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  1. The phosphatidylinositol 3 kinase (PI3K) signalling pathway is frequently altered in human cancer and a promising therapeutic target. AZD8186 (AstraZeneca) is a PI3Kβ/δ inhibitor, currently in phase 1 clinical...

    Authors: Juliana Maynard, Sally-Ann Emmas, Francois-Xavier Blé, Hervé Barjat, Emily Lawrie, Urs Hancox, Deborah Oakes, Urszula M. Polanska and Simon T. Barry

    Citation: EJNMMI Research 2016 6:62

    Content type: Original research

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  2. We quantified myocardial blood flow with 82Rb PET using parameters of the generalized Renkin-Crone model estimated from 82Rb and 15O-water images reconstructed with time-of-flight and point spread function modeli...

    Authors: Mary Germino, Jim Ropchan, Tim Mulnix, Kathryn Fontaine, Nabeel Nabulsi, Eric Ackah, Herman Feringa, Albert J. Sinusas, Chi Liu and Richard E. Carson

    Citation: EJNMMI Research 2016 6:68

    Content type: Original research

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  3. PET/CT with F-18-fluorodeoxyglucose (FDG) images of patients suffering from metastatic melanoma have been analysed using fractal and multifractal analysis to assess the impact of monoclonal antibody ipilimumab...

    Authors: Christina-Marina Breki, Antonia Dimitrakopoulou-Strauss, Jessica Hassel, Theoharis Theoharis, Christos Sachpekidis, Leyun Pan and Astero Provata

    Citation: EJNMMI Research 2016 6:61

    Content type: Original research

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  4. The therapy response of osseous metastases (OM) is commonly monitored by bone scintigraphies (BS). The aim of this study was to compare visual evaluation of changes in tracer uptake with quantitation in absolu...

    Authors: Michael Beck, James C. Sanders, Philipp Ritt, Julia Reinfelder and Torsten Kuwert

    Citation: EJNMMI Research 2016 6:60

    Content type: Original research

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  5. This study was designed to establish a chronic myocardial infarction (MI) model in minipigs with a novel coronary sequential balloons-sponge embolism technique.

    Authors: Bo Tao, Haokao Gao, Minwen Zheng, Zhonghua Luo, Liwen Liu, Wei Bai, Jing Wang, Daliang Liu, Sai Ma, Zhenli Luo, Lei Gao, Yabin Wang and Feng Cao

    Citation: EJNMMI Research 2016 6:59

    Content type: Original research

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  6. Though overexpression of epidermal growth factor receptor (EGFR) in several forms of cancer is considered to be an important prognostic biomarker related to poor prognosis, clear correlations between biomarker...

    Authors: Qing Cheng, Helena Wållberg, Jonas Grafström, Li Lu, Jan-Olov Thorell, Maria Hägg Olofsson, Stig Linder, Katarina Johansson, Tetyana Tegnebratt, Elias S. J. Arnér, Sharon Stone-Elander, Hanna-Stina Martinsson Ahlzén and Stefan Ståhl

    Citation: EJNMMI Research 2016 6:58

    Content type: Original research

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  7. Assessment of liver function is critical in hepatocellular carcinoma (HCC) patient management. We evaluated parameters of [99mTc] sulfur colloid (SC) SPECT/CT liver uptake for association with clinical measures o...

    Authors: Stephen R. Bowen, Tobias R. Chapman, Joshua Borgman, Robert S. Miyaoka, Paul E. Kinahan, Iris W. Liou, George A. Sandison, Hubert J. Vesselle, Matthew J. Nyflot and Smith Apisarnthanarax

    Citation: EJNMMI Research 2016 6:57

    Content type: Original research

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  8. Positron emission tomography (PET) with the liver-specific galactose tracer 2-[18F]fluoro-2-deoxy-d-galactose (18F-FDGal) may improve diagnosis of hepatocellular carcinoma (HCC). The aim of this study was to test...

    Authors: Jacob Horsager, Kirstine Bak-Fredslund, Lars Peter Larsen, Gerda Elisabeth Villadsen, Trond Velde Bogsrud and Michael Sørensen

    Citation: EJNMMI Research 2016 6:56

    Content type: Original research

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  9. Significant renal mass reduction induced by 5/6 subtotal nephrectomy (Nx) is associated with a chain of events that culminates in hypertension and chronic kidney disease (CKD). Numerous studies have provided e...

    Authors: Basma Ismail, Robert A. deKemp, Tayebeh Hadizad, Kumiko Mackasey, Rob S. Beanlands and Jean N. DaSilva

    Citation: EJNMMI Research 2016 6:55

    Content type: Original research

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  10. Organic cation transporters (OCTs) in the renal proximal tubule are important for the excretion of both exo- and endogenous compounds, and chronic kidney disease (CKD) alter the expression of OCT. Metformin is...

    Authors: Lea Pedersen, Jonas Brorson Jensen, Lise Wogensen, Ole Lajord Munk, Niels Jessen, Jørgen Frøkiær and Steen Jakobsen

    Citation: EJNMMI Research 2016 6:54

    Content type: Original research

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  11. We have demonstrated recently that the tumor-to-blood standard uptake ratio (SUR) is superior to tumor standardized uptake value (SUV) as a surrogate of the metabolic uptake rate K m of...

    Authors: Frank Hofheinz, Jörg van den Hoff, Ingo G. Steffen, Alexandr Lougovski, Kilian Ego, Holger Amthauer and Ivayla Apostolova

    Citation: EJNMMI Research 2016 6:53

    Content type: Original Research

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  12. Cardiac sarcoidosis (CS) is a potentially fatal condition lacking a single test with acceptable diagnostic accuracy. 18F-FDG PET/CT has emerged as a promising imaging modality, but is challenged by physiological ...

    Authors: Lars C. Gormsen, Ate Haraldsen, Stine Kramer, Andre H. Dias, Won Yong Kim and Per Borghammer

    Citation: EJNMMI Research 2016 6:52

    Content type: Original research

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  13. Authors: Anu Autio, Helena Virtanen, Tuula Tolvanen, Heidi Liljenbäck, Vesa Oikonen, Tiina Saanijoki, Riikka Siitonen, Meeri Käkelä, Andrea Schüssele, Mika Teräs and Anne Roivainen

    Citation: EJNMMI Research 2016 6:51

    Content type: Erratum

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    The original article was published in EJNMMI Research 2015 5:40

  14. 177Lu is used in peptide receptor radionuclide therapies for the treatment of neuroendocrine tumors. Based on the recent literature, SST2 antagonists are superior to agonists in tumor ...

    Authors: Seval Beykan, Jan S. Dam, Uta Eberlein, Jens Kaufmann, Benedict Kjærgaard, Lars Jødal, Hakim Bouterfa, Romain Bejot, Michael Lassmann and Svend Borup Jensen

    Citation: EJNMMI Research 2016 6:50

    Content type: Original research

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  15. Human T lymphocytes infiltrating tissues in autoimmune diseases are known to express somatostatin receptors amongst other activation markers. In this study, we evaluated whether somatostatin receptor scintigra...

    Authors: L. K. Anzola-Fuentes, M. Chianelli, F. Galli, A. W. J. M. Glaudemans, L. Martin Martin, V. Todino, A. Migliore and A. Signore

    Citation: EJNMMI Research 2016 6:49

    Content type: Original research

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  16. DNA damage occurs as a consequence of both direct and indirect effects of ionizing radiation. The severity of DNA damage depends on the physical characteristics of the radiation quality, e.g., the linear energ...

    Authors: Roswitha Runge, Liane Oehme, Jörg Kotzerke and Robert Freudenberg

    Citation: EJNMMI Research 2016 6:48

    Content type: Original research

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  17. In PET/MRI, linear photon attenuation coefficients for attenuation correction (AC) cannot be directly derived, and cortical bone is, so far, usually not considered. This results in an underestimation of the av...

    Authors: P. Werner, M. Rullmann, A. Bresch, S. Tiepolt, T. Jochimsen, D. Lobsien, M. L. Schroeter, O. Sabri and H. Barthel

    Citation: EJNMMI Research 2016 6:47

    Content type: Original research

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  18. Bone disease in multiple myeloma is characterized by reduced bone formation. The gold standard of bone formation is the mineral apposition rate (MAR), an invasive technique reflecting bone formation at a singl...

    Authors: J. C. Regelink, P. G. Raijmakers, N. Bravenboer, R. Milek, N. J. Hoetjes, A. M. de Kreuk, M. van Duin, M. J. Wondergem, P. Lips, P. Sonneveld, J. M. Zijlstra and S. Zweegman

    Citation: EJNMMI Research 2016 6:46

    Content type: Preliminary research

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  19. It is unclear how to predict which patients will respond to Y-90 radiosynoviorthesis. The aim of this study is to correlate clinical outcomes following Y-90 radiosynoviorthesis with bremsstrahlung and Y-90 PET...

    Authors: Thomas W. Barber, Martin H. Cherk, Anne Powell, Kenneth S. K. Yap, Baki Billah and Victor Kalff

    Citation: EJNMMI Research 2016 6:45

    Content type: Short communication

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  20. We aimed to determine the accuracy of laser Doppler perfusion imaging (LDPI) in an animal model for hind limb ischemia.

    Authors: Geert Hendrikx, Mark H. Vries, Matthias Bauwens, Marijke De Saint-Hubert, Allard Wagenaar, Joël Guillaume, Levinia Boonen, Mark J. Post and Felix M. Mottaghy

    Citation: EJNMMI Research 2016 6:44

    Content type: Original research

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  21. Pulmonary perfusion is not spatially homogeneously distributed, and its variations could be of diagnostic value in lung vascular disease. PulmoBind is a ligand of the adrenomedullin receptor densely expressed ...

    Authors: Xavier Levac, François Harel, Vincent Finnerty, Quang T. Nguyen, Myriam Letourneau, Sophie Marcil, Alain Fournier and Jocelyn Dupuis

    Citation: EJNMMI Research 2016 6:43

    Content type: Original research

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  22. The purposes of this study are to evaluate the prognostic value of posttreatment 18F-FDG PET/CT in predicting the survival of patients with ovarian carcinoma and to determine incremental value of combining posttr...

    Authors: Linda C. Chu, Hua-Ling Tsai, Hao Wang, John Crandall, Mehrbod S. Javadi and Richard L. Wahl

    Citation: EJNMMI Research 2016 6:42

    Content type: Original research

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  23. Accelerated clearance of 99mtechnetium-sestamibi (MIBI) has been observed after reperfusion therapy in patients with acute coronary syndrome (ACS), but the mechanisms have not been fully investigated. MIBI retent...

    Authors: Atsuro Masuda, Keiichiro Yoshinaga, Masanao Naya, Osamu Manabe, Satoshi Yamada, Hiroyuki Iwano, Tatsuya Okada, Chietsugu Katoh, Yasuchika Takeishi, Hiroyuki Tsutsui and Nagara Tamaki

    Citation: EJNMMI Research 2016 6:41

    Content type: Original research

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  24. Prostate-specific membrane antigen (PSMA) is frequently overexpressed and upregulated in prostate cancer. To date, various 18F- and 68Ga-labeled urea-based radiotracers for PET imaging of PSMA have been developed...

    Authors: Vincent Bouvet, Melinda Wuest, Hans-Soenke Jans, Nancy Janzen, Afaf R. Genady, John F. Valliant, Francois Benard and Frank Wuest

    Citation: EJNMMI Research 2016 6:40

    Content type: Original research

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  25. Studies on imaging of differentiated thyroid cancer (DTC) using 124I often require a multicenter approach, as the prevalence of DTC is low. Calibration of participating scanners is required to obtain comparable q...

    Authors: Jakob W. Kist, Manfred van der Vlies, Otto S. Hoekstra, Henri N. J. M. Greuter, Bart de Keizer, Marcel P. M. Stokkel, Wouter V. Vogel, Marc C. Huisman and Arthur van Lingen

    Citation: EJNMMI Research 2016 6:39

    Content type: Original research

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  26. Facilitation of the differentiation of the stem cells toward neuronal lineage is crucial for enhancing the differentiation efficacy of grafted stem cells for the possible treatment of neurodegenerative disorde...

    Authors: Jaeho Jang, Song Lee, Hyun Jeong Oh, Yoori Choi, Jae Hyouk Choi, Do Won Hwang and Dong Soo Lee

    Citation: EJNMMI Research 2016 6:38

    Content type: Original research

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  27. Cyclooxygenase-2 (COX-2) is the inducible isoform of the cyclooxygenase enzyme family. COX-2 is involved in tumor development and progression, and frequent overexpression of COX-2 in a variety of human cancers...

    Authors: Ole Tietz, Melinda Wuest, Alison Marshall, Darryl Glubrecht, Ingrit Hamann, Monica Wang, Cody Bergman, Jenilee D. Way and Frank Wuest

    Citation: EJNMMI Research 2016 6:37

    Content type: Original research

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  28. The overexpression of the chemokine receptor 4 (CXCR4) in different epithelial, mesenchymal, and hematopoietic cancers makes CXCR4 an attractive diagnostic and therapeutic target. However, targeting the CXCR4 ...

    Authors: Andreas Poschenrieder, Margret Schottelius, Markus Schwaiger, Horst Kessler and Hans-Jürgen Wester

    Citation: EJNMMI Research 2016 6:36

    Content type: Original research

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  29. Terbium has attracted the attention of researchers and physicians due to the existence of four medically interesting radionuclides, potentially useful for SPECT and PET imaging, as well as for α- and β-radionucl...

    Authors: Cristina Müller, Christiaan Vermeulen, Karl Johnston, Ulli Köster, Raffaella Schmid, Andreas Türler and Nicholas P. van der Meulen

    Citation: EJNMMI Research 2016 6:35

    Content type: Preliminary research

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  30. [18F]BF4 , the first 18F-labelled PET imaging agent for the sodium/iodide symporter (NIS), was produced by isotopic exchange yielding a product with limited specific activity (SA, ca. ...

    Authors: Alex Khoshnevisan, Maite Jauregui-Osoro, Karen Shaw, Julia Baguña Torres, Jennifer D. Young, Nisha K. Ramakrishnan, Alex Jackson, Gareth E. Smith, Antony D. Gee and Philip J. Blower

    Citation: EJNMMI Research 2016 6:34

    Content type: Original research

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  31. Hypoxia is associated with resistance to chemotherapy and radiotherapy and is randomly distributed within malignancies. Characterization of changes in intratumoral hypoxic regions is possible with specially de...

    Authors: Gerald S. M. A. Kerner, Vikram R. Bollineni, Thijo J. N. Hiltermann, Nanna M. Sijtsema, Alexander Fischer, Alphons H. H. Bongaerts, Jan Pruim and Harry J. M. Groen

    Citation: EJNMMI Research 2016 6:33

    Content type: Original research

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  32. A1 68Ga-PSMA PET/CT in staging and restaging of Prostate Cancer Patients: comparative study with 18F-Choline PET/CT

    Authors: W Langsteger, A Rezaee, W Loidl, HS Geinitz, F Fitz, M Steinmair, G Broinger, L Pallwien-Prettner, M Beheshti, L Imamovic, M Beheshti, G Rendl, D Hackl, O Tsybrovsky, M Steinmair, K Emmanuel…

    Citation: EJNMMI Research 2016 6(Suppl 1):32

    Content type: Meeting abstracts

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    This article is part of a Supplement: Volume 6 Supplement 1

  33. The melanin-concentrating hormone receptor 1 (MCHR1), which is highly expressed in the lateral hypothalamus, plays a key role in energy homeostasis, obesity and other endocrine diseases. Hence, there is a majo...

    Authors: Cécile Philippe, Daniela Haeusler, Thomas Scherer, Clemens Fürnsinn, Markus Zeilinger, Wolfgang Wadsak, Karem Shanab, Helmut Spreitzer, Marcus Hacker and Markus Mitterhauser

    Citation: EJNMMI Research 2016 6:31

    Content type: Original research

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  34. Peptide receptor radionuclide therapy (PRRT) plays an important role in the treatment of neuroendocrine tumors (NET). Pre-therapeutic dosimetry using the area under the measured time-activity curve (AUC) is im...

    Authors: Christian Maaß, Jan Philipp Sachs, Deni Hardiansyah, Felix M. Mottaghy, Peter Kletting and Gerhard Glatting

    Citation: EJNMMI Research 2016 6:30

    Content type: Original research

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  35. αVβ3-integrin is expressed by activated endothelial cells and macrophages in atherosclerotic plaques and may represent a valuable marker of high-risk plaques. We evaluated 99mTc-maraciclatide, an integrin-specifi...

    Authors: David Vancraeynest, Véronique Roelants, Caroline Bouzin, François-Xavier Hanin, Stephan Walrand, Vanesa Bol, Anne Bol, Anne-Catherine Pouleur, Agnès Pasquet, Bernhard Gerber, Philippe Lesnik, Thierry Huby, François Jamar and Jean-Louis Vanoverschelde

    Citation: EJNMMI Research 2016 6:29

    Content type: Original research

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  36. Absorbed dose estimates for pediatric patients require pharmacokinetics that are, to the extent possible, age-specific. Such age-specific pharmacokinetic data are lacking for many of the diagnostic agents typi...

    Authors: Kitiwat Khamwan, Donika Plyku, Shannon E. O’Reilly, Alison Goodkind, Xinhua Cao, Frederic H. Fahey, S. Ted Treves, Wesley E. Bolch and George Sgouros

    Citation: EJNMMI Research 2016 6:28

    Content type: Original research

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  37. Prostate cancer ranks as the second most lethal malignancy in the Western world. Previous targeting of prostate-specific antigen and human kallikrein-related peptidase 2, two related enzymes abundantly express...

    Authors: O. Vilhelmsson Timmermand, E. Larsson, D. Ulmert, T. A. Tran and SE. Strand

    Citation: EJNMMI Research 2016 6:27

    Content type: Original research

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  38. The aim of the study was to explore Fc mutations of a humanised anti-Lewis-Y antibody (IgG1) hu3S193 as a strategy to improve therapeutic ratios for therapeutic payload delivery.

    Authors: Ingrid J. G. Burvenich, Fook-Thean Lee, Graeme J. O’Keefe, Dahna Makris, Diana Cao, Sylvia Gong, Angela Rigopoulos, Laura C. Allan, Martin W. Brechbiel, Zhanqi Liu, Paul A. Ramsland and Andrew M. Scott

    Citation: EJNMMI Research 2016 6:26

    Content type: Original research

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  39. Gene therapy has been hampered by low expression upon in vivo delivery. Using a somatostatin receptor type 2 (SSTR2)-based reporter, we assessed whether angiotensin II (AII) can improve gene expression by aden...

    Authors: Sheela P. Singh, Murali K. Ravoori, Katherine A. Dixon, Lin Han, Sanjay Gupta, Rajesh Uthamanthil, Kenneth C. Wright and Vikas Kundra

    Citation: EJNMMI Research 2016 6:25

    Content type: Original research

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  40. Quantitative in vivo imaging of tau pathologies potentially improves diagnostic accuracy of neurodegenerative tauopathies and would facilitate evaluation of disease-modifying drugs targeting tau lesions in the...

    Authors: Yasuyuki Kimura, Hironobu Endo, Masanori Ichise, Hitoshi Shimada, Chie Seki, Yoko Ikoma, Hitoshi Shinotoh, Makiko Yamada, Makoto Higuchi, Ming-Rong Zhang and Tetsuya Suhara

    Citation: EJNMMI Research 2016 6:24

    Content type: Original research

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  41. Having performed analytical validation studies, we are now assessing the clinical utility of the upgraded automated Bone Scan Index (BSI) in metastatic castration-resistant prostate cancer (mCRPC). In the pres...

    Authors: Aseem Anand, Michael J. Morris, Steven M. Larson, David Minarik, Andreas Josefsson, John T. Helgstrand, Peter S. Oturai, Lars Edenbrandt, Martin Andreas Røder and Anders Bjartell

    Citation: EJNMMI Research 2016 6:23

    Content type: Original research

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  42. Automated protocols for measuring and dispensing solutions containing radioisotopes are essential not only for providing a safe environment for radiation workers but also to ensure accuracy of dispensed radioa...

    Authors: Alex A. Dooraghi, Lewis Carroll, Jeffrey Collins, R. Michael van Dam and Arion F. Chatziioannou

    Citation: EJNMMI Research 2016 6:22

    Content type: Original research

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  43. This study is an assessment of the impact of acquisition times on SUV with [18F]FDG-PET/CT on healthy livers (reference organ with stable uptake over time) and on tumors.

    Authors: Avigaëlle Sher, Franck Lacoeuille, Pacôme Fosse, Laurent Vervueren, Aurélie Cahouet-Vannier, Djamel Dabli, Francis Bouchet and Olivier Couturier

    Citation: EJNMMI Research 2016 6:21

    Content type: Original research

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  44. The standardized uptake value (SUV) is the nearly exclusive means for quantitative evaluation of clinical [18F-]fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) whole body investigations. Howeve...

    Authors: Frank Hofheinz, Rebecca Bütof, Ivayla Apostolova, Klaus Zöphel, Ingo G. Steffen, Holger Amthauer, Jörg Kotzerke, Michael Baumann and Jörg van den Hoff

    Citation: EJNMMI Research 2016 6:19

    Content type: Original Research

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  45. α3β1 integrin is overexpressed in several types of human cancer and is associated with poor prognosis, metastasis, and resistance to cancer treatment. We previously identified a cyclic peptide ligand LXY1 that...

    Authors: Wenwu Xiao, Tianhong Li, Fernanda C. Bononi, Diana Lac, Ivy A. Kekessie, Yanlei Liu, Eduardo Sanchez, Anisha Mazloom, Ai-hong Ma, Jia Lin, Jimmy Tran, Kevin Yang, Kit S. Lam and Ruiwu Liu

    Citation: EJNMMI Research 2016 6:18

    Content type: Original research

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  46. Overexpression of the gastrin-releasing peptide receptor (GRP-R) has been documented in several human neoplasms such as breast, prostate, and ovarian cancer. There is growing interest in developing radiolabele...

    Authors: Antonella Accardo, Filippo Galli, Rosalba Mansi, Luigi Del Pozzo, Michela Aurilio, Anna Morisco, Paola Ringhieri, Alberto Signore, Giancarlo Morelli and Luigi Aloj

    Citation: EJNMMI Research 2016 6:17

    Content type: Original research

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  47. In targeted radionuclide therapy (TRT), accurate quantification using SPECT/CT images is important for optimizing radiation dose delivered to both the tumour and healthy tissue. Quantitative SPECT images are r...

    Authors: Eero Hippeläinen, Mikko Tenhunen, Hanna Mäenpää and Antti Sohlberg

    Citation: EJNMMI Research 2016 6:16

    Content type: Original research

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  48. We have recently shown that treatment of mice with the neutral endopeptidase (NEP) inhibitor phosphoramidon (PA) improves the bioavailability and tumor uptake of biodegradable radiopeptides. For the truncated ...

    Authors: Aikaterini Kaloudi, Berthold A. Nock, Emmanouil Lymperis, Roelf Valkema, Eric P. Krenning, Marion de Jong and Theodosia Maina

    Citation: EJNMMI Research 2016 6:15

    Content type: Original research

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  49. Optical molecular imaging is an emerging novel technology with applications in the diagnosis of cancer and assistance in image-guided surgery. A high tumour-to-background (T/B) ratio is crucial for successful ...

    Authors: Marta M. Kijanka, Aram S. A. van Brussel, Elsken van der Wall, Willem P. T. M. Mali, Paul J. van Diest, Paul M. P. van Bergen en Henegouwen and Sabrina Oliveira

    Citation: EJNMMI Research 2016 6:14

    Content type: Original research

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