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  1. Serotonin 5-HT4 receptor (5-HT4-R) agonists are potential therapeutic agents for enterokinetic and cognitive disorders and are marketed for treatment of constipation. The aim of this study was to develop an agoni...

    Authors: Hans JC Buiter, Albert D Windhorst, Marc C Huisman, Joris H De Maeyer, Jan AJ Schuurkes, Adriaan A Lammertsma and Josée E Leysen

    Citation: EJNMMI Research 2013 3:24

    Content type: Original research

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  2. Breast cancer is one of the most prevalent forms of cancer in women. Breast-specific gamma imaging (BSGI) is a diagnostic imaging method that uses sestamibi-labelled 99Tc and a dedicated gamma camera to localize ...

    Authors: Dennis Dickerscheid, Jules Lavalaye, Leo Romijn and Jan Habraken

    Citation: EJNMMI Research 2013 3:21

    Content type: Original research

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  3. Technetium-labeled agents, which are most often used for assessing myocardial perfusion in myocardial perfusion scintigraphy (MPS), are cleared by the liver and excreted by the biliary system. Spillover from e...

    Authors: Allan Johansen, Milan Lomsky, Oke Gerke, Lars Edenbrandt, Lena Johansson, Gunhild Hansen, Birgitte Jensen, Maria Sallerup Reid, Lise-Lott Johansson, Camilla Olofsson, David Minarik, Karin Nyström, Per Wollmer and Elin Trägårdh

    Citation: EJNMMI Research 2013 3:20

    Content type: Original research

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  4. The M1 muscarinic acetylcholine receptor (M1ACh-R) is a G protein-coupled receptor that can occur in interconvertible coupled and uncoupled states. It is enriched in the basal ganglia, hippocampus, olfactory b...

    Authors: Hans JC Buiter, Albert D Windhorst, Marc C Huisman, Maqsood Yaqub, Dirk L Knol, Abraham Fisher, Adriaan A Lammertsma and Josée E Leysen

    Citation: EJNMMI Research 2013 3:19

    Content type: Original research

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  5. An unknown location hampers removal of pancreatic tumours. We studied the effects of enzyme inhibitors on the uptake of 6-[18F]fluoro-l-3,4-dihydroxyphenylalanine ([18F]FDOPA) in the pancreas, aiming at improved ...

    Authors: Johanna Tuomela, Sarita Forsback, Laura Haavisto, Tero Vahlberg, Tove J Grönroos, Olof Solin and Merja Haaparanta-Solin

    Citation: EJNMMI Research 2013 3:18

    Content type: Original research

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  6. In mice, 18F-fluorodeoxyglucose (18F-FDG) positron-emission tomography/computed tomography (PET/CT) lymphography enables detailed imaging of the lymphatic system and quantification of lymph node function. If this...

    Authors: Mads Radmer Jensen, Lene Simonsen, Markus Lonsdale and Jens Bjørn Bülow

    Citation: EJNMMI Research 2013 3:17

    Content type: Short communication

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  7. Assessment of dual time point (DTP) positron emission tomography was carried out with the aim of a quantitative determination of K m , the metabolic uptake rate of [18F]fluo...

    Authors: Jörg van den Hoff, Frank Hofheinz, Liane Oehme, Georg Schramm, Jens Langner, Bettina Beuthien-Baumann, Jörg Steinbach and Jörg Kotzerke

    Citation: EJNMMI Research 2013 3:16

    Content type: Original research

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  8. Phosphatidylserine (PS) is a phospholipid normally located in the inner leaflet of the cell membrane. PS is translocated from the inner to the outer leaflet of the plasma membrane during the early stages of ap...

    Authors: Runa H Poulsen, Jan T Rasmussen, June Anita Ejlersen, Christian Flø, Lise Falborg, Christian W Heegaard and Michael Rehling

    Citation: EJNMMI Research 2013 3:15

    Content type: Original research

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  9. Airway liquid hyper-absorption is a key pathophysiological link between the genetic mutations of cystic fibrosis (CF) and the development of lung disease. Here we consider whether the clearance of radiolabeled...

    Authors: Timothy E Corcoran, Kristina M Thomas, Stefanie Brown, Michael M Myerburg, Landon W Locke and Joseph M Pilewski

    Citation: EJNMMI Research 2013 3:14

    Content type: Original research

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  10. Using positron emission tomography (PET), we compared two tracers, [11C]metomidate ([11C]MTO) and [11C]acetate ([11C]ACE), for the characterization of hepatic tumors.

    Authors: Anne Roivainen, Alexandru Naum, Heikki Nuutinen, Rauli Leino, Heimo Nurmi, Kjell Någren, Riitta Parkkola, Johanna Virtanen, Markku Kallajoki, Harry Kujari, Jari Ovaska, Peter Roberts and Marko Seppänen

    Citation: EJNMMI Research 2013 3:13

    Content type: Original research

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  11. In the present study, we used multimodal imaging to investigate biodistribution in rats after intravenous administration of a new 99mTc-labeled delivery system consisting of polymer-shelled microbubbles (MBs) fun...

    Authors: Åsa A Barrefelt, Torkel B Brismar, Gabriella Egri, Peter Aspelin, Annie Olsson, Letizia Oddo, Silvia Margheritelli, Kenneth Caidahl, Gaio Paradossi, Lars Dähne, Rimma Axelsson and Moustapha Hassan

    Citation: EJNMMI Research 2013 3:12

    Content type: Original research

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  12. Despite the early theoretical prediction of the 0+-0+ transition of 90Zr, 90Y-PET underwent only recently a growing interest for the development of imaging radioembolization of liver tumors. The aim of this work ...

    Authors: Thomas Carlier, Thomas Eugène, Caroline Bodet-Milin, Etienne Garin, Catherine Ansquer, Caroline Rousseau, Ludovic Ferrer, Jacques Barbet, Frédéric Schoenahl and Françoise Kraeber-Bodéré

    Citation: EJNMMI Research 2013 3:11

    Content type: Original research

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  13. 11C-PiB has been developed as a positron-emission tomography (PET) ligand for evaluating fibrillar β-amyloid (Aβ) in the human brain. The ligand is rapidly metabolized, with approximately 10% of intact tracer re...

    Authors: Anne Van Vlaslaer, Russell J Mortishire-Smith, Claire Mackie, Xavier Langlois and Mark E Schmidt

    Citation: EJNMMI Research 2013 3:10

    Content type: Short communication

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  14. The objective of this study was to explore the prognostic value of the Bone Scan Index (BSI) obtained at the time of diagnosis in a group of high-risk prostate cancer patients receiving primary hormonal therapy.

    Authors: Reza Kaboteh, Jan-Erik Damber, Peter Gjertsson, Peter Höglund, Milan Lomsky, Mattias Ohlsson and Lars Edenbrandt

    Citation: EJNMMI Research 2013 3:9

    Content type: Original research

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  15. This letter points out the correct definition of inflammation and infection that is important for differential diagnosis. The most common nuclear medicine techniques and interpretation criteria to differentiat...

    Authors: Alberto Signore

    Citation: EJNMMI Research 2013 3:8

    Content type: Letter to the Editor

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  16. In single-photon emission computed tomography (SPECT), attenuation of photon flux in tissue affects quantitative accuracy of reconstructed images. Attenuation maps derived from X-ray computed tomography (CT) c...

    Authors: Chao Wu, Hugo A Gratama van Andel, Peter Laverman, Otto C Boerman and Freek J Beekman

    Citation: EJNMMI Research 2013 3:7

    Content type: Original research

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  17. The purpose of this work was to reveal the research interest value of positron emission tomography (PET) imaging in visualizing the induced tissue activity post high-energy photon radiation treatment. More spe...

    Authors: Sara Janek Strååt, Hans Jacobsson, Marilyn E Noz, Björn Andreassen, Ingemar Näslund and Cathrine Jonsson

    Citation: EJNMMI Research 2013 3:6

    Content type: Original research

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  18. The use of iodinated contrast media in small-animal positron emission tomography (PET)/computed tomography (CT) could improve anatomic referencing and tumor delineation but may introduce inaccuracies in the at...

    Authors: Charline Lasnon, Elske Quak, Mélanie Briand, Zheng Gu, Marie-Hélène Louis and Nicolas Aide

    Citation: EJNMMI Research 2013 3:5

    Content type: Original research

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  19. To date, few PET tracers for in vivo labeling of red blood cells (RBCs) are available. In this study, we report the radiosynthesis and in vitro and in vivo evaluation of 11C and 18F sulfonamide derivatives target...

    Authors: Olivier Gheysens, Vamsidhar Akurathi, Rufael Chekol, Tom Dresselaers, Sofie Celen, Michel Koole, Dieter Dauwe, Bernard J Cleynhens, Piet Claus, Stefan Janssens, Alfons M Verbruggen, Johan Nuyts, Uwe Himmelreich and Guy M Bormans

    Citation: EJNMMI Research 2013 3:4

    Content type: Original research

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  20. The characterization of fast-decaying radiotracers that are labeled with carbon-11 (t 1/2 = 20.38 min), including critical measurement of specific radioactivity (activity per mole at a specific time) before relea...

    Authors: H Umesha Shetty, Cheryl L Morse, Yi Zhang and Victor W Pike

    Citation: EJNMMI Research 2013 3:3

    Content type: Original research

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  21. Statistical parametric mapping (SPM) procedure is an objective tool to analyze 18F-fluoro-2-deoxy-d-glucose-positron-emission tomography (FDG-PET) images and a useful complement to visual analysis. However, SPM r...

    Authors: Frederique Archambaud, Viviane Bouilleret, Lucie Hertz-Pannier, Philippe Chaumet-Riffaud, Sebastian Rodrigo, Olivier Dulac, Francine Chassoux and Catherine Chiron

    Citation: EJNMMI Research 2013 3:2

    Content type: Original research

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  22. There is a growing interest in developing non-invasive imaging techniques permitting infarct size (IS) measurements in mice. The aim of this study was to validate the high-resolution rodent Linoview single pho...

    Authors: Véronique Roelants, Marie Delgaudine, Stephan Walrand, Renaud Lhommel, Yves Beguin, François Jamar and Jean-Louis Vanoverschelde

    Citation: EJNMMI Research 2012 2:64

    Content type: Original research

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  23. Positron emission tomography (PET) allows for the measurement of cerebral blood flow (CBF; based on [15O]H2O) and cerebral metabolic rate of glucose utilization (CMRglu; based on [18 F]-2-fluoro-2-deoxy-d-glucose...

    Authors: Marc C Huisman, Larissa W van Golen, Nikie J Hoetjes, Henri N Greuter, Patrick Schober, Richard G Ijzerman, Michaela Diamant and Adriaan A Lammertsma

    Citation: EJNMMI Research 2012 2:63

    Content type: Original research

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  24. By providing estimates of tumor glucose metabolism, 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) can potentially characterize the response of breast tumors to treatment. To assess therapy respons...

    Authors: Xia Li, Richard G Abramson, Lori R Arlinghaus, Anuradha Bapsi Chakravarthy, Vandana Abramson, Ingrid Mayer, Jaime Farley, Dominique Delbeke and Thomas E Yankeelov

    Citation: EJNMMI Research 2012 2:62

    Content type: Preliminary research

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  25. The estrogen receptor α (ERα) is known to play an important role in the modulation of tumor response to hormone therapy. In this work, the effect of different hormone therapies on tumors having different ERα e...

    Authors: Michel Paquette, Sébastien Tremblay, Francois Bénard and Roger Lecomte

    Citation: EJNMMI Research 2012 2:61

    Content type: Original research

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  26. Recently, inflammatory cascades have been suggested as a target for epilepsy therapy. Positron emission tomography (PET) imaging offers the unique possibility to evaluate brain inflammation longitudinally in a...

    Authors: Stefanie Dedeurwaerdere, Paul D Callaghan, Tien Pham, Gita L Rahardjo, Halima Amhaoul, Paula Berghofer, Mitchell Quinlivan, Filomena Mattner, Christian Loc'h, Andrew Katsifis and Marie-Claude Grégoire

    Citation: EJNMMI Research 2012 2:60

    Content type: Original research

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  27. This study evaluates the potential utility of a modular nanotransporter (MNT) for enhancing the nuclear delivery and cytotoxicity of the Auger electron emitter 125I in cancer cells that overexpress the epidermal ...

    Authors: Tatiana A Slastnikova, Eftychia Koumarianou, Andrey A Rosenkranz, Ganesan Vaidyanathan, Tatiana N Lupanova, Alexander S Sobolev and Michael R Zalutsky

    Citation: EJNMMI Research 2012 2:59

    Content type: Original research

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  28. This study investigated the influence of P-glycoprotein (P-gp) inhibitor tariquidar on the pharmacokinetics of P-gp substrate radiotracer (R)-[11C]verapamil in plasma and brain of rats and humans by means of posi...

    Authors: Julia Müllauer, Claudia Kuntner, Martin Bauer, Jens P Bankstahl, Markus Müller, Rob A Voskuyl, Oliver Langer and Stina Syvänen

    Citation: EJNMMI Research 2012 2:58

    Content type: Original research

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  29. P-glycoprotein is a blood–brain barrier efflux transporter involved in the clearance of amyloid-beta from the brain and, as such, might be involved in the pathogenesis of Alzheimer's disease. P-glycoprotein is...

    Authors: Daniëlle ME van Assema, Mark Lubberink, Patrizia Rizzu, John C van Swieten, Robert C Schuit, Jonas Eriksson, Philip Scheltens, Matthias Koepp, Adriaan A Lammertsma and Bart NM van Berckel

    Citation: EJNMMI Research 2012 2:57

    Content type: Original research

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  30. Positron emission tomography (PET) may be useful for defining the gross tumour volume for radiation treatment planning and for response monitoring of non-small cell lung cancer (NSCLC) patients. The purpose of...

    Authors: Patsuree Cheebsumon, Ronald Boellaard, Dirk de Ruysscher, Wouter van Elmpt, Angela van Baardwijk, Maqsood Yaqub, Otto S Hoekstra, Emile FI Comans, Adriaan A Lammertsma and Floris HP van Velden

    Citation: EJNMMI Research 2012 2:56

    Content type: Original research

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  31. Iodine-123-β-CIT, a single-photon emission computed tomography (SPECT) ligand for dopamine transporters (DATs), has been used for in vivo studies in humans, monkeys, and rats but has not yet been used extensively...

    Authors: Miia Pitkonen, Eero Hippeläinen, Mari Raki, Jaan-Olle Andressoo, Arto Urtti, Pekka T Männistö, Sauli Savolainen, Mart Saarma and Kim Bergström

    Citation: EJNMMI Research 2012 2:55

    Content type: Original research

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  32. Sigma receptors are highly expressed in human tumors and should be appropriate targets for developing tumor imaging agents. Previously, we synthesized a vesamicol analog, (+)-2-[4-(4-iodophenyl)piperidino]cycl...

    Authors: Kazuma Ogawa, Hiroya Kanbara, Kazuhiro Shiba, Yoji Kitamura, Takashi Kozaka, Tatsuto Kiwada and Akira Odani

    Citation: EJNMMI Research 2012 2:54

    Content type: Original research

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  33. Unspecific pain of the hand/wrist is a diagnostic challenge. Radiographs and planar bone scan are useful diagnostic tools in patients with unspecific wrist pain. Both modalities are deficient, either by not pr...

    Authors: Florian S Schleich, Maja Schürch, Martin W Huellner, Urs Hug, Urs von Wartburg, Klaus Strobel and Patrick Veit-Haibach

    Citation: EJNMMI Research 2012 2:53

    Content type: Original research

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  34. Ga-[1,4,7,10-tetraazacyclododecane-N,N′,N″,N′″- tetraacetic acid]-d-Phe1,Tyr3-octreotate (DOTATATE) positron emission tomography (PET) is commonly used for the visualization of somatostatin receptor (SSTR)-positi...

    Authors: Xiang Li, Samuel Samnick, Constantin Lapa, Ina Israel, Andreas K Buck, Michael C Kreissl and Wolfgang Bauer

    Citation: EJNMMI Research 2012 2:52

    Content type: Preliminary research

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  35. Freehand single photon emission computed tomography (fSPECT) is a three-dimensional (3-D) tomographic imaging modality based on data acquisition with a handheld detector that is moved freely, in contrast to co...

    Authors: Kambiz Rahbar, Mario Colombo-Benkmann, Christina Haane, Christian Wenning, Alexis Vrachimis, Matthias Weckesser and Otmar Schober

    Citation: EJNMMI Research 2012 2:51

    Content type: Preliminary research

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  36. We describe a new method for biodistribution studies with IRDye800CW fluorescent antibody probes. This method allows the quantification of the IRDye800CW fluorescent tracer in percentage of injected dose per g...

    Authors: Sabrina Oliveira, Ruth Cohen, Marijke Stigter-van Walsum, Guus AMS van Dongen, Sjoerd G Elias, Paul J van Diest, Willem Mali and Paul MP van Bergen en Henegouwen

    Citation: EJNMMI Research 2012 2:50

    Content type: Original research

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  37. Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate) is used to treat neuroendocrine tumors with high somatostatin-receptor expression. 177Lu-octreotate is mainly excreted via the kidneys, but to some extent, accumulat...

    Authors: Maria Larsson, Peter Bernhardt, Johanna B Svensson, Bo Wängberg, Håkan Ahlman and Eva Forssell-Aronsson

    Citation: EJNMMI Research 2012 2:49

    Content type: Original research

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  38. An intriguing biologic process in most adult mammals is post-pneumonectomy lung regeneration, that is, the removal of one lung (pneumonectomy) results in the rapid compensatory growth of the remaining lung. Th...

    Authors: Barry C Gibney, Mi-Ae Park, Kenji Chamoto, Alexandra Ysasi, Moritz A Konerding, Akira Tsuda and Steven J Mentzer

    Citation: EJNMMI Research 2012 2:48

    Content type: Original research

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  39. Arterial spin labeling magnetic resonance imaging (ASL-MRI) has been recognised as a valuable method for non-invasive assessment of cerebral blood flow but validation studies regarding quantification accuracy ...

    Authors: Agnieszka Boś, Ralf Bergmann, Klaus Strobel, Frank Hofheinz, Jörg Steinbach and Jörg van den Hoff

    Citation: EJNMMI Research 2012 2:47

    Content type: Original research

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  40. We aimed to develop a mouse spontaneous liver metastasis model from an orthotopically implanted human colon cancer cell line stably expressing a human sodium/iodide symporter (NIS) reporter gene, which can be ...

    Authors: Masayuki Inubushi, Yong-Nan Jin, Chika Murai, Hironobu Hata, Yoshimasa Kitagawa and Tsuneo Saga

    Citation: EJNMMI Research 2012 2:46

    Content type: Original research

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  41. The implementation of imaging technologies has dramatically increased the efficiency of preclinical studies, enabling a powerful, non-invasive and clinically translatable way for monitoring disease progression...

    Authors: Jordi L Tremoleda, Angela Kerton and Willy Gsell

    Citation: EJNMMI Research 2012 2:44

    Content type: Review

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  42. We performed an initial evaluation of non-invasive ECG-gated [18 F]FDG-positron emission tomography (FDG-PET) for serial measurements of left ventricular volumes and function in murine models of dilated (DCM) and...

    Authors: Stefan Brunner, Andrei Todica, Guido Böning, Stefan G Nekolla, Moritz Wildgruber, Sebastian Lehner, Martina Sauter, Christopher Übleis, Karin Klingel, Paul Cumming, Wolfgang Michael Franz and Marcus Hacker

    Citation: EJNMMI Research 2012 2:43

    Content type: Original research

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  43. Posterior lumbar interbody fusion (PLIF) is a method that allows decompression of the spinal canal and nerve roots by laminectomy combined with fusion by means of intervertebral cages filled with bone graft an...

    Authors: Boudewijn Brans, Rene Weijers, Serve Halders, Roel Wierts, Marloes Peters, Ilona Punt and Paul Willems

    Citation: EJNMMI Research 2012 2:42

    Content type: Preliminary research

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  44. 18F-FDG-PET imaging has emerged as a promising method in the diagnosis of chronic osteomyelitis commonly due to Staphylococcus aureus. The inaccuracy of 18 F-FDG-PET in the detection of periprosthetic joint infe...

    Authors: Petteri Lankinen, Kaisa Lehtimäki, Antti J Hakanen, Anne Roivainen and Hannu T Aro

    Citation: EJNMMI Research 2012 2:41

    Content type: Original research

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  45. Nanomedicine is emerging as a promising approach for diagnostic applications. Nanoparticles are structures in the nanometer size range, which can present different shapes, compositions, charges, surface modifi...

    Authors: AndréLuís Branco de Barros, Andrew Tsourkas, Babak Saboury, Valbert Nascimento Cardoso and Abass Alavi

    Citation: EJNMMI Research 2012 2:39

    Content type: Review

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  46. This study compares the frequency and distribution of increased activity on 18 F-fluoride PET/CT with the presence of bone marrow edema on whole-body MR imaging in the spine and sacroiliac joints (SIJ) of pati...

    Authors: Dorothee R Fischer, Christian W A Pfirrmann, Veronika Zubler, Katrin D M Stumpe, Burkhardt Seifert, Klaus Strobel, Giorgio Tamborrini, Gustav K von Schulthess, Beat A Michel and Adrian Ciurea

    Citation: EJNMMI Research 2012 2:38

    Content type: Original research

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  47. Dysfunction of the glycine transporter 1 (GlyT1) has been suggested to be involved in psychiatric disorders such as schizophrenia. GlyT1 inhibitors have therefore been considered to have antipsychotic therapeu...

    Authors: Takeshi Fuchigami, Akihiro Takano, Balázs Gulyás, Zhisheng Jia, Sjoerd J Finnema, Jan D Andersson, Ryuji Nakao, Yasuhiro Magata, Mamoru Haratake, Morio Nakayama and Christer Halldin

    Citation: EJNMMI Research 2012 2:37

    Content type: Original research

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