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  1. Content type: Original research

    The use of a normal database for [123I]FP-CIT SPECT imaging has been found to be helpful for cases which are difficult to interpret by visual assessment alone, and to improve reproducibility in scan interpretatio...

    Authors: John C. Dickson, Livia Tossici-Bolt, Terez Sera, Jan Booij, Morten Ziebell, Silvia Morbelli, Susanne Assenbaum-Nan, Thierry Vander Borght, Marco Pagani, Ozlem L. Kapucu, Swen Hesse, Koen Van Laere, Jacques Darcourt, Andrea Varrone and Klaus Tatsch

    Citation: EJNMMI Research 2017 7:10

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  2. Content type: Original research

    The aim of this study was to compare the percentage change in 18F-fluorothymidine (FLT) standard uptake value (SUV) between baseline and after one cycle of chemotherapy in patients categorized by RECIST 1.1 compu...

    Authors: John P. Crandall, Abdel K. Tahari, Rosalyn A. Juergens, Julie R. Brahmer, Charles M. Rudin, Giuseppe Esposito, Deepa S. Subramaniam, Michael V. Knopp, Nathan C. Hall, Prateek Gajwani, Jeffrey P. Leal, Martin A. Lodge, Joo H. O., Edward W. Gabrielson, Lalitha K. Shankar and Richard L. Wahl

    Citation: EJNMMI Research 2017 7:8

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  3. Content type: Original research

    The targeting of the prostate-specific membrane antigen (PSMA) is of particular interest for radiotheragnostic purposes of prostate cancer. Radiolabeled PSMA-617, a 1,4,7,10-tetraazacyclododecane-N,N′,N′′,N′′′-te...

    Authors: Christoph A. Umbricht, Martina Benešová, Raffaella M. Schmid, Andreas Türler, Roger Schibli, Nicholas P. van der Meulen and Cristina Müller

    Citation: EJNMMI Research 2017 7:9

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  4. Content type: Original research

    In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of 68Ga-DOTA PET for the in vivo quantitative determination of regi...

    Authors: Carlos Velasco, Jesus Mateo, Arnoldo Santos, Adriana Mota-Cobian, Fernando Herranz, Juan Pellico, Ruben A. Mota, Samuel España and Jesus Ruiz-Cabello

    Citation: EJNMMI Research 2017 7:7

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  5. Content type: Original research

    Osteomyelitis is a serious disease which can be difficult to treat despite properly instituted antibiotic therapy. This appears to be related at least partly to degraded vascularisation in the osteomyelitic (O...

    Authors: Lars Jødal, Ole L. Nielsen, Pia Afzelius, Aage K. O. Alstrup and Søren B. Hansen

    Citation: EJNMMI Research 2017 7:4

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  6. Content type: Original research

    Molecular breast imaging (MBI) performed with 99mTc sestamibi has been shown to be a valuable technique for the detection of breast cancer. Alternative radiotracers such as 99mTc maraciclatide may offer improved ...

    Authors: Michael K. O’Connor, Melissa M. B. Morrow, Katie N. Hunt, Judy C. Boughey, Dietlind L. Wahner-Roedler, Amy Lynn Conners, Deborah J. Rhodes and Carrie B. Hruska

    Citation: EJNMMI Research 2017 7:5

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  7. Content type: Original research

    The purpose of this study is to identify a method for optimising the administered activity and acquisition time for 18F-FDG PET imaging, yielding images of consistent quality for patients with varying body sizes ...

    Authors: Fred Wickham, Helena McMeekin, Maria Burniston, Daniel McCool, Deborah Pencharz, Annah Skillen and Thomas Wagner

    Citation: EJNMMI Research 2017 7:3

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  8. Content type: Original research

    177Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remissio...

    Authors: Johanna Dalmo, Johan Spetz, Mikael Montelius, Britta Langen, Yvonne Arvidsson, Henrik Johansson, Toshima Z. Parris, Khalil Helou, Bo Wängberg, Ola Nilsson, Maria Ljungberg and Eva Forssell-Aronsson

    Citation: EJNMMI Research 2017 7:6

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  9. Content type: Original research

    The aim of this study is to assess whether ultra-fast acquisition SPECT/CT (UF-SPECT/CT) can replace standard SPECT/CT (std-SPECT/CT) as “add-on” to whole-body bone scintigraphy (WB-BS) for the investigation o...

    Authors: Helle D. Zacho, José A. Biurrun Manresa, Ramune Aleksyniene, June A. Ejlersen, Joan Fledelius, Henrik Bertelsen and Lars J. Petersen

    Citation: EJNMMI Research 2017 7:1

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  10. Content type: Preliminary research

    Routine work-up for transarterial radioembolization, based on clinical and laboratory parameters, sometimes fails, resulting in severe hepatotoxicity in up to 5% of patients. Quantitative assessment of the pre...

    Authors: Manon N. G. J. A. Braat, Hugo W. de Jong, Beatrijs A. Seinstra, Mike V. Scholten, Maurice A. A. J. van den Bosch and Marnix G. E. H. Lam

    Citation: EJNMMI Research 2017 7:2

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  11. Content type: Original research

    Yttrium-90 radioembolization (90Y-RE) as a treatment for liver tumours induces radiation damage and hypoxia in liver tissue, which is also a trigger for systemic release of angiogenic factors, potentially stimula...

    Authors: C. E. N. M. Rosenbaum, A. F. van den Hoven, M. N. G. J. A. Braat, M. Koopman, M. G. E. H. Lam, B. A. Zonnenberg, H. M. Verkooijen and M. A. A. J. van den Bosch

    Citation: EJNMMI Research 2016 6:92

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  12. Content type: Original research

    Several radiometal-labeled, exendin-based tracers that target glucagon-like peptide-1 receptors (GLP-1R) have been intensively explored for β cell imaging. The main obstacle has been the high uptake of tracer ...

    Authors: Kirsi Mikkola, Cheng-Bin Yim, Paula Lehtiniemi, Saila Kauhanen, Miikka Tarkia, Tuula Tolvanen, Pirjo Nuutila and Olof Solin

    Citation: EJNMMI Research 2016 6:91

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  13. Content type: Original research

    Biologicals directed against tumour necrosis factor (TNF) have proven their efficacy in the treatment of spondyloarthritis and rheumatoid arthritis. We present a radiolabelling method for certolizumab pegol (C...

    Authors: Bieke Lambert, Philippe Carron, Yves D’Asseler, Klaus Bacher, Filip Van den Bosch, Dirk Elewaut, Gust Verbruggen, Rudi Beyaert, Caroline Dumolyn and Filip De Vos

    Citation: EJNMMI Research 2016 6:88

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  14. Content type: Original research

    90Y PET/CT post-radioembolization imaging has demonstrated that the distribution of 90Y in a tumor can be non-uniform. Using computational modeling, we predicted the dosimetric impact ...

    Authors: Alexander S. Pasciak, Abigail Lin, Christos Georgiades, Laura K. Findeiss, Shannon Kauffman and Yong C. Bradley

    Citation: EJNMMI Research 2016 6:89

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  15. Content type: Original research

    Sorafenib, an oral multikinase inhibitor, has anti-proliferative and anti-angiogenic activities and is therapeutically effective against renal cell carcinoma (RCC). Recently, we have evaluated the tumor respon...

    Authors: Naoyuki Ukon, Songji Zhao, Wenwen Yu, Yoichi Shimizu, Ken-ichi Nishijima, Naoki Kubo, Yoshimasa Kitagawa, Nagara Tamaki, Kei Higashikawa, Hironobu Yasui and Yuji Kuge

    Citation: EJNMMI Research 2016 6:90

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  16. Content type: Original research

    Quantitative biodistribution, venous blood and excretion data have been obtained following the intravenous bolus injection of AH113804 (18F) Injection in six healthy volunteers (HVs), four males and two females, ...

    Authors: E. J. Somer, R. Owenius, A. Wall, G. Antoni, A. Thibblin and J. Sörensen

    Citation: EJNMMI Research 2016 6:87

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  17. Content type: Original Research

    In preclinical positron emission tomography (PET) studies an anaesthetic is used to ensure that the animal does not move during the scan. However, anaesthesia may have confounding effects on the drug or tracer...

    Authors: Matthew G. Spangler-Bickell, Bart de Laat, Roger Fulton, Guy Bormans and Johan Nuyts

    Citation: EJNMMI Research 2016 6:86

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  18. Content type: Original research

    Accurate quantification in molecular imaging is essential to improve the assessment of novel drugs and compare the radiobiological effects of therapeutic agents prior to in-human studies. The aim of this study...

    Authors: Ana M. Denis-Bacelar, Sarah E. Cronin, Chiara Da Pieve, Rowena L. Paul, Sue A. Eccles, Terence J. Spinks, Carol Box, Adrian Hall, Jane K. Sosabowski, Gabriela Kramer-Marek and Glenn D. Flux

    Citation: EJNMMI Research 2016 6:85

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  19. Content type: Original research

    In the present study, 2-tert-butyl-4-chloro-5-[6-(4-18F-fluorobutoxy)-pyridin-3-ylmethoxy]-2H-pyridazin-3-one (18F-BCPP-BF), a PET probe for mitochondrial complex I (MC-I), was used to validate whether MC-I is a ...

    Authors: Hiroyuki Ohba, Masakatsu Kanazawa, Takeharu Kakiuchi and Hideo Tsukada

    Citation: EJNMMI Research 2016 6:82

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  20. Content type: Original research

    Targeted alpha therapy (TAT) offers advantages over current β-emitting conjugates for peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors. PRRT with 177Lu-DOTATATE or 90Y-DOTATOC has shown dose-...

    Authors: Ho Sze Chan, Mark W. Konijnenberg, Tamara Daniels, Monique Nysus, Mehran Makvandi, Erik de Blois, Wouter A. Breeman, Robert W. Atcher, Marion de Jong and Jeffrey P. Norenberg

    Citation: EJNMMI Research 2016 6:83

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  21. Content type: Original research

    The objective of this study is to explore the impact of PSA nadirs on detection rates of prostate cancer (PCa) recurrence with 18F-choline (CH) PET/CT after external beam radiation therapy (EBRT).

    Authors: Alison C. Johnson, Audrey Emmanuelle Dugué, Marlon Silva, Laura Moise, Xavier Tillou, Florence Joly and Nicolas Aide

    Citation: EJNMMI Research 2016 6:84

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  22. Content type: Original research

    3’-Deoxy-3’-[18F]fluorothymidine ([18F]FLT) PET has limited utility in abdominal imaging due to high physiological hepatic uptake of a tracer. We evaluated [18F]FLT-PET/CT combined with a temporal-intensity infor...

    Authors: R. Sharma, P. Mapelli, G. B. Hanna, R. Goldin, D. Power, A. Al-Nahhas, S. Merchant, R. Ramaswami, A. Challapalli, T. Barwick and E. O. Aboagye

    Citation: EJNMMI Research 2016 6:81

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  23. Content type: Original research

    The availability of GABAA receptor binding sites in the brain can be assessed by positron emission tomography (PET) using the radioligand, [18F]flumazenil. However, the brain uptake and binding of this PET radiol...

    Authors: Mikael Palner, Corinne Beinat, Sam Banister, Francesca Zanderigo, Jun Hyung Park, Bin Shen, Trine Hjoernevik, Jae Ho Jung, Byung Chul Lee, Sang Eun Kim, Lawrence Fung and Frederick T. Chin

    Citation: EJNMMI Research 2016 6:80

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  24. Content type: Original research

    Hypoxic tumours exhibit increased resistance to radiation, chemical, and immune therapies. 18F-fluoromisonidazole (FMISO) positron emission tomography (PET) is a non-invasive, quantitative imaging technique used ...

    Authors: Milan Grkovski, Jazmin Schwartz, Andreas Rimner, Heiko Schöder, Sean D. Carlin, Pat B. Zanzonico, John L. Humm and Sadek A. Nehmeh

    Citation: EJNMMI Research 2016 6:79

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  25. Content type: Original research

    Salvage radiotherapy (SRT) is clinically established in prostate cancer (PC) patients with PSA persistence or biochemical relapse (BCR) after prior radical surgery. PET/CT imaging prior to SRT may be performed...

    Authors: Christina Bluemel, Fraenze Linke, Ken Herrmann, Iva Simunovic, Matthias Eiber, Christian Kestler, Andreas K. Buck, Andreas Schirbel, Thorsten A. Bley, Hans-Juergen Wester, Daniel Vergho and Axel Becker

    Citation: EJNMMI Research 2016 6:78

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  26. Content type: Original research

    Circulating white blood cells crucially contribute to maintenance and repair of solid organs. Therefore, certain cell populations such as monocytes are attractive targets for use in molecular imaging and cell ...

    Authors: Evangelia Pardali, Timo Schmitz, Andreas Borgscheiper, Janette Iking, Lars Stegger and Johannes Waltenberger

    Citation: EJNMMI Research 2016 6:77

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  27. Content type: Original research

    In this study, we prospectively evaluate the diagnostic potential of a gallium-68 (68Ga) prostate-specific membrane antigen (PSMA)-binding ligand and positron emission tomography (PET) in detecting metastatic ...

    Authors: Handoo Rhee, John Blazak, Chui Ming Tham, Keng Lim Ng, Benjamin Shepherd, Malcolm Lawson, John Preston, Ian Vela, Paul Thomas and Simon Wood

    Citation: EJNMMI Research 2016 6:76

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  28. Content type: Original research

    In boron neutron capture therapy (BNCT), positron emission tomography (PET) with 4-borono-2-18F-fluoro-phenylalanine (FBPA) is the only method to estimate an accumulation of 10B to target tumor and surrounding no...

    Authors: Kayako Isohashi, Eku Shimosegawa, Sadahiro Naka, Yasukazu Kanai, Genki Horitsugi, Ikuko Mochida, Keiko Matsunaga, Tadashi Watabe, Hiroki Kato, Mitsuaki Tatsumi and Jun Hatazawa

    Citation: EJNMMI Research 2016 6:75

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  29. Content type: Original research

    The two main mechanisms of resistance to EGFR tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) are the occurrence of T790M secondary mutation in the kinase domain of EGFR and MET amplifi...

    Authors: Viviana De Rosa, Francesca Iommelli, Marcello Monti, Ciro Gabriele Mainolfi, Rosa Fonti and Silvana Del Vecchio

    Citation: EJNMMI Research 2016 6:74

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  30. Content type: Original research

    On April 1, 2015, Odense University Hospital (OUH) began a new diagnostic strategy, wherein all malignant melanoma (MM) patients in the Region of Southern Denmark with a positive sentinel lymph node biopsy (SL...

    Authors: Evan C. Frary, Dorte Gad, Lars Bastholt and Søren Hess

    Citation: EJNMMI Research 2016 6:73

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  31. Content type: Short communication

    In order to maximise the utility of [11C]-PBR28 for use in longitudinal studies and clinical trials in Alzheimer’s disease (AD), there is a need to develop non-invasive metrics of tracer binding that do not requi...

    Authors: Akshay Nair, Mattia Veronese, Xiaohui Xu, Charles Curtis, Federico Turkheimer, Robert Howard and Suzanne Reeves

    Citation: EJNMMI Research 2016 6:72

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    The Erratum to this article has been published in EJNMMI Research 2017 7:14

  32. Content type: Original research

    The purpose of this study is to determine whether a qualitative approach or a semi-quantitative approach provides the most robust method for early response evaluation with 2′-deoxy-2′-[18F]fluoro-d-glucose (F-18-...

    Authors: Joan Fledelius, Azza Khalil, Karin Hjorthaug and Jørgen Frøkiær

    Citation: EJNMMI Research 2016 6:71

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  33. Content type: Short Communication

    Due to its overexpression in a variety of tumor types, the chemokine receptor 4 (CXCR4) represents a highly relevant diagnostic and therapeutic target in nuclear oncology. Recently, [68Ga]pentixafor has emerged a...

    Authors: Andreas Poschenrieder, Margret Schottelius, Markus Schwaiger and Hans-Jürgen Wester

    Citation: EJNMMI Research 2016 6:70

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  34. Content type: Original research

    In addition to occipital hypoperfusion, preserved metabolism of the posterior cingulate gyri (PCG) relative to the precunei is known as the cingulate island sign (CIS) in the patients with dementia with Lewy b...

    Authors: Etsuko Imabayashi, Kota Yokoyama, Tadashi Tsukamoto, Daichi Sone, Kaoru Sumida, Yukio Kimura, Noriko Sato, Miho Murata and Hiroshi Matsuda

    Citation: EJNMMI Research 2016 6:67

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  35. Content type: Original research

    Ga-labeled radiotracers are increasingly used for PET imaging. During the labeling procedure, formation of 68Ga-colloid may occur. Upon i.v. injection, 68Ga-colloid will accumulate rapidly in the liver, spleen, a...

    Authors: Maarten Brom, Gerben M. Franssen, Lieke Joosten, Martin Gotthardt and Otto C. Boerman

    Citation: EJNMMI Research 2016 6:65

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  36. Content type: Original research

    The phosphatidylinositol 3 kinase (PI3K) signalling pathway is frequently altered in human cancer and a promising therapeutic target. AZD8186 (AstraZeneca) is a PI3Kβ/δ inhibitor, currently in phase 1 clinical...

    Authors: Juliana Maynard, Sally-Ann Emmas, Francois-Xavier Blé, Hervé Barjat, Emily Lawrie, Urs Hancox, Deborah Oakes, Urszula M. Polanska and Simon T. Barry

    Citation: EJNMMI Research 2016 6:62

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  37. Content type: Original research

    Recent studies have shown that 3′-deoxy-3′-[18F] fluorothymidine ([18F]FLT)) uptake depends on endogenous tumour thymidine concentration. The purpose of this study was to investigate tumour thymidine concentratio...

    Authors: Kathrin Heinzmann, Davina Jean Honess, David Yestin Lewis, Donna-Michelle Smith, Christopher Cawthorne, Heather Keen, Sandra Heskamp, Sonja Schelhaas, Timothy Howard Witney, Dmitry Soloviev, Kaye Janine Williams, Andreas Hans Jacobs, Eric Ofori Aboagye, John Richard Griffiths and Kevin Michael Brindle

    Citation: EJNMMI Research 2016 6:63

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    The Correction to this article has been published in EJNMMI Research 2017 7:99

  38. Content type: Original research

    Radiation-induced nephropathy is still dose limiting in radionuclide therapy of neuroendocrine tumors. We investigated the nephroprotective potential of the angiotensine converting enzyme inhibiting drug enalp...

    Authors: Harun Ilhan, Hao Wang, Franz J. Gildehaus, Carmen Wängler, Tanja Herrler, Andrei Todica, Julia Schlichtiger, Paul Cumming, Peter Bartenstein, Marcus Hacker and Alexander R. Haug

    Citation: EJNMMI Research 2016 6:64

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  39. Content type: Original research

    We quantified myocardial blood flow with 82Rb PET using parameters of the generalized Renkin-Crone model estimated from 82Rb and 15O-water images reconstructed with time-of-flight and point spread function modeli...

    Authors: Mary Germino, Jim Ropchan, Tim Mulnix, Kathryn Fontaine, Nabeel Nabulsi, Eric Ackah, Herman Feringa, Albert J. Sinusas, Chi Liu and Richard E. Carson

    Citation: EJNMMI Research 2016 6:68

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  40. Content type: Original research

    PET/CT with F-18-fluorodeoxyglucose (FDG) images of patients suffering from metastatic melanoma have been analysed using fractal and multifractal analysis to assess the impact of monoclonal antibody ipilimumab...

    Authors: Christina-Marina Breki, Antonia Dimitrakopoulou-Strauss, Jessica Hassel, Theoharis Theoharis, Christos Sachpekidis, Leyun Pan and Astero Provata

    Citation: EJNMMI Research 2016 6:61

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  41. Content type: Original research

    The therapy response of osseous metastases (OM) is commonly monitored by bone scintigraphies (BS). The aim of this study was to compare visual evaluation of changes in tracer uptake with quantitation in absolu...

    Authors: Michael Beck, James C. Sanders, Philipp Ritt, Julia Reinfelder and Torsten Kuwert

    Citation: EJNMMI Research 2016 6:60

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  42. Content type: Original research

    This study was designed to establish a chronic myocardial infarction (MI) model in minipigs with a novel coronary sequential balloons-sponge embolism technique.

    Authors: Bo Tao, Haokao Gao, Minwen Zheng, Zhonghua Luo, Liwen Liu, Wei Bai, Jing Wang, Daliang Liu, Sai Ma, Zhenli Luo, Lei Gao, Yabin Wang and Feng Cao

    Citation: EJNMMI Research 2016 6:59

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  43. Content type: Original research

    Though overexpression of epidermal growth factor receptor (EGFR) in several forms of cancer is considered to be an important prognostic biomarker related to poor prognosis, clear correlations between biomarker...

    Authors: Qing Cheng, Helena Wållberg, Jonas Grafström, Li Lu, Jan-Olov Thorell, Maria Hägg Olofsson, Stig Linder, Katarina Johansson, Tetyana Tegnebratt, Elias S. J. Arnér, Sharon Stone-Elander, Hanna-Stina Martinsson Ahlzén and Stefan Ståhl

    Citation: EJNMMI Research 2016 6:58

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  44. Content type: Original research

    Assessment of liver function is critical in hepatocellular carcinoma (HCC) patient management. We evaluated parameters of [99mTc] sulfur colloid (SC) SPECT/CT liver uptake for association with clinical measures o...

    Authors: Stephen R. Bowen, Tobias R. Chapman, Joshua Borgman, Robert S. Miyaoka, Paul E. Kinahan, Iris W. Liou, George A. Sandison, Hubert J. Vesselle, Matthew J. Nyflot and Smith Apisarnthanarax

    Citation: EJNMMI Research 2016 6:57

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  45. Content type: Original research

    Positron emission tomography (PET) with the liver-specific galactose tracer 2-[18F]fluoro-2-deoxy-d-galactose (18F-FDGal) may improve diagnosis of hepatocellular carcinoma (HCC). The aim of this study was to test...

    Authors: Jacob Horsager, Kirstine Bak-Fredslund, Lars Peter Larsen, Gerda Elisabeth Villadsen, Trond Velde Bogsrud and Michael Sørensen

    Citation: EJNMMI Research 2016 6:56

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  46. Content type: Original research

    Significant renal mass reduction induced by 5/6 subtotal nephrectomy (Nx) is associated with a chain of events that culminates in hypertension and chronic kidney disease (CKD). Numerous studies have provided e...

    Authors: Basma Ismail, Robert A. deKemp, Tayebeh Hadizad, Kumiko Mackasey, Rob S. Beanlands and Jean N. DaSilva

    Citation: EJNMMI Research 2016 6:55

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  47. Content type: Original research

    Organic cation transporters (OCTs) in the renal proximal tubule are important for the excretion of both exo- and endogenous compounds, and chronic kidney disease (CKD) alter the expression of OCT. Metformin is...

    Authors: Lea Pedersen, Jonas Brorson Jensen, Lise Wogensen, Ole Lajord Munk, Niels Jessen, Jørgen Frøkiær and Steen Jakobsen

    Citation: EJNMMI Research 2016 6:54

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  48. Content type: Original Research

    We have demonstrated recently that the tumor-to-blood standard uptake ratio (SUR) is superior to tumor standardized uptake value (SUV) as a surrogate of the metabolic uptake rate K m of...

    Authors: Frank Hofheinz, Jörg van den Hoff, Ingo G. Steffen, Alexandr Lougovski, Kilian Ego, Holger Amthauer and Ivayla Apostolova

    Citation: EJNMMI Research 2016 6:53

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