This study’s aim was to develop our dosimetric methodology using a commercial workstation for the routine evaluation of the organs at risk during peptide receptor radionuclide therapy (PRRT) with 177Lu.
Authors: Lore Santoro, Erick Mora-Ramirez, Dorian Trauchessec, Soufiane Chouaf, Pierre Eustache, Jean-Pierre Pouget, Pierre-Olivier Kotzki, Manuel Bardiès and Emmanuel Deshayes
The PET radioligand (R)-[11C]PK11195 is used to quantify the 18-kDa translocator protein (TSPO), a marker for glial activation. Since there is no brain region devoid of TSPO, an arterial input function (AIF) is i...
Authors: Pontus Plavén-Sigray, Granville James Matheson, Zsolt Cselényi, Aurelija Jucaite, Lars Farde and Simon Cervenka
Metastatic melanoma patients can have durable responses to systemic therapy and even long-term survival. However, a large subgroup of patients does not benefit. Tumour metabolic alterations may well be involve...
Authors: Ellen C. de Heer, Adrienne H. Brouwers, Ronald Boellaard, Wim J. Sluiter, Gilles F. H. Diercks, Geke A. P. Hospers, Elisabeth G. E. de Vries and Mathilde Jalving
Dopamine transporter (DAT) imaging may be of diagnostic value in patients with clinically suspected parkinsonian disease. The purpose of this study was to compare the diagnostic performance of DAT imaging with...
Authors: Susanna Jakobson Mo, Jan Axelsson, Lars Jonasson, Anne Larsson, Mattias J. Ögren, Margareta Ögren, Andrea Varrone, Linda Eriksson, David Bäckström, Sara af Bjerkén, Jan Linder and Katrine Riklund
In FDG-PET, SUV images are hampered by large potential biases. Our aim was to develop an alternative method (ParaPET) to generate 3D kinetic parametric FDG-PET images easy to perform in clinical oncology.
Authors: Elyse Colard, Sarkis Delcourt, Laetitia Padovani, Sébastien Thureau, Arthur Dumouchel, Pierrick Gouel, Justine Lequesne, Bardia Farman Ara, Pierre Vera, David Taïeb, Isabelle Gardin, Dominique Barbolosi and Sébastien Hapdey
The aim of this study was to assess the value of 18F-FDG PET/CT for quantitative assessment of hepatic metabolism in patients with different stages of liver fibrosis/cirrhosis.
Authors: Niklas Verloh, Ingo Einspieler, Kirsten Utpatel, Karin Menhart, Stefan Brunner, Frank Hofheinz, Jörg van den Hoff, Philipp Wiggermann, Matthias Evert, Christian Stroszczynski, Dirk Hellwig and Jirka Grosse
The first solid-state silicon photomultiplier (SiPM) digital photon counting (DPC) clinical PET/CT system was introduced by Philips in recent years. The system differs from other SiPM-based PET/CT systems and ...
Authors: Jun Zhang, Piotr Maniawski and Michael V. Knopp
Prostate-specific membrane antigen (PSMA)-directed radioligand therapy (RLT) is a promising yet not curative approach in castration-resistant (CR) prostate cancer (PC). Rational combination therapies may impro...
Authors: Katharina Lückerath, Liu Wei, Wolfgang P. Fendler, Susan Evans-Axelsson, Andreea D. Stuparu, Roger Slavik, Christine E. Mona, Jeremie Calais, Matthew Rettig, Robert E. Reiter, Ken Herrmann, Caius G. Radu, Johannes Czernin and Matthias Eiber
HEPES is a favorable buffer for 68Ga-complexations in radiochemical laboratories. The drawback of this buffer is its prescribed limit of 200 μg per recommended application volume in the final formulation. Current...
Authors: Sarah Pfaff, Tina Nehring, Verena Pichler, Jens Cardinale, Markus Mitterhauser, Marcus Hacker and Wolfgang Wadsak
Cardiac sarcoidosis (CS) is a rare but potentially life-threatening disease that causes conduction disturbance, systolic dysfunction, and, most notably, sudden cardiac death. 18F-fluorodeoxyglucose (FDG) positron...
We investigated the feasibility of left ventricular (LV) and right ventricular (RV) volume and function estimation using a first-pass gated 15O-water PET. This prospective study included 19 patients addressed for...
Authors: Fayçal Ben Bouallègue, Denis Mariano-Goulart, Denis Agostini and Alain Manrique
Glioma grading with dynamic 18F-FET PET (0–40 min p.i.) is typically performed by analysing the mean time-activity curve of the entire tumour or a suspicious area within a heterogeneous tumour. This work aimed to...
Authors: Lena Vomacka, Marcus Unterrainer, Adrien Holzgreve, Erik Mille, Astrid Gosewisch, Julia Brosch, Sibylle Ziegler, Bogdana Suchorska, Friedrich-Wilhelm Kreth, Jörg-Christian Tonn, Peter Bartenstein, Nathalie Lisa Albert and Guido Böning
CXCR4 is a chemokine receptor frequently overexpressed in invasive breast cancer that has been shown to play a major role in signaling pathways involved in metastasis. The aim of this retrospective analysis wa...
Authors: Tibor Vag, Katja Steiger, Andreas Rossmann, Ulrich Keller, Aurelia Noske, Peter Herhaus, Johannes Ettl, Markus Niemeyer, Hans-Jürgen Wester and Markus Schwaiger
The main challenge for systemic radiation therapy using radiopharmaceuticals (SRT) is to optimise the dose delivered to the tumour, while minimising normal tissue irradiation. Dosimetry could help to increase ...
Authors: Daphne Merel Valerie Huizing, Berlinda Jantina de Wit-van der Veen, Marcel Verheij and Marcellus Petrus Maria Stokkel
The validation of the most appropriate compartmental model that describes the kinetics of a specific tracer within a specific tissue is mandatory before estimating quantitative parameters, since the behaviour ...
Authors: Erica Silvestri, Valentina Scolozzi, Gaia Rizzo, Luca Indovina, Marco Castellaro, Maria Vittoria Mattoli, Paolo Graziano, Giuseppe Cardillo, Alessandra Bertoldo and Maria Lucia Calcagni
The folate receptor α (FRα)-targeting antibody-drug conjugate (ADC), IMGN853, shows great antitumor activity against FRα-expressing tumors in vivo, but patient selection and consequently therapy outcome are ba...
Authors: Christian Brand, Ahmad Sadique, Jacob L. Houghton, Kishore Gangangari, Jose F. Ponte, Jason S. Lewis, Naga Vara Kishore Pillarsetty, Jason A. Konner and Thomas Reiner
A radiomic approach was applied in 18F-FDG PET endometrial cancer, to investigate if imaging features computed on the primary tumour could improve sensitivity in nodal metastases detection. One hundred fifteen...
Authors: Elisabetta De Bernardi, Alessandro Buda, Luca Guerra, Debora Vicini, Federica Elisei, Claudio Landoni, Robert Fruscio, Cristina Messa and Cinzia Crivellaro
The InSPira HD system, a novel brain-dedicated SPECT scanner, allows for imaging with a high spatial resolution. Here, we tested whether this scanner can be used to image the dopamine transporter adequately. T...
Authors: Sofie M. Adriaanse, Tim C. de Wit, Mette Stam, Eline Verwer, Kora M. de Bruin and Jan Booij
Several radiolabeled prostate-specific membrane antigen (PSMA) inhibitors based on the lysine-urea-glutamate (KuE) motif as the pharmacophore proved to be suitable tools for PET/SPECT imaging of the PSMA expre...
Authors: Martina Wirtz, Alexander Schmidt, Margret Schottelius, Stephanie Robu, Thomas Günther, Markus Schwaiger and Hans-Jürgen Wester
Recent developments in hardware and software for PET technologies have resulted in wide variations in basic performance. Multicentre studies require a standard imaging protocol and SUV harmonization to reduce ...
Authors: Yuji Tsutsui, Hiromitsu Daisaki, Go Akamatsu, Takuro Umeda, Matsuyoshi Ogawa, Hironori Kajiwara, Shigeto Kawase, Minoru Sakurai, Hiroyuki Nishida, Keiichi Magota, Kazuaki Mori and Masayuki Sasaki
Programmed cell death 1 (PD-1) inhibitors act as immune checkpoint inhibitors and are more effective for improving survival time with less toxicity as compared with conventional chemotherapies. In anti PD-1 th...
Authors: Mayu Tomita, Hironobu Yasui, Kei Higashikawa, Kohei Nakajima, Hideo Takakura, Tohru Shiga, Yuji Kuge and Mikako Ogawa
Erlotinib is an epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitor approved for treatment of non-small cell lung cancer. The wide inter-individual pharmacokinetic (PK) variability of e...
Authors: Dorra Amor, Sébastien Goutal, Solène Marie, Fabien Caillé, Martin Bauer, Oliver Langer, Sylvain Auvity and Nicolas Tournier
[18F]Fluoro-2-deoxy-2-d-glucose positron emission tomography (FDG-PET) is commonly used in the clinic for diagnosis of cancer and for follow-up of therapy outcome. Additional to the well-established value in tumo...
Authors: Stefanie Pektor, Lina Hilscher, Kerstin C. Walzer, Isabelle Miederer, Nicole Bausbacher, Carmen Loquai, Mathias Schreckenberger, Ugur Sahin, Mustafa Diken and Matthias Miederer
Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using...
Authors: Emma E. Wolters, Sandeep S. V. Golla, Tessa Timmers, Rik Ossenkoppele, Chris W. J. van der Weijden, Philip Scheltens, Lothar Schwarte, Robert C. Schuit, Albert D. Windhorst, Frederik Barkhof, Maqsood Yaqub, Adriaan A. Lammertsma, Ronald Boellaard and Bart N. M. van Berckel
The recently growing interest in targeted alpha-therapy (TAT) calls for improvement of the labelling chemistry of the corresponding radionuclides. 213BiIII is a short-lived alpha emitter which emits only one alph...
Authors: Jakub Šimeček, Petr Hermann, Christof Seidl, Frank Bruchertseifer, Alfred Morgenstern, Hans-Jürgen Wester and Johannes Notni
Irradiation with α-particles creates densely packed damage tracks along particle trajectories in exposed cells, including complex DNA damage and closely spaced double-strand breaks (DSBs) in hit nuclei. Here, ...
Authors: Sarah Schumann, Uta Eberlein, Jessica Müller, Harry Scherthan and Michael Lassmann
The bone marrow (BM) is a main organ at risk in Lu-177-PSMA-617 therapy of prostate cancer and Lu-177-Octreotate therapy of neuroendocrine tumours. BM dosimetry is challenging and time-consuming, as different ...
Authors: Astrid Gosewisch, Andreas Delker, Sebastian Tattenberg, Harun Ilhan, Andrei Todica, Julia Brosch, Lena Vomacka, Anika Brunegraf, Franz Josef Gildehaus, Sibylle Ziegler, Peter Bartenstein and Guido Böning
Somatostatin receptor targeting radiopeptides are successfully being used to image, stage, and monitor patients with neuroendocrine tumours. They are exclusively agonists that internalise upon binding to the r...
Authors: Keelara Abiraj, Samer Ursillo, Maria Luisa Tamma, Svetlana N. Rylova, Beatrice Waser, Edwin C. Constable, Melpomeni Fani, Guillaume P. Nicolas, Jean Claude Reubi and Helmut R. Maecke
The D1-dopamine receptor radioligand [11C]SCH23390 has been frequently used in PET studies. In drug-naïve patients with schizophrenia, the findings have been inconsistent, with decreases, increases, and no change...
Authors: Per Stenkrona, Granville J. Matheson, Simon Cervenka, Pontus Plavén Sigray, Christer Halldin and Lars Farde
To determine the relative abilities of compartment models to describe time-courses of 18F-fluoromisonidazole (FMISO) tumor uptake in patients with advanced stage non-small cell lung cancer (NSCLC) imaged using...
Authors: Daniel R. McGowan, Michael Skwarski, Bartlomiej W. Papiez, Ruth E. Macpherson, Fergus V. Gleeson, Julia A. Schnabel, Geoff S. Higgins and John D. Fenwick
This study identified the optimal tracer kinetic model for quantification of dynamic O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) positron emission tomography (PET) studies in seven patients with diffuse glioma (...
Authors: Thomas Koopman, Niels Verburg, Robert C. Schuit, Petra J. W. Pouwels, Pieter Wesseling, Albert D. Windhorst, Otto S. Hoekstra, Philip C. de Witt Hamer, Adriaan A. Lammertsma, Ronald Boellaard and Maqsood Yaqub
We measured whole body distribution of 11C-BU99008, a new PET biomarker for non-invasive identification of the imidazoline2 binding site. The purpose of this phase I study was to evaluate the biodistribution and ...
Authors: Ashwin V. Venkataraman, Nicholas Keat, James F. Myers, Samuel Turton, Inge Mick, Roger N. Gunn, Eugenii A. Rabiner, Jan Passchier, Christine A. Parker, Robin J. Tyacke and David J. Nutt
In contrast to ordered subset expectation maximization (OSEM), block sequential regularized expectation maximization (BSREM) positron emission tomography (PET) reconstruction algorithms can run until full conv...
Authors: Edwin E. G. W. ter Voert, Urs J. Muehlematter, Gaspar Delso, Daniele A. Pizzuto, Julian Müller, Hannes W. Nagel and Irene A. Burger
Efforts to develop suitable positron emission tomography (PET) tracers for the ion channel site of human N-methyl-d-aspartate (NMDA) receptors have had limited success. [18F]PK-209 is a GMOM derivative that binds...
Authors: Jasper van der Aart, Sandeep S. V. Golla, Marieke van der Pluijm, Lothar A. Schwarte, Robert C. Schuit, Pieter J. Klein, Athanasios Metaxas, Albert D. Windhorst, Ronald Boellaard, Adriaan A. Lammertsma and Bart N. M. van Berckel
Unfortunately, after publication of this article [1], it was noticed that the name of Urs J. Muehlematter was incorrectly displayed as Urs J. Mühlematter. The corrected author list can be seen above and the or...
Authors: Urs J. Muehlematter, Hannes W. Nagel, Anton Becker, Julian Mueller, Kerstin N. Vokinger, Felipe de Galiza Barbosa, Edwin E. G. T. ter Voert, Patrick Veit-Haibach and Irene A. Burger
The ability to accurately and non-invasively distinguish high-grade glioma from low-grade glioma remains a challenge despite advances in molecular and magnetic resonance imaging. We investigated the ability of...
Authors: Ephraim E. Parent, Marc Benayoun, Ijeoma Ibeanu, Jeffrey J. Olson, Constantinos G. Hadjipanayis, Daniel J. Brat, Vikram Adhikarla, Jonathon Nye, David M. Schuster and Mark M. Goodman
Florbetaben, a 18F-labeled stilbene derivative (Neuraceq®, formerly known as BAY-949172), is a diagnostic radiopharmaceutical developed to visualize β-amyloid plaques in the brain. Here, we report a pilot study e...
Authors: Lucia Baratto, Sonya Youngju Park, Negin Hatami, Praveen Gulaka, Shreyas Vasanawala, Thomas Koshy Yohannan, Robert Herfkens, Ronald Witteles and Andrei Iagaru
Localizing and removing the infected sequestrum in long-standing trauma-related chronic osteomyelitis remains a clinical challenge. PET/CT with 18F-fluorodeoxyglucose (FDG-PET) has a high sensitivity for chron...
Authors: Albert Christersson, Sune Larsson and Jens Sörensen
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumor. Currently, 18F-fluoro-deoxy-glucose (18F-FDG) PET/CT is the functional imaging modality of choice. Few data are available on the use of 68Ga...
Authors: Silvia Taralli, Martina Sollini, Michele Milella, Germano Perotti, Angelina Filice, Massimo Menga, Annibale Versari and Vittoria Rufini
Graphical methods of radiotracer kinetic modeling in PET are ideal for parametric imaging and data quality assurance but can suffer from noise bias. This study compared the Logan and Multilinear Analysis-1 (MA...
Authors: Tong Wang, Kai Yi Wu, Robert C. Miner, Jennifer M. Renaud, Rob S. B. Beanlands and Robert A. deKemp
The 18F-THK-5351 radiotracer has been used to detect the in vivo tau protein distribution in patients with tauopathy, such as Alzheimer’s disease and corticobasal syndrome. In addition, 18F-THK-5351 can also moni...
Nonalcoholic fatty liver disease is a common disorder that progresses from simple fatty liver (steatosis) to nonalcoholic steatohepatitis (NASH). It is thought that mitochondrial dysfunction plays a critical r...
The aim of this work was to confirm that post-selective internal radiation therapy (SIRT) 90Y-PET/CT-based dosimetry correlates with lesion metabolic response and to determine its correlation with overall surviva...
Authors: Hugo Levillain, Ivan Duran Derijckere, Gwennaëlle Marin, Thomas Guiot, Michaël Vouche, Nick Reynaert, Alain Hendlisz, Bruno Vanderlinden and Patrick Flamen
Radiation injury can be indistinguishable from recurrent tumor on standard imaging. Current protocols for this differential diagnosis require one or more follow-up imaging studies, long dynamic acquisitions, o...
Authors: Patrick L. Donabedian, Susanne Kossatz, John A. Engelbach, Stephen A. Jannetti, Brandon Carney, Robert J. Young, Wolfgang A. Weber, Joel R. Garbow and Thomas Reiner
Kinetic analysis of dynamic PET data requires an accurate knowledge of available PET tracer concentration within blood plasma over time, known as the arterial input function (AIF). The gold standard method use...
Authors: Hasan Sari, Kjell Erlandsson, Lisbeth Marner, Ian Law, Henrik B.W. Larsson, Kris Thielemans, Sébastien Ourselin, Simon Arridge, David Atkinson and Brian F. Hutton
Inflammation is associated with major depressive disorder (MDD). Translocator protein 18 kDa (TSPO), a putative biomarker of neuroinflammation, is quantified using positron emission tomography (PET) and 11C-PBR28...
Authors: Erica M. Richards, Paolo Zanotti-Fregonara, Masahiro Fujita, Laura Newman, Cristan Farmer, Elizabeth D. Ballard, Rodrigo Machado-Vieira, Peixiong Yuan, Mark J. Niciu, Chul Hyoung Lyoo, Ioline D. Henter, Giacomo Salvadore, Wayne C. Drevets, Hartmuth Kolb, Robert B. Innis and Carlos A. Zarate Jr
External cooling of the salivary glands is advised to prevent xerostomia in lutetium-177-PSMA treatment for advanced prostate cancer. Since evidence addressing this subject is sparse, this study aims to determ...
Authors: Ludwike W. M. van Kalmthout, Marnix G. E. H. Lam, Bart de Keizer, Gerard C. Krijger, Tessa F. T. Ververs, Rememrt de Roos and Arthur J. A. T. Braat
There is a growing interest in the use of 18F-FDG PET-CT to monitor tuberculosis (TB) treatment response. However, TB causes complex and widespread pathology, which is challenging to segment and quantify in a rep...
Authors: Stephanus T. Malherbe, Patrick Dupont, Ilse Kant, Petri Ahlers, Magdalena Kriel, André G. Loxton, Ray Y. Chen, Laura E. Via, Friedrich Thienemann, Robert J. Wilkinson, Clifton E. Barry III, Stephanie Griffith-Richards, Annare Ellman, Katharina Ronacher, Jill Winter, Gerhard Walzl…
The present study proposed a new concept for targeted radionuclide therapy (TRT) to improve the intratumoral distribution of radioactivity using two different radiopharmaceuticals. We examined the efficacy of ...
Authors: Zhao-Hui Jin, Atsushi B. Tsuji, Mélissa Degardin, Aya Sugyo, Yukie Yoshii, Kotaro Nagatsu, Ming-Rong Zhang, Yasuhisa Fujibayashi, Pascal Dumy, Didier Boturyn and Tatsuya Higashi
