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  1. Nuclear imaging is increasingly being used in the diagnostic work-up of idiopathic inflammatory myopathy (IIM). Increased muscular uptake of technetium-99m-pyrophosphate (99mTc-PYP) has hitherto been assessed qua...

    Authors: Karin Folmer Thøgersen, Jane Angel Simonsen, Svend Hvidsten, Oke Gerke, Søren Jacobsen, Poul Flemming Høilund-Carlsen, Karen Middelbo Buch-Olsen and Louise Pyndt Diederichsen
    Citation: EJNMMI Research 2017 7:97
    Content type: Original research Published on:

  2. Mitochondrial dysfunction is one of the main causes of non-alcohol fatty liver disease (NAFLD). [18F]-BMS-747158-02 (18F-BMS) which was originally developed as a myocardial perfusion imaging agent was reported to...

    Authors: Takemi Rokugawa, Sotaro Momosaki, Miwa Ito, Hitoshi Iimori, Yuki Kato and Kohji Abe
    Citation: EJNMMI Research 2017 7:96
    Content type: Original research Published on:

  3. Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient. To date, only a few studies have used short-lived r...

    Authors: Outi Keinänen, Kimberly Fung, Jacob Pourat, Vilma Jallinoja, Delphine Vivier, NagaVara Kishore Pillarsetty, Anu J. Airaksinen, Jason S. Lewis, Brian M. Zeglis and Mirkka Sarparanta
    Citation: EJNMMI Research 2017 7:95
    Content type: Original research Published on:

  4. PET/CT has recently been shown to be a viable alternative to traditional post-infusion imaging methods providing good quality images of 90Y-laden microspheres after selective internal radiation therapy (SIRT). In...

    Authors: Marco D’Arienzo, Maria Pimpinella, Marco Capogni, Vanessa De Coste, Luca Filippi, Emiliano Spezi, Nick Patterson, Francesca Mariotti, Paolo Ferrari, Paola Chiaramida, Michael Tapner, Alexander Fischer, Timo Paulus, Roberto Pani, Giuseppe Iaccarino, Marco D’Andrea…
    Citation: EJNMMI Research 2017 7:94
    Content type: Original research Published on:

  5. In vivo positron-emission tomography (PET) imaging of transporter protein (TSPO) expression is an attractive and indispensable tool for the diagnosis and therapy evaluation of neuroinflammation after cerebral ...

    Authors: Krishna R. Pulagam, Lorena Colás, Daniel Padro, Sandra Plaza-García, Vanessa Gómez-Vallejo, Makoto Higuchi, Jordi Llop and Abraham Martín
    Citation: EJNMMI Research 2017 7:93
    Content type: Original research Published on:

  6. Estimation of functional relevance of a coronary stenosis by fractional flow reserve (FFR) from coronary computed tomography angiography (CCTA) has recently provided encouraging results. Due to its limited ava...

    Authors: Dominik C. Benz, Fran Mikulicic, Christoph Gräni, Marvin Grossmann, Andreas A. Giannopoulos, Michael Messerli, Catherine Gebhard, Oliver Gaemperli, Ronny R. Buechel, Philipp A. Kaufmann and Aju P. Pazhenkottil
    Citation: EJNMMI Research 2017 7:92
    Content type: Original research Published on:

  7. To date, the estimated radiation-absorbed dose to organs and tissues in patients undergoing diagnostic examinations in nuclear medicine is derived via calculations based on models of the human body and the bio...

    Authors: Martin Andersson, Lennart Johansson, Keith Eckerman and Sören Mattsson
    Citation: EJNMMI Research 2017 7:88
    Content type: Original research Published on:

  8. Positron emission tomography (PET) studies using 15O-labeled CO2, O2, and CO have been used in humans to evaluate cerebral blood flow (CBF), the cerebral oxygen extraction fraction (OEF), and the cerebral metabol...

    Authors: Genki Horitsugi, Tadashi Watabe, Yasukazu Kanai, Hayato Ikeda, Hiroki Kato, Sadahiro Naka, Mana Ishibashi, Keiko Matsunaga, Kayako Isohashi, Eku Shimosegawa and Jun Hatazawa
    Citation: EJNMMI Research 2017 7:91
    Content type: Original research Published on:

  9. 18F-Tetrafluoroborate (18F-TFB) is a promising iodide analog for PET imaging of thyroid cancer and sodium/iodide symporter (NIS) reporter activity in viral therapy applications. The ai...

    Authors: Huailei Jiang, Nicholas R. Schmit, Alex R. Koenen, Aditya Bansal, Mukesh K. Pandey, Robert B. Glynn, Bradley J. Kemp, Kera L. Delaney, Angela Dispenzieri, Jamie N. Bakkum-Gamez, Kah-Whye Peng, Stephen J. Russell, Tina M. Gunderson, Val J. Lowe and Timothy R. DeGrado
    Citation: EJNMMI Research 2017 7:90
    Content type: Original research Published on:

  10. PET ligands targeting the translocator protein (TSPO) represent promising tools to visualise neuroinflammation. Here, we analysed parameters obtained in dynamic and static PET images using the novel TSPO ligand [

    Authors: Lena Vomacka, Nathalie Lisa Albert, Simon Lindner, Marcus Unterrainer, Christoph Mahler, Matthias Brendel, Larissa Ermoschkin, Astrid Gosewisch, Anika Brunegraf, Christopher Buckley, Tania Kümpfel, Rainer Rupprecht, Sibylle Ziegler, Martin Kerschensteiner, Peter Bartenstein and Guido Böning
    Citation: EJNMMI Research 2017 7:89
    Content type: Original research Published on:

  11. Cervical dystonia (CD) is often accompanied by depressive symptoms, anxiety, and jerks/tremor. The dopamine transporter (DAT) binding is related with both depressive symptoms and jerks/tremor in CD. Serotonerg...

    Authors: E. Zoons, J. Booij, J. D. Speelman, Y. E. M. Dreissen, M. Smit and M. A. J. Tijssen
    Citation: EJNMMI Research 2017 7:87
    Content type: Original research Published on:

  12. Labelling proteins with gallium-68 using bifunctional chelators is often problematic because of unsuitably harsh labelling conditions such as low pH or high temperature and may entail post-labelling purificati...

    Authors: Saima Nawaz, Gregory E. D. Mullen, Kavitha Sunassee, Jayanta Bordoloi, Philip J. Blower and James R. Ballinger
    Citation: EJNMMI Research 2017 7:86
    Content type: Original research Published on:

  13. The aim of this study was to evaluate the diagnostic value of the asphericity (ASP) as a novel quantitative parameter, reflecting the spatial heterogeneity of tracer uptake, in the staging process of patients ...

    Authors: Sebastian Meißner, Jan-Carlo Janssen, Vikas Prasad, Winfried Brenner, Gerd Diederichs, Bernd Hamm, Frank Hofheinz and Marcus R. Makowski
    Citation: EJNMMI Research 2017 7:85
    Content type: Original research Published on:

  14. Translocator protein (TSPO) is a biomarker for detecting neuroinflammation by PET. 11C-(R)-PK11195 has been used to image TSPO since the 1980s. Here, we compared the utility of four 11C-labeled ligands—(R)-PK1119...

    Authors: Masahiro Fujita, Masato Kobayashi, Masamichi Ikawa, Roger N. Gunn, Eugenii A. Rabiner, David R. Owen, Sami S. Zoghbi, Mohamad B. Haskali, Sanjay Telu, Victor W. Pike and Robert B. Innis
    Citation: EJNMMI Research 2017 7:84
    Content type: Commentary Published on:

  15. The goal of this study was to evaluate the performance of the Celesteion positron emission tomography/computed tomography (PET/CT) scanner, which is characterized by a large-bore and time-of-flight (TOF) funct...

    Authors: Tomohiro Kaneta, Matsuyoshi Ogawa, Nobutoku Motomura, Hitoshi Iizuka, Tetsu Arisawa, Ayako Hino-Shishikura, Keisuke Yoshida and Tomio Inoue
    Citation: EJNMMI Research 2017 7:83
    Content type: Original research Published on:

  16. Functional volumes computed from 68Ga-ventilation/perfusion (V/Q) PET/CT, which we have shown to correlate with pulmonary function test parameters (PFTs), have potential diagnostic utility in a variety of clinica...

    Authors: Pierre-Yves Le Roux, Shankar Siva, Jason Callahan, Yannis Claudic, David Bourhis, Daniel P. Steinfort, Rodney J. Hicks and Michael S. Hofman
    Citation: EJNMMI Research 2017 7:82
    Content type: Original research Published on:

  17. Image-based measurement of absorbed dose of Ra-223 dichloride may be useful in predicting therapeutic outcome in patients with castration-resistant prostate cancer (CRPC). In general, SPECT has been found to b...

    Authors: Yoshiki Owaki, Tadaki Nakahara, Takeo Kosaka, Junichi Fukada, Atsuhiro Kumabe, Akira Ichimura, Mikoto Murakami, Kiyotaka Nakajima, Masahiro Fukushi, Kazumasa Inoue, Mototsugu Oya and Masahiro Jinzaki
    Citation: EJNMMI Research 2017 7:81
    Content type: Original research Published on:

  18. 99mTc-sestamibi single-photon emission computed tomography/computed tomography (SPECT/CT) has recently been explored for the characterization of indeterminate renal masses. As judged b...

    Authors: Steven P. Rowe, Michael A. Gorin, Lilja B. Solnes, Mark W. Ball, Ajuni Choudhary, Phillip M. Pierorazio, Jonathan I. Epstein, Mehrbod S. Javadi, Mohamad E. Allaf and Alex S. Baras
    Citation: EJNMMI Research 2017 7:80
    Content type: Original research Published on:

  19. Group-sequential testing is widely used in pivotal therapeutic, but rarely in diagnostic research, although it may save studies, time, and costs. The purpose of this paper was to demonstrate a group-sequential...

    Authors: Oke Gerke, Mie H. Vilstrup, Ulrich Halekoh, Malene Grubbe Hildebrandt and Poul Flemming Høilund-Carlsen
    Citation: EJNMMI Research 2017 7:79
    Content type: Short communication Published on:

  20. There is an increasing interest in developing predictive biomarkers of tissue hypoxia using functional imaging for personalised radiotherapy in patients with rectal cancer that are considered for neoadjuvant c...

    Authors: Tanuj Puri, Tessa A. Greenhalgh, James M. Wilson, Jamie Franklin, Lia Mun Wang, Victoria Strauss, Chris Cunningham, Mike Partridge and Tim Maughan
    Citation: EJNMMI Research 2017 7:78
    Content type: Original research Published on:

  21. PET/MRI can be used for the detection of disease in biochemical recurrence (BCR) patients imaged with 68Ga-PSMA-11 PET. This study was designed to determine the optimal MRI sequences to localize positive findings...

    Authors: Spencer T. Lake, Kirsten L. Greene, Antonio C. Westphalen, Spencer C. Behr, Ronald Zagoria, Eric J. Small, Peter R. Carroll and Thomas A. Hope
    Citation: EJNMMI Research 2017 7:77
    Content type: Original research Published on:

  22. We evaluated the suitability of 18F-fluorodeoxythymidine (18F-FLT) positron emission tomography (PET)/computed tomography (CT) for assessment of the early response to induction therapy and its value for predictin...

    Authors: Eun Ji Han, Bo-hee Lee, Jeong-A Kim, Young Ha Park and Woo Hee Choi
    Citation: EJNMMI Research 2017 7:75
    Content type: Original research Published on:

  23. Authors: Azeem Saleem, Graham E. Searle, Laura M. Kenny, Mickael Huiban, Kasia Kozlowski, Adam D. Waldman, Laura Woodley, Carlo Palmieri, Charles Lowdell, Tomomi Kaneko, Philip S. Murphy, Mike R. Lau, Eric O. Aboagye and Raoul C. Coombes
    Citation: EJNMMI Research 2017 7:74
    Content type: Erratum Published on:

    The original article was published in EJNMMI Research 2015 5:30

  26. We investigated the association between physiologic bowel FDG uptake and gut microbiota. FDG uptake in the normal large and small intestine is widely variable both in distribution and intensity. The etiology o...

    Authors: Ji Yeon Kang, Han-Na Kim, Yoosoo Chang, Yeojun Yun, Seungho Ryu, Hocheol Shin and Hyung-Lae Kim
    Citation: EJNMMI Research 2017 7:72
    Content type: Original research Published on:

  27. PET/CT with the radioactively labelled galactose analogue 2-18F-fluoro-2-deoxy-D-galactose (18F-FDGal) can be used to quantify the hepatic metabolic function and visualise regional metabolic heterogeneity. We det...

    Authors: Kirstine P. Bak-Fredslund, Peter Lykke Eriksen, Ole L. Munk, Gerda E. Villadsen, Susanne Keiding and Michael Sørensen
    Citation: EJNMMI Research 2017 7:71
    Content type: Original research Published on:

  29. 18F-FDG PET has been used in sarcoidosis for diagnosis and determination of the extent of the disease. However, assessing inflammatory lesions in cardiac sarcoidosis using 18F-FDG can ...

    Authors: Takashi Norikane, Yuka Yamamoto, Yukito Maeda, Takahisa Noma, Hiroaki Dobashi and Yoshihiro Nishiyama
    Citation: EJNMMI Research 2017 7:69
    Content type: Original research Published on:

    The original article was published in EJNMMI Research 2017 7:70

    The original article that this is related to.

  30. In Parkinson’s disease (PD), cerebral dopamine depletion is associated with PD subtype-specific metabolic patterns of hypo- and hypermetabolism. It has been hypothesised that hypometabolism reflects impairment...

    Authors: Elena Kordys, Nadine Apetz, Katharina Schneider, Eilidh Duncan, Beatriz Büschbell, Cathrin Rohleder, Michael Sué, Alexander Drzezga, Bernd Neumaier, Lars Timmermann and Heike Endepols
    Citation: EJNMMI Research 2017 7:68
    Content type: Original research Published on:

  31. Cardiac sarcoidosis is associated with major adverse cardiac events including cardiac arrest, for which anti-inflammatory treatment is indicated. Oral corticosteroid is the mainstay among treatment options; ho...

    Authors: Mitsutomi Ishiyama, Laurie A. Soine and Hubert J. Vesselle
    Citation: EJNMMI Research 2017 7:67
    Content type: Preliminary research Published on:

  32. Reference tissue-based quantification of brain PET data does not typically include correction for signal originating from blood vessels, which is known to result in biased outcome measures. The bias extent dep...

    Authors: Martin Schain, Patrik Fazio, Ladislav Mrzljak, Nahid Amini, Nabil Al-Tawil, Cheryl Fitzer-Attas, Juliana Bronzova, Bernhard Landwehrmeyer, Christina Sampaio, Christer Halldin and Andrea Varrone
    Citation: EJNMMI Research 2017 7:66
    Content type: Original research Published on:

  33. Intraoperative sentinel node (SN) identification in patients with head-and-neck malignancies can be challenging due to unexpected drainage patterns and anatomical complexity. Here, intraoperative navigation-ba...

    Authors: Gijs H. KleinJan, Baris Karakullukçu, W. Martin C. Klop, Thijs Engelen, Nynke S. van den Berg and Fijs W. B. van Leeuwen
    Citation: EJNMMI Research 2017 7:65
    Content type: Original research Published on:

  34. PET using O-(2-[18F]fluoroethyl)-l-tyrosine (18F-FET) is an established method for brain tumour diagnostics, but data processing varies in different centres. This study analyses the influence of methodological di...

    Authors: Christian P. Filss, Nathalie L. Albert, Guido Böning, Elena Rota Kops, Bogdana Suchorska, Gabriele Stoffels, Norbert Galldiks, Nadim J. Shah, Felix M. Mottaghy, Peter Bartenstein, Jörg C. Tonn and Karl-Josef Langen
    Citation: EJNMMI Research 2017 7:64
    Content type: Original research Published on:

  35. α-Amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor is a primary mediator of fast glutamatergic excitatory signaling in the brain and has been implicated in diverse neuropsychiatric diseases. We ...

    Authors: Keisuke Takahata, Yasuyuki Kimura, Chie Seki, Masaki Tokunaga, Masanori Ichise, Kazunori Kawamura, Maiko Ono, Soichiro Kitamura, Manabu Kubota, Sho Moriguchi, Tatsuya Ishii, Yuhei Takado, Fumitoshi Niwa, Hironobu Endo, Tomohisa Nagashima, Yoko Ikoma…
    Citation: EJNMMI Research 2017 7:63
    Content type: Original research Published on:

  36. The purpose of this study was to develop a positron emission tomography (PET) imaging probe that is easy to synthesize and selectively targets melanoma in vivo. Herein, we report the synthesis and preclinical ...

    Authors: Pradeep K. Garg, Rachid Nazih, Yanjun Wu, Vladimir P. Grinevich and Sudha Garg
    Citation: EJNMMI Research 2017 7:61
    Content type: Original research Published on:

  37. Measures of tumour heterogeneity derived from 18-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) scans are increasingly reported as potential biomarkers of non-small cell l...

    Authors: Usman Bashir, Gurdip Azad, Muhammad Musib Siddique, Saana Dhillon, Nikheel Patel, Paul Bassett, David Landau, Vicky Goh and Gary Cook
    Citation: EJNMMI Research 2017 7:60
    Content type: Original research Published on:

  38. The 18-kDa translocator protein (TSPO) is an important target for assessing neuroimmune function in brain with positron-emission tomography (PET) imaging. The goal of this work was to assess two [11C]PBR28 imagin...

    Authors: Ansel T. Hillmer, Daniel Holden, Krista Fowles, Nabeel Nabulsi, Brian L. West, Richard E. Carson and Kelly P. Cosgrove
    Citation: EJNMMI Research 2017 7:59
    Content type: Preliminary research Published on:

  39. Kinetic modelling with metabolite-corrected arterial plasma is considered the gold standard for quantification of [11C]PBR28 binding to the translocator protein (TSPO), since there is no brain region devoid of TS...

    Authors: Granville J. Matheson, Pontus Plavén-Sigray, Anton Forsberg, Andrea Varrone, Lars Farde and Simon Cervenka
    Citation: EJNMMI Research 2017 7:58
    Content type: Short communication Published on:

  40. Studies combining immune checkpoint inhibitors with external beam radiation have shown a therapeutic advantage over each modality alone. The purpose of these works is to evaluate the potential of targeted deli...

    Authors: Jessie R. Nedrow, Anders Josefsson, Sunju Park, Tom Bäck, Robert F. Hobbs, Cory Brayton, Frank Bruchertseifer, Alfred Morgenstern and George Sgouros
    Citation: EJNMMI Research 2017 7:57
    Content type: Original research Published on:

  41. Fluoro-L-thymidine (FLT) is a positron emission tomography/computed tomography (PET/CT) tracer which reflects proliferative activity in a cancer lesion. The main objective of this prospective explorative study...

    Authors: Marie Benzon Mogensen, Annika Loft, Marianne Aznar, Thomas Axelsen, Ben Vainer, Kell Osterlind and Andreas Kjaer
    Citation: EJNMMI Research 2017 7:56
    Content type: Original research Published on:

  43. [11C]-l-deprenyl-D2 is a positron emission tomography (PET) radioligand for measurement of the monoamine oxidase B (MAO-B) activity in vivo brain. The estimation of the test-retest reproducibility is important fo...

    Authors: Ryosuke Arakawa, Per Stenkrona, Akihiro Takano, Sangram Nag, Rafael S. Maior and Christer Halldin
    Citation: EJNMMI Research 2017 7:54
    Content type: Original research Published on:

  44. Although quantitative analysis using standardized uptake value (SUV) becomes realistic in clinical single-photon emission computed tomography/computed tomography (SPECT/CT) imaging, reconstruction parameter se...

    Authors: Tadaki Nakahara, Hiromitsu Daisaki, Yasushi Yamamoto, Takashi Iimori, Kazuyuki Miyagawa, Tomoya Okamoto, Yoshiki Owaki, Nobuhiro Yada, Koichi Sawada, Ryotaro Tokorodani and Masahiro Jinzaki
    Citation: EJNMMI Research 2017 7:53
    Content type: Preliminary Research Published on:

  45. The quantification of myocardial blood flow (MBF) and coronary flow reserve (CFR) are useful approaches for evaluating the functional severity of coronary artery disease (CAD). 15O-water positron emission tomogra...

    Authors: Osamu Manabe, Masanao Naya, Tadao Aikawa, Masahiko Obara, Keiichi Magota, Markus Kroenke, Noriko Oyama-Manabe, Kenji Hirata, Daiki Shinyama, Chietsugu Katoh and Nagara Tamaki
    Citation: EJNMMI Research 2017 7:52
    Content type: Original research Published on:

  46. CXCR4 belongs to the family of chemokine receptors. Together with its sole known ligand CXCL12 (SDF-1alpha), it has a pivotal role during organogenesis and for homing of hematopoietic stem cells. CXCR4 is over...

    Authors: Peter Herhaus, Stefan Habringer, Tibor Vag, Katja Steiger, Julia Slotta-Huspenina, Carlos Gerngroß, Benedikt Wiestler, Hans-Jürgen Wester, Markus Schwaiger and Ulrich Keller
    Citation: EJNMMI Research 2017 7:51
    Content type: Short communication Published on:

  47. We investigated the relationship between metabolic activity and histological features of gliomas using fluorine-18α-methyltyrosine (18F-FAMT) positron emission tomography (PET) compared with fluorine-18 fluorodeo...

    Authors: Keishi Horiguchi, Masahiko Tosaka, Tetsuya Higuchi, Yukiko Arisaka, Kenichi Sugawara, Junko Hirato, Hideaki Yokoo, Yoshito Tsushima and Yuhei Yoshimoto
    Citation: EJNMMI Research 2017 7:50
    Content type: Original research Published on:

  48. The ability to image vascular endothelial growth factor (VEGF) could enable prospective, non-invasive monitoring of patients receiving anti-angiogenic therapy. This study investigates the specificity and pharm...

    Authors: Neel Patel, Sarah Able, Danny Allen, Emmanouil Fokas, Bart Cornelissen, Fergus V. Gleeson, Adrian L. Harris and Katherine A. Vallis
    Citation: EJNMMI Research 2017 7:49
    Content type: Original research Published on:

  49. PET with O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) has reached increasing clinical significance for patients with brain neoplasms. For quantification of standard PET-derived parameters such as the tumor-to-backg...

    Authors: Marcus Unterrainer, Franziska Vettermann, Matthias Brendel, Adrien Holzgreve, Michael Lifschitz, Matthias Zähringer, Bogdana Suchorska, Vera Wenter, Ben M. Illigens, Peter Bartenstein and Nathalie L. Albert
    Citation: EJNMMI Research 2017 7:48
    Content type: Original research Published on:

  50. An inflammatory reaction in the airways and lung parenchyma, comprised mainly of neutrophils and alveolar macrophages, is present in some patients with chronic obstructive pulmonary disease (COPD). Thoracic fl...

    Authors: Christopher Coello, Marie Fisk, Divya Mohan, Frederick J. Wilson, Andrew P. Brown, Michael I. Polkey, Ian Wilkinson, Ruth Tal-Singer, Philip S. Murphy, Joseph Cheriyan and Roger N. Gunn
    Citation: EJNMMI Research 2017 7:47
    Content type: Original research Published on:

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