This study explores various volume of interest (VOI) delineation techniques for fluorine-18-fluorodeoxyglucose positron emission tomography with computed tomography (18F-FDG PET-CT) scans during neoadjuvant extre...
Authors: Marc G. Stevenson, Lukas B. Been, Harald J. Hoekstra, Albert J. H. Suurmeijer, Ronald Boellaard and Adrienne H. Brouwers
Accurate attenuation correction (AC) is an inherent problem of positron emission tomography magnetic resonance imaging (PET/MRI) systems. Simulation studies showed that time-of-flight (TOF) detectors can reduc...
Authors: Urs J. Muehlematter, Hannes W. Nagel, Anton Becker, Julian Mueller, Kerstin N. Vokinger, Felipe de Galiza Barbosa, Edwin E. G. T. ter Voert, Patrick Veit-Haibach and Irene A. Burger
Activated hepatic stellate cells (HSCs), which express integrin αvβ3, are a major fibrogenic factor in NASH pathophysiology. 18F-labeled cyclic arginine-glycine-aspartic acid penta-peptide (18F-FPP-RGD2) has been...
Authors: Takemi Rokugawa, Haruyo Konishi, Miwa Ito, Hitoshi Iimori, Ryohei Nagai, Eku Shimosegawa, Jun Hatazawa and Kohji Abe
The protein cross-linking enzyme tissue transglutaminase (TG2; EC 2.3.2.13) is associated with the pathogenesis of various diseases, including cancer. Recently, the synthesis and initial evaluation of two high...
Authors: Berend van der Wildt, Micha M. M. Wilhelmus, Wissam Beaino, Esther J. M. Kooijman, Robert C. Schuit, John G. J. M. Bol, John J. P. Breve, Ralf Pasternack, Adriaan A. Lammertsma, Albert D. Windhorst and Benjamin Drukarch
The current de facto standard for quantification of tumor metabolism in oncological whole-body PET is the standardized uptake value (SUV) approach. SUV determination requires accurate scanner calibration. Resi...
Authors: Jens Maus, Frank Hofheinz, Ivayla Apostolova, Michael C. Kreissl, Jörg Kotzerke and Jörg van den Hoff
A method was developed to assess the kidney parameters glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) from 2-deoxy-2-[18F]fluoro-d-glucose (FDG) concentration behavior in kidneys, measure...
Authors: Barbara K. Geist, Pascal Baltzer, Barbara Fueger, Martina Hamboeck, Thomas Nakuz, Laszlo Papp, Sazan Rasul, Lalith Kumar Shiyam Sundar, Marcus Hacker and Anton Staudenherz
For (123I)FP-CIT imaging, a number of algorithms have shown high performance in distinguishing normal patient images from those with disease, but none have yet been tested as part of reporting workflows. This stu...
Authors: Jonathan Christopher Taylor, Charles Romanowski, Eleanor Lorenz, Christine Lo, Oliver Bandmann and John Fenner
The potential application of bone marrow stromal cell (BMSC) therapy in stroke has been anticipated due to its immunomodulatory effects. Recently, positron emission tomography (PET) with [18F]DPA-714, a transloca...
Authors: Chengbo Tan, Songji Zhao, Kei Higashikawa, Zifeng Wang, Masahito Kawabori, Takeo Abumiya, Naoki Nakayama, Ken Kazumata, Naoyuki Ukon, Hironobu Yasui, Nagara Tamaki, Yuji Kuge, Hideo Shichinohe and Kiyohiro Houkin
In epilepsy patients, SISCOM or subtraction ictal single photon emission computed tomography co-registered to magnetic resonance imaging has become a routinely used, non-invasive technique to localize the icta...
Authors: Liesbeth De Coster, Koen Van Laere, Evy Cleeren, Kristof Baete, Patrick Dupont, Wim Van Paesschen and Karolien E. Goffin
The cholecystokinin receptor subtype 2 (CCK-2R) is an important target for diagnostic imaging and targeted radionuclide therapy (TRNT) due to its overexpression in certain cancers (e.g., medullary thyroid carc...
Authors: Piotr F. J. Lipiński, Piotr Garnuszek, Michał Maurin, Raphael Stoll, Nils Metzler-Nolte, Artur Wodyński, Jan Cz. Dobrowolski, Marta K. Dudek, Monika Orzełowska and Renata Mikołajczak
Prostate-specific membrane antigen (PSMA)-targeted therapy with 177Lu-PSMA-617 is a therapeutic option for patients with metastatic castration-resistant prostate cancer (mCRPC). To optimize the therapy procedure,...
Authors: J. Kurth, B. J. Krause, S. M. Schwarzenböck, L. Stegger, M. Schäfers and K. Rahbar
Epilepsy surgery often causes changes in cognition and cerebral glucose metabolism. Our aim was to explore relationships between pre- and postoperative cerebral metabolism as measured with 18F-fluorodeoxyglucose ...
Authors: Canan Güvenç, Patrick Dupont, Jan Van den Stock, Laura Seynaeve, Kathleen Porke, Eva Dries, Karen Van Bouwel, Johannes van Loon, Tom Theys, Karolien E. Goffin and Wim Van Paesschen
Due to its high and consistent expression in prostate cancer (PCa), the prostate-specific membrane antigen (PSMA) represents an ideal target for molecular imaging and targeted therapy using highly specific rad...
Authors: Stephanie Robu, Alexander Schmidt, Matthias Eiber, Margret Schottelius, Thomas Günther, Behrooz Hooshyar Yousefi, Markus Schwaiger and Hans-Jürgen Wester
Prognosis in oesophageal cancer (OC) is poor. The 5-year overall survival (OS) rate is approximately 15%. Personalised medicine is hoped to increase the 5- and 10-year OS rates. Quantitative analysis of PET is...
Authors: Craig Parkinson, Kieran Foley, Philip Whybra, Robert Hills, Ashley Roberts, Chris Marshall, John Staffurth and Emiliano Spezi
Despite the significant upgrading in recent years of the role of 18F-FDG PET/CT in multiple myeloma (MM) diagnostics, there is a still unmet need for myeloma-specific radiotracers. 3′-Deoxy-3′-[18F]fluorothymidin...
Authors: C. Sachpekidis, H. Goldschmidt, K. Kopka, A. Kopp-Schneider and A. Dimitrakopoulou-Strauss
Gallium-68-labeled prostate-specific antigen positron emission tomography/computed tomography imaging (Ga68-PSMA-11-PET/CT) has emerged as a potential gold standard for prostate cancer (PCa) diagnosis. However...
Authors: Alejandro Sanchez-Crespo, Emma Jussing, Ann-Charlotte Björklund and Katja Pokrovskaja Tamm
Assessment of the status of tumor biomarkers in individual patients would facilitate personalizing treatment strategy, and continuous monitoring of those biomarkers and their binding process to the therapeutic...
Authors: Yasaman Ardeshirpour, Dan L. Sackett, Jay R. Knutson and Amir H. Gandjbakhche
The goal of the study was to assess the potential of the vascular endothelial growth factor receptor (VEGFR)-2-targeting carbon-11 labeled (R)-N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-3-piperidinyl)metho...
Authors: T. Tegnebratt, L. Lu, S. Eksborg, A. Chireh, P. Damberg, S. Nikkhou-Aski, T. Foukakis, H. Rundqvist, S. Holmin, R. V. Kuiper and E. Samen
Patlak’s graphical analysis can provide tracer net influx constant (Ki) with limitation of assuming irreversible tracer trapping, that is, release rate constant (kb) set to zero. We compared linear Patlak’s analy...
Authors: E. Laffon, M. L. Calcagni, G. Galli, A. Giordano, A. Capotosti, R. Marthan and L. Indovina
The study aims to assess the accuracy of multi-parametric prostate MRI (mpMRI) and 18F-choline PET/CT in tumor segmentation for clinically significant prostate cancer. 18F-choline PET/CT and 3 T mpMRI were perfor...
Authors: Morand Piert, Prasad R. Shankar, Jeffrey Montgomery, Lakshmi Priya Kunju, Virginia Rogers, Javed Siddiqui, Thekkelnaycke Rajendiran, Jason Hearn, Arvin George, Xia Shao and Matthew S. Davenport
3′-Deoxy-3′-[18F]fluorothymidine ([18F]FLT) was proposed as an imaging biomarker for the assessment of in vivo cellular proliferation with positron emission tomography (PET). The current study aimed to validate [
Authors: R. Iqbal, G. M. Kramer, V. Frings, E. F. Smit, O. S. Hoekstra and R. Boellaard
Cerebral blood flow (CBF) quantitation using technetium-99m hexamethylpropyleneamine oxime (99mTc-HMPAO) generally requires assessment of input function by arterial blood sampling, which would be invasive for sma...
Authors: Chie Suzuki, Mutsumi Kosugi and Yasuhiro Magata
I-124 codrituzumab (aka GC33), an antibody directed at Glypican 3, was evaluated in patients with hepatocellular carcinoma (HCC). Fourteen patients with HCC underwent baseline imaging with I-124 codrituzumab (...
Authors: Jorge A. Carrasquillo, Joseph A. O’Donoghue, Volkan Beylergil, Shutian Ruan, Neeta Pandit-Taskar, Steven M. Larson, Peter M. Smith-Jones, Serge K. Lyashchenko, Norihisa Ohishi, Toshihiko Ohtomo and Ghassan K. Abou-Alfa
AD is a progressive neurodegenerative disorder that is associated with the accumulation of two different insoluble protein aggregates, Aβ plaques and hyperphosphorylated tau. This study aimed to investigate th...
Authors: Azadeh Firouzian, Alex Whittington, Graham E. Searle, Ivan Koychev, Giovanna Zamboni, Simon Lovestone and Roger N. Gunn
Amino acid co-infusion for renal protection in endoradiotherapy (ERT) applied as prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) or peptide receptor radionuclide therapy (PRRT) has...
Authors: Christian H. Pfob, Matthias Eiber, Peter Luppa, Florian Maurer, Tobias Maurer, Robert Tauber, Calogero D’Alessandria, Benedikt Feuerecker, Klemens Scheidhauer, Armin Ott, Uwe Heemann, Markus Schwaiger and Christoph Schmaderer
In this work, the in vitro and in vivo stabilities and the pharmacology of HPMA-made homopolymers were studied by means of radiometal-labeled derivatives. Aiming to identify the fewer amount and the optimal DO...
Authors: Elisabeth Eppard, Ana de la Fuente, Nicole Mohr, Mareli Allmeroth, Rudolf Zentel, Matthias Miederer, Stefanie Pektor and Frank Rösch
PET/CT lymphoscintigraphy using 89Zr-nanocolloidal albumin has the potential to improve the preoperative identification of sentinel lymph nodes (SLNs), especially if located in the near proximity of the primary t...
Authors: Derrek A. Heuveling, K. Hakki Karagozoglu, Arthur Van Lingen, Otto S. Hoekstra, Guus A. M. S. Van Dongen and Remco De Bree
xSPECT Bone® (xB) is a new reconstruction algorithm developed by Siemens® in bone hybrid imaging (SPECT/CT). A CT-based tissue segmentation is incorporated into SPECT reconstruction to provide SPECT images wit...
Authors: Olivier Delcroix, Philippe Robin, Maelenn Gouillou, Alexandra Le Duc-Pennec, Zarrin Alavi, Pierre-Yves Le Roux, Ronan Abgral, Pierre-Yves Salaun, David Bourhis and Solène Querellou
Positron emission tomography (PET) is a molecular imaging technology that enables in vivo quantification of metabolic activity or receptor density, among other applications. Examples of applications of PET ima...
Authors: Richard Baumgartner, Aniket Joshi, Dai Feng, Francesca Zanderigo and R. Todd Ogden
18F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (18F-LMI1195) is a new class of PET tracer designed for sympathetic nervous imaging of the heart. The favorable image quality with high and specific neural up...
Authors: Xinyu Chen, Rudolf A. Werner, Constantin Lapa, Naoko Nose, Mitsuru Hirano, Mehrbod S. Javadi, Simon Robinson and Takahiro Higuchi
15O-Water positron emission tomography (PET) enables functional imaging of the auditory system during stimulation via a promontory electrode or cochlear implant, which is not possible using functional magnetic r....
Authors: Martin Mamach, Florian Wilke, Martin Durisin, Frank A. Beger, Mareike Finke, Andreas Büchner, Barbara Schultz, Arthur Schultz, Lilli Geworski, Frank M. Bengel, Thomas Lenarz, Anke Lesinski-Schiedat and Georg Berding
Renal scans are among the most frequent exams performed on infants and toddlers. Due to the young age, this patient group can be classified as a high-risk group with a higher probability for developing stochas...
Authors: J. Soares Machado, J. Tran-Gia, S. Schlögl, A. K. Buck and M. Lassmann
Radionuclide therapy, which until 15 years ago included only a few approved therapies, is gaining importance in the treatment of various malignancies. The future of oncology will not be limited to surgery, che...
Catheter-based renal sympathetic denervation (RDN) has been considered a potential treatment for therapy resistant hypertension (RHT). However, in a randomized placebo-controlled trial, RDN did not lead to a s...
Authors: Linn C. Dobrowolski, Daan W. Eeftinck Schattenkerk, C. T. Paul Krediet, Peter M. Van Brussel, Liffert Vogt, Frederike J. Bemelman, Jim A. Reekers, Bert-Jan H. Van Den Born and Hein J. Verberne
Authors: K. Binzel, A. Adelaja, C. L. Wright, D. Scharre, J. Zhang, M. V. Knopp, E. J. Teoh, D. Bottomley, A. Scarsbrook, H. Payne, A. Afaq, J. Bomanji, N. van As, S. Chua, P. Hoskin, A. Chambers…
Post-therapy SPECT/CT imaging of 90Y microspheres delivered to hepatic malignancies is difficult, owing to the continuous, high-energy Bremsstrahlung spectrum emitted by 90Y. This study aimed to evaluate the util...
Authors: Charlotte A. Porter, Kevin M. Bradley, Eero T. Hippeläinen, Matthew D. Walker and Daniel R. McGowan
Ideally, monoclonal antibodies provide selective treatment by targeting the tumour, without affecting normal tissues. Therefore, antibody imaging is of interest, preferably in early stages of drug development....
Authors: Yvonne W. S. Jauw, Marc C. Huisman, Tapan K. Nayak, Danielle J. Vugts, Randolph Christen, Valerie Meresse Naegelen, Dominik Ruettinger, Florian Heil, Adriaan A. Lammertsma, Henk M. W. Verheul, Otto S. Hoekstra, Guus A. M. S. van Dongen and C. Willemien Menke-van der Houven van Oordt
Building a universal genomic signature predicting the intensity of FDG uptake in diverse metastatic tumors may allow us to understand better the biological processes underlying this phenomenon and their requir...
Authors: Aurora Crespo-Jara, Maria Carmen Redal-Peña, Elena Maria Martinez-Navarro, Manuel Sureda, Francisco Jose Fernandez-Morejon, Francisco J. Garcia-Cases, Ramon Gonzalez Manzano and Antonio Brugarolas
We evaluated the diagnostic implications of a small-voxel reconstruction for lymph node characterization in breast cancer patients, using state-of-the-art FDG-PET/CT. We included 69 FDG-PET/CT scans from breas...
Authors: Daniëlle Koopman, Jorn A. van Dalen, Hester Arkies, Ad H. J. Oostdijk, Anne Brecht Francken, Jos Bart, Cornelis H. Slump, Siert Knollema and Pieter L. Jager
The aim of this study was to determine the usefulness of combined positron emission tomography (PET)/magnetic resonance imaging (MRI) parameters provided by simultaneous 18F-fluorodeoxyglucose (FDG) PET/MRI for t...
Authors: Yong-il Kim, Gi Jeong Cheon, Seo Young Kang, Jin Chul Paeng, Keon Wook Kang, Dong Soo Lee and June-Key Chung
Advanced stage cervical cancer is primarily treated by radiotherapy. Local tumor control is a prerequisite for cure. Imaging after treatment is controversial. Positron emission tomography (PET) combined with c...
Authors: J. E. Mongula, F. C. H. Bakers, S. Vöö, L. Lutgens, T. van Gorp, R. F. P. M. Kruitwagen and B. F. M. Slangen
Selective internal radiation therapy (SIRT) with embolization of branches of the hepatic artery is a valuable therapeutic tool for patients with hepatic malignancies; however, it is also associated with lung i...
Authors: Tunc Ones, Emel Eryuksel, Feyyaz Baltacioglu, Berrin Ceyhan and Tanju Yusuf Erdil
Physiological measures per lung parenchyma, rather than per lung volume, sometimes reflect the disease status. PET images of the lung, which are usually expressed per lung volume, could confound the interpreta...
Authors: Keiko Matsunaga, Masahiro Yanagawa, Tomoyuki Otsuka, Haruhiko Hirata, Takashi Kijima, Atsushi Kumanogoh, Noriyuki Tomiyama, Eku Shimosegawa and Jun Hatazawa
The clinical impact of hypoxia in solid tumours is indisputable and yet questions about the sensitivity of hypoxia-PET imaging have impeded its uptake into routine clinical practice. Notably, the binding rate ...
Authors: Edward Taylor, Jennifer Gottwald, Ivan Yeung, Harald Keller, Michael Milosevic, Neesha C. Dhani, Iram Siddiqui, David W. Hedley and David A. Jaffray
Breast lesions closer than 2 cm to the chest wall are difficult to position in the field of view of dedicated breast PET (db-PET) systems. This inability to detect such lesions is a significant limitation of t...
Authors: Michael K. O’Connor, Thuy D. Tran, Tiffinee N. Swanson, Lacey R. Ellingson, Katie N. Hunt and Dana H. Whaley
Unfortunately, the original version of Figs. 4, 5 and 6b in the article [1] contained errors in the n numbers as indicated on the columns. Please note that column heights and error bars in the original figures an...
Authors: Kathrin Heinzmann, Davina Jean Honess, David Yestin Lewis, Donna-Michelle Smith, Christopher Cawthorne, Heather Keen, Sandra Heskamp, Sonja Schelhaas, Timothy Howard Witney, Dmitry Soloviev, Kaye Janine Williams, Andreas Hans Jacobs, Eric Ofori Aboagye, John Richard Griffiths and Kevin Michael Brindle
In recent years, Copper-64 (T1/2 = 12.7 h) in the chemical form of copper dichloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper tran...
Authors: M.A. Avila-Rodriguez, C. Rios, J. Carrasco-Hernandez, J. C. Manrique-Arias, R. Martinez-Hernandez, F. O. García-Pérez, A. R. Jalilian, E. Martinez-Rodriguez, M. E. Romero-Piña and A. Diaz-Ruiz
Nuclear imaging is increasingly being used in the diagnostic work-up of idiopathic inflammatory myopathy (IIM). Increased muscular uptake of technetium-99m-pyrophosphate (99mTc-PYP) has hitherto been assessed qua...
Authors: Karin Folmer Thøgersen, Jane Angel Simonsen, Svend Hvidsten, Oke Gerke, Søren Jacobsen, Poul Flemming Høilund-Carlsen, Karen Middelbo Buch-Olsen and Louise Pyndt Diederichsen
Mitochondrial dysfunction is one of the main causes of non-alcohol fatty liver disease (NAFLD). [18F]-BMS-747158-02 (18F-BMS) which was originally developed as a myocardial perfusion imaging agent was reported to...
