael Mix
    Citation: EJNMMI Research 2020 10:62
    Content type: Original research Published on:

  2. 4-[18F] fluorobenzyl dexetimide (F-DEX) is the first non-subtype selective fluorine-18 labelled tracer for muscarinic receptors (mAChR) used in humans. A recent first-in-human study found high regional brain upta...

    Authors: Cameron D. Pain, Graeme J. O’Keefe, Uwe Ackermann, Vincent Dore, Victor L. Villemagne and Christopher C. Rowe
    Citation: EJNMMI Research 2020 10:61
    Content type: Original Research Published on:

  3. Quantitative analysis of brain positron-emission tomography (PET) depends on structural segmentation, which can be time-consuming and operator-dependent when performed manually. Previous automatic segmentation...

    Authors: Weiwei Ruan, Xun Sun, Xuehan Hu, Fang Liu, Fan Hu, Jinxia Guo, Yongxue Zhang and Xiaoli Lan
    Citation: EJNMMI Research 2020 10:60
    Content type: Original research Published on:

  4. The radioligand [11C]VC-002 was introduced in a small initial study long ago for imaging of muscarinic acetylcholine receptors (mAChRs) in human lungs using positron emission tomography (PET). The objectives of t...

    Authors: Zsolt Cselényi, Aurelija Jucaite, Cecilia Kristensson, Per Stenkrona, Pär Ewing, Andrea Varrone, Peter Johnström, Magnus Schou, Ana Vazquez-Romero, Mohammad Mahdi Moein, Martin Bolin, Jonathan Siikanen, Pär Grybäck, Bengt Larsson, Christer Halldin, Ken Grime…
    Citation: EJNMMI Research 2020 10:59
    Content type: Original research Published on:

  5. Human epidermal growth factor receptor-2 (HER2) is an essential biomarker for tumor treatment. Affibody is an ideal vector for preparing HER2 specific probes because of high affinity and rapid clearance from n...

    Authors: Yuping Xu, Lizhen Wang, Donghui Pan, Junjie Yan, Xinyu Wang, Runlin Yang, Mingzhu Li, Yu Liu and Min Yang
    Citation: EJNMMI Research 2020 10:58
    Content type: Original research Published on:

  6. Perfusion CT can offer functional information about tumor angiogenesis, and 18F-FDG PET/CT quantifies the glucose metabolic activity of tumors. This prospective study aims to investigate the value of biologically...

    Authors: Kewei Zhao, Chunsheng Wang, Qingfeng Mao, Dongping Shang, Yong Huang, Li Ma, Jinming Yu and Minghuan Li
    Citation: EJNMMI Research 2020 10:57
    Content type: Original research Published on:

  7. Static [18F]-F-DOPA PET images are currently used for identifying patients with glioma recurrence/progression after treatment, although the additional diagnostic value of dynamic parameters remains unknown in thi...

    Authors: Timothée Zaragori, Merwan Ginet, Pierre-Yves Marie, Véronique Roch, Rachel Grignon, Guillaume Gauchotte, Fabien Rech, Marie Blonski, Zohra Lamiral, Luc Taillandier, Laëtitia Imbert and Antoine Verger
    Citation: EJNMMI Research 2020 10:56
    Content type: Original research Published on:

  8. Recent studies reported on high uptake of the PSMA ligands [68Ga]HBED-CC (68Ga-PSMA) and 18F-DCFPyL in cerebral gliomas. This study explores the regional uptake and cellular targets of 68Ga-PSMA and 18F-DCFPyL in...

    Authors: Dennis Oliveira, Carina Stegmayr, Alexander Heinzel, Johannes Ermert, Bernd Neumaier, N. Jon Shah, Felix M. Mottaghy, Karl-Josef Langen and Antje Willuweit
    Citation: EJNMMI Research 2020 10:55
    Content type: Original research Published on:

  9. To compare the diagnostic sensitivity of [18F]fluoroestradiol ([18F]FES) and [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) for breast cancer recurrence in patients w...

    Authors: Sun Young Chae, Hye Joo Son, Dong Yun Lee, Eonwoo Shin, Jungsu S. Oh, Seung Yeon Seo, Sora Baek, Ji Young Kim, Sae Jung Na and Dae Hyuk Moon
    Citation: EJNMMI Research 2020 10:54
    Content type: Original research Published on:

  10. Attenuation correction (AC) of PET data is usually performed using a second imaging for the generation of attenuation maps. In certain situations however—when CT- or MR-derived attenuation maps are corrupted o...

    Authors: Karim Armanious, Tobias Hepp, Thomas Küstner, Helmut Dittmann, Konstantin Nikolaou, Christian La Fougère, Bin Yang and Sergios Gatidis
    Citation: EJNMMI Research 2020 10:53
    Content type: Original research Published on:

  11. PSMA-targeted radioligand therapy (PSMA-RLT) yielded impressive results in the metastasized castration-resistant prostate carcinoma (mCRPC) setting. High expression of PSMA is essential for successful PSMA-RLT...

    Authors: Florian Rosar, Kalle Ribbat, Martin Ries, Johannes Linxweiler, Mark Bartholomä, Stephan Maus, Mathias Schreckenberger, Samer Ezziddin and Fadi Khreish
    Citation: EJNMMI Research 2020 10:52
    Content type: Original research Published on:

  12. Immunotherapy targeting programmed cell death 1 (PD-1) or its ligand 1 (PD-L1) has shown promising results in non-small cell lung cancer (NSCLC) patients. Exploring PD-L1 expression could help to select NSCLC ...

    Authors: Xiaodong Wu, Yan Huang, Qingping Zhao, Lei Wang, Xiao Song, Yi Li and Lei Jiang
    Citation: EJNMMI Research 2020 10:51
    Content type: Original research Published on:

  13. Yoga is increasingly popular worldwide with several physical and mental benefits, but the underlying neurobiology remains unclear. Whereas many studies have focused on pure meditational aspects, the triad of y...

    Authors: June van Aalst, Jenny Ceccarini, Georg Schramm, Donatienne Van Weehaeghe, Ahmadreza Rezaei, Koen Demyttenaere, Stefan Sunaert and Koen Van Laere
    Citation: EJNMMI Research 2020 10:50
    Content type: Original research Published on:

  14. Accidental peripheral nerve injury during surgical intervention results in a broad spectrum of potentially debilitating side effects. Tissue distortion and poor visibility can significantly increase the risk o...

    Authors: Junior Gonzales, Giacomo Pirovano, Chun Yuen Chow, Paula Demetrio de Souza Franca, Lukas M. Carter, Julie K. Klint, Navjot Guru, Jason S. Lewis, Glenn F. King and Thomas Reiner
    Citation: EJNMMI Research 2020 10:49
    Content type: Original research Published on:

  15. New therapies to treat diabetic peripheral artery disease (PAD) require target-specific non-invasive imaging modalities to follow efficacy. As a translational study, we performed targeted imaging of receptors ...

    Authors: Lynne L. Johnson, Jordan Johnson, Ziad Ali, Yared Tekabe, Rebecca Ober, Gail Geist, Alicia McLuckie, Aram Safarov, April Holland, Geping Zhang, Marina Backer and Joseph Backer
    Citation: EJNMMI Research 2020 10:48
    Content type: Original research Published on:

  16. Angiogenesis plays an important role in head and neck squamous cell carcinoma (HNSCC) progression. This pilot study was designed to compare the distribution of 68Ga-NODAGA-RGD PET/CT for imaging αvβ3 integrins in...

    Authors: Steve Durante, Vincent Dunet, François Gorostidi, Periklis Mitsakis, Niklaus Schaefer, Judith Delage and John O. Prior
    Citation: EJNMMI Research 2020 10:47
    Content type: Original research Published on:

  17. Chimeric antibody Miltuximab®, a human IgG1 engineered from the parent antibody MIL-38, is in clinical development for solid tumour therapy. Miltuximab® targets glypican-1 (GPC-1), a cell surface protein invol...

    Authors: Mei-Chun Yeh, Brian W. C. Tse, Nicholas L. Fletcher, Zachary H. Houston, Maria Lund, Marianna Volpert, Chelsea Stewart, Kamil A. Sokolowski, Varinder Jeet, Kristofer J. Thurecht, Douglas H. Campbell, Bradley J. Walsh, Colleen C. Nelson and Pamela J. Russell
    Citation: EJNMMI Research 2020 10:46
    Content type: Original research Published on:

  18. Prostate-specific membrane antigen (PSMA) SPECT imaging in prostate cancer (PCa) could be a valuable alternative in regions where access to PSMA-PET imaging is restricted. [99mTc]Tc-PSMA-I&S is a new 99mTc-labele...

    Authors: P. Werner, C. Neumann, M. Eiber, H. J. Wester and M. Schottelius
    Citation: EJNMMI Research 2020 10:45
    Content type: Original research Published on:

  19. The molecular features of isocitrate dehydrogenase (IDH) mutation and chromosome 1p and 19q (1p/19q) codeletion status have pivotal role for differentiating gliomas and have been integrated in the World Health Or...

    Authors: Tomoya Ogawa, Nobuyuki Kawai, Keisuke Miyake, Aya Shinomiya, Yuka Yamamoto, Yoshihiro Nishiyama and Takashi Tamiya
    Citation: EJNMMI Research 2020 10:44
    Content type: Original research Published on:

  20. Given the increasing clinical use of PET/MRI, potential risks to patients from simultaneous exposure to ionising radiation and (electro)magnetic fields should be thoroughly investigated as a precaution. With t...

    Authors: Gunnar Brix, Elisabeth Günther, Ute Rössler, David Endesfelder, Alexandra Kamp, Ambros Beer and Matthias Eiber
    Citation: EJNMMI Research 2020 10:43
    Content type: Original research Published on:

  21. Although somatostatin receptor (SST) is a promising theranostic target and is widely expressed in tumors of various organs, the indication for therapies targeting SST is limited to typical gastroenteropancreat...

    Authors: Hyunjong Lee, Minseok Suh, Hongyoon Choi, Seunggyun Ha, Jin Chul Paeng, Gi Jeong Cheon, Keon Wook Kang and Dong Soo Lee
    Citation: EJNMMI Research 2020 10:42
    Content type: Original research Published on:

  22. Peptide receptor radionuclide therapy (PRRT) with [177Lu]Lu-DOTA0,TYR3-octreotate ([177Lu]Lu-DOTA-TATE) and the mechanistic target of rapamycin (mTOR) inhibitor everolimus are both approved for the treatment of n...

    Authors: Johannes Zellmer, Hsi-Yu Yen, Lena Kaiser, Erik Mille, Franz Josef Gildehaus, Guido Böning, Katja Steiger, Marcus Hacker, Peter Bartenstein, Andrei Todica, Alexander R. Haug and Harun Ilhan
    Citation: EJNMMI Research 2020 10:41
    Content type: Original research Published on:

  23. Correct identification of tumour receptor status is important for treatment decisions in breast cancer. [18F]FES PET and [18F]FDHT PET allow non-invasive assessment of the oestrogen (ER) and androgen receptor (AR...

    Authors: Lemonitsa H. Mammatas, Clasina M. Venema, Carolina P. Schröder, Henrica C. W. de Vet, Michel van Kruchten, Andor W. J. M. Glaudemans, Maqsood M. Yaqub, Henk M. W. Verheul, Epie Boven, Bert van der Vegt, Erik F. J. de Vries, Elisabeth G. E. de Vries, Otto S. Hoekstra, Geke A. P. Hospers and C. Willemien Menke-van der Houven van Oordt
    Citation: EJNMMI Research 2020 10:40
    Content type: Original research Published on:

  24. Schizophrenia is a disease diagnosed by visible signs and symptoms from late adolescence to early adulthood. The etiology of this disease remains unknown. An objective diagnostic approach is required. Here, we...

    Authors: Eugenia Tomasella, German Falasco, Leandro Urrutia, Lucila Bechelli, Lucia Padilla and Diego M. Gelman
    Citation: EJNMMI Research 2020 10:39
    Content type: Original research Published on:

  25. Precision therapeutics continuously make advances in cancer therapy, and a field of growing interest is the combination of targeted radionuclide therapy (TRNT) with potential radiosensitizing agents. This stud...

    Authors: Anja C. L. Mortensen, Eric Morin, Christopher J. Brown, David P. Lane and Marika Nestor
    Citation: EJNMMI Research 2020 10:38
    Content type: Original research Published on:

  26. Knowing the precise flow of cerebrospinal fluid (CSF) is important in the management of multiple neurological diseases. Technology for non-invasively quantifying CSF flow would allow for precise localization o...

    Authors: Hua Guo, Harikrishna Kommidi, Carl C. Lekaye, Jason Koutcher, Martin S. Judenhofer, Simon R. Cherry, Amy P. Wu, Oguz Akin, Mark M. Souweidane, Omer Aras, Zhaohui Zhu and Richard Ting
    Citation: EJNMMI Research 2020 10:37
    Content type: Original research Published on:

  27. 68Ga-labelled peptides targeting somatostatin receptor 2 (SSTR2) have demonstrated encouraging results in managing patients with neuroendocrine tumours (NETs). In addition to metal chelation, bifunctional chelat....

    Authors: Yuxiao Xia, Chengrun Zeng, Yanhong Zhao, Xinyi Zhang, Zibo Li and Yue Chen
    Citation: EJNMMI Research 2020 10:36
    Content type: Original research Published on:

  29. Statins are lipid-lowering agents that inhibit cholesterol synthesis and are clinically used in the primary and secondary prevention of cardiovascular diseases. However, a considerable group of patients does n...

    Authors: Gonçalo S. Clemente, Jens Rickmeier, Inês F. Antunes, Tryfon Zarganes-Tzitzikas, Alexander Dömling, Tobias Ritter and Philip H. Elsinga
    Citation: EJNMMI Research 2020 10:34
    Content type: Original research Published on:

  30. Tumor hypoxia (low tissue oxygenation) is an adverse condition of the solid tumor environment, associated with malignant progression, radiotherapy resistance, and poor prognosis. One method to detect tumor hyp...

    Authors: Tengzhi Liu, Morten Karlsen, Anna Maria Karlberg and Kathrine Røe Redalen
    Citation: EJNMMI Research 2020 10:33
    Content type: Review Published on:

  31. The folate receptor alpha (FRα) is an interesting target for imaging and therapy of different cancers. We present the first in-human radiation dosimetry and radiation safety results acquired within a prospecti...

    Authors: Silvano Gnesin, Joachim Müller, Irene A. Burger, Alexander Meisel, Marco Siano, Martin Früh, Matthias Choschzick, Cristina Müller, Roger Schibli, Simon M. Ametamey, Philipp A. Kaufmann, Valerie Treyer, John O. Prior and Niklaus Schaefer
    Citation: EJNMMI Research 2020 10:32
    Content type: Original research Published on:

  32. To investigate the added value and diagnostic accuracy of 68Ga-PSMA PET/CT versus bone scintigraphy (BS) for bone metastasis detection at the primary staging of prostate cancer (PCa).

    Authors: Helle D. Zacho, Søren Ravn, Ali Afshar-Oromieh, Joan Fledelius, June A. Ejlersen and Lars J. Petersen
    Citation: EJNMMI Research 2020 10:31
    Content type: Original research Published on:

  33. Multimodal PET/MRI image data simultaneously obtained from patients with early-stage of Alzheimer’s disease (eAD) were assessed in order to observe pathophysiologic and functional changes, as well as alteratio...

    Authors: Hidehiko Okazawa, Masamichi Ikawa, Minyoung Jung, Rikiya Maruyama, Tetsuya Tsujikawa, Tetsuya Mori, Mahmudur G. M. Rahman, Akira Makino, Yasushi Kiyono and Hirotaka Kosaka
    Citation: EJNMMI Research 2020 10:30
    Content type: Original research Published on:

  34. Positron emission tomography (PET) imaging with 68Gallium labeled somatostatin analogues (68Ga-DOTA-SSA) plays a key role in neuroendocrine tumor management. The impact of patient size on PET image quality is not...

    Authors: Christina P. W. Cox, Marcel Segbers, Laura H. Graven, Tessa Brabander and Daniëlle M. E. van Assema
    Citation: EJNMMI Research 2020 10:27
    Content type: Original research Published on:

  35. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease leading to neuromuscular palsy and death. We propose a computational approach to [18F]-fluorodeoxyglucose (FDG) PET/CT images to analyze the s...

    Authors: Matteo Bauckneht, Rita Lai, Alberto Miceli, Daniela Schenone, Vanessa Cossu, Maria Isabella Donegani, Stefano Raffa, Anna Borra, Stefano Marra, Cristina Campi, Annamaria Orengo, Anna Maria Massone, Alberto Tagliafico, Claudia Caponnetto, Corrado Cabona, Angelina Cistaro…
    Citation: EJNMMI Research 2020 10:23
    Content type: Original research Published on:

  36. High expression of human epidermal growth factor receptor type 2 (HER2) represents an aggressive subtype of breast cancer. Anti-HER2 treatment requires a theragnostic approach wherein sufficiently high recepto...

    Authors: Ali Alhuseinalkhudhur, Mark Lubberink, Henrik Lindman, Vladimir Tolmachev, Fredrik Y. Frejd, Joachim Feldwisch, Irina Velikyan and Jens Sörensen
    Citation: EJNMMI Research 2020 10:21
    Content type: Original research Published on:

  37. Functional somatic syndrome (FSS) is a disorder characterized by clusters of medically unexplained symptoms. Some women suffer from persistent FSS after human papillomavirus (HPV) vaccination. However, a causa...

    Authors: Takashi Matsudaira, Tatsuhiro Terada, Tomokazu Obi, Masamichi Yokokura, Yukitoshi Takahashi and Yasuomi Ouchi
    Citation: EJNMMI Research 2020 10:29
    Content type: Original research Published on:

  38. Anal cancer is a relatively rare tumor of which incidence increases in developed countries. 18F-FDG PET has been increasingly used for its post radio-chemotherapy evaluation. However, several authors have reporte...

    Authors: Nicolas Aide, Laure-Eugénie Tainturier, Cathy Nganoa, Benjamin Houdu, Jennifer Kammerer, Marie-Pierre Galais, Renaud Ciappuccini and Charline Lasnon
    Citation: EJNMMI Research 2020 10:28
    Content type: Original research Published on:

  39. Dosimetry for diagnostic agents is performed to assess the risk of radiation detriment (e.g., cancer) associated with the imaging agent and the risk is assessed by computing the effective dose coefficient, e. Sty...

    Authors: Anders Josefsson, Klaikangwol Siritantikorn, Sagar Ranka, Jose Willegaignon de Amorim de Carvalho, Carlos Alberto Buchpiguel, Marcelo Tatit Sapienza, Wesley E. Bolch and George Sgouros
    Citation: EJNMMI Research 2020 10:26
    Content type: Original research Published on:

  40. [18F]AmBF3-TATE is a somatostatin agonist that selectively binds to somatostatin receptor subtype 2 (SSTR2). For clinical translation, pharmacokinetics, radiation dosimetry, and acute toxicity of [18F]AmBF3-TATE ...

    Authors: Joseph Lau, Jinhe Pan, Etienne Rousseau, Carlos F. Uribe, Sudhakara Reddy Seelam, Brent W. Sutherland, David M. Perrin, Kuo-Shyan Lin and François Bénard
    Citation: EJNMMI Research 2020 10:25
    Content type: Original research Published on:

  41. Anti-programmed cell death 1 (PD-1) antibody is an immune checkpoint inhibitor, and anti-PD-1 therapy improves the anti-tumor functions of T cells and affects tumor microenvironment. We previously reported tha...

    Authors: Mayu Tomita, Motofumi Suzuki, Yusuke Kono, Kohei Nakajima, Takuma Matsuda, Yuji Kuge and Mikako Ogawa
    Citation: EJNMMI Research 2020 10:24
    Content type: Original research Published on:

  42. It is well known that a severe cell injury after exposure to ionizing radiation is the induction of DNA double-strand breaks (DSBs). After exposure, an early response to DSBs is the phosphorylation of the hist...

    Authors: Anna Stenvall, Erik Larsson, Bo Holmqvist, Sven-Erik Strand and Bo-Anders Jönsson
    Citation: EJNMMI Research 2020 10:22
    Content type: Original research Published on:

  43. Previous studies found that [18F]LSN3316612 was a promising positron emission tomography (PET) radioligand for imaging O-GlcNAcase in nonhuman primates and human volunteers. This study sought to further evaluate ...

    Authors: Jae-Hoon Lee, Jeih-San Liow, Soumen Paul, Cheryl L. Morse, Mohammad B. Haskali, Lester Manly, Sergey Shcherbinin, J. Craig Ruble, Nancy Kant, Emily C. Collins, Hugh N. Nuthall, Paolo Zanotti-Fregonara, Sami S. Zoghbi, Victor W. Pike and Robert B. Innis
    Citation: EJNMMI Research 2020 10:20
    Content type: Original research Published on:

  44. Lipopolysaccharide (LPS) is a classic immune stimulus. LPS combined with positron emission tomography (PET) 18 kDa translocator protein (TSPO) brain imaging provides a robust human laboratory model to study ne...

    Authors: Eric A. Woodcock, Martin Schain, Kelly P. Cosgrove and Ansel T. Hillmer
    Citation: EJNMMI Research 2020 10:19
    Content type: Short communication Published on:

  45. Differentiated thyroid carcinoma (DTC) is the most common type of thyroid cancer. Treatment with surgery, radioactive iodine (RAI), and TSH suppression is effective in most patients. Five to 15% of patients be...

    Authors: Lisa H. de Vries, Lutske Lodewijk, Arthur J. A. T. Braat, Gerard C. Krijger, Gerlof D. Valk, Marnix G. E. H. Lam, Inne H. M. Borel Rinkes, Menno R. Vriens and Bart de Keizer
    Citation: EJNMMI Research 2020 10:18
    Content type: Preliminary research Published on:

  46. Identification of suspicious PSMA-PET/CT-positive lymph node (LN) metastases (LNM) from prostate cancer (PCa) during lymphadenectomy (LA) is challenging. We evaluated an 111In-labelled PSMA ligand (DKFZ-617, refe...

    Authors: Cordula A. Jilg, Kathrin Reichel, Christian Stoykow, H. Christian Rischke, Mark Bartholomä, Vanessa Drendel, Moritz von Büren, Wolfgang Schultze-Seemann, Philipp T. Meyer and Michael Mix
    Citation: EJNMMI Research 2020 10:17
    Content type: Original research Published on:

  47. Targeting G protein-coupled receptors on the surface of cancer cells with peptide ligands is a promising concept for the selective tumor delivery of therapeutically active cargos, including radiometals for tar...

    Authors: Adrien Chastel, Dennis J. Worm, Isabel D. Alves, Delphine Vimont, Melina Petrel, Samantha Fernandez, Philippe Garrigue, Philippe Fernandez, Elif Hindié, Annette G. Beck-Sickinger and Clément Morgat
    Citation: EJNMMI Research 2020 10:16
    Content type: Original research Published on:

  48. Prostate-specific membrane antigen (PSMA) ligand PET/CT has already provided promising results in prostate cancer (PC) imaging, yet simple and reproductible reporting criteria are still lacking. This study aim...

    Authors: Céline Derwael, Olivier Lavergne, Pierre Lovinfosse, Vlad Nechifor, Mallory Salvé, David Waltregny, Roland Hustinx and Nadia Withofs
    Citation: EJNMMI Research 2020 10:15
    Content type: Original research Published on:

  49. Several scan parameters for PET imaging with 18F-PSMA-11 such as dosage, acquisition time and scan duration were evaluated to determine the most appropriate scan protocol, as well as the effect of furosemide admi...

    Authors: Sarah Piron, Kathia De Man, Vanessa Schelfhout, Nick Van Laeken, Ken Kersemans, Eric Achten, Filip De Vos and Piet Ost
    Citation: EJNMMI Research 2020 10:14
    Content type: Original research Published on:

  50. Cancer stem cells (CSCs) are involved in drug resistance, metastasis, and relapse of cancers, which can significantly affect tumor therapy. Hence, to develop specifically therapeutic target probe at CSCs for i...

    Authors: Siao-Syun Guan, Cheng-Tien Wu, Tse-Zung Liao, Tsai-Yueh Luo, Kun-Liang Lin and Shing-Hwa Liu
    Citation: EJNMMI Research 2020 10:13
    Content type: Original research Published on:

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