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  1. Increases in fasting plasma glucose (PG) levels lead to a decrease in 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) uptake in the normal brain, especially in the precuneus, resulting in an Alzheimer’s disease (AD)-l...

    Authors: Jun Toyohara, Norihiro Harada, Takeharu Kakiuchi, Hiroyuki Ohba, Masakatsu Kanazawa, Tetsuro Tago, Muneyuki Sakata and Kiichi Ishiwata
    Citation: EJNMMI Research 2020 10:115
  2. Clinical positron emission tomography (PET) imaging of the presynaptic norepinephrine transporter (NET) function provides valuable diagnostic information on sympathetic outflow and neuronal status. As data on ...

    Authors: Linjing Mu, Stefanie D. Krämer, Geoffrey I. Warnock, Ahmed Haider, Susan Bengs, Giovanni Cartolano, Dominic S. Bräm, Claudia Keller, Roger Schibli, Simon M. Ametamey, Philipp A. Kaufmann and Catherine Gebhard
    Citation: EJNMMI Research 2020 10:114
  3. Accurate and sensitive imaging biomarkers are required to study the progression of white matter (WM) inflammation in neurodegenerative diseases. Radioligands targeting the translocator protein (TSPO) are consi...

    Authors: Nassir U. Al-Khishman, Qi Qi, Austyn D. Roseborough, Alexander Levit, Brian L. Allman, Udunna C. Anazodo, Matthew S. Fox, Shawn N. Whitehead and Jonathan D. Thiessen
    Citation: EJNMMI Research 2020 10:113
  4. Stress exposure can significantly affect serotonergic signaling with a particular impact on 5-HT1A receptor expression. Positron emission tomography (PET) provides opportunities for molecular imaging of alteratio...

    Authors: Verena Buchecker, Ann-Marie Waldron, R. Maarten van Dijk, Ines Koska, Matthias Brendel, Barbara von Ungern-Sternberg, Simon Lindner, Franz Josef Gildehaus, Sibylle Ziegler, Peter Bartenstein and Heidrun Potschka
    Citation: EJNMMI Research 2020 10:112
  5. The reoperation rate for breast-conserving surgery is as high as 15–30% due to residual tumor in the surgical cavity after surgery. In vivo tumor-targeted optical molecular imaging may serve as a red-flag tech...

    Authors: Frans V. Suurs, Si-Qi Qiu, Joshua J. Yim, Carolien P. Schröder, Hetty Timmer-Bosscha, Eric S. Bensen, John T. Santini Jr, Elisabeth G. E. de Vries, Matthew Bogyo and Gooitzen M. van Dam
    Citation: EJNMMI Research 2020 10:111
  6. The aim of this study was to explore the prognostic value of total metabolic tumor volume (TMTV) at baseline 18F-FDG PET/CT in patients diagnosed with peripheral T-cell lymphoma (PTCL).

    Authors: Chong Jiang, Yue Teng, Jieyu Chen, Zhen Wang, Zhengyang Zhou, Chongyang Ding and Jingyan Xu
    Citation: EJNMMI Research 2020 10:110
  7. Positron emission tomography (PET) offers the study of biochemical, physiological, and pharmacological functions at a cellular and molecular level. The performance of a ...

    Authors: Krishna Kanta Ghosh, Parasuraman Padmanabhan, Chang-Tong Yang, Sachin Mishra, Christer Halldin and Balázs Gulyás
    Citation: EJNMMI Research 2020 10:109
  8. Brain metastases from prostate cancer are rare and usually only occur in the context of widespread systemic disease. This is the first case report of a solitary brain oligometastasis, in a neurologically intac...

    Authors: M. I. Ross, N. Bird, I. A. Mendichovszky and Y. L. Rimmer
    Citation: EJNMMI Research 2020 10:108

    The Correction to this article has been published in EJNMMI Research 2020 10:129

  9. Radioembolization is an established treatment modality in colorectal cancer patients with liver-dominant disease in a salvage setting. Selection of patients who will benefit most is of vital importance. The ai...

    Authors: Caren van Roekel, Jennifer M. J. Jongen, Maarten L. J. Smits, Sjoerd G. Elias, Miriam Koopman, Onno Kranenburg, Inne H. M. Borel Rinkes and Marnix G. E. H. Lam
    Citation: EJNMMI Research 2020 10:107
  10. Albumin is commonly used as a carrier platform for drugs to extend their circulatory half-lives and influence their uptake into tissues that have altered permeability to the plasma protein. The albumin-binding...

    Authors: Emma Jussing, Li Lu, Jonas Grafström, Tetyana Tegnebratt, Fabian Arnberg, Helena Wållberg Rosik, Anders Wennborg, Staffan Holmin, Joachim Feldwisch and Sharon Stone-Elander
    Citation: EJNMMI Research 2020 10:106
  11. PET is a relatively noisy process compared to other imaging modalities, and sparsity of acquisition data leads to noise in the images. Recent work has focused on machine learning techniques to improve PET imag...

    Authors: Josh Schaefferkoetter, Jianhua Yan, Claudia Ortega, Andrew Sertic, Eli Lechtman, Yael Eshet, Ur Metser and Patrick Veit-Haibach
    Citation: EJNMMI Research 2020 10:105
  12. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Alexander S. Pasciak, Sasicha Manupipatpong, Ferdinand K. Hui, Larry Gainsburg, Rebecca Krimins, M. Christine Zink, Cory F. Brayton, Meaghan Morris, Jaime Sage, Danielle R. Donahue, Matthew R. Dreher, Dara L. Kraitchman and Clifford R. Weiss
    Citation: EJNMMI Research 2020 10:104

    The original article was published in EJNMMI Research 2020 10:96

  13. Radiomics is aimed at image-based tumor phenotyping, enabling application within clinical-decision-support-systems to improve diagnostic accuracy and allow for personalized treatment. The purpose was to identi...

    Authors: Roland M. Martens, Thomas Koopman, Daniel P. Noij, Elisabeth Pfaehler, Caroline Übelhör, Sughandi Sharma, Marije R. Vergeer, C. René Leemans, Otto S. Hoekstra, Maqsood Yaqub, Gerben J. Zwezerijnen, Martijn W. Heymans, Carel F. W. Peeters, Remco de Bree, Pim de Graaf, Jonas A. Castelijns…
    Citation: EJNMMI Research 2020 10:102
  14. Several nuclear imaging methods may predict postoperative liver function and outcome, but none has achieved recommendations in clinical guidelines. The purpose of this systematic review was to summarize the ex...

    Authors: Caroline Espersen, Lise Borgwardt, Peter Nørgaard Larsen, Trine Borup Andersen, Louise Stenholt and Lars Jelstrup Petersen
    Citation: EJNMMI Research 2020 10:101
  15. (4S)-4-(3-[18F]Fluoropropyl)-l-glutamic acid ([18F]FSPG) measures system xC transporter activity and shows promise for oncologic imaging. We present data on tumor uptake of this radiopharmaceutical in human subj...

    Authors: Sonya Y. Park, Camila Mosci, Meena Kumar, Mirwais Wardak, Norman Koglin, Santiago Bullich, Andre Mueller, Mathias Berndt, Andrew W. Stephens, Frederick T. Chin, Sanjiv S. Gambhir and Erik S. Mittra
    Citation: EJNMMI Research 2020 10:100
  16. Q.Clear is a new Bayesian penalized-likelihood PET reconstruction algorithm. It has been documented that Q.Clear increases the SUVmax values of different malignant lesions.

    Authors: Michał Wyrzykowski, Natalia Siminiak, Maciej Kaźmierczak, Marek Ruchała and Rafał Czepczyński
    Citation: EJNMMI Research 2020 10:99
  17. TEM-1 (tumor endothelial marker-1) is a single-pass transmembrane cell surface glycoprotein expressed at high levels by tumor vasculature and malignant cells. We aimed to perform a preclinical investigation of...

    Authors: J. A. Delage, A. Faivre-Chauvet, J. K. Fierle, S. Gnesin, N. Schaefer, G. Coukos, S. M. Dunn, D. Viertl and J. O. Prior
    Citation: EJNMMI Research 2020 10:98
  18. Only a subgroup of non-small cell lung cancer (NSCLC) patients benefit from treatment using epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) such as afatinib. Tumour uptake of [18F]afatini...

    Authors: E. A. van de Stadt, M. Yaqub, A. A. Lammertsma, A. J. Poot, P. R. Schober, R. C. Schuit, E. F. Smit, I. Bahce and N. H. Hendrikse
    Citation: EJNMMI Research 2020 10:97
  19. To evaluate the safety, feasibility, and preliminary efficacy of yttrium-90 (90Y) radioembolization (RE) as a minimally invasive treatment in a canine model with presumed spontaneous brain cancers.

    Authors: Alexander S. Pasciak, Sasicha Manupipatpong, Ferdinand K. Hui, Larry Gainsburg, Rebecca Krimins, M. Christine Zink, Cory F. Brayton, Meaghan Morris, Jaime Sage, Danielle R. Donahue, Matthew R. Dreher, Dara L. Kraitchman and Clifford R. Weiss
    Citation: EJNMMI Research 2020 10:96

    The Correction to this article has been published in EJNMMI Research 2020 10:104

  20. Reliable quantification of dopamine transporter (DAT), a biomarker for Parkinson’s disease (PD), is essential for diagnostic purposes as well as for evaluation of potential disease-modifying treatment. Due to ...

    Authors: Vera S. Kerstens, Patrik Fazio, Mathias Sundgren, Granville J. Matheson, Erika Franzén, Christer Halldin, Simon Cervenka, Per Svenningsson and Andrea Varrone
    Citation: EJNMMI Research 2020 10:95
  21. Selective internal radiation therapy (SIRT) is a promising treatment for unresectable hepatic malignancies. Predictive dose calculation based on a simulation using 99mTc-labeled macro-aggregated albumin (99mTc-MA...

    Authors: Esmaeel Jafargholi Rangraz, Xikai Tang, Charlotte Van Laeken, Geert Maleux, Jeroen Dekervel, Eric Van Cutsem, Chris Verslype, Kristof Baete, Johan Nuyts and Christophe M. Deroose
    Citation: EJNMMI Research 2020 10:94
  22. The aim of this study was to examine whether the translocator protein 18-kDa (TSPO) PET ligand [18F]FEPPA has the sensitivity for detecting changes in CD68-positive microglial/macrophage activation in hemiparkins...

    Authors: Matthew Zammit, Yunlong Tao, Miles E. Olsen, Jeanette Metzger, Scott C. Vermilyea, Kathryn Bjornson, Maxim Slesarev, Walter F. Block, Kerri Fuchs, Sean Phillips, Viktorya Bondarenko, Su-Chun Zhang, Marina E. Emborg and Bradley T. Christian
    Citation: EJNMMI Research 2020 10:93
  23. Recently, a flexible DROP-IN gamma-probe was introduced for robot-assisted radioguided surgery, using traditional low-energy SPECT-isotopes. In parallel, a novel approach to achieve sensitive radioguidance usi...

    Authors: Francesco Collamati, Matthias N. van Oosterom, Micol De Simoni, Riccardo Faccini, Marta Fischetti, Carlo Mancini Terracciano, Riccardo Mirabelli, Roberto Moretti, Judith olde Heuvel, Elena Solfaroli Camillocci, Florian van Beurden, Henk G. van der Poel, Renato A. Valdes Olmos, Pim J. van Leeuwen, Fijs W. B. van Leeuwen and Silvio Morganti
    Citation: EJNMMI Research 2020 10:92
  24. The lack of visualization of the spinal cord hinders the evaluation of [18F]Fluoro-deoxy-glucose (FDG) uptake of the spinal cord in PET/CT. By exploiting the capability of MRI to precisely outline the spinal cord...

    Authors: Marco Aiello, Vincenzo Alfano, Elena Salvatore, Carlo Cavaliere, Marco Picardi, Roberta Della Pepa, Emanuele Nicolai, Andrea Soricelli, Alessandra Vella, Marco Salvatore and Mario Mascalchi
    Citation: EJNMMI Research 2020 10:91
  25. Somatostatin receptor (SST) targeting, specifically of the subtype 2 (SST2), with radiolabeled somatostatin analogs, is established for imaging and treatment of neuroendocrine tumors. Owing to the concomitant ...

    Authors: Rosalba Mansi, Karim Abid, Guillaume P. Nicolas, Luigi Del Pozzo, Eric Grouzmann and Melpomeni Fani
    Citation: EJNMMI Research 2020 10:90
  26. In order to study the CXCR4 expression with [68Ga]pentixafor PET in different types of non-Hodgkin lymphoma, we performed a retrospective study to describe the [68Ga]pentixafor PET/CT imaging in a spectrum of lym...

    Authors: Qingqing Pan, Yaping Luo, Yan Zhang, Long Chang, Ji Li, Xinxin Cao, Jian Li and Fang Li
    Citation: EJNMMI Research 2020 10:89
  27. To decipher the correlations between PET and DCE kinetic parameters in non-small-cell lung cancer (NSCLC), by using voxel-wise analysis of dynamic simultaneous [18F]FDG PET-MRI.

    Authors: Florent L. Besson, Brice Fernandez, Sylvain Faure, Olaf Mercier, Andrei Seferian, Xavier Mignard, Sacha Mussot, Cecile le Pechoux, Caroline Caramella, Angela Botticella, Antonin Levy, Florence Parent, Sophie Bulifon, David Montani, Delphine Mitilian, Elie Fadel…
    Citation: EJNMMI Research 2020 10:88
  28. The urokinase plasminogen activator receptor (uPAR) plays a multifaceted role in almost any process where migration of cells and tissue-remodeling is involved such as inflammation, but also in diseases as arth...

    Authors: V. M. Baart, R. D. Houvast, L. F. de Geus-Oei, P. H. A. Quax, P. J. K. Kuppen, A. L. Vahrmeijer and C. F. M. Sier
    Citation: EJNMMI Research 2020 10:87
  29. Emphysema severity is frequently measured on CT via densitometry. Correlation with scintigraphic and spirometric functional measures of ventilation or perfusion varies widely, and no prior study has evaluated ...

    Authors: Asha Bonney, Carrie-Anne Wagner, Shankar Siva, Jason Callahan, Pierre-Yves Le Roux, Diane M. Pascoe, Louis Irving, Michael S. Hofman and Daniel P. Steinfort
    Citation: EJNMMI Research 2020 10:86
  30. Brown adipose tissue (BAT) is a thermogenic tissue which can generate heat in response to mild cold exposure. As it constitutes a promising target in the fight against obesity, we need reliable techniques to q...

    Authors: Jonas Gabriel William Fischer, Claudia Irene Maushart, Anton S. Becker, Julian Müller, Philipp Madoerin, Alin Chirindel, Damian Wild, Edwin E. G. W. ter Voert, Oliver Bieri, Irene Burger and Matthias Johannes Betz
    Citation: EJNMMI Research 2020 10:85
  31. [18F]MC225 is a selective substrate for P-glycoprotein (P-gp) that has good metabolic stability and shows higher baseline uptake compared with other P-gp substrates such as (R)-[11C]Verapamil. Prior to clinical t...

    Authors: Jun Toyohara, Muneyuki Sakata, Tetsuro Tago, Nicola A. Colabufo and Gert Luurtsema
    Citation: EJNMMI Research 2020 10:84
  32. The ability to quantify synaptic density in vivo in human adults and adolescents is of vital importance to understanding neuropsychiatric disorders. Here, we performed whole-body scans to determine organ radia...

    Authors: Jason Bini, Daniel Holden, Kathryn Fontaine, Tim Mulnix, Yihuan Lu, David Matuskey, Jim Ropchan, Nabeel Nabulsi, Yiyun Huang and Richard E. Carson
    Citation: EJNMMI Research 2020 10:83
  33. Tracking cells in vivo using imaging can provide non-invasive information to understand the pharmacology, efficacy, and safety of novel cell therapies. Zirconium-89 (t1/2 = 78.4 h) has recently been used to synth...

    Authors: Laura M. Lechermann, Roido Manavaki, Bala Attili, Doreen Lau, Lorna B. Jarvis, Tim D. Fryer, Nick Bird, Luigi Aloj, Neel Patel, Bristi Basu, Matthew Cleveland, Franklin I. Aigbirhio, Joanne L. Jones and Ferdia A. Gallagher
    Citation: EJNMMI Research 2020 10:82
  34. Careful selection of malignant pleural mesothelioma (MPM) patients for curative treatment is of highest importance, as the multimodal treatment regimen is challenging for patients and harbors a high risk of su...

    Authors: M. Pavic, M. Bogowicz, J. Kraft, D. Vuong, M. Mayinger, S. G. C. Kroeze, M. Friess, T. Frauenfelder, N. Andratschke, M. Huellner, W. Weder, M. Guckenberger, S. Tanadini-Lang and I. Opitz
    Citation: EJNMMI Research 2020 10:81
  35. To establish and validate 18F-fluorodeoxyglucose (18F-FDG) PET/CT-based radiomics model and use it to predict the intermediate-high risk growth patterns in early invasive adenocarcinoma (IAC).

    Authors: Xiaonan Shao, Rong Niu, Xiaoliang Shao, Zhenxing Jiang and Yuetao Wang
    Citation: EJNMMI Research 2020 10:80
  36. Recently, a new family of 99mTc(I)-tricarbonyl complexes bearing an acridine orange (AO) DNA targeting unit and different linkers between the Auger emitter (99mTc) and the AO moiety was evaluated for Auger therap...

    Authors: Ana Belchior, Salvatore Di Maria, Célia Fernandes, Pedro Vaz, António Paulo and Paula Raposinho
    Citation: EJNMMI Research 2020 10:79
  37. The therapeutic use of [131I]meta-iodobenzylguanidine ([131I]MIBG) is often accompanied by hematological toxicity, mainly consisting of persistent and severe thrombocytopenia. While MIBG accumulates in neuroblast...

    Authors: Thomas Blom, Rutger Meinsma, Marja Rutgers, Corine Buitenhuis, Marieke Dekken-Van den Burg, André B. P. van Kuilenburg and Godelieve A. M. Tytgat
    Citation: EJNMMI Research 2020 10:78
  38. In positron emission tomography (PET) imaging, binding is typically estimated by fitting pharmacokinetic models to the series of measurements of radioactivity in the target tissue following intravenous injecti...

    Authors: Jonathan Tjerkaski, Simon Cervenka, Lars Farde and Granville James Matheson
    Citation: EJNMMI Research 2020 10:77
  39. We recently reported that enhanced [18F]-fluorodeoxyglucose (FDG) uptake in skeletal muscles predicts disease aggressiveness in patients with amyotrophic lateral sclerosis (ALS). The present experimental study...

    Authors: Cecilia Marini, Vanessa Cossu, Tiziana Bonifacino, Matteo Bauckneht, Carola Torazza, Silvia Bruno, Patrizia Castellani, Silvia Ravera, Marco Milanese, Consuelo Venturi, Sebastiano Carlone, Patrizia Piccioli, Laura Emionite, Silvia Morbelli, Anna Maria Orengo, Maria Isabella Donegani…
    Citation: EJNMMI Research 2020 10:76
  40. 18F-FDG PET/CT is a key molecular imaging modality to noninvasively assess and differentiate benign and malignant cardiac tumors. However, few benign cardiac tumors can be characterized by increased 18F-FDG uptak...

    Authors: En-Tao Liu, Tao-Tao Sun, Hao-Jian Dong, Si-Yun Wang, Ze-Rui Chen, Chao Liu, Dan Shao, Zhou-Yang Lian, Qiu Xie and Shu-Xia Wang
    Citation: EJNMMI Research 2020 10:75
  41. The aim of this study was to develop and validate a prognostic model incorporating [18F]FDG PET/CT radiomics for patients of minor salivary gland carcinoma (MSGC).

    Authors: Nai-Ming Cheng, Cheng-En Hsieh, Yu-Hua Dean Fang, Chun-Ta Liao, Shu-Hang Ng, Hung-Ming Wang, Wen-Chi Chou, Chien-Yu Lin and Tzu-Chen Yen
    Citation: EJNMMI Research 2020 10:74
  42. Nuclear medicine is on the constant search of precision radiopharmaceutical approaches to improve patient management. Although discordant expression of the estrogen receptor (ER) and the human epidermal growth...

    Authors: Michel Paquette, Serge Phoenix, Christine Lawson, Brigitte Guérin, Roger Lecomte, Lee-Hwa Tai, Éric E. Turcotte and Jeffrey V. Leyton
    Citation: EJNMMI Research 2020 10:69
  43. Mesenchymal stem cells (MSCs) have shown potential for treatment of different diseases. However, their working mechanism is still unknown. To elucidate this, the non-invasive and longitudinal tracking of MSCs ...

    Authors: Sarah Belderbos, Manuel Antonio González-Gómez, Frederik Cleeren, Jens Wouters, Yolanda Piñeiro, Christophe M. Deroose, An Coosemans, Willy Gsell, Guy Bormans, Jose Rivas and Uwe Himmelreich
    Citation: EJNMMI Research 2020 10:73
  44. The objective of this study was to investigate the prognostic value of 2-Deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) uptake of bone marrow (BM) and metabolic parameters of primary tumor on positron emission tomograp...

    Authors: Jeong Won Lee, Sung Yong Kim, Sun Wook Han, Jong Eun Lee, Hyun Ju Lee, Nam Hun Heo and Sang Mi Lee
    Citation: EJNMMI Research 2020 10:72
  45. Two novel methods of image reconstruction, xSPECT Quant (xQ) and xSPECT Bone (xB), that use an ordered subset conjugate gradient minimizer (OSCGM) for SPECT/CT reconstruction have been proposed. The present st...

    Authors: Noriaki Miyaji, Kenta Miwa, Ayaka Tokiwa, Hajime Ichikawa, Takashi Terauchi, Mitsuru Koizumi and Masahisa Onoguchi
    Citation: EJNMMI Research 2020 10:71
  46. Preclinical in vivo nuclear imaging of mice offers an enabling perspective to evaluate drug efficacy at optimal dose and schedule. In this study, we interrogated sufficient estrogen receptor occupancy and degr...

    Authors: Laurent Besret, Sébastien d’Heilly, Cathy Aubert, Guillaume Bluet, Florence Gruss-Leleu, Françoise Le-Gall, Anne Caron, Laurent Andrieu, Sylvie Vincent, Maysoun Shomali, Monsif Bouaboula, Carole Voland, Jeffrey Ming, Sébastien Roy, Srinivas Rao, Chantal Carrez…
    Citation: EJNMMI Research 2020 10:70
  47. In the case of extravasation of radioactive drugs used in peptide-receptor radionuclide therapy of neuroendocrine tumors, or in radionuclide therapy in general, rapid action is important to reduce or avoid com...

    Authors: Anne Kirstine Arveschoug, Anne Charlotte Bekker, Peter Iversen, Henrik Bluhme, Gerda Elisabeth Villadsen and Peter Frøhlich Staanum
    Citation: EJNMMI Research 2020 10:68
  48. Soluble epoxide hydrolase (sEH) is a promising candidate positron emission tomography (PET) imaging biomarker altered in various disorders, including vascular cognitive impairment (VCI), Alzheimer’s disease (A...

    Authors: Yong Du, Il Minn, Catherine Foss, Wojciech G. Lesniak, Feng Hu, Robert F. Dannals, Martin G. Pomper and Andrew G. Horti
    Citation: EJNMMI Research 2020 10:67