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  1. Absorbed dose estimates for pediatric patients require pharmacokinetics that are, to the extent possible, age-specific. Such age-specific pharmacokinetic data are lacking for many of the diagnostic agents typi...

    Authors: Kitiwat Khamwan, Donika Plyku, Shannon E. O’Reilly, Alison Goodkind, Xinhua Cao, Frederic H. Fahey, S. Ted Treves, Wesley E. Bolch and George Sgouros
    Citation: EJNMMI Research 2016 6:28
    Content type: Original research Published on:

  2. Prostate cancer ranks as the second most lethal malignancy in the Western world. Previous targeting of prostate-specific antigen and human kallikrein-related peptidase 2, two related enzymes abundantly express...

    Authors: O. Vilhelmsson Timmermand, E. Larsson, D. Ulmert, T. A. Tran and SE. Strand
    Citation: EJNMMI Research 2016 6:27
    Content type: Original research Published on:

  3. The aim of the study was to explore Fc mutations of a humanised anti-Lewis-Y antibody (IgG1) hu3S193 as a strategy to improve therapeutic ratios for therapeutic payload delivery.

    Authors: Ingrid J. G. Burvenich, Fook-Thean Lee, Graeme J. O’Keefe, Dahna Makris, Diana Cao, Sylvia Gong, Angela Rigopoulos, Laura C. Allan, Martin W. Brechbiel, Zhanqi Liu, Paul A. Ramsland and Andrew M. Scott
    Citation: EJNMMI Research 2016 6:26
    Content type: Original research Published on:

  4. Gene therapy has been hampered by low expression upon in vivo delivery. Using a somatostatin receptor type 2 (SSTR2)-based reporter, we assessed whether angiotensin II (AII) can improve gene expression by aden...

    Authors: Sheela P. Singh, Murali K. Ravoori, Katherine A. Dixon, Lin Han, Sanjay Gupta, Rajesh Uthamanthil, Kenneth C. Wright and Vikas Kundra
    Citation: EJNMMI Research 2016 6:25
    Content type: Original research Published on:

  5. Quantitative in vivo imaging of tau pathologies potentially improves diagnostic accuracy of neurodegenerative tauopathies and would facilitate evaluation of disease-modifying drugs targeting tau lesions in the...

    Authors: Yasuyuki Kimura, Hironobu Endo, Masanori Ichise, Hitoshi Shimada, Chie Seki, Yoko Ikoma, Hitoshi Shinotoh, Makiko Yamada, Makoto Higuchi, Ming-Rong Zhang and Tetsuya Suhara
    Citation: EJNMMI Research 2016 6:24
    Content type: Original research Published on:

  6. Having performed analytical validation studies, we are now assessing the clinical utility of the upgraded automated Bone Scan Index (BSI) in metastatic castration-resistant prostate cancer (mCRPC). In the pres...

    Authors: Aseem Anand, Michael J. Morris, Steven M. Larson, David Minarik, Andreas Josefsson, John T. Helgstrand, Peter S. Oturai, Lars Edenbrandt, Martin Andreas Røder and Anders Bjartell
    Citation: EJNMMI Research 2016 6:23
    Content type: Original research Published on:

  7. Automated protocols for measuring and dispensing solutions containing radioisotopes are essential not only for providing a safe environment for radiation workers but also to ensure accuracy of dispensed radioa...

    Authors: Alex A. Dooraghi, Lewis Carroll, Jeffrey Collins, R. Michael van Dam and Arion F. Chatziioannou
    Citation: EJNMMI Research 2016 6:22
    Content type: Original research Published on:

  8. This study is an assessment of the impact of acquisition times on SUV with [18F]FDG-PET/CT on healthy livers (reference organ with stable uptake over time) and on tumors.

    Authors: Avigaëlle Sher, Franck Lacoeuille, Pacôme Fosse, Laurent Vervueren, Aurélie Cahouet-Vannier, Djamel Dabli, Francis Bouchet and Olivier Couturier
    Citation: EJNMMI Research 2016 6:21
    Content type: Original research Published on:

  10. The standardized uptake value (SUV) is the nearly exclusive means for quantitative evaluation of clinical [18F-]fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) whole body investigations. Howeve...

    Authors: Frank Hofheinz, Rebecca Bütof, Ivayla Apostolova, Klaus Zöphel, Ingo G. Steffen, Holger Amthauer, Jörg Kotzerke, Michael Baumann and Jörg van den Hoff
    Citation: EJNMMI Research 2016 6:19
    Content type: Original Research Published on:

  11. α3β1 integrin is overexpressed in several types of human cancer and is associated with poor prognosis, metastasis, and resistance to cancer treatment. We previously identified a cyclic peptide ligand LXY1 that...

    Authors: Wenwu Xiao, Tianhong Li, Fernanda C. Bononi, Diana Lac, Ivy A. Kekessie, Yanlei Liu, Eduardo Sanchez, Anisha Mazloom, Ai-hong Ma, Jia Lin, Jimmy Tran, Kevin Yang, Kit S. Lam and Ruiwu Liu
    Citation: EJNMMI Research 2016 6:18
    Content type: Original research Published on:

  12. Overexpression of the gastrin-releasing peptide receptor (GRP-R) has been documented in several human neoplasms such as breast, prostate, and ovarian cancer. There is growing interest in developing radiolabele...

    Authors: Antonella Accardo, Filippo Galli, Rosalba Mansi, Luigi Del Pozzo, Michela Aurilio, Anna Morisco, Paola Ringhieri, Alberto Signore, Giancarlo Morelli and Luigi Aloj
    Citation: EJNMMI Research 2016 6:17
    Content type: Original research Published on:

  13. In targeted radionuclide therapy (TRT), accurate quantification using SPECT/CT images is important for optimizing radiation dose delivered to both the tumour and healthy tissue. Quantitative SPECT images are r...

    Authors: Eero Hippeläinen, Mikko Tenhunen, Hanna Mäenpää and Antti Sohlberg
    Citation: EJNMMI Research 2016 6:16
    Content type: Original research Published on:

  14. We have recently shown that treatment of mice with the neutral endopeptidase (NEP) inhibitor phosphoramidon (PA) improves the bioavailability and tumor uptake of biodegradable radiopeptides. For the truncated ...

    Authors: Aikaterini Kaloudi, Berthold A. Nock, Emmanouil Lymperis, Roelf Valkema, Eric P. Krenning, Marion de Jong and Theodosia Maina
    Citation: EJNMMI Research 2016 6:15
    Content type: Original research Published on:

  15. Optical molecular imaging is an emerging novel technology with applications in the diagnosis of cancer and assistance in image-guided surgery. A high tumour-to-background (T/B) ratio is crucial for successful ...

    Authors: Marta M. Kijanka, Aram S. A. van Brussel, Elsken van der Wall, Willem P. T. M. Mali, Paul J. van Diest, Paul M. P. van Bergen en Henegouwen and Sabrina Oliveira
    Citation: EJNMMI Research 2016 6:14
    Content type: Original research Published on:

  16. The radiolanthanide 161Tb has, in recent years, attracted increasing interest due to its favorable characteristics for medical application. 161Tb exhibits similar properties to the widely-used therapeutic radionu...

    Authors: Stephanie Haller, Giovanni Pellegrini, Christiaan Vermeulen, Nicholas P. van der Meulen, Ulli Köster, Peter Bernhardt, Roger Schibli and Cristina Müller
    Citation: EJNMMI Research 2016 6:13
    Content type: Original research Published on:

  17. Single photon emission computed tomography (SPECT) is an indispensable tool in the determination of the in vivo fate of polymeric micelles. However, for this purpose, the micelles need to be radiolabeled, and ...

    Authors: Adrianus C. Laan, Costanza Santini, Laurence Jennings, Marion de Jong, Monique R. Bernsen and Antonia G. Denkova
    Citation: EJNMMI Research 2016 6:12
    Content type: Original Research Published on:

  18. Histamine H3 receptor (H3R) is a potential therapeutic target of sleep- and cognition-related disorders. The purpose of the present study is to develop a novel positron emission tomography (PET) ligand for H3Rs f...

    Authors: Kazumi Koga, Jun Maeda, Masaki Tokunaga, Masayuki Hanyu, Kazunori Kawamura, Mari Ohmichi, Toshio Nakamura, Yuji Nagai, Chie Seki, Yasuyuki Kimura, Takafumi Minamimoto, Ming-Rong Zhang, Toshimitsu Fukumura, Tetsuya Suhara and Makoto Higuchi
    Citation: EJNMMI Research 2016 6:11
    Content type: Original research Published on:

  19. In non-small cell lung cancer (NSCLC) patients off erlotinib therapy, positron emission tomography (PET) using [11C]erlotinib distinguished epidermal growth factor receptor (EGFR) mutations from wild-type EGFR. H...

    Authors: Idris Bahce, Maqsood Yaqub, Hanane Errami, Robert C. Schuit, Patrick Schober, Erik Thunnissen, Albert D. Windhorst, Adriaan A. Lammertsma, Egbert F. Smit and N. Harry Hendrikse
    Citation: EJNMMI Research 2016 6:10
    Content type: Original research Published on:

  20. In patients with small hearts, the Quantitative Gated single-photon emission computed tomography (SPECT) (QGS) program frequently underestimates the left ventricular (LV) end-systolic volume (ESV) and overesti...

    Authors: Chisato Kondo, Eri Watanabe, Mitsuru Momose, Kenji Fukushima, Koichiro Abe, Nobuhisa Hagiwara and Shuji Sakai
    Citation: EJNMMI Research 2016 6:9
    Content type: Original research Published on:

  22. We applied a non-linear immunokinetic model to quantitatively compare absolute antibody uptake and turnover in subcutaneous LNCaP human prostate cancer (PCa) xenografts of two radiolabeled forms of the humaniz...

    Authors: Edward K. Fung, Sarah M. Cheal, Shoaib B. Fareedy, Blesida Punzalan, Volkan Beylergil, Jawaria Amir, Sandhya Chalasani, Wolfgang A. Weber, Daniel E. Spratt, Darren R. Veach, Neil H. Bander, Steven M. Larson, Pat B. Zanzonico and Joseph R. Osborne
    Citation: EJNMMI Research 2016 6:7
    Content type: Original research Published on:

  23. Targeted alpha therapy has been postulated to have great potential for the treatment of small clusters of tumour cells as well as small metastases. 213Bismuth, an α-emitter with a half-life of 46 min, has shown t...

    Authors: Ho Sze Chan, Mark W. Konijnenberg, Erik de Blois, Stuart Koelewijn, Richard P. Baum, Alfred Morgenstern, Frank Bruchertseifer, Wouter A. Breeman and Marion de Jong
    Citation: EJNMMI Research 2016 6:6
    Content type: Original research Published on:

  24. Metastatic bone lesion is a common syndrome of many cancer diseases in an advanced state. The major symptom is severe pain, spinal cord compression, and pathological fracture, associated with an obvious morbid...

    Authors: Ralf Bergmann, Marian Meckel, Vojtěch Kubíček, Jens Pietzsch, Jörg Steinbach, Petr Hermann and Frank Rösch
    Citation: EJNMMI Research 2016 6:5
    Content type: Original research Published on:

  25. scVEGF/177Lu is a novel radiopharmaceutical targeted by recombinant single-chain (sc) derivative of vascular endothelial growth factor (VEGF) that binds to and is internalized by vascular endothelial growth facto...

    Authors: Mary Rusckowski, Yuzhen Wang, Francis G. Blankenberg, Zoia Levashova, Marina V. Backer and Joseph M. Backer
    Citation: EJNMMI Research 2016 6:4
    Content type: Original research Published on:

  26. As model system, a solid-tumor patient-derived xenograft (PDX) model characterized by high peptide receptor expression and histological tissue homogeneity was used to study radiopeptide targeting. In this soli...

    Authors: J. C. Haeck, K. Bol, C. M. A. de Ridder, L. Brunel, J. A. Fehrentz, J. Martinez, W. M. van Weerden, M. R. Bernsen, M. de Jong and J. F. Veenland
    Citation: EJNMMI Research 2016 6:3
    Content type: Original research Published on:

  27. 18F-fluorocholine PET/CT is used to detect lymph node metastases in prostate cancer patients. Physiological 18F-fluorocholine in the gastrointestinal tract, especially in the intestine...

    Authors: Maurits Wondergem, Friso M. van der Zant, Remco J. J. Knol, Jan Pruim and Igle J. de Jong
    Citation: EJNMMI Research 2016 6:2
    Content type: Short communication Published on:

  28. The inflammatory nature of atherosclerosis provides a broad range of potential molecular targets for atherosclerosis imaging. Growing interest is focused on targets related to plaque vulnerability such as the ...

    Authors: Romana Meletta, Adrienne Müller Herde, Patrick Dennler, Eliane Fischer, Roger Schibli and Stefanie D. Krämer
    Citation: EJNMMI Research 2016 6:1
    Content type: Original research Published on:

  29. Clinical applicability of newly discovered reagents for molecular imaging is hampered by the lack of translational models. As the dog prostate cancer (DPC-1) model recapitulates in dogs the natural history of ...

    Authors: Simone Chevalier, Serge Moffett, Eric Turcotte, Murillo Luz, Lyne Chauvette, Vilma Derbekyan, Eleonora Scarlata, Fatima Zouanat, Armen G. Aprikian and Maurice Anidjar
    Citation: EJNMMI Research 2015 5:77
    Content type: Original research Published on:

  30. The purpose of this study is to give an overview of studies investigating the role of fludeoxyglucose F18 (18F-FDG) positron emission tomography (PET) scanning in patients with aortic aneurysms with a focus on mo...

    Authors: U. T. Timur, J. A. van Herwaarden, D. Mihajlovic, P. De Jong, W. Mali and F. L. Moll
    Citation: EJNMMI Research 2015 5:76
    Content type: Review Published on:

  31. Circadian variation of gene expression is often neglected when ionizing radiation-induced effects are studied, whether in animal models or in cell culture. This study characterized diurnal variation of genome-...

    Authors: Britta Langen, Nils Rudqvist, Toshima Z. Parris, Khalil Helou and Eva Forssell-Aronsson
    Citation: EJNMMI Research 2015 5:75
    Content type: Original research Published on:

  32. 6-[Bis(carboxymethyl)amino]-1,4-bis(carboxymethyl)-6-methyl-1,4-diazepane (AAZTA ) is a promising chelator with potential advantages over 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) for rad...

    Authors: Joachim Pfister, Dominik Summer, Christine Rangger, Milos Petrik, Elisabeth von Guggenberg, Paolo Minazzi, Giovanni B. Giovenzana, Luigi Aloj and Clemens Decristoforo
    Citation: EJNMMI Research 2015 5:74
    Content type: Original research Published on:

  33. The objective of this study is to determine the radiation dosimetry of a novel radiotracer for vesicular acetylcholine transporter (−)-(1-((2R,3R)-8-(2-[18F]fluoro-ethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2...

    Authors: Morvarid Karimi, Zhude Tu, Xuyi Yue, Xiang Zhang, Hongjun Jin, Joel S. Perlmutter and Richard Laforest
    Citation: EJNMMI Research 2015 5:73
    Content type: Original research Published on:

  34. To investigate whether an apoptotic process demonstrated by 99mTc-annexin-V (99mTc-AV) uptake correlates with left ventricular remodeling (LVR) after myocardial infarction, we assessed 99mTc-AV uptake in rat mode...

    Authors: Hiroshi Wakabayashi, Junichi Taki, Anri Inaki, Kazuhiro Shiba, Ichiro Matsunari and Seigo Kinuya
    Citation: EJNMMI Research 2015 5:72
    Content type: Original research Published on:

  36. [18F]-tetrafluoroborate is a PET radiotracer taken up by the sodium/iodide symporter (NIS). Albeit the in vivo behavior in rodents is similar to the 99mTc-pertechnetate, no studies exist in primates or in humans....

    Authors: J. M. Marti-Climent, M. Collantes, M. Jauregui-Osoro, G. Quincoces, E. Prieto, I. Bilbao, M. Ecay, J. A. Richter and I. Peñuelas
    Citation: EJNMMI Research 2015 5:70
    Content type: Original research Published on:

  37. Macrophages represent a critical cell type in host defense, development and homeostasis. The ability to image non-invasively pro-inflammatory macrophage infiltrate into a transplanted organ may provide an addi...

    Authors: Alexander S. G. O’Neill, Samantha Y. A. Terry, Kathryn Brown, Lucy Meader, Andrew M. S. Wong, Jonathan D. Cooper, Paul R. Crocker, Wilson Wong and Gregory E. D. Mullen
    Citation: EJNMMI Research 2015 5:69
    Content type: Original research Published on:

  38. The relevance of prostate-specific membrane antigen (PSMA) targeting in the clinical management of prostate cancer (PCa) is continually increasing, entailing the development of PSMA-targeted molecular probes. ...

    Authors: Margret Schottelius, Martina Wirtz, Matthias Eiber, Tobias Maurer and Hans-Jürgen Wester
    Citation: EJNMMI Research 2015 5:68
    Content type: Short communication Published on:

  40. Prostate-specific membrane antigen (PSMA) is a promising target for diagnostics and therapy of prostate carcinoma (PCa). Based on the hypothesis that PSMA expression can be modulated by variations in androgen ...

    Authors: B. Meller, F. Bremmer, C. O. Sahlmann, S. Hijazi, C. Bouter, L. Trojan, J. Meller and P. Thelen
    Citation: EJNMMI Research 2015 5:66
    Content type: Original research Published on:

  41. The pathogenesis and immune response to Middle East respiratory syndrome (MERS) caused by a recently discovered coronavirus, MERS-CoV, have not been fully characterized because a suitable animal model is curre...

    Authors: Svetlana Chefer, David Thomasson, Jurgen Seidel, Richard C. Reba, J. Kyle Bohannon, Mathew G. Lackemeyer, Chris Bartos, Philip J. Sayre, Laura Bollinger, Lisa E. Hensley, Peter B. Jahrling and Reed F. Johnson
    Citation: EJNMMI Research 2015 5:65
    Content type: Original research Published on:

  42. Accurate alignment between histopathology slices and positron emission tomography (PET) images is important for radiopharmaceutical validation studies. Limited data is available on the registration accuracy th...

    Authors: Tanuj Puri, Anastasia Chalkidou, Rhonda Henley-Smith, Arunabha Roy, Paul R. Barber, Teresa Guerrero-Urbano, Richard Oakley, Ricard Simo, Jean-Pierre Jeannon, Mark McGurk, Edward W. Odell, Michael J. O’Doherty and Paul K. Marsden
    Citation: EJNMMI Research 2015 5:64
    Content type: Original research Published on:

  43. Cadmium zinc telluride (CZT) solid-state detectors have been recently introduced in the field of nuclear medicine in cardiology and breast imaging. The aim of the current study was to evaluate the performance ...

    Authors: Victoria Koulikov, Hedva Lerman, Mikhail Kesler and Einat Even-Sapir
    Citation: EJNMMI Research 2015 5:63
    Content type: Original research Published on:

  44. Successful treatments of patients with somatostatin receptor (SSTR)-overexpressing neuroendocrine tumours (NET) comprise somatostatin-analogue lutetium-177-labelled octreotate (177Lu-TATE) treatment, also referre...

    Authors: Sander M. Bison, Joost C. Haeck, K. Bol, S. J. Koelewijn, H. C. Groen, M. Melis, J. F. Veenland, M. R. Bernsen and M. de Jong
    Citation: EJNMMI Research 2015 5:62
    Content type: Original research Published on:

  45. Tail vein injection under short anesthesia is the most commonly used route for administering radiopharmaceuticals. However, the small caliber of the vein in rodents may lead to tracer extravasation and thereby...

    Authors: Charline Lasnon, Audrey Emmanuelle Dugué, Mélanie Briand, Soizic Dutoit and Nicolas Aide
    Citation: EJNMMI Research 2015 5:61
    Content type: Original research Published on:

  46. Hybrid PET/optical imaging provides quantitative and complementary information for diagnosis of tumors. Herein, we developed a 64Cu-labeled AlexaFluor 680-streptavidin ((AF)SAv)/biotin-based dimeric cyclic RGD pe...

    Authors: Choong Mo Kang, Hyun-Jung Koo, Gwang Il An, Yearn Seong Choe, Joon Young Choi, Kyung-Han Lee and Byung-Tae Kim
    Citation: EJNMMI Research 2015 5:60
    Content type: Original research Published on:

  47. 131I and 211At are used in nuclear medicine and accumulate in the thyroid gland and may impact normal thyroid function. The aim of this study was to determine transcriptional profile v...

    Authors: Nils Rudqvist, Johan Spetz, Emil Schüler, Britta Langen, Toshima Z. Parris, Khalil Helou and Eva Forssell-Aronsson
    Citation: EJNMMI Research 2015 5:59
    Content type: Original research Published on:

  48. The goal of the study is to investigate 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET)’s ability to delineate the viable portion of a tumor in an animal model using cross-sectional histology as...

    Authors: Ingrid Wu, Hao Wang, David Huso and Richard L. Wahl
    Citation: EJNMMI Research 2015 5:58
    Content type: Original research Published on:

  49. Non-invasive measurement of tumor hypoxia has demonstrated potential for the evaluation of disease progression, as well as prediction and assessment of treatment outcome. [18F]fluoroazomycin arabinoside (FAZA) po...

    Authors: Jinzi Zheng, Stephan G. Klinz, Raquel De Souza, Jonathan Fitzgerald and David A. Jaffray
    Citation: EJNMMI Research 2015 5:57
    Content type: Original research Published on:

  50. Depression in patients with brain tumors is associated with impaired quality of life and shorter survival. Altered metabolism of tryptophan to serotonin and kynurenine metabolites may play a role in tumor-asso...

    Authors: Edit Bosnyák, David O. Kamson, Michael E. Behen, Geoffrey R. Barger, Sandeep Mittal and Csaba Juhász
    Citation: EJNMMI Research 2015 5:56
    Content type: Original research Published on:

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