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  1. Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disease of the nervous system involving both upper and lower motor neurons. The patterns of structural and metabolic brain alterations are still unc...

    Authors: M-S. Buhour, F. Doidy, A. Mondou, A. Pélerin, L. Carluer, F. Eustache, F. Viader and B. Desgranges

    Citation: EJNMMI Research 2017 7:21

    Content type: Original research

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  2. We aimed to assess the positivity, distribution, quantitative degree of vessel inflammation, and clinical characteristics of IgG4-related aortitis/periarteritis and periarteritis (IgG4-aortitis), and to examin...

    Authors: Satoshi Yabusaki, Noriko Oyama-Manabe, Osamu Manabe, Kenji Hirata, Fumi Kato, Noriyuki Miyamoto, Yoshihiro Matsuno, Kohsuke Kudo, Nagara Tamaki and Hiroki Shirato

    Citation: EJNMMI Research 2017 7:20

    Content type: Original research

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  3. Red blood cells (RBCs) labeled with single-photon emitters have been clinically used for blood-pool imaging. Although some PET tracers have been introduced for blood-pool imaging, they have not yet been widely...

    Authors: Yohji Matsusaka, Tadaki Nakahara, Kazuhiro Takahashi, Yu Iwabuchi, Chiyoko Nishime, Mayumi Kajimura and Masahiro Jinzaki

    Citation: EJNMMI Research 2017 7:19

    Content type: Original research

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  4. Dosimetry in radionuclide therapy has the potential to allow for a treatment tailored to the individual patient. One therapeutic radiopharmaceutical where patient-specific dosimetry is feasible is 177Lu-DOTATATE,...

    Authors: Johan Gustafsson, Anna Sundlöv and Katarina Sjögreen Gleisner

    Citation: EJNMMI Research 2017 7:18

    Content type: Original Research

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  5. Preferred models for the pharmacokinetic analysis of [11C]flumazenil human studies have been previously established. However, direct translation of these models and settings to animal studies might be sub-optimal...

    Authors: Isadora Lopes Alves, David Vállez García, Andrea Parente, Janine Doorduin, Rudi Dierckx, Ana Maria Marques da Silva, Michel Koole, Antoon Willemsen and Ronald Boellaard

    Citation: EJNMMI Research 2017 7:17

    Content type: Original research

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  6. Intratumoral hypoxia is one of the resistant factors in radiotherapy and chemotherapy for cancer. Although it is detected by 18F-fluoromisonidazole (FMISO) PET, the relationship between intratumoral hypoxia and o...

    Authors: Tadashi Watabe, Yasukazu Kanai, Hayato Ikeda, Genki Horitsugi, Keiko Matsunaga, Hiroki Kato, Kayako Isohashi, Kohji Abe, Eku Shimosegawa and Jun Hatazawa

    Citation: EJNMMI Research 2017 7:16

    Content type: Original research

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  7. Sodium fluoride (NaF) positron emission tomography combined with computer tomography (PET/CT) has shown to be more sensitive than the whole-body bone scan in the detection of skeletal uptake due to metastases ...

    Authors: Sarah Lindgren Belal, May Sadik, Reza Kaboteh, Nezar Hasani, Olof Enqvist, Linus Svärm, Fredrik Kahl, Jane Simonsen, Mads H. Poulsen, Mattias Ohlsson, Poul F. Høilund-Carlsen, Lars Edenbrandt and Elin Trägårdh

    Citation: EJNMMI Research 2017 7:15

    Content type: Original research

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    The Correction to this article has been published in EJNMMI Research 2019 9:44

  8. In FDG PET/CT, standardized uptake value (SUV) is used to measure metabolic activity but detects un-phosphorylated FDG as well as phosphorylated FDG (FDG6P). Our aim was to determine the proportions of intrahe...

    Authors: Georgia Keramida, Constantinos D. Anagnostopoulos and A. Michael Peters

    Citation: EJNMMI Research 2017 7:13

    Content type: Original research

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  9. While 68Ga-PSMA PET-MRI might be superior to PET-CT with regard to soft tissue assessment in prostate cancer evaluation, it is also known to potentially introduce additional PET image artefacts. Therefore, the im...

    Authors: Benjamin Noto, Florian Büther, Katharina Auf der Springe, Nemanja Avramovic, Walter Heindel, Michael Schäfers, Thomas Allkemper and Lars Stegger

    Citation: EJNMMI Research 2017 7:12

    Content type: Original research

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  10. This study aimed to compare one state-of-the-art deep learning method and four classical machine learning methods for classifying mediastinal lymph node metastasis of non-small cell lung cancer (NSCLC) from 18F-F...

    Authors: Hongkai Wang, Zongwei Zhou, Yingci Li, Zhonghua Chen, Peiou Lu, Wenzhi Wang, Wanyu Liu and Lijuan Yu

    Citation: EJNMMI Research 2017 7:11

    Content type: Original research

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  11. The use of a normal database for [123I]FP-CIT SPECT imaging has been found to be helpful for cases which are difficult to interpret by visual assessment alone, and to improve reproducibility in scan interpretatio...

    Authors: John C. Dickson, Livia Tossici-Bolt, Terez Sera, Jan Booij, Morten Ziebell, Silvia Morbelli, Susanne Assenbaum-Nan, Thierry Vander Borght, Marco Pagani, Ozlem L. Kapucu, Swen Hesse, Koen Van Laere, Jacques Darcourt, Andrea Varrone and Klaus Tatsch

    Citation: EJNMMI Research 2017 7:10

    Content type: Original research

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  12. The targeting of the prostate-specific membrane antigen (PSMA) is of particular interest for radiotheragnostic purposes of prostate cancer. Radiolabeled PSMA-617, a 1,4,7,10-tetraazacyclododecane-N,N′,N′′,N′′′-te...

    Authors: Christoph A. Umbricht, Martina Benešová, Raffaella M. Schmid, Andreas Türler, Roger Schibli, Nicholas P. van der Meulen and Cristina Müller

    Citation: EJNMMI Research 2017 7:9

    Content type: Original research

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  13. The aim of this study was to compare the percentage change in 18F-fluorothymidine (FLT) standard uptake value (SUV) between baseline and after one cycle of chemotherapy in patients categorized by RECIST 1.1 compu...

    Authors: John P. Crandall, Abdel K. Tahari, Rosalyn A. Juergens, Julie R. Brahmer, Charles M. Rudin, Giuseppe Esposito, Deepa S. Subramaniam, Michael V. Knopp, Nathan C. Hall, Prateek Gajwani, Jeffrey P. Leal, Martin A. Lodge, Joo H. O., Edward W. Gabrielson, Lalitha K. Shankar and Richard L. Wahl

    Citation: EJNMMI Research 2017 7:8

    Content type: Original research

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  14. In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of 68Ga-DOTA PET for the in vivo quantitative determination of regi...

    Authors: Carlos Velasco, Jesus Mateo, Arnoldo Santos, Adriana Mota-Cobian, Fernando Herranz, Juan Pellico, Ruben A. Mota, Samuel España and Jesus Ruiz-Cabello

    Citation: EJNMMI Research 2017 7:7

    Content type: Original research

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  15. Molecular breast imaging (MBI) performed with 99mTc sestamibi has been shown to be a valuable technique for the detection of breast cancer. Alternative radiotracers such as 99mTc maraciclatide may offer improved ...

    Authors: Michael K. O’Connor, Melissa M. B. Morrow, Katie N. Hunt, Judy C. Boughey, Dietlind L. Wahner-Roedler, Amy Lynn Conners, Deborah J. Rhodes and Carrie B. Hruska

    Citation: EJNMMI Research 2017 7:5

    Content type: Original research

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  16. Osteomyelitis is a serious disease which can be difficult to treat despite properly instituted antibiotic therapy. This appears to be related at least partly to degraded vascularisation in the osteomyelitic (O...

    Authors: Lars Jødal, Ole L. Nielsen, Pia Afzelius, Aage K. O. Alstrup and Søren B. Hansen

    Citation: EJNMMI Research 2017 7:4

    Content type: Original research

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  17. The purpose of this study is to identify a method for optimising the administered activity and acquisition time for 18F-FDG PET imaging, yielding images of consistent quality for patients with varying body sizes ...

    Authors: Fred Wickham, Helena McMeekin, Maria Burniston, Daniel McCool, Deborah Pencharz, Annah Skillen and Thomas Wagner

    Citation: EJNMMI Research 2017 7:3

    Content type: Original research

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  18. 177Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remissio...

    Authors: Johanna Dalmo, Johan Spetz, Mikael Montelius, Britta Langen, Yvonne Arvidsson, Henrik Johansson, Toshima Z. Parris, Khalil Helou, Bo Wängberg, Ola Nilsson, Maria Ljungberg and Eva Forssell-Aronsson

    Citation: EJNMMI Research 2017 7:6

    Content type: Original research

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  19. Routine work-up for transarterial radioembolization, based on clinical and laboratory parameters, sometimes fails, resulting in severe hepatotoxicity in up to 5% of patients. Quantitative assessment of the pre...

    Authors: Manon N. G. J. A. Braat, Hugo W. de Jong, Beatrijs A. Seinstra, Mike V. Scholten, Maurice A. A. J. van den Bosch and Marnix G. E. H. Lam

    Citation: EJNMMI Research 2017 7:2

    Content type: Preliminary research

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  20. The aim of this study is to assess whether ultra-fast acquisition SPECT/CT (UF-SPECT/CT) can replace standard SPECT/CT (std-SPECT/CT) as “add-on” to whole-body bone scintigraphy (WB-BS) for the investigation o...

    Authors: Helle D. Zacho, José A. Biurrun Manresa, Ramune Aleksyniene, June A. Ejlersen, Joan Fledelius, Henrik Bertelsen and Lars J. Petersen

    Citation: EJNMMI Research 2017 7:1

    Content type: Original research

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  21. Yttrium-90 radioembolization (90Y-RE) as a treatment for liver tumours induces radiation damage and hypoxia in liver tissue, which is also a trigger for systemic release of angiogenic factors, potentially stimula...

    Authors: C. E. N. M. Rosenbaum, A. F. van den Hoven, M. N. G. J. A. Braat, M. Koopman, M. G. E. H. Lam, B. A. Zonnenberg, H. M. Verkooijen and M. A. A. J. van den Bosch

    Citation: EJNMMI Research 2016 6:92

    Content type: Original research

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  22. Several radiometal-labeled, exendin-based tracers that target glucagon-like peptide-1 receptors (GLP-1R) have been intensively explored for β cell imaging. The main obstacle has been the high uptake of tracer ...

    Authors: Kirsi Mikkola, Cheng-Bin Yim, Paula Lehtiniemi, Saila Kauhanen, Miikka Tarkia, Tuula Tolvanen, Pirjo Nuutila and Olof Solin

    Citation: EJNMMI Research 2016 6:91

    Content type: Original research

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  23. Sorafenib, an oral multikinase inhibitor, has anti-proliferative and anti-angiogenic activities and is therapeutically effective against renal cell carcinoma (RCC). Recently, we have evaluated the tumor respon...

    Authors: Naoyuki Ukon, Songji Zhao, Wenwen Yu, Yoichi Shimizu, Ken-ichi Nishijima, Naoki Kubo, Yoshimasa Kitagawa, Nagara Tamaki, Kei Higashikawa, Hironobu Yasui and Yuji Kuge

    Citation: EJNMMI Research 2016 6:90

    Content type: Original research

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  24. 90Y PET/CT post-radioembolization imaging has demonstrated that the distribution of 90Y in a tumor can be non-uniform. Using computational modeling, we predicted the dosimetric impact ...

    Authors: Alexander S. Pasciak, Abigail Lin, Christos Georgiades, Laura K. Findeiss, Shannon Kauffman and Yong C. Bradley

    Citation: EJNMMI Research 2016 6:89

    Content type: Original research

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  25. Biologicals directed against tumour necrosis factor (TNF) have proven their efficacy in the treatment of spondyloarthritis and rheumatoid arthritis. We present a radiolabelling method for certolizumab pegol (C...

    Authors: Bieke Lambert, Philippe Carron, Yves D’Asseler, Klaus Bacher, Filip Van den Bosch, Dirk Elewaut, Gust Verbruggen, Rudi Beyaert, Caroline Dumolyn and Filip De Vos

    Citation: EJNMMI Research 2016 6:88

    Content type: Original research

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  26. Quantitative biodistribution, venous blood and excretion data have been obtained following the intravenous bolus injection of AH113804 (18F) Injection in six healthy volunteers (HVs), four males and two females, ...

    Authors: E. J. Somer, R. Owenius, A. Wall, G. Antoni, A. Thibblin and J. Sörensen

    Citation: EJNMMI Research 2016 6:87

    Content type: Original research

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  27. In preclinical positron emission tomography (PET) studies an anaesthetic is used to ensure that the animal does not move during the scan. However, anaesthesia may have confounding effects on the drug or tracer...

    Authors: Matthew G. Spangler-Bickell, Bart de Laat, Roger Fulton, Guy Bormans and Johan Nuyts

    Citation: EJNMMI Research 2016 6:86

    Content type: Original Research

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  28. Accurate quantification in molecular imaging is essential to improve the assessment of novel drugs and compare the radiobiological effects of therapeutic agents prior to in-human studies. The aim of this study...

    Authors: Ana M. Denis-Bacelar, Sarah E. Cronin, Chiara Da Pieve, Rowena L. Paul, Sue A. Eccles, Terence J. Spinks, Carol Box, Adrian Hall, Jane K. Sosabowski, Gabriela Kramer-Marek and Glenn D. Flux

    Citation: EJNMMI Research 2016 6:85

    Content type: Original research

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  29. The objective of this study is to explore the impact of PSA nadirs on detection rates of prostate cancer (PCa) recurrence with 18F-choline (CH) PET/CT after external beam radiation therapy (EBRT).

    Authors: Alison C. Johnson, Audrey Emmanuelle Dugué, Marlon Silva, Laura Moise, Xavier Tillou, Florence Joly and Nicolas Aide

    Citation: EJNMMI Research 2016 6:84

    Content type: Original research

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  30. Targeted alpha therapy (TAT) offers advantages over current β-emitting conjugates for peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors. PRRT with 177Lu-DOTATATE or 90Y-DOTATOC has shown dose-...

    Authors: Ho Sze Chan, Mark W. Konijnenberg, Tamara Daniels, Monique Nysus, Mehran Makvandi, Erik de Blois, Wouter A. Breeman, Robert W. Atcher, Marion de Jong and Jeffrey P. Norenberg

    Citation: EJNMMI Research 2016 6:83

    Content type: Original research

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  31. In the present study, 2-tert-butyl-4-chloro-5-[6-(4-18F-fluorobutoxy)-pyridin-3-ylmethoxy]-2H-pyridazin-3-one (18F-BCPP-BF), a PET probe for mitochondrial complex I (MC-I), was used to validate whether MC-I is a ...

    Authors: Hiroyuki Ohba, Masakatsu Kanazawa, Takeharu Kakiuchi and Hideo Tsukada

    Citation: EJNMMI Research 2016 6:82

    Content type: Original research

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  32. 3’-Deoxy-3’-[18F]fluorothymidine ([18F]FLT) PET has limited utility in abdominal imaging due to high physiological hepatic uptake of a tracer. We evaluated [18F]FLT-PET/CT combined with a temporal-intensity infor...

    Authors: R. Sharma, P. Mapelli, G. B. Hanna, R. Goldin, D. Power, A. Al-Nahhas, S. Merchant, R. Ramaswami, A. Challapalli, T. Barwick and E. O. Aboagye

    Citation: EJNMMI Research 2016 6:81

    Content type: Original research

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  33. The availability of GABAA receptor binding sites in the brain can be assessed by positron emission tomography (PET) using the radioligand, [18F]flumazenil. However, the brain uptake and binding of this PET radiol...

    Authors: Mikael Palner, Corinne Beinat, Sam Banister, Francesca Zanderigo, Jun Hyung Park, Bin Shen, Trine Hjoernevik, Jae Ho Jung, Byung Chul Lee, Sang Eun Kim, Lawrence Fung and Frederick T. Chin

    Citation: EJNMMI Research 2016 6:80

    Content type: Original research

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  34. Hypoxic tumours exhibit increased resistance to radiation, chemical, and immune therapies. 18F-fluoromisonidazole (FMISO) positron emission tomography (PET) is a non-invasive, quantitative imaging technique used ...

    Authors: Milan Grkovski, Jazmin Schwartz, Andreas Rimner, Heiko Schöder, Sean D. Carlin, Pat B. Zanzonico, John L. Humm and Sadek A. Nehmeh

    Citation: EJNMMI Research 2016 6:79

    Content type: Original research

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  35. Salvage radiotherapy (SRT) is clinically established in prostate cancer (PC) patients with PSA persistence or biochemical relapse (BCR) after prior radical surgery. PET/CT imaging prior to SRT may be performed...

    Authors: Christina Bluemel, Fraenze Linke, Ken Herrmann, Iva Simunovic, Matthias Eiber, Christian Kestler, Andreas K. Buck, Andreas Schirbel, Thorsten A. Bley, Hans-Juergen Wester, Daniel Vergho and Axel Becker

    Citation: EJNMMI Research 2016 6:78

    Content type: Original research

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  36. Circulating white blood cells crucially contribute to maintenance and repair of solid organs. Therefore, certain cell populations such as monocytes are attractive targets for use in molecular imaging and cell ...

    Authors: Evangelia Pardali, Timo Schmitz, Andreas Borgscheiper, Janette Iking, Lars Stegger and Johannes Waltenberger

    Citation: EJNMMI Research 2016 6:77

    Content type: Original research

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  37. In this study, we prospectively evaluate the diagnostic potential of a gallium-68 (68Ga) prostate-specific membrane antigen (PSMA)-binding ligand and positron emission tomography (PET) in detecting metastatic ...

    Authors: Handoo Rhee, John Blazak, Chui Ming Tham, Keng Lim Ng, Benjamin Shepherd, Malcolm Lawson, John Preston, Ian Vela, Paul Thomas and Simon Wood

    Citation: EJNMMI Research 2016 6:76

    Content type: Original research

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  38. In boron neutron capture therapy (BNCT), positron emission tomography (PET) with 4-borono-2-18F-fluoro-phenylalanine (FBPA) is the only method to estimate an accumulation of 10B to target tumor and surrounding no...

    Authors: Kayako Isohashi, Eku Shimosegawa, Sadahiro Naka, Yasukazu Kanai, Genki Horitsugi, Ikuko Mochida, Keiko Matsunaga, Tadashi Watabe, Hiroki Kato, Mitsuaki Tatsumi and Jun Hatazawa

    Citation: EJNMMI Research 2016 6:75

    Content type: Original research

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  39. The two main mechanisms of resistance to EGFR tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) are the occurrence of T790M secondary mutation in the kinase domain of EGFR and MET amplifi...

    Authors: Viviana De Rosa, Francesca Iommelli, Marcello Monti, Ciro Gabriele Mainolfi, Rosa Fonti and Silvana Del Vecchio

    Citation: EJNMMI Research 2016 6:74

    Content type: Original research

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  40. On April 1, 2015, Odense University Hospital (OUH) began a new diagnostic strategy, wherein all malignant melanoma (MM) patients in the Region of Southern Denmark with a positive sentinel lymph node biopsy (SL...

    Authors: Evan C. Frary, Dorte Gad, Lars Bastholt and Søren Hess

    Citation: EJNMMI Research 2016 6:73

    Content type: Original research

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  41. In order to maximise the utility of [11C]-PBR28 for use in longitudinal studies and clinical trials in Alzheimer’s disease (AD), there is a need to develop non-invasive metrics of tracer binding that do not requi...

    Authors: Akshay Nair, Mattia Veronese, Xiaohui Xu, Charles Curtis, Federico Turkheimer, Robert Howard and Suzanne Reeves

    Citation: EJNMMI Research 2016 6:72

    Content type: Short communication

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    The Erratum to this article has been published in EJNMMI Research 2017 7:14

  42. The purpose of this study is to determine whether a qualitative approach or a semi-quantitative approach provides the most robust method for early response evaluation with 2′-deoxy-2′-[18F]fluoro-d-glucose (F-18-...

    Authors: Joan Fledelius, Azza Khalil, Karin Hjorthaug and Jørgen Frøkiær

    Citation: EJNMMI Research 2016 6:71

    Content type: Original research

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  43. Due to its overexpression in a variety of tumor types, the chemokine receptor 4 (CXCR4) represents a highly relevant diagnostic and therapeutic target in nuclear oncology. Recently, [68Ga]pentixafor has emerged a...

    Authors: Andreas Poschenrieder, Margret Schottelius, Markus Schwaiger and Hans-Jürgen Wester

    Citation: EJNMMI Research 2016 6:70

    Content type: Short Communication

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  44. In addition to occipital hypoperfusion, preserved metabolism of the posterior cingulate gyri (PCG) relative to the precunei is known as the cingulate island sign (CIS) in the patients with dementia with Lewy b...

    Authors: Etsuko Imabayashi, Kota Yokoyama, Tadashi Tsukamoto, Daichi Sone, Kaoru Sumida, Yukio Kimura, Noriko Sato, Miho Murata and Hiroshi Matsuda

    Citation: EJNMMI Research 2016 6:67

    Content type: Original research

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  45. Ga-labeled radiotracers are increasingly used for PET imaging. During the labeling procedure, formation of 68Ga-colloid may occur. Upon i.v. injection, 68Ga-colloid will accumulate rapidly in the liver, spleen, a...

    Authors: Maarten Brom, Gerben M. Franssen, Lieke Joosten, Martin Gotthardt and Otto C. Boerman

    Citation: EJNMMI Research 2016 6:65

    Content type: Original research

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  46. Radiation-induced nephropathy is still dose limiting in radionuclide therapy of neuroendocrine tumors. We investigated the nephroprotective potential of the angiotensine converting enzyme inhibiting drug enalp...

    Authors: Harun Ilhan, Hao Wang, Franz J. Gildehaus, Carmen Wängler, Tanja Herrler, Andrei Todica, Julia Schlichtiger, Paul Cumming, Peter Bartenstein, Marcus Hacker and Alexander R. Haug

    Citation: EJNMMI Research 2016 6:64

    Content type: Original research

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  47. Recent studies have shown that 3′-deoxy-3′-[18F] fluorothymidine ([18F]FLT)) uptake depends on endogenous tumour thymidine concentration. The purpose of this study was to investigate tumour thymidine concentratio...

    Authors: Kathrin Heinzmann, Davina Jean Honess, David Yestin Lewis, Donna-Michelle Smith, Christopher Cawthorne, Heather Keen, Sandra Heskamp, Sonja Schelhaas, Timothy Howard Witney, Dmitry Soloviev, Kaye Janine Williams, Andreas Hans Jacobs, Eric Ofori Aboagye, John Richard Griffiths and Kevin Michael Brindle

    Citation: EJNMMI Research 2016 6:63

    Content type: Original research

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    The Correction to this article has been published in EJNMMI Research 2017 7:99