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  1. Content type: Original research

    Integrin-targeting radiopharmaceuticals have potential broad applications, spanning from cancer theranostics to cardiovascular diseases. We have previously reported preclinical dosimetry results of 68Ga-NODAGA-RG...

    Authors: Silvano Gnesin, Periklis Mitsakis, Francesco Cicone, Emmanuel Deshayes, Vincent Dunet, Augusto F. Gallino, Marek Kosinski, Sébastien Baechler, Franz Buchegger, David Viertl and John O. Prior

    Citation: EJNMMI Research 2017 7:43

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  2. Content type: Original research

    18F-fluoride PET/CT exhibits high sensitivity to delineate and measure the extent of bone metastatic disease in patients with prostate cancer. 18F-fluoride PET/CT could potentially replace traditional bone sci...

    Authors: Cecilia Wassberg, Mark Lubberink, Jens Sörensen and Silvia Johansson

    Citation: EJNMMI Research 2017 7:42

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  3. Content type: Review

    Mesenchymal–epithelial transition factor also named c-MET is a receptor tyrosine kinase for the hepatocyte growth factor that plays a pivotal role in tumorigenesis. c-MET-targeted therapies have been tested in...

    Authors: Zhaoguo Han, Yongyi Wu, Kai Wang, Yadi Xiao, Zhen Cheng, Xilin Sun and Baozhong Shen

    Citation: EJNMMI Research 2017 7:41

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  4. Content type: Original research

    Atherosclerotic plaque phenotypes are classified based on the extent of macrophage infiltration into the lesions, and the presence of certain macrophage subsets might be a sign for plaque vulnerability. The ma...

    Authors: Zohreh Varasteh, Fabien Hyafil, Nadège Anizan, Devy Diallo, Rachida Aid-Launais, Sarajo Mohanta, Yuanfang Li, Miriam Braeuer, Katja Steiger, Jonathan Vigne, Zhengtao Qin, Stephan G. Nekolla, Jean-Etienne Fabre, Yvonne Döring, Dominique Le Guludec, Andreas Habenicht…

    Citation: EJNMMI Research 2017 7:40

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  5. Content type: Original research

    Positron emission tomography–computed tomography (PET-CT) carotid standardised uptake values (SUV) of 18F-fluorodeoxyglucose (18FDG) have been proposed as an inflammatory biomarker for determining cerebrovascular...

    Authors: Nicola Giannotti, Martin J. O’Connell, Shane J. Foley, Peter J. Kelly and Jonathan P. McNulty

    Citation: EJNMMI Research 2017 7:39

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  6. Content type: Original research

    The aim of this study was to compare the therapeutic efficacy of two different activity levels of the 213Bi-labeled monoclonal antibody MX35 in an ovarian cancer model. Sixty female BALB/c (nu/nu) mice were inocu...

    Authors: Anna Gustafsson-Lutz, Tom Bäck, Emma Aneheim, Ragnar Hultborn, Stig Palm, Lars Jacobsson, Alfred Morgenstern, Frank Bruchertseifer, Per Albertsson and Sture Lindegren

    Citation: EJNMMI Research 2017 7:38

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  7. Content type: Original research

    The aim of this study was to retrospectively evaluate the patient effective dose (ED) for different PET/CT procedures performed with a variety of PET radiopharmaceutical compounds.

    Authors: Josep M. Martí-Climent, Elena Prieto, Verónica Morán, Lidia Sancho, Macarena Rodríguez-Fraile, Javier Arbizu, María J. García-Velloso and José A. Richter

    Citation: EJNMMI Research 2017 7:37

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  8. Content type: Original research

    Accurate quantification of PET studies depends on the spatial resolution of the PET data. The commonly limited PET resolution results in partial volume effects (PVE). Iterative deconvolution methods (IDM) have...

    Authors: Sandeep S. V. Golla, Mark Lubberink, Bart N. M. van Berckel, Adriaan A. Lammertsma and Ronald Boellaard

    Citation: EJNMMI Research 2017 7:36

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  9. Content type: Original research

    Texture features are being increasingly evaluated in 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) as adjunctive imaging biomarkers in a number of different cancers. Whilst studies have report...

    Authors: Eitan Lovat, Musib Siddique, Vicky Goh, Rosalie E. Ferner, Gary J. R. Cook and Victoria S. Warbey

    Citation: EJNMMI Research 2017 7:35

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  10. Content type: Original research

    Preclinical single-photon emission computed tomography (SPECT)/CT imaging studies are hampered by low throughput, hence are found typically within small volume feasibility studies. Here, imaging and image anal...

    Authors: Sven Macholl, Ciara M. Finucane, Jacob Hesterman, Stephen J. Mather, Rachel Pauplis, Deirdre Scully, Jane K. Sosabowski and Erwan Jouannot

    Citation: EJNMMI Research 2017 7:33

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  11. Content type: Original research

    Recently, 18F-tetrafluoroborate (TFB) was used as a substrate for the human sodium/iodide symporter (hNIS) reporter gene. This study evaluated the feasibility of performing molecular-genetic imaging by using the ...

    Authors: Sang Bong Lee, Ho Won Lee, Hongje Lee, Yong Hyun Jeon, Sang-Woo Lee, Byeong-Cheol Ahn, Jaetae Lee and Shin Young Jeong

    Citation: EJNMMI Research 2017 7:32

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  12. Content type: Original research

    The P2X7 receptor has been shown to play a fundamental role in the initiation and sustenance of the inflammatory cascade. The development of a novel fluorine-18 PET tracer superior and with a longer half-life ...

    Authors: Enrico Raffaele Fantoni, Diego Dal Ben, Simonetta Falzoni, Francesco Di Virgilio, Simon Lovestone and Antony Gee

    Citation: EJNMMI Research 2017 7:31

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  13. Content type: Short communication

    The clinical validation of the EARL harmonization program for standardised uptake value (SUV) metrics is well documented; however, its potential for defining metabolic active tumour volume (MATV) has not yet b...

    Authors: Charline Lasnon, Blandine Enilorac, Hosni Popotte and Nicolas Aide

    Citation: EJNMMI Research 2017 7:30

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  14. Content type: Preliminary research

    Despite the progress in the quality of multiphasic CT and MRI scans, it is still difficult to fully characterize a solid kidney lesion. Approximately 10% of all solid renal tumours turn out to be oncocytomas. ...

    Authors: Antonios Tzortzakakis, Ove Gustafsson, Mattias Karlsson, Linnea Ekström-Ehn, Rammin Ghaffarpour and Rimma Axelsson

    Citation: EJNMMI Research 2017 7:29

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  15. Content type: Original research

    Traumatic brain injury (TBI) causes brain dysfunction in many patients. Using C-11 flumazenil (FMZ) positron emission tomography (PET), we have detected and reported the loss of neuronal integrity, leading to ...

    Authors: Kagari Abiko, Katsunori Ikoma, Tohru Shiga, Chietsugu Katoh, Kenji Hirata, Yuji Kuge, Kentaro Kobayashi and Nagara Tamaki

    Citation: EJNMMI Research 2017 7:28

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  16. Content type: Original research

    Phase analysis of gated myocardial perfusion single-photon emission computed tomography (SPECT) for assessment of left ventricular (LV) dyssynchrony was investigated using the following dedicated software pack...

    Authors: Koichi Okuda, Kenichi Nakajima, Shinro Matsuo, Soichiro Kashiwaya, Hiroto Yoneyama, Takayuki Shibutani, Masahisa Onoguchi, Mitsumasa Hashimoto and Seigo Kinuya

    Citation: EJNMMI Research 2017 7:27

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  17. Content type: Original research

    N,N-di-n-propyl-2-[2-(4-[11C]methoxyphenyl)-6,8-dichloroimidazol[1,2-a]pyridine-3-yl]acetamide ([11C]CB184) is a novel selective radioligand for the 18-kD translocator protein (TSPO), ...

    Authors: Muneyuki Sakata, Kenji Ishibashi, Masamichi Imai, Kei Wagatsuma, Kenji Ishii, Kentaro Hatano, Kiichi Ishiwata and Jun Toyohara

    Citation: EJNMMI Research 2017 7:26

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  18. Content type: Original research

    The use of radiolabeled choline as a positron emission tomography (PET) agent for imaging primary tumors in the prostate has been evaluated extensively over the past two decades. There are, however, conflictin...

    Authors: Joshua D. Schaefferkoetter, Ziting Wang, Mary C. Stephenson, Sharmili Roy, Maurizio Conti, Lars Eriksson, David W. Townsend, Thomas Thamboo and Edmund Chiong

    Citation: EJNMMI Research 2017 7:25

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    The Erratum to this article has been published in EJNMMI Research 2017 7:55

  19. Content type: Original research

    Lack of treatment response in patients with late-life depression is common. The role of brain beta-amyloid (Aβ) deposition in treatment outcome in subjects with late-life depression remains unclear. The presen...

    Authors: Peng Li, Ing-Tsung Hsiao, Chia-Yih Liu, Chia-Hsiang Chen, She-Yao Huang, Tzu-Chen Yen, Kuan-Yi Wu and Kun-Ju Lin

    Citation: EJNMMI Research 2017 7:24

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  20. Content type: Original research

    Resolving the kinetic mechanisms of biomolecular interactions have become increasingly important in early-phase drug development. Since traditional in vitro methods belong to dose-dependent assessments, bindin...

    Authors: Markus Zeilinger, Florian Pichler, Lukas Nics, Wolfgang Wadsak, Helmut Spreitzer, Marcus Hacker and Markus Mitterhauser

    Citation: EJNMMI Research 2017 7:22

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  21. Content type: Original research

    Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disease of the nervous system involving both upper and lower motor neurons. The patterns of structural and metabolic brain alterations are still unc...

    Authors: M-S. Buhour, F. Doidy, A. Mondou, A. Pélerin, L. Carluer, F. Eustache, F. Viader and B. Desgranges

    Citation: EJNMMI Research 2017 7:21

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  22. Content type: Original research

    We aimed to assess the positivity, distribution, quantitative degree of vessel inflammation, and clinical characteristics of IgG4-related aortitis/periarteritis and periarteritis (IgG4-aortitis), and to examin...

    Authors: Satoshi Yabusaki, Noriko Oyama-Manabe, Osamu Manabe, Kenji Hirata, Fumi Kato, Noriyuki Miyamoto, Yoshihiro Matsuno, Kohsuke Kudo, Nagara Tamaki and Hiroki Shirato

    Citation: EJNMMI Research 2017 7:20

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  23. Content type: Original research

    Red blood cells (RBCs) labeled with single-photon emitters have been clinically used for blood-pool imaging. Although some PET tracers have been introduced for blood-pool imaging, they have not yet been widely...

    Authors: Yohji Matsusaka, Tadaki Nakahara, Kazuhiro Takahashi, Yu Iwabuchi, Chiyoko Nishime, Mayumi Kajimura and Masahiro Jinzaki

    Citation: EJNMMI Research 2017 7:19

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  24. Content type: Original Research

    Dosimetry in radionuclide therapy has the potential to allow for a treatment tailored to the individual patient. One therapeutic radiopharmaceutical where patient-specific dosimetry is feasible is 177Lu-DOTATATE,...

    Authors: Johan Gustafsson, Anna Sundlöv and Katarina Sjögreen Gleisner

    Citation: EJNMMI Research 2017 7:18

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  25. Content type: Original research

    Preferred models for the pharmacokinetic analysis of [11C]flumazenil human studies have been previously established. However, direct translation of these models and settings to animal studies might be sub-optimal...

    Authors: Isadora Lopes Alves, David Vállez García, Andrea Parente, Janine Doorduin, Rudi Dierckx, Ana Maria Marques da Silva, Michel Koole, Antoon Willemsen and Ronald Boellaard

    Citation: EJNMMI Research 2017 7:17

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  26. Content type: Original research

    Intratumoral hypoxia is one of the resistant factors in radiotherapy and chemotherapy for cancer. Although it is detected by 18F-fluoromisonidazole (FMISO) PET, the relationship between intratumoral hypoxia and o...

    Authors: Tadashi Watabe, Yasukazu Kanai, Hayato Ikeda, Genki Horitsugi, Keiko Matsunaga, Hiroki Kato, Kayako Isohashi, Kohji Abe, Eku Shimosegawa and Jun Hatazawa

    Citation: EJNMMI Research 2017 7:16

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  27. Content type: Original research

    Sodium fluoride (NaF) positron emission tomography combined with computer tomography (PET/CT) has shown to be more sensitive than the whole-body bone scan in the detection of skeletal uptake due to metastases ...

    Authors: Sarah Lindgren Belal, May Sadik, Reza Kaboteh, Nezar Hasani, Olof Enqvist, Linus Svärm, Fredrik Kahl, Jane Simonsen, Mads H. Poulsen, Mattias Ohlsson, Poul F. Høilund-Carlsen, Lars Edenbrandt and Elin Trägårdh

    Citation: EJNMMI Research 2017 7:15

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  28. Content type: Original research

    In FDG PET/CT, standardized uptake value (SUV) is used to measure metabolic activity but detects un-phosphorylated FDG as well as phosphorylated FDG (FDG6P). Our aim was to determine the proportions of intrahe...

    Authors: Georgia Keramida, Constantinos D. Anagnostopoulos and A. Michael Peters

    Citation: EJNMMI Research 2017 7:13

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  29. Content type: Original research

    While 68Ga-PSMA PET-MRI might be superior to PET-CT with regard to soft tissue assessment in prostate cancer evaluation, it is also known to potentially introduce additional PET image artefacts. Therefore, the im...

    Authors: Benjamin Noto, Florian Büther, Katharina Auf der Springe, Nemanja Avramovic, Walter Heindel, Michael Schäfers, Thomas Allkemper and Lars Stegger

    Citation: EJNMMI Research 2017 7:12

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  30. Content type: Original research

    This study aimed to compare one state-of-the-art deep learning method and four classical machine learning methods for classifying mediastinal lymph node metastasis of non-small cell lung cancer (NSCLC) from 18F-F...

    Authors: Hongkai Wang, Zongwei Zhou, Yingci Li, Zhonghua Chen, Peiou Lu, Wenzhi Wang, Wanyu Liu and Lijuan Yu

    Citation: EJNMMI Research 2017 7:11

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  31. Content type: Original research

    The use of a normal database for [123I]FP-CIT SPECT imaging has been found to be helpful for cases which are difficult to interpret by visual assessment alone, and to improve reproducibility in scan interpretatio...

    Authors: John C. Dickson, Livia Tossici-Bolt, Terez Sera, Jan Booij, Morten Ziebell, Silvia Morbelli, Susanne Assenbaum-Nan, Thierry Vander Borght, Marco Pagani, Ozlem L. Kapucu, Swen Hesse, Koen Van Laere, Jacques Darcourt, Andrea Varrone and Klaus Tatsch

    Citation: EJNMMI Research 2017 7:10

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  32. Content type: Original research

    The targeting of the prostate-specific membrane antigen (PSMA) is of particular interest for radiotheragnostic purposes of prostate cancer. Radiolabeled PSMA-617, a 1,4,7,10-tetraazacyclododecane-N,N′,N′′,N′′′-te...

    Authors: Christoph A. Umbricht, Martina Benešová, Raffaella M. Schmid, Andreas Türler, Roger Schibli, Nicholas P. van der Meulen and Cristina Müller

    Citation: EJNMMI Research 2017 7:9

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  33. Content type: Original research

    The aim of this study was to compare the percentage change in 18F-fluorothymidine (FLT) standard uptake value (SUV) between baseline and after one cycle of chemotherapy in patients categorized by RECIST 1.1 compu...

    Authors: John P. Crandall, Abdel K. Tahari, Rosalyn A. Juergens, Julie R. Brahmer, Charles M. Rudin, Giuseppe Esposito, Deepa S. Subramaniam, Michael V. Knopp, Nathan C. Hall, Prateek Gajwani, Jeffrey P. Leal, Martin A. Lodge, Joo H. O., Edward W. Gabrielson, Lalitha K. Shankar and Richard L. Wahl

    Citation: EJNMMI Research 2017 7:8

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  34. Content type: Original research

    In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of 68Ga-DOTA PET for the in vivo quantitative determination of regi...

    Authors: Carlos Velasco, Jesus Mateo, Arnoldo Santos, Adriana Mota-Cobian, Fernando Herranz, Juan Pellico, Ruben A. Mota, Samuel España and Jesus Ruiz-Cabello

    Citation: EJNMMI Research 2017 7:7

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  35. Content type: Original research

    Molecular breast imaging (MBI) performed with 99mTc sestamibi has been shown to be a valuable technique for the detection of breast cancer. Alternative radiotracers such as 99mTc maraciclatide may offer improved ...

    Authors: Michael K. O’Connor, Melissa M. B. Morrow, Katie N. Hunt, Judy C. Boughey, Dietlind L. Wahner-Roedler, Amy Lynn Conners, Deborah J. Rhodes and Carrie B. Hruska

    Citation: EJNMMI Research 2017 7:5

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  36. Content type: Original research

    Osteomyelitis is a serious disease which can be difficult to treat despite properly instituted antibiotic therapy. This appears to be related at least partly to degraded vascularisation in the osteomyelitic (O...

    Authors: Lars Jødal, Ole L. Nielsen, Pia Afzelius, Aage K. O. Alstrup and Søren B. Hansen

    Citation: EJNMMI Research 2017 7:4

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  37. Content type: Original research

    The purpose of this study is to identify a method for optimising the administered activity and acquisition time for 18F-FDG PET imaging, yielding images of consistent quality for patients with varying body sizes ...

    Authors: Fred Wickham, Helena McMeekin, Maria Burniston, Daniel McCool, Deborah Pencharz, Annah Skillen and Thomas Wagner

    Citation: EJNMMI Research 2017 7:3

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  38. Content type: Original research

    177Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remissio...

    Authors: Johanna Dalmo, Johan Spetz, Mikael Montelius, Britta Langen, Yvonne Arvidsson, Henrik Johansson, Toshima Z. Parris, Khalil Helou, Bo Wängberg, Ola Nilsson, Maria Ljungberg and Eva Forssell-Aronsson

    Citation: EJNMMI Research 2017 7:6

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  39. Content type: Preliminary research

    Routine work-up for transarterial radioembolization, based on clinical and laboratory parameters, sometimes fails, resulting in severe hepatotoxicity in up to 5% of patients. Quantitative assessment of the pre...

    Authors: Manon N. G. J. A. Braat, Hugo W. de Jong, Beatrijs A. Seinstra, Mike V. Scholten, Maurice A. A. J. van den Bosch and Marnix G. E. H. Lam

    Citation: EJNMMI Research 2017 7:2

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  40. Content type: Original research

    The aim of this study is to assess whether ultra-fast acquisition SPECT/CT (UF-SPECT/CT) can replace standard SPECT/CT (std-SPECT/CT) as “add-on” to whole-body bone scintigraphy (WB-BS) for the investigation o...

    Authors: Helle D. Zacho, José A. Biurrun Manresa, Ramune Aleksyniene, June A. Ejlersen, Joan Fledelius, Henrik Bertelsen and Lars J. Petersen

    Citation: EJNMMI Research 2017 7:1

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  41. Content type: Original research

    Yttrium-90 radioembolization (90Y-RE) as a treatment for liver tumours induces radiation damage and hypoxia in liver tissue, which is also a trigger for systemic release of angiogenic factors, potentially stimula...

    Authors: C. E. N. M. Rosenbaum, A. F. van den Hoven, M. N. G. J. A. Braat, M. Koopman, M. G. E. H. Lam, B. A. Zonnenberg, H. M. Verkooijen and M. A. A. J. van den Bosch

    Citation: EJNMMI Research 2016 6:92

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  42. Content type: Original research

    Several radiometal-labeled, exendin-based tracers that target glucagon-like peptide-1 receptors (GLP-1R) have been intensively explored for β cell imaging. The main obstacle has been the high uptake of tracer ...

    Authors: Kirsi Mikkola, Cheng-Bin Yim, Paula Lehtiniemi, Saila Kauhanen, Miikka Tarkia, Tuula Tolvanen, Pirjo Nuutila and Olof Solin

    Citation: EJNMMI Research 2016 6:91

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  43. Content type: Original research

    Sorafenib, an oral multikinase inhibitor, has anti-proliferative and anti-angiogenic activities and is therapeutically effective against renal cell carcinoma (RCC). Recently, we have evaluated the tumor respon...

    Authors: Naoyuki Ukon, Songji Zhao, Wenwen Yu, Yoichi Shimizu, Ken-ichi Nishijima, Naoki Kubo, Yoshimasa Kitagawa, Nagara Tamaki, Kei Higashikawa, Hironobu Yasui and Yuji Kuge

    Citation: EJNMMI Research 2016 6:90

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  44. Content type: Original research

    90Y PET/CT post-radioembolization imaging has demonstrated that the distribution of 90Y in a tumor can be non-uniform. Using computational modeling, we predicted the dosimetric impact ...

    Authors: Alexander S. Pasciak, Abigail Lin, Christos Georgiades, Laura K. Findeiss, Shannon Kauffman and Yong C. Bradley

    Citation: EJNMMI Research 2016 6:89

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  45. Content type: Original research

    Biologicals directed against tumour necrosis factor (TNF) have proven their efficacy in the treatment of spondyloarthritis and rheumatoid arthritis. We present a radiolabelling method for certolizumab pegol (C...

    Authors: Bieke Lambert, Philippe Carron, Yves D’Asseler, Klaus Bacher, Filip Van den Bosch, Dirk Elewaut, Gust Verbruggen, Rudi Beyaert, Caroline Dumolyn and Filip De Vos

    Citation: EJNMMI Research 2016 6:88

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  46. Content type: Original research

    Quantitative biodistribution, venous blood and excretion data have been obtained following the intravenous bolus injection of AH113804 (18F) Injection in six healthy volunteers (HVs), four males and two females, ...

    Authors: E. J. Somer, R. Owenius, A. Wall, G. Antoni, A. Thibblin and J. Sörensen

    Citation: EJNMMI Research 2016 6:87

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