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EJNMMI Research
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  1. Molecular imaging techniques visualise biomarkers for both drug development and personalised medicine. In this field, Cherenkov luminescence imaging (CLI) seems to be very attractive by allowing imaging with c...

    Authors: Emiko Desvaux, Alan Courteau, Pierre-Simon Bellaye, Mélanie Guillemin, Camille Drouet, Paul Walker, Bertrand Collin and Richard A. Decréau

    Citation: EJNMMI Research 2018 8:111

    Content type: Short communication

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  2. 18F-FDG brain PET measures metabolic changes in neurodegenerative disorders and may discriminate between different diseases even at an early stage. The objective of this study was to classify patients with amyot....

    Authors: Martijn Devrome, Donatienne Van Weehaeghe, Joke De Vocht, Philip Van Damme, Koen Van Laere and Michel Koole

    Citation: EJNMMI Research 2018 8:110

    Content type: Original research

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  3. Bone fracture healing is dependent upon the rapid migration and engraftment of bone marrow (BM) progenitor and stem cells to the site of injury. Stromal cell-derived factor-1 plays a crucial role in recruiting...

    Authors: Kingsley O. Asiedu, Munira Ferdousi, Phuongnga T. Ton, Stephen S. Adler, Peter L. Choyke and Noriko Sato

    Citation: EJNMMI Research 2018 8:109

    Content type: Original research

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  4. Gastrin-releasing peptide receptor antagonists have promise in theranostics of several highly incident tumours, including prostate and breast. This study presents the first human dosimetry of 68Ga-NODAGA-MJ9 in t...

    Authors: Silvano Gnesin, Francesco Cicone, Periklis Mitsakis, Axel Van der Gucht, Sébastien Baechler, Raymond Miralbell, Valentina Garibotto, Thomas Zilli and John O. Prior

    Citation: EJNMMI Research 2018 8:108

    Content type: Original research

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  5. A standardised method for quantifying β-amyloid PET tracers would allow comparison across different tracers and different sites. The development of the Centiloid scale has aimed to achieve this, applying a com...

    Authors: Mark R. Battle, Lovena Chedumbarum Pillay, Val J. Lowe, David Knopman, Bradley Kemp, Christopher C. Rowe, Vincent Doré, Victor L. Villemagne and Christopher J. Buckley

    Citation: EJNMMI Research 2018 8:107

    Content type: Original research

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  6. Due to the high noise emission generated by the gradients in magnetic resonance imaging (MRI), an efficient method of noise protection is mandatory. In addition to providing hearing protection, appropriate hea...

    Authors: Lutz Tellmann, Hans Herzog, Frank Boers, Christoph Lerche and N. Jon Shah

    Citation: EJNMMI Research 2018 8:106

    Content type: Short communication

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  7. Sentinel lymph node biopsy (SLNB) after intratumoral injection of 99mTc labeled nanocolloid and imaging with scintigraphy and SPECT/CT in renal tumors is feasible. However, sentinel lymph node (SN) non-detection ...

    Authors: Teele Kuusk, Maarten L. Donswijk, Renato A. Valdés Olmos, Roderick E. De Bruijn, Oscar R. Brouwer, Kees Hendricksen, Simon Horenblas, Katarzyna Jóźwiak, Warner Prevoo, Henk G. Van Der Poel, Bas W. G. Van Rhijn, Esther M. Wit and Axel Bex

    Citation: EJNMMI Research 2018 8:105

    Content type: Original research

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  8. 18FDG PET/CT is crucial before neck surgery for nodal recurrence localization in iodine-refractory differentiated or poorly differentiated thyroid cancer (DTC/PDTC). A dedicated head-and-neck (HN) acquisition pe....

    Authors: Renaud Ciappuccini, Cédric Desmonts, Idlir Licaj, Cécile Blanc-Fournier, Stéphane Bardet and Nicolas Aide

    Citation: EJNMMI Research 2018 8:104

    Content type: Original research

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  9. This study’s aim was to develop our dosimetric methodology using a commercial workstation for the routine evaluation of the organs at risk during peptide receptor radionuclide therapy (PRRT) with 177Lu.

    Authors: Lore Santoro, Erick Mora-Ramirez, Dorian Trauchessec, Soufiane Chouaf, Pierre Eustache, Jean-Pierre Pouget, Pierre-Olivier Kotzki, Manuel Bardiès and Emmanuel Deshayes

    Citation: EJNMMI Research 2018 8:103

    Content type: Original research

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  10. The PET radioligand (R)-[11C]PK11195 is used to quantify the 18-kDa translocator protein (TSPO), a marker for glial activation. Since there is no brain region devoid of TSPO, an arterial input function (AIF) is i...

    Authors: Pontus Plavén-Sigray, Granville James Matheson, Zsolt Cselényi, Aurelija Jucaite, Lars Farde and Simon Cervenka

    Citation: EJNMMI Research 2018 8:102

    Content type: Original research

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  11. Metastatic melanoma patients can have durable responses to systemic therapy and even long-term survival. However, a large subgroup of patients does not benefit. Tumour metabolic alterations may well be involve...

    Authors: Ellen C. de Heer, Adrienne H. Brouwers, Ronald Boellaard, Wim J. Sluiter, Gilles F. H. Diercks, Geke A. P. Hospers, Elisabeth G. E. de Vries and Mathilde Jalving

    Citation: EJNMMI Research 2018 8:101

    Content type: Original research

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  12. Dopamine transporter (DAT) imaging may be of diagnostic value in patients with clinically suspected parkinsonian disease. The purpose of this study was to compare the diagnostic performance of DAT imaging with...

    Authors: Susanna Jakobson Mo, Jan Axelsson, Lars Jonasson, Anne Larsson, Mattias J. Ögren, Margareta Ögren, Andrea Varrone, Linda Eriksson, David Bäckström, Sara af Bjerkén, Jan Linder and Katrine Riklund

    Citation: EJNMMI Research 2018 8:100

    Content type: Original research

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  13. In FDG-PET, SUV images are hampered by large potential biases. Our aim was to develop an alternative method (ParaPET) to generate 3D kinetic parametric FDG-PET images easy to perform in clinical oncology.

    Authors: Elyse Colard, Sarkis Delcourt, Laetitia Padovani, Sébastien Thureau, Arthur Dumouchel, Pierrick Gouel, Justine Lequesne, Bardia Farman Ara, Pierre Vera, David Taïeb, Isabelle Gardin, Dominique Barbolosi and Sébastien Hapdey

    Citation: EJNMMI Research 2018 8:99

    Content type: Original research

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  14. The aim of this study was to assess the value of 18F-FDG PET/CT for quantitative assessment of hepatic metabolism in patients with different stages of liver fibrosis/cirrhosis.

    Authors: Niklas Verloh, Ingo Einspieler, Kirsten Utpatel, Karin Menhart, Stefan Brunner, Frank Hofheinz, Jörg van den Hoff, Philipp Wiggermann, Matthias Evert, Christian Stroszczynski, Dirk Hellwig and Jirka Grosse

    Citation: EJNMMI Research 2018 8:98

    Content type: Original research

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  16. Prostate-specific membrane antigen (PSMA)-directed radioligand therapy (RLT) is a promising yet not curative approach in castration-resistant (CR) prostate cancer (PC). Rational combination therapies may impro...

    Authors: Katharina Lückerath, Liu Wei, Wolfgang P. Fendler, Susan Evans-Axelsson, Andreea D. Stuparu, Roger Slavik, Christine E. Mona, Jeremie Calais, Matthew Rettig, Robert E. Reiter, Ken Herrmann, Caius G. Radu, Johannes Czernin and Matthias Eiber

    Citation: EJNMMI Research 2018 8:96

    Content type: Original research

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  17. HEPES is a favorable buffer for 68Ga-complexations in radiochemical laboratories. The drawback of this buffer is its prescribed limit of 200 μg per recommended application volume in the final formulation. Current...

    Authors: Sarah Pfaff, Tina Nehring, Verena Pichler, Jens Cardinale, Markus Mitterhauser, Marcus Hacker and Wolfgang Wadsak

    Citation: EJNMMI Research 2018 8:95

    Content type: Original Research

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  18. Cardiac sarcoidosis (CS) is a rare but potentially life-threatening disease that causes conduction disturbance, systolic dysfunction, and, most notably, sudden cardiac death. 18F-fluorodeoxyglucose (FDG) positron...

    Authors: Sho Furuya, Osamu Manabe, Hiroshi Ohira, Kenji Hirata, Tadao Aikawa, Masanao Naya, Ichizo Tsujino, Kazuhiro Koyanagawa, Toshihisa Anzai, Noriko Oyama-Manabe and Tohru Shiga

    Citation: EJNMMI Research 2018 8:94

    Content type: Original research

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  19. The aim of this pilot study is to investigate the impact of virtual reality exposure therapy (VRET) on brain metabolism and connectivity.

    Authors: Antoine Verger, Eric Malbos, Emmanuelle Reynaud, Pierre Mallet, Daniel Mestre, Jean-Marie Pergandi, Stéphanie Khalfa and Eric Guedj

    Citation: EJNMMI Research 2018 8:93

    Content type: Original research

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  20. We investigated the feasibility of left ventricular (LV) and right ventricular (RV) volume and function estimation using a first-pass gated 15O-water PET. This prospective study included 19 patients addressed for...

    Authors: Fayçal Ben Bouallègue, Denis Mariano-Goulart, Denis Agostini and Alain Manrique

    Citation: EJNMMI Research 2018 8:92

    Content type: Original research

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  21. Glioma grading with dynamic 18F-FET PET (0–40 min p.i.) is typically performed by analysing the mean time-activity curve of the entire tumour or a suspicious area within a heterogeneous tumour. This work aimed to...

    Authors: Lena Vomacka, Marcus Unterrainer, Adrien Holzgreve, Erik Mille, Astrid Gosewisch, Julia Brosch, Sibylle Ziegler, Bogdana Suchorska, Friedrich-Wilhelm Kreth, Jörg-Christian Tonn, Peter Bartenstein, Nathalie Lisa Albert and Guido Böning

    Citation: EJNMMI Research 2018 8:91

    Content type: Original research

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  22. CXCR4 is a chemokine receptor frequently overexpressed in invasive breast cancer that has been shown to play a major role in signaling pathways involved in metastasis. The aim of this retrospective analysis wa...

    Authors: Tibor Vag, Katja Steiger, Andreas Rossmann, Ulrich Keller, Aurelia Noske, Peter Herhaus, Johannes Ettl, Markus Niemeyer, Hans-Jürgen Wester and Markus Schwaiger

    Citation: EJNMMI Research 2018 8:90

    Content type: Original research

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  23. The main challenge for systemic radiation therapy using radiopharmaceuticals (SRT) is to optimise the dose delivered to the tumour, while minimising normal tissue irradiation. Dosimetry could help to increase ...

    Authors: Daphne Merel Valerie Huizing, Berlinda Jantina de Wit-van der Veen, Marcel Verheij and Marcellus Petrus Maria Stokkel

    Citation: EJNMMI Research 2018 8:89

    Content type: Review

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  24. The validation of the most appropriate compartmental model that describes the kinetics of a specific tracer within a specific tissue is mandatory before estimating quantitative parameters, since the behaviour ...

    Authors: Erica Silvestri, Valentina Scolozzi, Gaia Rizzo, Luca Indovina, Marco Castellaro, Maria Vittoria Mattoli, Paolo Graziano, Giuseppe Cardillo, Alessandra Bertoldo and Maria Lucia Calcagni

    Citation: EJNMMI Research 2018 8:88

    Content type: Original research

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  25. The folate receptor α (FRα)-targeting antibody-drug conjugate (ADC), IMGN853, shows great antitumor activity against FRα-expressing tumors in vivo, but patient selection and consequently therapy outcome are ba...

    Authors: Christian Brand, Ahmad Sadique, Jacob L. Houghton, Kishore Gangangari, Jose F. Ponte, Jason S. Lewis, Naga Vara Kishore Pillarsetty, Jason A. Konner and Thomas Reiner

    Citation: EJNMMI Research 2018 8:87

    Content type: Original research

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  26. A radiomic approach was applied in 18F-FDG PET endometrial cancer, to investigate if imaging features computed on the primary tumour could improve sensitivity in nodal metastases detection. One hundred fifteen...

    Authors: Elisabetta De Bernardi, Alessandro Buda, Luca Guerra, Debora Vicini, Federica Elisei, Claudio Landoni, Robert Fruscio, Cristina Messa and Cinzia Crivellaro

    Citation: EJNMMI Research 2018 8:86

    Content type: Original research

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  27. The InSPira HD system, a novel brain-dedicated SPECT scanner, allows for imaging with a high spatial resolution. Here, we tested whether this scanner can be used to image the dopamine transporter adequately. T...

    Authors: Sofie M. Adriaanse, Tim C. de Wit, Mette Stam, Eline Verwer, Kora M. de Bruin and Jan Booij

    Citation: EJNMMI Research 2018 8:85

    Content type: Short communication

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  28. Several radiolabeled prostate-specific membrane antigen (PSMA) inhibitors based on the lysine-urea-glutamate (KuE) motif as the pharmacophore proved to be suitable tools for PET/SPECT imaging of the PSMA expre...

    Authors: Martina Wirtz, Alexander Schmidt, Margret Schottelius, Stephanie Robu, Thomas Günther, Markus Schwaiger and Hans-Jürgen Wester

    Citation: EJNMMI Research 2018 8:84

    Content type: Original research

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  29. Recent developments in hardware and software for PET technologies have resulted in wide variations in basic performance. Multicentre studies require a standard imaging protocol and SUV harmonization to reduce ...

    Authors: Yuji Tsutsui, Hiromitsu Daisaki, Go Akamatsu, Takuro Umeda, Matsuyoshi Ogawa, Hironori Kajiwara, Shigeto Kawase, Minoru Sakurai, Hiroyuki Nishida, Keiichi Magota, Kazuaki Mori and Masayuki Sasaki

    Citation: EJNMMI Research 2018 8:83

    Content type: Original research

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  30. Programmed cell death 1 (PD-1) inhibitors act as immune checkpoint inhibitors and are more effective for improving survival time with less toxicity as compared with conventional chemotherapies. In anti PD-1 th...

    Authors: Mayu Tomita, Hironobu Yasui, Kei Higashikawa, Kohei Nakajima, Hideo Takakura, Tohru Shiga, Yuji Kuge and Mikako Ogawa

    Citation: EJNMMI Research 2018 8:82

    Content type: Original research

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  31. Erlotinib is an epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitor approved for treatment of non-small cell lung cancer. The wide inter-individual pharmacokinetic (PK) variability of e...

    Authors: Dorra Amor, Sébastien Goutal, Solène Marie, Fabien Caillé, Martin Bauer, Oliver Langer, Sylvain Auvity and Nicolas Tournier

    Citation: EJNMMI Research 2018 8:81

    Content type: Original research

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  32. [18F]Fluoro-2-deoxy-2-d-glucose positron emission tomography (FDG-PET) is commonly used in the clinic for diagnosis of cancer and for follow-up of therapy outcome. Additional to the well-established value in tumo...

    Authors: Stefanie Pektor, Lina Hilscher, Kerstin C. Walzer, Isabelle Miederer, Nicole Bausbacher, Carmen Loquai, Mathias Schreckenberger, Ugur Sahin, Mustafa Diken and Matthias Miederer

    Citation: EJNMMI Research 2018 8:80

    Content type: Original research

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  33. Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using...

    Authors: Emma E. Wolters, Sandeep S. V. Golla, Tessa Timmers, Rik Ossenkoppele, Chris W. J. van der Weijden, Philip Scheltens, Lothar Schwarte, Robert C. Schuit, Albert D. Windhorst, Frederik Barkhof, Maqsood Yaqub, Adriaan A. Lammertsma, Ronald Boellaard and Bart N. M. van Berckel

    Citation: EJNMMI Research 2018 8:79

    Content type: Short communication

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  34. The recently growing interest in targeted alpha-therapy (TAT) calls for improvement of the labelling chemistry of the corresponding radionuclides. 213BiIII is a short-lived alpha emitter which emits only one alph...

    Authors: Jakub Šimeček, Petr Hermann, Christof Seidl, Frank Bruchertseifer, Alfred Morgenstern, Hans-Jürgen Wester and Johannes Notni

    Citation: EJNMMI Research 2018 8:78

    Content type: Short communication

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  35. Irradiation with α-particles creates densely packed damage tracks along particle trajectories in exposed cells, including complex DNA damage and closely spaced double-strand breaks (DSBs) in hit nuclei. Here, ...

    Authors: Sarah Schumann, Uta Eberlein, Jessica Müller, Harry Scherthan and Michael Lassmann

    Citation: EJNMMI Research 2018 8:77

    Content type: Original research

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  36. The bone marrow (BM) is a main organ at risk in Lu-177-PSMA-617 therapy of prostate cancer and Lu-177-Octreotate therapy of neuroendocrine tumours. BM dosimetry is challenging and time-consuming, as different ...

    Authors: Astrid Gosewisch, Andreas Delker, Sebastian Tattenberg, Harun Ilhan, Andrei Todica, Julia Brosch, Lena Vomacka, Anika Brunegraf, Franz Josef Gildehaus, Sibylle Ziegler, Peter Bartenstein and Guido Böning

    Citation: EJNMMI Research 2018 8:76

    Content type: Original research

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  37. Somatostatin receptor targeting radiopeptides are successfully being used to image, stage, and monitor patients with neuroendocrine tumours. They are exclusively agonists that internalise upon binding to the r...

    Authors: Keelara Abiraj, Samer Ursillo, Maria Luisa Tamma, Svetlana N. Rylova, Beatrice Waser, Edwin C. Constable, Melpomeni Fani, Guillaume P. Nicolas, Jean Claude Reubi and Helmut R. Maecke

    Citation: EJNMMI Research 2018 8:75

    Content type: Original research

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  38. The D1-dopamine receptor radioligand [11C]SCH23390 has been frequently used in PET studies. In drug-naïve patients with schizophrenia, the findings have been inconsistent, with decreases, increases, and no change...

    Authors: Per Stenkrona, Granville J. Matheson, Simon Cervenka, Pontus Plavén Sigray, Christer Halldin and Lars Farde

    Citation: EJNMMI Research 2018 8:74

    Content type: Original research

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  39. To determine the relative abilities of compartment models to describe time-courses of 18F-fluoromisonidazole (FMISO) tumor uptake in patients with advanced stage non-small cell lung cancer (NSCLC) imaged using...

    Authors: Daniel R. McGowan, Michael Skwarski, Bartlomiej W. Papiez, Ruth E. Macpherson, Fergus V. Gleeson, Julia A. Schnabel, Geoff S. Higgins and John D. Fenwick

    Citation: EJNMMI Research 2018 8:73

    Content type: Original research

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  40. This study identified the optimal tracer kinetic model for quantification of dynamic O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) positron emission tomography (PET) studies in seven patients with diffuse glioma (...

    Authors: Thomas Koopman, Niels Verburg, Robert C. Schuit, Petra J. W. Pouwels, Pieter Wesseling, Albert D. Windhorst, Otto S. Hoekstra, Philip C. de Witt Hamer, Adriaan A. Lammertsma, Ronald Boellaard and Maqsood Yaqub

    Citation: EJNMMI Research 2018 8:72

    Content type: Original research

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  41. We measured whole body distribution of 11C-BU99008, a new PET biomarker for non-invasive identification of the imidazoline2 binding site. The purpose of this phase I study was to evaluate the biodistribution and ...

    Authors: Ashwin V. Venkataraman, Nicholas Keat, James F. Myers, Samuel Turton, Inge Mick, Roger N. Gunn, Eugenii A. Rabiner, Jan Passchier, Christine A. Parker, Robin J. Tyacke and David J. Nutt

    Citation: EJNMMI Research 2018 8:71

    Content type: Original research

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  42. In contrast to ordered subset expectation maximization (OSEM), block sequential regularized expectation maximization (BSREM) positron emission tomography (PET) reconstruction algorithms can run until full conv...

    Authors: Edwin E. G. W. ter Voert, Urs J. Muehlematter, Gaspar Delso, Daniele A. Pizzuto, Julian Müller, Hannes W. Nagel and Irene A. Burger

    Citation: EJNMMI Research 2018 8:70

    Content type: Original research

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  43. Efforts to develop suitable positron emission tomography (PET) tracers for the ion channel site of human N-methyl-d-aspartate (NMDA) receptors have had limited success. [18F]PK-209 is a GMOM derivative that binds...

    Authors: Jasper van der Aart, Sandeep S. V. Golla, Marieke van der Pluijm, Lothar A. Schwarte, Robert C. Schuit, Pieter J. Klein, Athanasios Metaxas, Albert D. Windhorst, Ronald Boellaard, Adriaan A. Lammertsma and Bart N. M. van Berckel

    Citation: EJNMMI Research 2018 8:69

    Content type: Original research

    Published on:

  44. Unfortunately, after publication of this article [1], it was noticed that the name of Urs J. Muehlematter was incorrectly displayed as Urs J. Mühlematter. The corrected author list can be seen above and the or...

    Authors: Urs J. Muehlematter, Hannes W. Nagel, Anton Becker, Julian Mueller, Kerstin N. Vokinger, Felipe de Galiza Barbosa, Edwin E. G. T. ter Voert, Patrick Veit-Haibach and Irene A. Burger

    Citation: EJNMMI Research 2018 8:68

    Content type: Correction

    Published on:

    The original article was published in EJNMMI Research 2018 8:41

  45. The ability to accurately and non-invasively distinguish high-grade glioma from low-grade glioma remains a challenge despite advances in molecular and magnetic resonance imaging. We investigated the ability of...

    Authors: Ephraim E. Parent, Marc Benayoun, Ijeoma Ibeanu, Jeffrey J. Olson, Constantinos G. Hadjipanayis, Daniel J. Brat, Vikram Adhikarla, Jonathon Nye, David M. Schuster and Mark M. Goodman

    Citation: EJNMMI Research 2018 8:67

    Content type: Original research

    Published on:

  46. Florbetaben, a 18F-labeled stilbene derivative (Neuraceq®, formerly known as BAY-949172), is a diagnostic radiopharmaceutical developed to visualize β-amyloid plaques in the brain. Here, we report a pilot study e...

    Authors: Lucia Baratto, Sonya Youngju Park, Negin Hatami, Praveen Gulaka, Shreyas Vasanawala, Thomas Koshy Yohannan, Robert Herfkens, Ronald Witteles and Andrei Iagaru

    Citation: EJNMMI Research 2018 8:66

    Content type: Short communication

    Published on:

  47. Localizing and removing the infected sequestrum in long-standing trauma-related chronic osteomyelitis remains a clinical challenge. PET/CT with 18F-fluorodeoxyglucose (FDG-PET) has a high sensitivity for chron...

    Authors: Albert Christersson, Sune Larsson and Jens Sörensen

    Citation: EJNMMI Research 2018 8:65

    Content type: Original research

    Published on:

  48. Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumor. Currently, 18F-fluoro-deoxy-glucose (18F-FDG) PET/CT is the functional imaging modality of choice. Few data are available on the use of 68Ga...

    Authors: Silvia Taralli, Martina Sollini, Michele Milella, Germano Perotti, Angelina Filice, Massimo Menga, Annibale Versari and Vittoria Rufini

    Citation: EJNMMI Research 2018 8:64

    Content type: Original research

    Published on:

  49. Graphical methods of radiotracer kinetic modeling in PET are ideal for parametric imaging and data quality assurance but can suffer from noise bias. This study compared the Logan and Multilinear Analysis-1 (MA...

    Authors: Tong Wang, Kai Yi Wu, Robert C. Miner, Jennifer M. Renaud, Rob S. B. Beanlands and Robert A. deKemp

    Citation: EJNMMI Research 2018 8:63

    Content type: Original research

    Published on:

  50. The 18F-THK-5351 radiotracer has been used to detect the in vivo tau protein distribution in patients with tauopathy, such as Alzheimer’s disease and corticobasal syndrome. In addition, 18F-THK-5351 can also moni...

    Authors: Kuo-Lun Huang, Jung-Lung Hsu, Kun-Ju Lin, Chien-Hung Chang, Yi-Ming Wu, Ting-Yu Chang, Yeu-Jhy Chang, Chi-Hung Liu, Meng-Yang Ho, Shiaw-Pyng Wey, Tzu-Chen Yen, Nobuyuki Okamura, Ing-Tsung Hsiao and Tsong-Hai Lee

    Citation: EJNMMI Research 2018 8:62

    Content type: Original research

    Published on:

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