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EJNMMI Research
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  1. Radiation injury can be indistinguishable from recurrent tumor on standard imaging. Current protocols for this differential diagnosis require one or more follow-up imaging studies, long dynamic acquisitions, o...

    Authors: Patrick L. Donabedian, Susanne Kossatz, John A. Engelbach, Stephen A. Jannetti, Brandon Carney, Robert J. Young, Wolfgang A. Weber, Joel R. Garbow and Thomas Reiner

    Citation: EJNMMI Research 2018 8:59

    Content type: Original research

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  2. Kinetic analysis of dynamic PET data requires an accurate knowledge of available PET tracer concentration within blood plasma over time, known as the arterial input function (AIF). The gold standard method use...

    Authors: Hasan Sari, Kjell Erlandsson, Lisbeth Marner, Ian Law, Henrik B.W. Larsson, Kris Thielemans, Sébastien Ourselin, Simon Arridge, David Atkinson and Brian F. Hutton

    Citation: EJNMMI Research 2018 8:58

    Content type: Original research

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  3. Inflammation is associated with major depressive disorder (MDD). Translocator protein 18 kDa (TSPO), a putative biomarker of neuroinflammation, is quantified using positron emission tomography (PET) and 11C-PBR28...

    Authors: Erica M. Richards, Paolo Zanotti-Fregonara, Masahiro Fujita, Laura Newman, Cristan Farmer, Elizabeth D. Ballard, Rodrigo Machado-Vieira, Peixiong Yuan, Mark J. Niciu, Chul Hyoung Lyoo, Ioline D. Henter, Giacomo Salvadore, Wayne C. Drevets, Hartmuth Kolb, Robert B. Innis and Carlos A. Zarate Jr

    Citation: EJNMMI Research 2018 8:57

    Content type: Original research

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  4. External cooling of the salivary glands is advised to prevent xerostomia in lutetium-177-PSMA treatment for advanced prostate cancer. Since evidence addressing this subject is sparse, this study aims to determ...

    Authors: Ludwike W. M. van Kalmthout, Marnix G. E. H. Lam, Bart de Keizer, Gerard C. Krijger, Tessa F. T. Ververs, Rememrt de Roos and Arthur J. A. T. Braat

    Citation: EJNMMI Research 2018 8:56

    Content type: Original research

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  5. There is a growing interest in the use of 18F-FDG PET-CT to monitor tuberculosis (TB) treatment response. However, TB causes complex and widespread pathology, which is challenging to segment and quantify in a rep...

    Authors: Stephanus T. Malherbe, Patrick Dupont, Ilse Kant, Petri Ahlers, Magdalena Kriel, André G. Loxton, Ray Y. Chen, Laura E. Via, Friedrich Thienemann, Robert J. Wilkinson, Clifton E. Barry III, Stephanie Griffith-Richards, Annare Ellman, Katharina Ronacher, Jill Winter, Gerhard Walzl…

    Citation: EJNMMI Research 2018 8:55

    Content type: Original research

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  6. The present study proposed a new concept for targeted radionuclide therapy (TRT) to improve the intratumoral distribution of radioactivity using two different radiopharmaceuticals. We examined the efficacy of ...

    Authors: Zhao-Hui Jin, Atsushi B. Tsuji, Mélissa Degardin, Aya Sugyo, Yukie Yoshii, Kotaro Nagatsu, Ming-Rong Zhang, Yasuhisa Fujibayashi, Pascal Dumy, Didier Boturyn and Tatsuya Higashi

    Citation: EJNMMI Research 2018 8:54

    Content type: Original research

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  7. Quantitative imaging can facilitate patient stratification in clinical trials. The hypoxia-activated prodrug evofosfamide recently failed a phase III trial in pancreatic cancer. However, the study did not atte...

    Authors: Milan Grkovski, Louise Fanchon, Naga Vara Kishore Pillarsetty, James Russell and John L. Humm

    Citation: EJNMMI Research 2018 8:53

    Content type: Short communication

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  8. This study investigated the spatial relationship of 2-deoxy-2-[18F]-fluoro-D-glucose positron emission tomography ([18F]FDG-PET) standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs) derive...

    Authors: John M. Floberg, Kathryn J. Fowler, Dominique Fuser, Todd A. DeWees, Farrokh Dehdashti, Barry A. Siegel, Richard L. Wahl, Julie K. Schwarz and Perry W. Grigsby

    Citation: EJNMMI Research 2018 8:52

    Content type: Original research

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  9. Tracers triggering αvβ3 integrins, such as certain RGD-containing peptides, were found promising in previous pilot studies characterizing high-grade gliomas. However, only limited comparisons have been perform...

    Authors: Sibel Isal, Julien Pierson, Laetitia Imbert, Alexandra Clement, Charlotte Collet, Sophie Pinel, Nicolas Veran, Aurélie Reinhard, Sylvain Poussier, Guillaume Gauchotte, Steeven Frezier, Gilles Karcher, Pierre-Yves Marie and Fatiha Maskali

    Citation: EJNMMI Research 2018 8:51

    Content type: Original research

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  10. A major toxicity concern in radioembolization therapy of hepatic malignancies is radiation-induced pneumonitis and sclerosis due to hepatopulmonary shunting of 90Y microspheres. Currently, 99mTc macroaggregated a...

    Authors: Jonathan D. Allred, Jeremy Niedbala, Justin K. Mikell, Dawn Owen, Kirk A. Frey and Yuni K. Dewaraja

    Citation: EJNMMI Research 2018 8:50

    Content type: Original research

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  11. Suboptimal temporal sampling of time-activity curves (TAC) from dynamic 18F-fluoromethylcholine (FCH) PET images may introduce bias in quantification of FCH uptake in prostate cancer assessment. We sought to defi...

    Authors: Xavier Palard-Novello, Anne-Lise Blin, Florence Le Jeune, Etienne Garin, Pierre-Yves Salaün, Anne Devillers, Giulio Gambarota, Solène Querellou, Patrick Bourguet and Hervé Saint-Jalmes

    Citation: EJNMMI Research 2018 8:49

    Content type: Original research

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  12. The histamine H3 receptor is regarded as a drug target for cognitive impairments in psychiatric disorders. H3 receptors are expressed in neocortical areas, including the prefrontal cortex, the key region of cogni...

    Authors: Takehito Ito, Yasuyuki Kimura, Chie Seki, Masanori Ichise, Keita Yokokawa, Kazunori Kawamura, Hidehiko Takahashi, Makoto Higuchi, Ming-Rong Zhang, Tetsuya Suhara and Makiko Yamada

    Citation: EJNMMI Research 2018 8:48

    Content type: Short communication

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  13. The potential of the D-isomerization of 4-borono-2-18F-fluoro-phenylalanine (18F-FBPA) to improve its target tumor to non-target normal brain tissue ratio (TBR) was evaluated in rat brain glioma and compared with...

    Authors: Masakatsu Kanazawa, Shingo Nishiyama, Fumio Hashimoto, Takeharu Kakiuchi and Hideo Tsukada

    Citation: EJNMMI Research 2018 8:47

    Content type: Original research

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  14. The NMDA receptor radiotracer [18F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible.

    Authors: Colm J. McGinnity, Daniela A. Riaño Barros, William Trigg, David J. Brooks, Rainer Hinz, John S. Duncan, Matthias J. Koepp and Alexander Hammers

    Citation: EJNMMI Research 2018 8:46

    Content type: Short Communication

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  15. Microvascular function plays an important role in ARVD (atherosclerotic renovascular disease). RFR (renal flow reserve), the capacity of renal vasculature to dilate, is known to reflect renal microvascular fun...

    Authors: Johanna Päivärinta, Niina Koivuviita, Vesa Oikonen, Hidehiro Iida, Kaisa Liukko, Ilkka Manner, Eliisa Löyttyniemi, Pirjo Nuutila and Kaj Metsärinne

    Citation: EJNMMI Research 2018 8:45

    Content type: Original research

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  16. The close connection between neuronal activity and glucose consumption accounts for the clinical value of 18F-fluoro-2-deoxyglucose (FDG) imaging in neurodegenerative disorders. Nevertheless, brain metabolic r...

    Authors: Ambra Buschiazzo, Vanessa Cossu, Matteo Bauckneht, Annamaria Orengo, Patrizia Piccioli, Laura Emionite, Giovanna Bianchi, Federica Grillo, Anna Rocchi, Francesco Di Giulio, Francesco Fiz, Lizzia Raffaghello, Flavio Nobili, Silvia Bruno, Giacomo Caviglia, Silvia Ravera…

    Citation: EJNMMI Research 2018 8:44

    Content type: Original research

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  17. Translocator protein (TSPO) imaging can be used to detect neuroinflammation (including microglial activation) after acute cerebral infarction. However, longitudinal changes of TSPO binding after mild ischemia ...

    Authors: Natsumi Miyajima, Miwa Ito, Takemi Rokugawa, Hitoshi Iimori, Sotaro Momosaki, Shigeki Omachi, Eku Shimosegawa, Jun Hatazawa and Kohji Abe

    Citation: EJNMMI Research 2018 8:43

    Content type: Original research

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  18. This study explores various volume of interest (VOI) delineation techniques for fluorine-18-fluorodeoxyglucose positron emission tomography with computed tomography (18F-FDG PET-CT) scans during neoadjuvant extre...

    Authors: Marc G. Stevenson, Lukas B. Been, Harald J. Hoekstra, Albert J. H. Suurmeijer, Ronald Boellaard and Adrienne H. Brouwers

    Citation: EJNMMI Research 2018 8:42

    Content type: Original Research

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  19. Accurate attenuation correction (AC) is an inherent problem of positron emission tomography magnetic resonance imaging (PET/MRI) systems. Simulation studies showed that time-of-flight (TOF) detectors can reduc...

    Authors: Urs J. Muehlematter, Hannes W. Nagel, Anton Becker, Julian Mueller, Kerstin N. Vokinger, Felipe de Galiza Barbosa, Edwin E. G. T. ter Voert, Patrick Veit-Haibach and Irene A. Burger

    Citation: EJNMMI Research 2018 8:41

    Content type: Original research

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    The Correction to this article has been published in EJNMMI Research 2018 8:68

  20. Activated hepatic stellate cells (HSCs), which express integrin αvβ3, are a major fibrogenic factor in NASH pathophysiology. 18F-labeled cyclic arginine-glycine-aspartic acid penta-peptide (18F-FPP-RGD2) has been...

    Authors: Takemi Rokugawa, Haruyo Konishi, Miwa Ito, Hitoshi Iimori, Ryohei Nagai, Eku Shimosegawa, Jun Hatazawa and Kohji Abe

    Citation: EJNMMI Research 2018 8:40

    Content type: Original Research

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  21. The protein cross-linking enzyme tissue transglutaminase (TG2; EC 2.3.2.13) is associated with the pathogenesis of various diseases, including cancer. Recently, the synthesis and initial evaluation of two high...

    Authors: Berend van der Wildt, Micha M. M. Wilhelmus, Wissam Beaino, Esther J. M. Kooijman, Robert C. Schuit, John G. J. M. Bol, John J. P. Breve, Ralf Pasternack, Adriaan A. Lammertsma, Albert D. Windhorst and Benjamin Drukarch

    Citation: EJNMMI Research 2018 8:39

    Content type: Original research

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  22. The current de facto standard for quantification of tumor metabolism in oncological whole-body PET is the standardized uptake value (SUV) approach. SUV determination requires accurate scanner calibration. Resi...

    Authors: Jens Maus, Frank Hofheinz, Ivayla Apostolova, Michael C. Kreissl, Jörg Kotzerke and Jörg van den Hoff

    Citation: EJNMMI Research 2018 8:38

    Content type: Original research

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  23. A method was developed to assess the kidney parameters glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) from 2-deoxy-2-[18F]fluoro-d-glucose (FDG) concentration behavior in kidneys, measure...

    Authors: Barbara K. Geist, Pascal Baltzer, Barbara Fueger, Martina Hamboeck, Thomas Nakuz, Laszlo Papp, Sazan Rasul, Lalith Kumar Shiyam Sundar, Marcus Hacker and Anton Staudenherz

    Citation: EJNMMI Research 2018 8:37

    Content type: Original research

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  24. For (123I)FP-CIT imaging, a number of algorithms have shown high performance in distinguishing normal patient images from those with disease, but none have yet been tested as part of reporting workflows. This stu...

    Authors: Jonathan Christopher Taylor, Charles Romanowski, Eleanor Lorenz, Christine Lo, Oliver Bandmann and John Fenner

    Citation: EJNMMI Research 2018 8:36

    Content type: Original research

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  25. The potential application of bone marrow stromal cell (BMSC) therapy in stroke has been anticipated due to its immunomodulatory effects. Recently, positron emission tomography (PET) with [18F]DPA-714, a transloca...

    Authors: Chengbo Tan, Songji Zhao, Kei Higashikawa, Zifeng Wang, Masahito Kawabori, Takeo Abumiya, Naoki Nakayama, Ken Kazumata, Naoyuki Ukon, Hironobu Yasui, Nagara Tamaki, Yuji Kuge, Hideo Shichinohe and Kiyohiro Houkin

    Citation: EJNMMI Research 2018 8:35

    Content type: Original research

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  26. In epilepsy patients, SISCOM or subtraction ictal single photon emission computed tomography co-registered to magnetic resonance imaging has become a routinely used, non-invasive technique to localize the icta...

    Authors: Liesbeth De Coster, Koen Van Laere, Evy Cleeren, Kristof Baete, Patrick Dupont, Wim Van Paesschen and Karolien E. Goffin

    Citation: EJNMMI Research 2018 8:34

    Content type: Original research

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  27. The cholecystokinin receptor subtype 2 (CCK-2R) is an important target for diagnostic imaging and targeted radionuclide therapy (TRNT) due to its overexpression in certain cancers (e.g., medullary thyroid carc...

    Authors: Piotr F. J. Lipiński, Piotr Garnuszek, Michał Maurin, Raphael Stoll, Nils Metzler-Nolte, Artur Wodyński, Jan Cz. Dobrowolski, Marta K. Dudek, Monika Orzełowska and Renata Mikołajczak

    Citation: EJNMMI Research 2018 8:33

    Content type: Original research

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  28. Prostate-specific membrane antigen (PSMA)-targeted therapy with 177Lu-PSMA-617 is a therapeutic option for patients with metastatic castration-resistant prostate cancer (mCRPC). To optimize the therapy procedure,...

    Authors: J. Kurth, B. J. Krause, S. M. Schwarzenböck, L. Stegger, M. Schäfers and K. Rahbar

    Citation: EJNMMI Research 2018 8:32

    Content type: Original research

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  29. Epilepsy surgery often causes changes in cognition and cerebral glucose metabolism. Our aim was to explore relationships between pre- and postoperative cerebral metabolism as measured with 18F-fluorodeoxyglucose ...

    Authors: Canan Güvenç, Patrick Dupont, Jan Van den Stock, Laura Seynaeve, Kathleen Porke, Eva Dries, Karen Van Bouwel, Johannes van Loon, Tom Theys, Karolien E. Goffin and Wim Van Paesschen

    Citation: EJNMMI Research 2018 8:31

    Content type: Original research

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  30. Due to its high and consistent expression in prostate cancer (PCa), the prostate-specific membrane antigen (PSMA) represents an ideal target for molecular imaging and targeted therapy using highly specific rad...

    Authors: Stephanie Robu, Alexander Schmidt, Matthias Eiber, Margret Schottelius, Thomas Günther, Behrooz Hooshyar Yousefi, Markus Schwaiger and Hans-Jürgen Wester

    Citation: EJNMMI Research 2018 8:30

    Content type: Original research

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  31. Prognosis in oesophageal cancer (OC) is poor. The 5-year overall survival (OS) rate is approximately 15%. Personalised medicine is hoped to increase the 5- and 10-year OS rates. Quantitative analysis of PET is...

    Authors: Craig Parkinson, Kieran Foley, Philip Whybra, Robert Hills, Ashley Roberts, Chris Marshall, John Staffurth and Emiliano Spezi

    Citation: EJNMMI Research 2018 8:29

    Content type: Original research

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  32. Despite the significant upgrading in recent years of the role of 18F-FDG PET/CT in multiple myeloma (MM) diagnostics, there is a still unmet need for myeloma-specific radiotracers. 3′-Deoxy-3′-[18F]fluorothymidin...

    Authors: C. Sachpekidis, H. Goldschmidt, K. Kopka, A. Kopp-Schneider and A. Dimitrakopoulou-Strauss

    Citation: EJNMMI Research 2018 8:28

    Content type: Original research

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  33. Gallium-68-labeled prostate-specific antigen positron emission tomography/computed tomography imaging (Ga68-PSMA-11-PET/CT) has emerged as a potential gold standard for prostate cancer (PCa) diagnosis. However...

    Authors: Alejandro Sanchez-Crespo, Emma Jussing, Ann-Charlotte Björklund and Katja Pokrovskaja Tamm

    Citation: EJNMMI Research 2018 8:27

    Content type: Original research

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  35. The goal of the study was to assess the potential of the vascular endothelial growth factor receptor (VEGFR)-2-targeting carbon-11 labeled (R)-N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-3-piperidinyl)metho...

    Authors: T. Tegnebratt, L. Lu, S. Eksborg, A. Chireh, P. Damberg, S. Nikkhou-Aski, T. Foukakis, H. Rundqvist, S. Holmin, R. V. Kuiper and E. Samen

    Citation: EJNMMI Research 2018 8:25

    Content type: Preliminary research

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  36. Patlak’s graphical analysis can provide tracer net influx constant (Ki) with limitation of assuming irreversible tracer trapping, that is, release rate constant (kb) set to zero. We compared linear Patlak’s analy...

    Authors: E. Laffon, M. L. Calcagni, G. Galli, A. Giordano, A. Capotosti, R. Marthan and L. Indovina

    Citation: EJNMMI Research 2018 8:24

    Content type: Original research

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    The Correction to this article has been published in EJNMMI Research 2019 9:30

  37. The study aims to assess the accuracy of multi-parametric prostate MRI (mpMRI) and 18F-choline PET/CT in tumor segmentation for clinically significant prostate cancer. 18F-choline PET/CT and 3 T mpMRI were perfor...

    Authors: Morand Piert, Prasad R. Shankar, Jeffrey Montgomery, Lakshmi Priya Kunju, Virginia Rogers, Javed Siddiqui, Thekkelnaycke Rajendiran, Jason Hearn, Arvin George, Xia Shao and Matthew S. Davenport

    Citation: EJNMMI Research 2018 8:23

    Content type: Original research

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  38. 3′-Deoxy-3′-[18F]fluorothymidine ([18F]FLT) was proposed as an imaging biomarker for the assessment of in vivo cellular proliferation with positron emission tomography (PET). The current study aimed to validate [

    Authors: R. Iqbal, G. M. Kramer, V. Frings, E. F. Smit, O. S. Hoekstra and R. Boellaard

    Citation: EJNMMI Research 2018 8:22

    Content type: Original research

    Published on:

  39. Cerebral blood flow (CBF) quantitation using technetium-99m hexamethylpropyleneamine oxime (99mTc-HMPAO) generally requires assessment of input function by arterial blood sampling, which would be invasive for sma...

    Authors: Chie Suzuki, Mutsumi Kosugi and Yasuhiro Magata

    Citation: EJNMMI Research 2018 8:21

    Content type: Original research

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  40. I-124 codrituzumab (aka GC33), an antibody directed at Glypican 3, was evaluated in patients with hepatocellular carcinoma (HCC). Fourteen patients with HCC underwent baseline imaging with I-124 codrituzumab (...

    Authors: Jorge A. Carrasquillo, Joseph A. O’Donoghue, Volkan Beylergil, Shutian Ruan, Neeta Pandit-Taskar, Steven M. Larson, Peter M. Smith-Jones, Serge K. Lyashchenko, Norihisa Ohishi, Toshihiko Ohtomo and Ghassan K. Abou-Alfa

    Citation: EJNMMI Research 2018 8:20

    Content type: Original research

    Published on:

  41. AD is a progressive neurodegenerative disorder that is associated with the accumulation of two different insoluble protein aggregates, Aβ plaques and hyperphosphorylated tau. This study aimed to investigate th...

    Authors: Azadeh Firouzian, Alex Whittington, Graham E. Searle, Ivan Koychev, Giovanna Zamboni, Simon Lovestone and Roger N. Gunn

    Citation: EJNMMI Research 2018 8:19

    Content type: Original research

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  42. The aim of the present study is to evaluate the kinetics and dosimetry of 64CuCl2 in human prostate cancer (PCa) lesions.

    Authors: Sergio Righi, Martina Ugolini, Gianluca Bottoni, Matteo Puntoni, Massimiliano Iacozzi, Francesco Paparo, Manlio Cabria, Luca Ceriani, Monica Gambaro, Luca Giovanella and Arnoldo Piccardo

    Citation: EJNMMI Research 2018 8:18

    Content type: Original research

    Published on:

  43. Amino acid co-infusion for renal protection in endoradiotherapy (ERT) applied as prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) or peptide receptor radionuclide therapy (PRRT) has...

    Authors: Christian H. Pfob, Matthias Eiber, Peter Luppa, Florian Maurer, Tobias Maurer, Robert Tauber, Calogero D’Alessandria, Benedikt Feuerecker, Klemens Scheidhauer, Armin Ott, Uwe Heemann, Markus Schwaiger and Christoph Schmaderer

    Citation: EJNMMI Research 2018 8:17

    Content type: Original research

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  44. In this work, the in vitro and in vivo stabilities and the pharmacology of HPMA-made homopolymers were studied by means of radiometal-labeled derivatives. Aiming to identify the fewer amount and the optimal DO...

    Authors: Elisabeth Eppard, Ana de la Fuente, Nicole Mohr, Mareli Allmeroth, Rudolf Zentel, Matthias Miederer, Stefanie Pektor and Frank Rösch

    Citation: EJNMMI Research 2018 8:16

    Content type: Original research

    Published on:

  45. PET/CT lymphoscintigraphy using 89Zr-nanocolloidal albumin has the potential to improve the preoperative identification of sentinel lymph nodes (SLNs), especially if located in the near proximity of the primary t...

    Authors: Derrek A. Heuveling, K. Hakki Karagozoglu, Arthur Van Lingen, Otto S. Hoekstra, Guus A. M. S. Van Dongen and Remco De Bree

    Citation: EJNMMI Research 2018 8:15

    Content type: Preliminary research

    Published on:

  46. xSPECT Bone® (xB) is a new reconstruction algorithm developed by Siemens® in bone hybrid imaging (SPECT/CT). A CT-based tissue segmentation is incorporated into SPECT reconstruction to provide SPECT images wit...

    Authors: Olivier Delcroix, Philippe Robin, Maelenn Gouillou, Alexandra Le Duc-Pennec, Zarrin Alavi, Pierre-Yves Le Roux, Ronan Abgral, Pierre-Yves Salaun, David Bourhis and Solène Querellou

    Citation: EJNMMI Research 2018 8:14

    Content type: Original research

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  47. Positron emission tomography (PET) is a molecular imaging technology that enables in vivo quantification of metabolic activity or receptor density, among other applications. Examples of applications of PET ima...

    Authors: Richard Baumgartner, Aniket Joshi, Dai Feng, Francesca Zanderigo and R. Todd Ogden

    Citation: EJNMMI Research 2018 8:13

    Content type: Original research

    Published on:

  48. 18F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (18F-LMI1195) is a new class of PET tracer designed for sympathetic nervous imaging of the heart. The favorable image quality with high and specific neural up...

    Authors: Xinyu Chen, Rudolf A. Werner, Constantin Lapa, Naoko Nose, Mitsuru Hirano, Mehrbod S. Javadi, Simon Robinson and Takahiro Higuchi

    Citation: EJNMMI Research 2018 8:12

    Content type: Original research

    Published on:

  49. 15O-Water positron emission tomography (PET) enables functional imaging of the auditory system during stimulation via a promontory electrode or cochlear implant, which is not possible using functional magnetic r....

    Authors: Martin Mamach, Florian Wilke, Martin Durisin, Frank A. Beger, Mareike Finke, Andreas Büchner, Barbara Schultz, Arthur Schultz, Lilli Geworski, Frank M. Bengel, Thomas Lenarz, Anke Lesinski-Schiedat and Georg Berding

    Citation: EJNMMI Research 2018 8:11

    Content type: Original research

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