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  1. Content type: Original research

    Catheter-based renal sympathetic denervation (RDN) has been considered a potential treatment for therapy resistant hypertension (RHT). However, in a randomized placebo-controlled trial, RDN did not lead to a s...

    Authors: Linn C. Dobrowolski, Daan W. Eeftinck Schattenkerk, C. T. Paul Krediet, Peter M. Van Brussel, Liffert Vogt, Frederike J. Bemelman, Jim A. Reekers, Bert-Jan H. Van Den Born and Hein J. Verberne

    Citation: EJNMMI Research 2018 8:8

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  2. Content type: Original research

    Ideally, monoclonal antibodies provide selective treatment by targeting the tumour, without affecting normal tissues. Therefore, antibody imaging is of interest, preferably in early stages of drug development....

    Authors: Yvonne W. S. Jauw, Marc C. Huisman, Tapan K. Nayak, Danielle J. Vugts, Randolph Christen, Valerie Meresse Naegelen, Dominik Ruettinger, Florian Heil, Adriaan A. Lammertsma, Henk M. W. Verheul, Otto S. Hoekstra, Guus A. M. S. van Dongen and C. Willemien Menke-van der Houven van Oordt

    Citation: EJNMMI Research 2018 8:6

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  3. Content type: Original research

    Post-therapy SPECT/CT imaging of 90Y microspheres delivered to hepatic malignancies is difficult, owing to the continuous, high-energy Bremsstrahlung spectrum emitted by 90Y. This study aimed to evaluate the util...

    Authors: Charlotte A. Porter, Kevin M. Bradley, Eero T. Hippeläinen, Matthew D. Walker and Daniel R. McGowan

    Citation: EJNMMI Research 2018 8:7

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  4. Content type: Original research

    Building a universal genomic signature predicting the intensity of FDG uptake in diverse metastatic tumors may allow us to understand better the biological processes underlying this phenomenon and their requir...

    Authors: Aurora Crespo-Jara, Maria Carmen Redal-Peña, Elena Maria Martinez-Navarro, Manuel Sureda, Francisco Jose Fernandez-Morejon, Francisco J. Garcia-Cases, Ramon Gonzalez Manzano and Antonio Brugarolas

    Citation: EJNMMI Research 2018 8:4

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  5. Content type: Original research

    We evaluated the diagnostic implications of a small-voxel reconstruction for lymph node characterization in breast cancer patients, using state-of-the-art FDG-PET/CT. We included 69 FDG-PET/CT scans from breas...

    Authors: Daniëlle Koopman, Jorn A. van Dalen, Hester Arkies, Ad H. J. Oostdijk, Anne Brecht Francken, Jos Bart, Cornelis H. Slump, Siert Knollema and Pieter L. Jager

    Citation: EJNMMI Research 2018 8:3

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  6. Content type: Original research

    The aim of this study was to determine the usefulness of combined positron emission tomography (PET)/magnetic resonance imaging (MRI) parameters provided by simultaneous 18F-fluorodeoxyglucose (FDG) PET/MRI for t...

    Authors: Yong-il Kim, Gi Jeong Cheon, Seo Young Kang, Jin Chul Paeng, Keon Wook Kang, Dong Soo Lee and June-Key Chung

    Citation: EJNMMI Research 2018 8:2

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  7. Content type: Preliminary research

    Advanced stage cervical cancer is primarily treated by radiotherapy. Local tumor control is a prerequisite for cure. Imaging after treatment is controversial. Positron emission tomography (PET) combined with c...

    Authors: J. E. Mongula, F. C. H. Bakers, S. Vöö, L. Lutgens, T. van Gorp, R. F. P. M. Kruitwagen and B. F. M. Slangen

    Citation: EJNMMI Research 2018 8:1

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  8. Content type: Original research

    Selective internal radiation therapy (SIRT) with embolization of branches of the hepatic artery is a valuable therapeutic tool for patients with hepatic malignancies; however, it is also associated with lung i...

    Authors: Tunc Ones, Emel Eryuksel, Feyyaz Baltacioglu, Berrin Ceyhan and Tanju Yusuf Erdil

    Citation: EJNMMI Research 2017 7:103

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  9. Content type: Original research

    The clinical impact of hypoxia in solid tumours is indisputable and yet questions about the sensitivity of hypoxia-PET imaging have impeded its uptake into routine clinical practice. Notably, the binding rate ...

    Authors: Edward Taylor, Jennifer Gottwald, Ivan Yeung, Harald Keller, Michael Milosevic, Neesha C. Dhani, Iram Siddiqui, David W. Hedley and David A. Jaffray

    Citation: EJNMMI Research 2017 7:101

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  10. Content type: Original research

    Physiological measures per lung parenchyma, rather than per lung volume, sometimes reflect the disease status. PET images of the lung, which are usually expressed per lung volume, could confound the interpreta...

    Authors: Keiko Matsunaga, Masahiro Yanagawa, Tomoyuki Otsuka, Haruhiko Hirata, Takashi Kijima, Atsushi Kumanogoh, Noriyuki Tomiyama, Eku Shimosegawa and Jun Hatazawa

    Citation: EJNMMI Research 2017 7:102

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  11. Content type: Original research

    Breast lesions closer than 2 cm to the chest wall are difficult to position in the field of view of dedicated breast PET (db-PET) systems. This inability to detect such lesions is a significant limitation of t...

    Authors: Michael K. O’Connor, Thuy D. Tran, Tiffinee N. Swanson, Lacey R. Ellingson, Katie N. Hunt and Dana H. Whaley

    Citation: EJNMMI Research 2017 7:100

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  12. Content type: Correction

    Unfortunately, the original version of Figs. 4, 5 and 6b in the article [1] contained errors in the n numbers as indicated on the columns. Please note that column heights and error bars in the original figures an...

    Authors: Kathrin Heinzmann, Davina Jean Honess, David Yestin Lewis, Donna-Michelle Smith, Christopher Cawthorne, Heather Keen, Sandra Heskamp, Sonja Schelhaas, Timothy Howard Witney, Dmitry Soloviev, Kaye Janine Williams, Andreas Hans Jacobs, Eric Ofori Aboagye, John Richard Griffiths and Kevin Michael Brindle

    Citation: EJNMMI Research 2017 7:99

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    The original article was published in EJNMMI Research 2016 6:63

  13. Content type: Original research

    In recent years, Copper-64 (T1/2 = 12.7 h) in the chemical form of copper dichloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper tran...

    Authors: M.A. Avila-Rodriguez, C. Rios, J. Carrasco-Hernandez, J. C. Manrique-Arias, R. Martinez-Hernandez, F. O. García-Pérez, A. R. Jalilian, E. Martinez-Rodriguez, M. E. Romero-Piña and A. Diaz-Ruiz

    Citation: EJNMMI Research 2017 7:98

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  14. Content type: Original research

    Nuclear imaging is increasingly being used in the diagnostic work-up of idiopathic inflammatory myopathy (IIM). Increased muscular uptake of technetium-99m-pyrophosphate (99mTc-PYP) has hitherto been assessed qua...

    Authors: Karin Folmer Thøgersen, Jane Angel Simonsen, Svend Hvidsten, Oke Gerke, Søren Jacobsen, Poul Flemming Høilund-Carlsen, Karen Middelbo Buch-Olsen and Louise Pyndt Diederichsen

    Citation: EJNMMI Research 2017 7:97

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  15. Content type: Original research

    Mitochondrial dysfunction is one of the main causes of non-alcohol fatty liver disease (NAFLD). [18F]-BMS-747158-02 (18F-BMS) which was originally developed as a myocardial perfusion imaging agent was reported to...

    Authors: Takemi Rokugawa, Sotaro Momosaki, Miwa Ito, Hitoshi Iimori, Yuki Kato and Kohji Abe

    Citation: EJNMMI Research 2017 7:96

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  16. Content type: Original research

    Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient. To date, only a few studies have used short-lived r...

    Authors: Outi Keinänen, Kimberly Fung, Jacob Pourat, Vilma Jallinoja, Delphine Vivier, NagaVara Kishore Pillarsetty, Anu J. Airaksinen, Jason S. Lewis, Brian M. Zeglis and Mirkka Sarparanta

    Citation: EJNMMI Research 2017 7:95

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  17. Content type: Original research

    PET/CT has recently been shown to be a viable alternative to traditional post-infusion imaging methods providing good quality images of 90Y-laden microspheres after selective internal radiation therapy (SIRT). In...

    Authors: Marco D’Arienzo, Maria Pimpinella, Marco Capogni, Vanessa De Coste, Luca Filippi, Emiliano Spezi, Nick Patterson, Francesca Mariotti, Paolo Ferrari, Paola Chiaramida, Michael Tapner, Alexander Fischer, Timo Paulus, Roberto Pani, Giuseppe Iaccarino, Marco D’Andrea…

    Citation: EJNMMI Research 2017 7:94

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  18. Content type: Original research

    In vivo positron-emission tomography (PET) imaging of transporter protein (TSPO) expression is an attractive and indispensable tool for the diagnosis and therapy evaluation of neuroinflammation after cerebral ...

    Authors: Krishna R. Pulagam, Lorena Colás, Daniel Padro, Sandra Plaza-García, Vanessa Gómez-Vallejo, Makoto Higuchi, Jordi Llop and Abraham Martín

    Citation: EJNMMI Research 2017 7:93

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  19. Content type: Original research

    Estimation of functional relevance of a coronary stenosis by fractional flow reserve (FFR) from coronary computed tomography angiography (CCTA) has recently provided encouraging results. Due to its limited ava...

    Authors: Dominik C. Benz, Fran Mikulicic, Christoph Gräni, Marvin Grossmann, Andreas A. Giannopoulos, Michael Messerli, Catherine Gebhard, Oliver Gaemperli, Ronny R. Buechel, Philipp A. Kaufmann and Aju P. Pazhenkottil

    Citation: EJNMMI Research 2017 7:92

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  20. Content type: Original research

    To date, the estimated radiation-absorbed dose to organs and tissues in patients undergoing diagnostic examinations in nuclear medicine is derived via calculations based on models of the human body and the bio...

    Authors: Martin Andersson, Lennart Johansson, Keith Eckerman and Sören Mattsson

    Citation: EJNMMI Research 2017 7:88

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  21. Content type: Original research

    18F-Tetrafluoroborate (18F-TFB) is a promising iodide analog for PET imaging of thyroid cancer and sodium/iodide symporter (NIS) reporter activity in viral therapy applications. The ai...

    Authors: Huailei Jiang, Nicholas R. Schmit, Alex R. Koenen, Aditya Bansal, Mukesh K. Pandey, Robert B. Glynn, Bradley J. Kemp, Kera L. Delaney, Angela Dispenzieri, Jamie N. Bakkum-Gamez, Kah-Whye Peng, Stephen J. Russell, Tina M. Gunderson, Val J. Lowe and Timothy R. DeGrado

    Citation: EJNMMI Research 2017 7:90

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  22. Content type: Original research

    Positron emission tomography (PET) studies using 15O-labeled CO2, O2, and CO have been used in humans to evaluate cerebral blood flow (CBF), the cerebral oxygen extraction fraction (OEF), and the cerebral metabol...

    Authors: Genki Horitsugi, Tadashi Watabe, Yasukazu Kanai, Hayato Ikeda, Hiroki Kato, Sadahiro Naka, Mana Ishibashi, Keiko Matsunaga, Kayako Isohashi, Eku Shimosegawa and Jun Hatazawa

    Citation: EJNMMI Research 2017 7:91

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  23. Content type: Original research

    PET ligands targeting the translocator protein (TSPO) represent promising tools to visualise neuroinflammation. Here, we analysed parameters obtained in dynamic and static PET images using the novel TSPO ligand [

    Authors: Lena Vomacka, Nathalie Lisa Albert, Simon Lindner, Marcus Unterrainer, Christoph Mahler, Matthias Brendel, Larissa Ermoschkin, Astrid Gosewisch, Anika Brunegraf, Christopher Buckley, Tania Kümpfel, Rainer Rupprecht, Sibylle Ziegler, Martin Kerschensteiner, Peter Bartenstein and Guido Böning

    Citation: EJNMMI Research 2017 7:89

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  24. Content type: Original research

    Labelling proteins with gallium-68 using bifunctional chelators is often problematic because of unsuitably harsh labelling conditions such as low pH or high temperature and may entail post-labelling purificati...

    Authors: Saima Nawaz, Gregory E. D. Mullen, Kavitha Sunassee, Jayanta Bordoloi, Philip J. Blower and James R. Ballinger

    Citation: EJNMMI Research 2017 7:86

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  25. Content type: Original research

    Cervical dystonia (CD) is often accompanied by depressive symptoms, anxiety, and jerks/tremor. The dopamine transporter (DAT) binding is related with both depressive symptoms and jerks/tremor in CD. Serotonerg...

    Authors: E. Zoons, J. Booij, J. D. Speelman, Y. E. M. Dreissen, M. Smit and M. A. J. Tijssen

    Citation: EJNMMI Research 2017 7:87

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  26. Content type: Original research

    The aim of this study was to evaluate the diagnostic value of the asphericity (ASP) as a novel quantitative parameter, reflecting the spatial heterogeneity of tracer uptake, in the staging process of patients ...

    Authors: Sebastian Meißner, Jan-Carlo Janssen, Vikas Prasad, Winfried Brenner, Gerd Diederichs, Bernd Hamm, Frank Hofheinz and Marcus R. Makowski

    Citation: EJNMMI Research 2017 7:85

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  27. Content type: Commentary

    Translocator protein (TSPO) is a biomarker for detecting neuroinflammation by PET. 11C-(R)-PK11195 has been used to image TSPO since the 1980s. Here, we compared the utility of four 11C-labeled ligands—(R)-PK1119...

    Authors: Masahiro Fujita, Masato Kobayashi, Masamichi Ikawa, Roger N. Gunn, Eugenii A. Rabiner, David R. Owen, Sami S. Zoghbi, Mohamad B. Haskali, Sanjay Telu, Victor W. Pike and Robert B. Innis

    Citation: EJNMMI Research 2017 7:84

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  28. Content type: Original research

    The goal of this study was to evaluate the performance of the Celesteion positron emission tomography/computed tomography (PET/CT) scanner, which is characterized by a large-bore and time-of-flight (TOF) funct...

    Authors: Tomohiro Kaneta, Matsuyoshi Ogawa, Nobutoku Motomura, Hitoshi Iizuka, Tetsu Arisawa, Ayako Hino-Shishikura, Keisuke Yoshida and Tomio Inoue

    Citation: EJNMMI Research 2017 7:83

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  29. Content type: Original research

    Functional volumes computed from 68Ga-ventilation/perfusion (V/Q) PET/CT, which we have shown to correlate with pulmonary function test parameters (PFTs), have potential diagnostic utility in a variety of clinica...

    Authors: Pierre-Yves Le Roux, Shankar Siva, Jason Callahan, Yannis Claudic, David Bourhis, Daniel P. Steinfort, Rodney J. Hicks and Michael S. Hofman

    Citation: EJNMMI Research 2017 7:82

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  30. Content type: Original research

    Image-based measurement of absorbed dose of Ra-223 dichloride may be useful in predicting therapeutic outcome in patients with castration-resistant prostate cancer (CRPC). In general, SPECT has been found to b...

    Authors: Yoshiki Owaki, Tadaki Nakahara, Takeo Kosaka, Junichi Fukada, Atsuhiro Kumabe, Akira Ichimura, Mikoto Murakami, Kiyotaka Nakajima, Masahiro Fukushi, Kazumasa Inoue, Mototsugu Oya and Masahiro Jinzaki

    Citation: EJNMMI Research 2017 7:81

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  31. Content type: Original research

    99mTc-sestamibi single-photon emission computed tomography/computed tomography (SPECT/CT) has recently been explored for the characterization of indeterminate renal masses. As judged b...

    Authors: Steven P. Rowe, Michael A. Gorin, Lilja B. Solnes, Mark W. Ball, Ajuni Choudhary, Phillip M. Pierorazio, Jonathan I. Epstein, Mehrbod S. Javadi, Mohamad E. Allaf and Alex S. Baras

    Citation: EJNMMI Research 2017 7:80

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  32. Content type: Short communication

    Group-sequential testing is widely used in pivotal therapeutic, but rarely in diagnostic research, although it may save studies, time, and costs. The purpose of this paper was to demonstrate a group-sequential...

    Authors: Oke Gerke, Mie H. Vilstrup, Ulrich Halekoh, Malene Grubbe Hildebrandt and Poul Flemming Høilund-Carlsen

    Citation: EJNMMI Research 2017 7:79

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  33. Content type: Original research

    There is an increasing interest in developing predictive biomarkers of tissue hypoxia using functional imaging for personalised radiotherapy in patients with rectal cancer that are considered for neoadjuvant c...

    Authors: Tanuj Puri, Tessa A. Greenhalgh, James M. Wilson, Jamie Franklin, Lia Mun Wang, Victoria Strauss, Chris Cunningham, Mike Partridge and Tim Maughan

    Citation: EJNMMI Research 2017 7:78

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  34. Content type: Original research

    PET/MRI can be used for the detection of disease in biochemical recurrence (BCR) patients imaged with 68Ga-PSMA-11 PET. This study was designed to determine the optimal MRI sequences to localize positive findings...

    Authors: Spencer T. Lake, Kirsten L. Greene, Antonio C. Westphalen, Spencer C. Behr, Ronald Zagoria, Eric J. Small, Peter R. Carroll and Thomas A. Hope

    Citation: EJNMMI Research 2017 7:77

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  35. Content type: Original research

    We evaluated the suitability of 18F-fluorodeoxythymidine (18F-FLT) positron emission tomography (PET)/computed tomography (CT) for assessment of the early response to induction therapy and its value for predictin...

    Authors: Eun Ji Han, Bo-hee Lee, Jeong-A Kim, Young Ha Park and Woo Hee Choi

    Citation: EJNMMI Research 2017 7:75

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  36. Content type: Erratum

    Authors: Azeem Saleem, Graham E. Searle, Laura M. Kenny, Mickael Huiban, Kasia Kozlowski, Adam D. Waldman, Laura Woodley, Carlo Palmieri, Charles Lowdell, Tomomi Kaneko, Philip S. Murphy, Mike R. Lau, Eric O. Aboagye and Raoul C. Coombes

    Citation: EJNMMI Research 2017 7:74

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    The original article was published in EJNMMI Research 2015 5:30

  37. Content type: Original research

    We investigated the association between physiologic bowel FDG uptake and gut microbiota. FDG uptake in the normal large and small intestine is widely variable both in distribution and intensity. The etiology o...

    Authors: Ji Yeon Kang, Han-Na Kim, Yoosoo Chang, Yeojun Yun, Seungho Ryu, Hocheol Shin and Hyung-Lae Kim

    Citation: EJNMMI Research 2017 7:72

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  38. Content type: Original research

    PET/CT with the radioactively labelled galactose analogue 2-18F-fluoro-2-deoxy-D-galactose (18F-FDGal) can be used to quantify the hepatic metabolic function and visualise regional metabolic heterogeneity. We det...

    Authors: Kirstine P. Bak-Fredslund, Peter Lykke Eriksen, Ole L. Munk, Gerda E. Villadsen, Susanne Keiding and Michael Sørensen

    Citation: EJNMMI Research 2017 7:71

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  39. Content type: Original research

    18F-FDG PET has been used in sarcoidosis for diagnosis and determination of the extent of the disease. However, assessing inflammatory lesions in cardiac sarcoidosis using 18F-FDG can ...

    Authors: Takashi Norikane, Yuka Yamamoto, Yukito Maeda, Takahisa Noma, Hiroaki Dobashi and Yoshihiro Nishiyama

    Citation: EJNMMI Research 2017 7:69

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    The original article was published in EJNMMI Research 2017 7:70

    The original article that this is related to.

  40. Content type: Original research

    In Parkinson’s disease (PD), cerebral dopamine depletion is associated with PD subtype-specific metabolic patterns of hypo- and hypermetabolism. It has been hypothesised that hypometabolism reflects impairment...

    Authors: Elena Kordys, Nadine Apetz, Katharina Schneider, Eilidh Duncan, Beatriz Büschbell, Cathrin Rohleder, Michael Sué, Alexander Drzezga, Bernd Neumaier, Lars Timmermann and Heike Endepols

    Citation: EJNMMI Research 2017 7:68

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  41. Content type: Original research

    Reference tissue-based quantification of brain PET data does not typically include correction for signal originating from blood vessels, which is known to result in biased outcome measures. The bias extent dep...

    Authors: Martin Schain, Patrik Fazio, Ladislav Mrzljak, Nahid Amini, Nabil Al-Tawil, Cheryl Fitzer-Attas, Juliana Bronzova, Bernhard Landwehrmeyer, Christina Sampaio, Christer Halldin and Andrea Varrone

    Citation: EJNMMI Research 2017 7:66

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  42. Content type: Preliminary research

    Cardiac sarcoidosis is associated with major adverse cardiac events including cardiac arrest, for which anti-inflammatory treatment is indicated. Oral corticosteroid is the mainstay among treatment options; ho...

    Authors: Mitsutomi Ishiyama, Laurie A. Soine and Hubert J. Vesselle

    Citation: EJNMMI Research 2017 7:67

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  43. Content type: Original research

    Intraoperative sentinel node (SN) identification in patients with head-and-neck malignancies can be challenging due to unexpected drainage patterns and anatomical complexity. Here, intraoperative navigation-ba...

    Authors: Gijs H. KleinJan, Baris Karakullukçu, W. Martin C. Klop, Thijs Engelen, Nynke S. van den Berg and Fijs W. B. van Leeuwen

    Citation: EJNMMI Research 2017 7:65

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  44. Content type: Original research

    α-Amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor is a primary mediator of fast glutamatergic excitatory signaling in the brain and has been implicated in diverse neuropsychiatric diseases. We ...

    Authors: Keisuke Takahata, Yasuyuki Kimura, Chie Seki, Masaki Tokunaga, Masanori Ichise, Kazunori Kawamura, Maiko Ono, Soichiro Kitamura, Manabu Kubota, Sho Moriguchi, Tatsuya Ishii, Yuhei Takado, Fumitoshi Niwa, Hironobu Endo, Tomohisa Nagashima, Yoko Ikoma…

    Citation: EJNMMI Research 2017 7:63

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  45. Content type: Original research

    PET using O-(2-[18F]fluoroethyl)-l-tyrosine (18F-FET) is an established method for brain tumour diagnostics, but data processing varies in different centres. This study analyses the influence of methodological di...

    Authors: Christian P. Filss, Nathalie L. Albert, Guido Böning, Elena Rota Kops, Bogdana Suchorska, Gabriele Stoffels, Norbert Galldiks, Nadim J. Shah, Felix M. Mottaghy, Peter Bartenstein, Jörg C. Tonn and Karl-Josef Langen

    Citation: EJNMMI Research 2017 7:64

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  46. Content type: Original research

    The purpose of this study was to develop a positron emission tomography (PET) imaging probe that is easy to synthesize and selectively targets melanoma in vivo. Herein, we report the synthesis and preclinical ...

    Authors: Pradeep K. Garg, Rachid Nazih, Yanjun Wu, Vladimir P. Grinevich and Sudha Garg

    Citation: EJNMMI Research 2017 7:61

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