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  1. Successful treatments of patients with somatostatin receptor (SSTR)-overexpressing neuroendocrine tumours (NET) comprise somatostatin-analogue lutetium-177-labelled octreotate (177Lu-TATE) treatment, also referre...

    Authors: Sander M. Bison, Joost C. Haeck, K. Bol, S. J. Koelewijn, H. C. Groen, M. Melis, J. F. Veenland, M. R. Bernsen and M. de Jong
    Citation: EJNMMI Research 2015 5:62
    Content type: Original research Published on:

  2. Tail vein injection under short anesthesia is the most commonly used route for administering radiopharmaceuticals. However, the small caliber of the vein in rodents may lead to tracer extravasation and thereby...

    Authors: Charline Lasnon, Audrey Emmanuelle Dugué, Mélanie Briand, Soizic Dutoit and Nicolas Aide
    Citation: EJNMMI Research 2015 5:61
    Content type: Original research Published on:

  3. Hybrid PET/optical imaging provides quantitative and complementary information for diagnosis of tumors. Herein, we developed a 64Cu-labeled AlexaFluor 680-streptavidin ((AF)SAv)/biotin-based dimeric cyclic RGD pe...

    Authors: Choong Mo Kang, Hyun-Jung Koo, Gwang Il An, Yearn Seong Choe, Joon Young Choi, Kyung-Han Lee and Byung-Tae Kim
    Citation: EJNMMI Research 2015 5:60
    Content type: Original research Published on:

  4. 131I and 211At are used in nuclear medicine and accumulate in the thyroid gland and may impact normal thyroid function. The aim of this study was to determine transcriptional profile v...

    Authors: Nils Rudqvist, Johan Spetz, Emil Schüler, Britta Langen, Toshima Z. Parris, Khalil Helou and Eva Forssell-Aronsson
    Citation: EJNMMI Research 2015 5:59
    Content type: Original research Published on:

  5. The goal of the study is to investigate 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET)’s ability to delineate the viable portion of a tumor in an animal model using cross-sectional histology as...

    Authors: Ingrid Wu, Hao Wang, David Huso and Richard L. Wahl
    Citation: EJNMMI Research 2015 5:58
    Content type: Original research Published on:

  6. Non-invasive measurement of tumor hypoxia has demonstrated potential for the evaluation of disease progression, as well as prediction and assessment of treatment outcome. [18F]fluoroazomycin arabinoside (FAZA) po...

    Authors: Jinzi Zheng, Stephan G. Klinz, Raquel De Souza, Jonathan Fitzgerald and David A. Jaffray
    Citation: EJNMMI Research 2015 5:57
    Content type: Original research Published on:

  7. Depression in patients with brain tumors is associated with impaired quality of life and shorter survival. Altered metabolism of tryptophan to serotonin and kynurenine metabolites may play a role in tumor-asso...

    Authors: Edit Bosnyák, David O. Kamson, Michael E. Behen, Geoffrey R. Barger, Sandeep Mittal and Csaba Juhász
    Citation: EJNMMI Research 2015 5:56
    Content type: Original research Published on:

  8. This feasibility study established an experimental protocol to evaluate brain activation patterns using fluorodeoxyglucose positron emission tomography ((18F)FDG-PET) during volume-induced voiding and isovolum...

    Authors: Yves Deruyver, Roma Rietjens, Jan Franken, Silvia Pinto, Ann Van Santvoort, Cindy Casteels, Thomas Voets and Dirk De Ridder
    Citation: EJNMMI Research 2015 5:55
    Content type: Original research Published on:

  9. The purpose of this study is to evaluate the impact of switching from sterile water to 5 % glucose (G5W) for the administration of yttrium-90 (90Y)-resin microspheres on the total activity of 90Y administered (ex...

    Authors: Hojjat Ahmadzadehfar, Carsten Meyer, Claus Christian Pieper, Ralph Bundschuh, Marianne Muckle, Florian Gärtner, Hans Heinz Schild and Markus Essler
    Citation: EJNMMI Research 2015 5:54
    Content type: Original research Published on:

  10. To assess the role of somatostatin receptor (SR) PET/CT using Ga-68 DOTATOC or DOTATATE in staging and restaging of typical (TC) and atypical (AC) lung carcinoids.

    Authors: Vikas Prasad, Ingo G. Steffen, Marianne Pavel, Timm Denecke, Elisabeth Tischer, Konstantina Apostolopoulou, Andreas Pascher, Ruza Arsenic and Winfried Brenner
    Citation: EJNMMI Research 2015 5:53
    Content type: Original research Published on:

  11. Ge/68Ga generators provide an inexpensive source of a PET isotope to hospitals without cyclotron facilities. The development of new 68Ga-based molecular imaging agents and subsequent clinical translation would be...

    Authors: Michelle T. Ma, Carleen Cullinane, Kelly Waldeck, Peter Roselt, Rodney J. Hicks and Philip J. Blower
    Citation: EJNMMI Research 2015 5:52
    Content type: Preliminary research Published on:

  12. Myocardial perfusion gated single photon emission computed tomography (SPECT) can be used for non-invasive detection of coronary artery stenosis and cardiac allograft vasculopathy (CAV), which is a crucial fac...

    Authors: Christian Wenning, Alexis Vrachimis, Angelo Dell´Aquila, Alvyda Penning, Jörg Stypmann and Michael Schäfers
    Citation: EJNMMI Research 2015 5:51
    Content type: Original research Published on:

  13. We found that 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) uptake in malignant lesion was enhanced, and it was decreased in the inflammatory lesion after the use of peroxisome proliferator activated receptor-γ (PPAR-...

    Authors: Yeon-Hee Han, Seong Young Kwon, Jeonghun Kim, Chang Ju Na, Sehun Choi, Jung-Joon Min, Hee-Seung Bom, Young-Chul Kim, In-Jae Oh, Han-Jung Chae, Seok Tae Lim, Myung-Hee Sohn and Hwan-Jeong Jeong
    Citation: EJNMMI Research 2015 5:50
    Content type: Original research Published on:

  14. This study aims to further evaluate the specificity and selectivity of [18F]FTC-146 and obtain additional data to support its clinical translation.

    Authors: Bin Shen, Michelle L. James, Lauren Andrews, Christopher Lau, Stephanie Chen, Mikael Palner, Zheng Miao, Natasha C. Arksey, Adam J. Shuhendler, Shawn Scatliffe, Kota Kaneshige, Stanley M. Parsons, Christopher R. McCurdy, Ahmad Salehi, Sanjiv S. Gambhir and Frederick T. Chin
    Citation: EJNMMI Research 2015 5:49
    Content type: Original research Published on:

  15. Reducing scan-time while maintaining sufficient image quality is a common issue in nuclear medicine diagnostics. This matter can be addressed by different post-processing methods such as Pixon® image processin...

    Authors: Oscar Ardenfors, Ulrika Svanholm, Hans Jacobsson, Patricia Sandqvist, Per Grybäck and Cathrine Jonsson
    Citation: EJNMMI Research 2015 5:48
    Content type: Original research Published on:

  16. Immune cells within the tumor can act either to promote growth or rejection of tumor cells. The aim of the present study was to evaluate immune cell markers (number and localization) within the tumor before an...

    Authors: Erika Elgström, Sophie E. Eriksson, Otto Ljungberg, Pär-Ola Bendahl, Tomas G. Ohlsson, Rune Nilsson and Jan Tennvall
    Citation: EJNMMI Research 2015 5:47
    Content type: Original research Published on:

  17. Although the understanding of the genetic and molecular basis of cancer has advanced significantly over the past several decades, imaging and treatment options for glioblastoma patients have been more limited ...

    Authors: Beatriz Salinas, Christopher P. Irwin, Susanne Kossatz, Alexander Bolaender, Gabriela Chiosis, Nagavarakishore Pillarsetty, Wolfgang A. Weber and Thomas Reiner
    Citation: EJNMMI Research 2015 5:46
    Content type: Original research Published on:

  18. Nucleoside analogs labeled with positrons, such as 11C and 18F, are considered valuable in visualizing the proliferative activity of tumor cells in vivo using positron emission tomography (PET). We recently devel...

    Authors: Tsuyoshi Tahara, Zhouen Zhang, Masahiro Ohno, Yukako Hirao, Nami Hosaka, Hisashi Doi, Masaaki Suzuki and Hirotaka Onoe
    Citation: EJNMMI Research 2015 5:45
    Content type: Research Article Published on:

  19. Non-invasive imaging of peritoneal carcinomatosis remains challenging. The aim of this study was to compare positron emission tomography (PET) and bioluminescence imaging (BLI) for the early detection of perit...

    Authors: J. Stollfuss, N. Landvogt, M. Abenstein, S. Ziegler, M. Schwaiger, R. Senekowitsch-Schmidtke and H. Wieder
    Citation: EJNMMI Research 2015 5:44
    Content type: Original research Published on:

  20. Fluorescent imaging agents are becoming evermore important in preclinical and clinical research. They do, however, suffer from poor tissue penetration, which makes optical fluorescence imaging incompatible wit...

    Authors: Andreas Paulus, Pooja Desai, Brandon Carney, Giuseppe Carlucci, Thomas Reiner, Christian Brand and Wolfgang A Weber
    Citation: EJNMMI Research 2015 5:43
    Content type: Original research Published on:

  21. The interpretation of myocardial perfusion scintigraphy (MPS) largely relies on visual assessment by the physician of the localization and extent of a perfusion defect. The aim of this study was to introduce t...

    Authors: David Minarik, Martin Senneby, Per Wollmer, Alva Mansten, Karl Sjöstrand, Lars Edenbrandt and Elin Trägårdh
    Citation: EJNMMI Research 2015 5:42
    Content type: Original research Published on:

  22. Agonist positron emission tomography (PET) tracers for dopamine D2/3 receptors (D2/3Rs) offer greater sensitivity to changes in endogenous dopamine levels than D2/3R antagonist tracers. D2/3R agonist tracers curr...

    Authors: Vladimir Shalgunov, Jan-Peter van Wieringen, Henk M. Janssen, P. Michel Fransen, Rudi A.J.O. Dierckx, Martin C. Michel, Jan Booij and Philip H. Elsinga
    Citation: EJNMMI Research 2015 5:41
    Content type: Original research Published on:

  23. This study evaluated the absorption, distribution, and excretion of Gallium-68 (68Ga) radionuclide after a single intravenous (i.v.) injection of 68Ge/68Ga generator eluate in healthy rats. Additionally, human ra...

    Authors: Anu Autio, Helena Virtanen, Tuula Tolvanen, Heidi Liljenbäck, Vesa Oikonen, Tiina Saanijoki, Riikka Siitonen, Meeri Käkelä, Andrea Schüssele, Mika Teräs and Anne Roivainen
    Citation: EJNMMI Research 2015 5:40
    Content type: Original research Published on:

    The Erratum to this article has been published in EJNMMI Research 2016 6:51

  24. We aimed to evaluate and define the general clinical applicability and impact of pulmonary radioaerosol mucociliary clearance (PRMC) on the work up of patients suspected of having primary ciliary dyskinesia (P...

    Authors: Mathias Munkholm, Kim Gjerum Nielsen and Jann Mortensen
    Citation: EJNMMI Research 2015 5:39
    Content type: Original research Published on:

  25. Reactive oxygen species (ROS) have been implicated in cisplatin-induced nephrotoxicity. The aim of this study was to investigate the potential of using [3H]-labeled N-methyl-2,3-diamino-6-phenyl-dihydrophenanthri...

    Authors: Nozomi Takai, Kohji Abe, Misato Tonomura, Natsumi Imamoto, Kazumi Fukumoto, Miwa Ito, Sotaro Momosaki, Kae Fujisawa, Kenji Morimoto, Nobuo Takasu and Osamu Inoue
    Citation: EJNMMI Research 2015 5:38
    Content type: Research Article Published on:

  26. Reactive oxygen species (ROS) have been implicated in the pathophysiology of the brain after ischemic stroke. In this study, we investigate the generation of brain ROS after transient focal ischemia in mice us...

    Authors: Kohji Abe, Misato Tonomura, Miwa Ito, Nozomi Takai, Natsumi Imamoto, Takemi Rokugawa, Sotaro Momosaki, Kazumi Fukumoto, Kenji Morimoto and Osamu Inoue
    Citation: EJNMMI Research 2015 5:37
    Content type: Original research Published on:

  27. Radioligand therapy (RLT) with 177Lu-DKFZ-617 PSMA (Lu-PSMA) (prostate-specific membrane antigen) is a novel targeted therapy of metastatic prostate cancer. We analysed retrospectively the early side effects and ...

    Authors: Hojjat Ahmadzadehfar, Kambiz Rahbar, Stefan Kürpig, Martin Bögemann, Michael Claesener, Elisabeth Eppard, Florian Gärtner, Sebastian Rogenhofer, Michael Schäfers and Markus Essler
    Citation: EJNMMI Research 2015 5:36
    Content type: Research Article Published on:

  28. Compartmental analysis is a standard method to quantify metabolic processes using fluorodeoxyglucose-positron emission tomography (FDG-PET). For liver studies, this analysis is complex due to the hepatocyte ca...

    Authors: Sara Garbarino, Valentina Vivaldi, Fabrice Delbary, Giacomo Caviglia, Michele Piana, Cecilia Marini, Selene Capitanio, Iolanda Calamia, Ambra Buschiazzo and Gianmario Sambuceti
    Citation: EJNMMI Research 2015 5:35
    Content type: Original research Published on:

  29. The norepinephrine transporter (NET) has been demonstrated to be relevant to a multitude of neurological, psychiatric and cardiovascular pathologies. Due to the wide range of possible applications for PET imag...

    Authors: Christina Rami-Mark, Neydher Berroterán-Infante, Cecile Philippe, Stefanie Foltin, Chrysoula Vraka, Alexander Hoepping, Rupert Lanzenberger, Marcus Hacker, Markus Mitterhauser and Wolfgang Wadsak
    Citation: EJNMMI Research 2015 5:34
    Content type: Original research Published on:

  30. PET radiopharmaceuticals capable of imaging β-amyloid (Aβ) plaque burden in the brain could offer highly valuable diagnostic tools for clinical studies of Alzheimer’s disease. To further supplement existing ar...

    Authors: Guruswami SM Sundaram, Dhruva Dhavale, Julie L Prior, Jothilingam Sivapackiam, Richard Laforest, Paul Kotzbauer and Vijay Sharma
    Citation: EJNMMI Research 2015 5:33
    Content type: Original research Published on:

  32. The maximum standardized uptake value (SUVmax) is a common clinical parameter for quantification in F18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT), but it is influenced by...

    Authors: Julian MM Rogasch, Ingo G Steffen, Frank Hofheinz, Oliver S Großer, Christian Furth, Konrad Mohnike, Peter Hass, Mathias Walke, Ivayla Apostolova and Holger Amthauer
    Citation: EJNMMI Research 2015 5:31
    Content type: Original research Published on:

  33. Brain metastases are common in human epidermal growth factor receptor (Her)-2-positive breast cancer. Drug access to brain metastases and normal brain is key to management of cranial disease. In this study, po...

    Authors: Azeem Saleem, Graham E Searle, Laura M Kenny, Mickael Huiban, Kasia Kozlowski, Adam D Waldman, Laura Woodley, Carlo Palmieri, Charles Lowdell, Tomomi Kaneko, Philip S Murphy, Mike R Lau, Eric O Aboagye and Raoul C Coombes
    Citation: EJNMMI Research 2015 5:30
    Content type: Original research Published on:

    The Erratum to this article has been published in EJNMMI Research 2017 7:74

    A Erratum has been published.

  34. Previous clinical studies have revealed the potential of [18F]-fluoro-L-α-methyltyrosine (18F-FAMT) for the differential diagnosis of malignant tumours from sarcoidosis. However, one concern regarding the differe...

    Authors: Aiko Yamaguchi, Hirofumi Hanaoka, Yutaka Fujisawa, Songji Zhao, Kazutomo Suzue, Akihiro Morita, Hideyuki Tominaga, Tetsuya Higuchi, Hajime Hisaeda, Yoshito Tsushima, Yuji Kuge and Yasuhiko Iida
    Citation: EJNMMI Research 2015 5:29
    Content type: Original research Published on:

  35. J591 is a monoclonal antibody that targets the external domain of the prostate-specific membrane antigen (PSMA). Besides prostate cancer cells, it also targets the neovasculature of non-prostate solid tumors. ...

    Authors: Neeta Pandit-Taskar, Joseph A O’Donoghue, Chaitanya R Divgi, Eze A Wills, Lawrence Schwartz, Mithat Gönen, Peter Smith-Jones, Neil H Bander, Howard I Scher, Steven M Larson and Michael J Morris
    Citation: EJNMMI Research 2015 5:28
    Content type: Original research Published on:

  36. The number of routine care patient examinations with 68Ga radiopharmaceuticals is still relatively limited, probably caused by the presumed need for large investments in hot cells, automated synthesis modules, la...

    Authors: Roeland Vis, Jules Lavalaye and Ewoudt MW van de Garde
    Citation: EJNMMI Research 2015 5:27
    Content type: Original research Published on:

  37. Positron emission tomography (PET) with 18F-3′-deoxy-3′-fluorothymidine ([18F]FLT) can be used to assess tumour proliferation. A kinetic-filtering (KF) classification algorithm has been suggested for segmentation...

    Authors: Lieke L Hoyng, Virginie Frings, Otto S Hoekstra, Laura M Kenny, Eric O Aboagye and Ronald Boellaard
    Citation: EJNMMI Research 2015 5:26
    Content type: Research article Published on:

  38. High-grade gliomas (HGGs) express somatostatin receptors (SSTR), rendering them candidates for peptide receptor radionuclide therapy (PRRT). Our purpose was to evaluate the potential of 68Ga-DOTA-1-Nal3-octreotid...

    Authors: Aida Kiviniemi, Maria Gardberg, Janek Frantzén, Marko Pesola, Ville Vuorinen, Riitta Parkkola, Tuula Tolvanen, Sami Suilamo, Jarkko Johansson, Pauliina Luoto, Jukka Kemppainen, Anne Roivainen and Heikki Minn
    Citation: EJNMMI Research 2015 5:25
    Content type: Original research Published on:

  39. Features of the tumor microenvironment influence the efficacy of cancer nanotherapeutics. The ability to directly radiolabel nanotherapeutics offers a valuable translational tool to obtain biodistribution and ...

    Authors: Daniel F Gaddy, Helen Lee, Jinzi Zheng, David A Jaffray, Thomas J Wickham and Bart S Hendriks
    Citation: EJNMMI Research 2015 5:24
    Content type: Original research Published on:

  40. [18F]Fludarabine is a novel positron emission tomography (PET) radiotracer for imaging lymphoma. The purpose of this preclinical study was to evaluate the robustness of [18F]fludarabine during rituximab therapy. ...

    Authors: Narinée Hovhannisyan, Stéphane Guillouet, Fabien Fillesoye, Martine Dhilly, Delphine Patin, Françoise Galateau, Michel Leporrier and Louisa Barré
    Citation: EJNMMI Research 2015 5:23
    Content type: Original research Published on:

  41. Recently, an intra-patient comparison demonstrated that the somatostatin (sst) ligand [68Ga]HA-DOTATATE ([68Ga]DOTA-3-iodo-Tyr3-octreotate) provides PET images comparable to or superior to those obtained with [68

    Authors: Margret Schottelius, Jakub Šimeček, Frauke Hoffmann, Marina Willibald, Markus Schwaiger and Hans-Jürgen Wester
    Citation: EJNMMI Research 2015 5:22
    Content type: Original research Published on:

  42. Tenascin-C (TNC), an extracellular matrix glycoprotein, is expressed transiently in distinct areas in association with active tissue remodeling. This study aimed to explore how ischemic postconditioning (PC) a...

    Authors: Junichi Taki, Anri Inaki, Hiroshi Wakabayashi, Ichiro Matsunari, Kyoko Imanaka-Yoshida, Kazuma Ogawa, Michiaki Hiroe, Kazuhiro Shiba, Toshimichi Yoshida and Seigo Kinuya
    Citation: EJNMMI Research 2015 5:21
    Content type: Original research Published on:

  43. Over the last decade, an increasing number of studies have been published on the use of amyloid-β (Aβ) PET imaging with different 18F-radiopharmaceuticals for clinical characterization of Alzheimer’s disease (AD)...

    Authors: Behrooz H Yousefi, Boris von Reutern, Daniela Scherübl, André Manook, Markus Schwaiger, Timo Grimmer, Gjermund Henriksen, Stefan Förster, Alexander Drzezga and Hans-Jürgen Wester
    Citation: EJNMMI Research 2015 5:20
    Content type: Original research Published on:

  44. With the recent growth of interest in cell-based therapies and radiolabeled cell products, there is a need to develop more robust cell labeling and imaging methods for in vivo tracking of living cells. This study...

    Authors: Aditya Bansal, Mukesh K Pandey, Yunus E Demirhan, Jonathan J Nesbitt, Ruben J Crespo-Diaz, Andre Terzic, Atta Behfar and Timothy R DeGrado
    Citation: EJNMMI Research 2015 5:19
    Content type: Original research Published on:

  45. In vivo imaging using genetic reporters is a central supporting tool in the development of cell and gene therapies affording us the ability to selectively track the therapeutic indefinitely. Pr...

    Authors: Adam Badar, Louise Kiru, Tammy L Kalber, Amit Jathoul, Karin Straathof, Erik Årstad, Mark F Lythgoe and Martin Pule
    Citation: EJNMMI Research 2015 5:18
    Content type: Original research Published on:

  46. The frequent expression of neurotensin receptors (NT-R) in primaries of pancreatic ductal carcinomas has triggered the development of radioactive neurotensin analogs for possible in vivo targeting of these tumors...

    Authors: Meike Körner, Beatrice Waser, Oliver Strobel, Markus Büchler and Jean Claude Reubi
    Citation: EJNMMI Research 2015 5:17
    Content type: Original research Published on:

  47. The amount of inhomogeneities in a 99mTc Technegas single-photon emission computed tomography (SPECT) lung image, caused by reduced ventilation in lung regions affected by chronic obstructive pulmonary disease (C...

    Authors: Pernilla Norberg, Anna Olsson, Gudrun Alm Carlsson, Michael Sandborg and Agnetha Gustafsson
    Citation: EJNMMI Research 2015 5:16
    Content type: Original research Published on:

  48. Deformable image registration allows volume of interest (VOI)- and voxel-based analysis of longitudinal changes in fluorodeoxyglucose (FDG) tumor uptake in patients with non-small cell lung cancer (NSCLC). Thi...

    Authors: Gerald SMA Kerner, Alexander Fischer, Michel JB Koole, Jan Pruim and Harry JM Groen
    Citation: EJNMMI Research 2015 5:15
    Content type: Original research Published on:

  49. Tyrosine kinase inhibitors (TKIs) have experienced a tremendous boost in the last decade, where more than 15 small molecule TKIs have been approved by the FDA. Unfortunately, despite their promising clinical s...

    Authors: Paul Slobbe, Albert D Windhorst, Marijke Stigter-van Walsum, Egbert F Smit, Heiko G Niessen, Flavio Solca, Gerd Stehle, Guus A M S van Dongen and Alex J Poot
    Citation: EJNMMI Research 2015 5:14
    Content type: Original research Published on:

  50. Management of infection is a major clinical problem. Staphylococcus aureus is a Gram-positive bacterium which colonises approximately one third of the adult human population. Staphylococcal infections can be life...

    Authors: Bethany Mills, Ramla O Awais, Jeni Luckett, Dave Turton, Paul Williams, Alan C Perkins and Philip J Hill
    Citation: EJNMMI Research 2015 5:13
    Content type: Original research Published on:

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