Articles

The impact of reconstruction and scanner characterisation on the diagnostic capability of a normal database for [¹²³I]FP-CIT SPECT imaging

The use of a normal database for [¹²³I]FP-CIT SPECT imaging has been found to be helpful for cases which are difficult to interpret by visual assessment alone, and to improve reproducibility in scan interpretatio...

Authors: John C. Dickson, Livia Tossici-Bolt, Terez Sera, Jan Booij, Morten Ziebell, Silvia Morbelli, Susanne Assenbaum-Nan, Thierry Vander Borght, Marco Pagani, Ozlem L. Kapucu, Swen Hesse, Koen Van Laere, Jacques Darcourt, Andrea Varrone and Klaus Tatsch

A comparison of FLT to FDG PET/CT in the early assessment of chemotherapy response in stages IB–IIIA resectable NSCLC

The aim of this study was to compare the percentage change in ¹⁸F-fluorothymidine (FLT) standard uptake value (SUV) between baseline and after one cycle of chemotherapy in patients categorized by RECIST 1.1 compu...

Authors: John P. Crandall, Abdel K. Tahari, Rosalyn A. Juergens, Julie R. Brahmer, Charles M. Rudin, Giuseppe Esposito, Deepa S. Subramaniam, Michael V. Knopp, Nathan C. Hall, Prateek Gajwani, Jeffrey P. Leal, Martin A. Lodge, Joo H. O., Edward W. Gabrielson, Lalitha K. Shankar and Richard L. Wahl

⁴⁴Sc-PSMA-617 for radiotheragnostics in tandem with ¹⁷⁷Lu-PSMA-617—preclinical investigations in comparison with ⁶⁸Ga-PSMA-11 and ⁶⁸Ga-PSMA-617

The targeting of the prostate-specific membrane antigen (PSMA) is of particular interest for radiotheragnostic purposes of prostate cancer. Radiolabeled PSMA-617, a 1,4,7,10-tetraazacyclododecane-N,N′,N′′,N′′′-te...

Authors: Christoph A. Umbricht, Martina Benešová, Raffaella M. Schmid, Andreas Türler, Roger Schibli, Nicholas P. van der Meulen and Cristina Müller

Assessment of regional pulmonary blood flow using ⁶⁸Ga-DOTA PET

In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of ⁶⁸Ga-DOTA PET for the in vivo quantitative determination of regi...

Authors: Carlos Velasco, Jesus Mateo, Arnoldo Santos, Adriana Mota-Cobian, Fernando Herranz, Juan Pellico, Ruben A. Mota, Samuel España and Jesus Ruiz-Cabello

Blood perfusion in osteomyelitis studied with [¹⁵O]water PET in a juvenile porcine model

Osteomyelitis is a serious disease which can be difficult to treat despite properly instituted antibiotic therapy. This appears to be related at least partly to degraded vascularisation in the osteomyelitic (O...

Authors: Lars Jødal, Ole L. Nielsen, Pia Afzelius, Aage K. O. Alstrup and Søren B. Hansen

Comparison of Tc-99m maraciclatide and Tc-99m sestamibi molecular breast imaging in patients with suspected breast cancer

Molecular breast imaging (MBI) performed with ^99mTc sestamibi has been shown to be a valuable technique for the detection of breast cancer. Alternative radiotracers such as ^99mTc maraciclatide may offer improved ...

Authors: Michael K. O’Connor, Melissa M. B. Morrow, Katie N. Hunt, Judy C. Boughey, Dietlind L. Wahner-Roedler, Amy Lynn Conners, Deborah J. Rhodes and Carrie B. Hruska

Patient-specific optimisation of administered activity and acquisition times for ¹⁸F-FDG PET imaging

The purpose of this study is to identify a method for optimising the administered activity and acquisition time for ¹⁸F-FDG PET imaging, yielding images of consistent quality for patients with varying body sizes ...

Authors: Fred Wickham, Helena McMeekin, Maria Burniston, Daniel McCool, Deborah Pencharz, Annah Skillen and Thomas Wagner

Priming increases the anti-tumor effect and therapeutic window of ¹⁷⁷Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1

¹⁷⁷Lu-[DOTA⁰, Tyr³]-octreotate (¹⁷⁷Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remissio...

Authors: Johanna Dalmo, Johan Spetz, Mikael Montelius, Britta Langen, Yvonne Arvidsson, Henrik Johansson, Toshima Z. Parris, Khalil Helou, Bo Wängberg, Ola Nilsson, Maria Ljungberg and Eva Forssell-Aronsson

Three-minute SPECT/CT is sufficient for the assessment of bone metastasis as add-on to planar bone scintigraphy: prospective head-to-head comparison to 11-min SPECT/CT

The aim of this study is to assess whether ultra-fast acquisition SPECT/CT (UF-SPECT/CT) can replace standard SPECT/CT (std-SPECT/CT) as “add-on” to whole-body bone scintigraphy (WB-BS) for the investigation o...

Authors: Helle D. Zacho, José A. Biurrun Manresa, Ramune Aleksyniene, June A. Ejlersen, Joan Fledelius, Henrik Bertelsen and Lars J. Petersen

Hepatobiliary scintigraphy may improve radioembolization treatment planning in HCC patients

Routine work-up for transarterial radioembolization, based on clinical and laboratory parameters, sometimes fails, resulting in severe hepatotoxicity in up to 5% of patients. Quantitative assessment of the pre...

Authors: Manon N. G. J. A. Braat, Hugo W. de Jong, Beatrijs A. Seinstra, Mike V. Scholten, Maurice A. A. J. van den Bosch and Marnix G. E. H. Lam

Yttrium-90 radioembolization for colorectal cancer liver metastases: a prospective cohort study on circulating angiogenic factors and treatment response

Yttrium-90 radioembolization (⁹⁰Y-RE) as a treatment for liver tumours induces radiation damage and hypoxia in liver tissue, which is also a trigger for systemic release of angiogenic factors, potentially stimula...

Authors: C. E. N. M. Rosenbaum, A. F. van den Hoven, M. N. G. J. A. Braat, M. Koopman, M. G. E. H. Lam, B. A. Zonnenberg, H. M. Verkooijen and M. A. A. J. van den Bosch

Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer, ¹⁸F-labeled [Nle¹⁴,Lys⁴⁰]exendin-4 analog, shows promise for clinical imaging

Several radiometal-labeled, exendin-based tracers that target glucagon-like peptide-1 receptors (GLP-1R) have been intensively explored for β cell imaging. The main obstacle has been the high uptake of tracer ...

Authors: Kirsi Mikkola, Cheng-Bin Yim, Paula Lehtiniemi, Saila Kauhanen, Miikka Tarkia, Tuula Tolvanen, Pirjo Nuutila and Olof Solin

^99mTc-labelled S-HYNIC certolizumab pegol in rheumatoid arthritis and spondyloarthritis patients: a biodistribution and dosimetry study

Biologicals directed against tumour necrosis factor (TNF) have proven their efficacy in the treatment of spondyloarthritis and rheumatoid arthritis. We present a radiolabelling method for certolizumab pegol (C...

Authors: Bieke Lambert, Philippe Carron, Yves D’Asseler, Klaus Bacher, Filip Van den Bosch, Dirk Elewaut, Gust Verbruggen, Rudi Beyaert, Caroline Dumolyn and Filip De Vos

Computational simulation of the predicted dosimetric impact of adjuvant yttrium-90 PET/CT-guided percutaneous ablation following radioembolization

⁹⁰Y PET/CT post-radioembolization imaging has demonstrated that the distribution of ⁹⁰Y in a tumor can be non-uniform. Using computational modeling, we predicted the dosimetric impact ...

Authors: Alexander S. Pasciak, Abigail Lin, Christos Georgiades, Laura K. Findeiss, Shannon Kauffman and Yong C. Bradley

Dynamic PET evaluation of elevated FLT level after sorafenib treatment in mice bearing human renal cell carcinoma xenograft

Sorafenib, an oral multikinase inhibitor, has anti-proliferative and anti-angiogenic activities and is therapeutically effective against renal cell carcinoma (RCC). Recently, we have evaluated the tumor respon...

Authors: Naoyuki Ukon, Songji Zhao, Wenwen Yu, Yoichi Shimizu, Ken-ichi Nishijima, Naoki Kubo, Yoshimasa Kitagawa, Nagara Tamaki, Kei Higashikawa, Hironobu Yasui and Yuji Kuge

The clinical safety, biodistribution and internal radiation dosimetry of [¹⁸F]AH113804 in healthy adult volunteers

Quantitative biodistribution, venous blood and excretion data have been obtained following the intravenous bolus injection of AH113804 (¹⁸F) Injection in six healthy volunteers (HVs), four males and two females, ...

Authors: E. J. Somer, R. Owenius, A. Wall, G. Antoni, A. Thibblin and J. Sörensen

The effect of isoflurane on ¹⁸F-FDG uptake in the rat brain: a fully conscious dynamic PET study using motion compensation

In preclinical positron emission tomography (PET) studies an anaesthetic is used to ensure that the animal does not move during the scan. However, anaesthesia may have confounding effects on the drug or tracer...

Authors: Matthew G. Spangler-Bickell, Bart de Laat, Roger Fulton, Guy Bormans and Johan Nuyts

Pre-clinical quantitative imaging and mouse-specific dosimetry for ¹¹¹In-labelled radiotracers

Accurate quantification in molecular imaging is essential to improve the assessment of novel drugs and compare the radiobiological effects of therapeutic agents prior to in-human studies. The aim of this study...

Authors: Ana M. Denis-Bacelar, Sarah E. Cronin, Chiara Da Pieve, Rowena L. Paul, Sue A. Eccles, Terence J. Spinks, Carol Box, Adrian Hall, Jane K. Sosabowski, Gabriela Kramer-Marek and Glenn D. Flux

Effects of acetaminophen on mitochondrial complex I activity in the rat liver and kidney: a PET study with ¹⁸F-BCPP-BF

In the present study, 2-tert-butyl-4-chloro-5-[6-(4-¹⁸F-fluorobutoxy)-pyridin-3-ylmethoxy]-2H-pyridazin-3-one (¹⁸F-BCPP-BF), a PET probe for mitochondrial complex I (MC-I), was used to validate whether MC-I is a ...

Authors: Hiroyuki Ohba, Masakatsu Kanazawa, Takeharu Kakiuchi and Hideo Tsukada

Improved safety and efficacy of ²¹³Bi-DOTATATE-targeted alpha therapy of somatostatin receptor-expressing neuroendocrine tumors in mice pre-treated with l-lysine

Targeted alpha therapy (TAT) offers advantages over current β-emitting conjugates for peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors. PRRT with ¹⁷⁷Lu-DOTATATE or ⁹⁰Y-DOTATOC has shown dose-...

Authors: Ho Sze Chan, Mark W. Konijnenberg, Tamara Daniels, Monique Nysus, Mehran Makvandi, Erik de Blois, Wouter A. Breeman, Robert W. Atcher, Marion de Jong and Jeffrey P. Norenberg

Predictive factors of ¹⁸F-choline PET/CT positivity in patients with prostate cancer recurrence after radiation therapy: is the impact of PSA nadir underestimated?

The objective of this study is to explore the impact of PSA nadirs on detection rates of prostate cancer (PCa) recurrence with ¹⁸F-choline (CH) PET/CT after external beam radiation therapy (EBRT).

Authors: Alison C. Johnson, Audrey Emmanuelle Dugué, Marlon Silva, Laura Moise, Xavier Tillou, Florence Joly and Nicolas Aide

Evaluation of ¹⁸F-fluorothymidine positron emission tomography ([¹⁸F]FLT-PET/CT) methodology in assessing early response to chemotherapy in patients with gastro-oesophageal cancer

3’-Deoxy-3’-[¹⁸F]fluorothymidine ([¹⁸F]FLT) PET has limited utility in abdominal imaging due to high physiological hepatic uptake of a tracer. We evaluated [¹⁸F]FLT-PET/CT combined with a temporal-intensity infor...

Authors: R. Sharma, P. Mapelli, G. B. Hanna, R. Goldin, D. Power, A. Al-Nahhas, S. Merchant, R. Ramaswami, A. Challapalli, T. Barwick and E. O. Aboagye

Effects of common anesthetic agents on [¹⁸F]flumazenil binding to the GABA_A receptor

The availability of GABA_A receptor binding sites in the brain can be assessed by positron emission tomography (PET) using the radioligand, [¹⁸F]flumazenil. However, the brain uptake and binding of this PET radiol...

Authors: Mikael Palner, Corinne Beinat, Sam Banister, Francesca Zanderigo, Jun Hyung Park, Bin Shen, Trine Hjoernevik, Jae Ho Jung, Byung Chul Lee, Sang Eun Kim, Lawrence Fung and Frederick T. Chin

Reproducibility of ¹⁸F-fluoromisonidazole intratumour distribution in non-small cell lung cancer

Hypoxic tumours exhibit increased resistance to radiation, chemical, and immune therapies. ¹⁸F-fluoromisonidazole (FMISO) positron emission tomography (PET) is a non-invasive, quantitative imaging technique used ...

Authors: Milan Grkovski, Jazmin Schwartz, Andreas Rimner, Heiko Schöder, Sean D. Carlin, Pat B. Zanzonico, John L. Humm and Sadek A. Nehmeh

Impact of ⁶⁸Ga-PSMA PET/CT on salvage radiotherapy planning in patients with prostate cancer and persisting PSA values or biochemical relapse after prostatectomy

Salvage radiotherapy (SRT) is clinically established in prostate cancer (PC) patients with PSA persistence or biochemical relapse (BCR) after prior radical surgery. PET/CT imaging prior to SRT may be performed...

Authors: Christina Bluemel, Fraenze Linke, Ken Herrmann, Iva Simunovic, Matthias Eiber, Christian Kestler, Andreas K. Buck, Andreas Schirbel, Thorsten A. Bley, Hans-Juergen Wester, Daniel Vergho and Axel Becker

Cryopreservation of primary human monocytes does not negatively affect their functionality or their ability to be labelled with radionuclides: basis for molecular imaging and cell therapy

Circulating white blood cells crucially contribute to maintenance and repair of solid organs. Therefore, certain cell populations such as monocytes are attractive targets for use in molecular imaging and cell ...

Authors: Evangelia Pardali, Timo Schmitz, Andreas Borgscheiper, Janette Iking, Lars Stegger and Johannes Waltenberger

Pilot study: use of gallium-68 PSMA PET for detection of metastatic lesions in patients with renal tumour

In this study, we prospectively evaluate the diagnostic potential of a gallium-68 (68Ga) prostate-specific membrane antigen (PSMA)-binding ligand and positron emission tomography (PET) in detecting metastatic ...

Authors: Handoo Rhee, John Blazak, Chui Ming Tham, Keng Lim Ng, Benjamin Shepherd, Malcolm Lawson, John Preston, Ian Vela, Paul Thomas and Simon Wood

Comparison of the image-derived radioactivity and blood-sample radioactivity for estimating the clinical indicators of the efficacy of boron neutron capture therapy (BNCT): 4-borono-2-¹⁸F-fluoro-phenylalanine (FBPA) PET study

In boron neutron capture therapy (BNCT), positron emission tomography (PET) with 4-borono-2-¹⁸F-fluoro-phenylalanine (FBPA) is the only method to estimate an accumulation of ¹⁰B to target tumor and surrounding no...

Authors: Kayako Isohashi, Eku Shimosegawa, Sadahiro Naka, Yasukazu Kanai, Genki Horitsugi, Ikuko Mochida, Keiko Matsunaga, Tadashi Watabe, Hiroki Kato, Mitsuaki Tatsumi and Jun Hatazawa

Early ¹⁸F-FDG uptake as a reliable imaging biomarker of T790M-mediated resistance but not MET amplification in non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors

The two main mechanisms of resistance to EGFR tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) are the occurrence of T790M secondary mutation in the kinase domain of EGFR and MET amplifi...

Authors: Viviana De Rosa, Francesca Iommelli, Marcello Monti, Ciro Gabriele Mainolfi, Rosa Fonti and Silvana Del Vecchio

The role of FDG-PET/CT in preoperative staging of sentinel lymph node biopsy-positive melanoma patients

On April 1, 2015, Odense University Hospital (OUH) began a new diagnostic strategy, wherein all malignant melanoma (MM) patients in the Region of Southern Denmark with a positive sentinel lymph node biopsy (SL...

Authors: Evan C. Frary, Dorte Gad, Lars Bastholt and Søren Hess

Test-retest analysis of a non-invasive method of quantifying [¹¹C]-PBR28 binding in Alzheimer’s disease

In order to maximise the utility of [¹¹C]-PBR28 for use in longitudinal studies and clinical trials in Alzheimer’s disease (AD), there is a need to develop non-invasive metrics of tracer binding that do not requi...

Authors: Akshay Nair, Mattia Veronese, Xiaohui Xu, Charles Curtis, Federico Turkheimer, Robert Howard and Suzanne Reeves

Inter-observer agreement improves with PERCIST 1.0 as opposed to qualitative evaluation in non-small cell lung cancer patients evaluated with F-18-FDG PET/CT early in the course of chemo-radiotherapy

The purpose of this study is to determine whether a qualitative approach or a semi-quantitative approach provides the most robust method for early response evaluation with 2′-deoxy-2′-[¹⁸F]fluoro-d-glucose (F-18-...

Authors: Joan Fledelius, Azza Khalil, Karin Hjorthaug and Jørgen Frøkiær

Preclinical evaluation of [⁶⁸Ga]NOTA-pentixafor for PET imaging of CXCR4 expression in vivo — a comparison to [⁶⁸Ga]pentixafor

Due to its overexpression in a variety of tumor types, the chemokine receptor 4 (CXCR4) represents a highly relevant diagnostic and therapeutic target in nuclear oncology. Recently, [⁶⁸Ga]pentixafor has emerged a...

Authors: Andreas Poschenrieder, Margret Schottelius, Markus Schwaiger and Hans-Jürgen Wester

⁸²Rb PET imaging of myocardial blood flow—have we achieved the 4 “R”s to support routine use?

Authors: Robert A. deKemp, Ran Klein and Rob S. B. Beanlands

The cingulate island sign within early Alzheimer’s disease-specific hypoperfusion volumes of interest is useful for differentiating Alzheimer’s disease from dementia with Lewy bodies

In addition to occipital hypoperfusion, preserved metabolism of the posterior cingulate gyri (PCG) relative to the precunei is known as the cingulate island sign (CIS) in the patients with dementia with Lewy b...

Authors: Etsuko Imabayashi, Kota Yokoyama, Tadashi Tsukamoto, Daichi Sone, Kaoru Sumida, Yukio Kimura, Noriko Sato, Miho Murata and Hiroshi Matsuda

Erratum to: Toxicity and radiation dosimetry studies of the serotonin transporter radioligand [¹⁸F]AFM in rats and monkeys

Authors: Ya-Yao Huang, Cheng-Yi Cheng, Wen-Sheng Huang, Kuo-Hsing Ma, Ta-Wei Tseng, Ta-Kai Chou, Yiyun Huang and Chyng-Yann Shiue

The effect of purification of Ga-68-labeled exendin on in vivo distribution

Ga-labeled radiotracers are increasingly used for PET imaging. During the labeling procedure, formation of ⁶⁸Ga-colloid may occur. Upon i.v. injection, ⁶⁸Ga-colloid will accumulate rapidly in the liver, spleen, a...

Authors: Maarten Brom, Gerben M. Franssen, Lieke Joosten, Martin Gotthardt and Otto C. Boerman

The use of ¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG PET) as a pathway-specific biomarker with AZD8186, a PI3Kβ/δ inhibitor

The phosphatidylinositol 3 kinase (PI3K) signalling pathway is frequently altered in human cancer and a promising therapeutic target. AZD8186 (AstraZeneca) is a PI3Kβ/δ inhibitor, currently in phase 1 clinical...

Authors: Juliana Maynard, Sally-Ann Emmas, Francois-Xavier Blé, Hervé Barjat, Emily Lawrie, Urs Hancox, Deborah Oakes, Urszula M. Polanska and Simon T. Barry

The relationship between endogenous thymidine concentrations and [¹⁸F]FLT uptake in a range of preclinical tumour models

Recent studies have shown that 3′-deoxy-3′-[¹⁸F] fluorothymidine ([¹⁸F]FLT)) uptake depends on endogenous tumour thymidine concentration. The purpose of this study was to investigate tumour thymidine concentratio...

Authors: Kathrin Heinzmann, Davina Jean Honess, David Yestin Lewis, Donna-Michelle Smith, Christopher Cawthorne, Heather Keen, Sandra Heskamp, Sonja Schelhaas, Timothy Howard Witney, Dmitry Soloviev, Kaye Janine Williams, Andreas Hans Jacobs, Eric Ofori Aboagye, John Richard Griffiths and Kevin Michael Brindle

Nephroprotective effects of enalapril after [177Lu]-DOTATATE therapy using serial renal scintigraphies in a murine model of radiation-induced nephropathy

Radiation-induced nephropathy is still dose limiting in radionuclide therapy of neuroendocrine tumors. We investigated the nephroprotective potential of the angiotensine converting enzyme inhibiting drug enalp...

Authors: Harun Ilhan, Hao Wang, Franz J. Gildehaus, Carmen Wängler, Tanja Herrler, Andrei Todica, Julia Schlichtiger, Paul Cumming, Peter Bartenstein, Marcus Hacker and Alexander R. Haug

Quantification of myocardial blood flow with ⁸²Rb: Validation with ¹⁵O-water using time-of-flight and point-spread-function modeling

We quantified myocardial blood flow with ⁸²Rb PET using parameters of the generalized Renkin-Crone model estimated from ⁸²Rb and ¹⁵O-water images reconstructed with time-of-flight and point spread function modeli...

Authors: Mary Germino, Jim Ropchan, Tim Mulnix, Kathryn Fontaine, Nabeel Nabulsi, Eric Ackah, Herman Feringa, Albert J. Sinusas, Chi Liu and Richard E. Carson

Fractal and multifractal analysis of PET/CT images of metastatic melanoma before and after treatment with ipilimumab

PET/CT with F-18-fluorodeoxyglucose (FDG) images of patients suffering from metastatic melanoma have been analysed using fractal and multifractal analysis to assess the impact of monoclonal antibody ipilimumab...

Authors: Christina-Marina Breki, Antonia Dimitrakopoulou-Strauss, Jessica Hassel, Theoharis Theoharis, Christos Sachpekidis, Leyun Pan and Astero Provata

Longitudinal analysis of bone metabolism using SPECT/CT and ^99mTc-diphosphono-propanedicarboxylic acid: comparison of visual and quantitative analysis

The therapy response of osseous metastases (OM) is commonly monitored by bone scintigraphies (BS). The aim of this study was to compare visual evaluation of changes in tracer uptake with quantitation in absolu...

Authors: Michael Beck, James C. Sanders, Philipp Ritt, Julia Reinfelder and Torsten Kuwert

Preclinical modeling and multimodality imaging of chronic myocardial infarction in minipigs induced by novel interventional embolization technique

This study was designed to establish a chronic myocardial infarction (MI) model in minipigs with a novel coronary sequential balloons-sponge embolism technique.

Authors: Bo Tao, Haokao Gao, Minwen Zheng, Zhonghua Luo, Liwen Liu, Wei Bai, Jing Wang, Daliang Liu, Sai Ma, Zhenli Luo, Lei Gao, Yabin Wang and Feng Cao

Preclinical PET imaging of EGFR levels: pairing a targeting with a non-targeting Sel-tagged Affibody-based tracer to estimate the specific uptake

Though overexpression of epidermal growth factor receptor (EGFR) in several forms of cancer is considered to be an important prognostic biomarker related to poor prognosis, clear correlations between biomarker...

Authors: Qing Cheng, Helena Wållberg, Jonas Grafström, Li Lu, Jan-Olov Thorell, Maria Hägg Olofsson, Stig Linder, Katarina Johansson, Tetyana Tegnebratt, Elias S. J. Arnér, Sharon Stone-Elander, Hanna-Stina Martinsson Ahlzén and Stefan Ståhl

Measuring total liver function on sulfur colloid SPECT/CT for improved risk stratification and outcome prediction of hepatocellular carcinoma patients

Assessment of liver function is critical in hepatocellular carcinoma (HCC) patient management. We evaluated parameters of [^99mTc] sulfur colloid (SC) SPECT/CT liver uptake for association with clinical measures o...

Authors: Stephen R. Bowen, Tobias R. Chapman, Joshua Borgman, Robert S. Miyaoka, Paul E. Kinahan, Iris W. Liou, George A. Sandison, Hubert J. Vesselle, Matthew J. Nyflot and Smith Apisarnthanarax

Optimal 2-[¹⁸F]fluoro-2-deoxy-d-galactose PET/CT protocol for detection of hepatocellular carcinoma

Positron emission tomography (PET) with the liver-specific galactose tracer 2-[¹⁸F]fluoro-2-deoxy-d-galactose (¹⁸F-FDGal) may improve diagnosis of hepatocellular carcinoma (HCC). The aim of this study was to test...

Authors: Jacob Horsager, Kirstine Bak-Fredslund, Lars Peter Larsen, Gerda Elisabeth Villadsen, Trond Velde Bogsrud and Michael Sørensen

Decreased renal AT₁ receptor binding in rats after subtotal nephrectomy: PET study with [¹⁸F]FPyKYNE-losartan

Significant renal mass reduction induced by 5/6 subtotal nephrectomy (Nx) is associated with a chain of events that culminates in hypertension and chronic kidney disease (CKD). Numerous studies have provided e...

Authors: Basma Ismail, Robert A. deKemp, Tayebeh Hadizad, Kumiko Mackasey, Rob S. Beanlands and Jean N. DaSilva

Renal PET-imaging with ¹¹C-metformin in a transgenic mouse model for chronic kidney disease

Organic cation transporters (OCTs) in the renal proximal tubule are important for the excretion of both exo- and endogenous compounds, and chronic kidney disease (CKD) alter the expression of OCT. Metformin is...

Authors: Lea Pedersen, Jonas Brorson Jensen, Lise Wogensen, Ole Lajord Munk, Niels Jessen, Jørgen Frøkiær and Steen Jakobsen

Comparative evaluation of SUV, tumor-to-blood standard uptake ratio (SUR), and dual time point measurements for assessment of the metabolic uptake rate in FDG PET

We have demonstrated recently that the tumor-to-blood standard uptake ratio (SUR) is superior to tumor standardized uptake value (SUV) as a surrogate of the metabolic uptake rate K _m of...

Authors: Frank Hofheinz, Jörg van den Hoff, Ingo G. Steffen, Alexandr Lougovski, Kilian Ego, Holger Amthauer and Ivayla Apostolova