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  1. Content type: Original research

    This study is to evaluate the predictive value of FDG-PET (PET) in pediatric and adolescent patients suffering from non-Hodgkin lymphoma (pNHL) in comparison to information provided by conventional imaging met...

    Authors: Christian Furth, Ingo G Steffen, Anne S Erdrich, Patrick Hundsdoerfer, Juri Ruf, Günter Henze, Stefan Schönberger, Holger Amthauer and Hubertus Hautzel

    Citation: EJNMMI Research 2013 3:71

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  2. Content type: Original research

    Fluorine-18 fluoroethoxybenzovesamicol ([18F]FEOBV) is a radioligand for the selective imaging of the vesicular acetylcholine transporter with positron emission tomography (PET). The current study demonstrates th...

    Authors: Maxime J Parent, Marilyn Cyr, Antonio Aliaga, Alexey Kostikov, Esther Schirrmacher, Jean-Paul Soucy, Naguib Mechawar, Pedro Rosa-Neto and Marc-Andre Bedard

    Citation: EJNMMI Research 2013 3:70

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  3. Content type: Original research

    [18 F]fluorodopa (FDOPA) positron emission tomography (PET) allows assessment of levodopa (LDOPA) metabolism and is widely used to study Parkinson's disease. We examined how [18 F]FDOPA PET-derived kinetic parame...

    Authors: Matthew D Walker, Katherine Dinelle, Rick Kornelsen, Anna Lee, Matthew J Farrer, A Jon Stoessl and Vesna Sossi

    Citation: EJNMMI Research 2013 3:69

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  4. Content type: Original research

    The folate receptor (FR) is a well-established target for tumor imaging and therapy. To date, only a few 18 F-folate conjugates via 18 F-prosthetic group labeling for positron emission tomography (PET) imaging ha...

    Authors: Hanno Schieferstein, Thomas Betzel, Cindy R Fischer and Tobias L Ross

    Citation: EJNMMI Research 2013 3:68

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  5. Content type: Original research

    Positron emission tomography (PET) with [2-18 F]-2-fluoro-2-deoxy-D-glucose ([18 F]FDG-PET) was acquired at multiple time-points a) to monitor the early response to RO5126766 (CH5126766) in xenograft models b) to...

    Authors: Tetyana Tegnebratt, Li Lu, Lucy Lee, Valerie Meresse, Jean Tessier, Nobuya Ishii, Naoki Harada, Pavel Pisa and Sharon Stone-Elander

    Citation: EJNMMI Research 2013 3:67

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  6. Content type: Original research

    Until now, no kinetic model was described for the oncologic tracer [18F]fluoromethylcholine ([18F]FCho), so it was aimed to validate a proper model, which is easy to implement and allows tracer quantification in ...

    Authors: Dominique Slaets and Filip De Vos

    Citation: EJNMMI Research 2013 3:66

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  7. Content type: Original research

    Adenosine may have beneficial effects on left ventricular function after myocardial infarction (MI), but the magnitude of this effect on remote and MI areas is controversial. We assessed the long-term effects ...

    Authors: Mélanie Bousquenaud, Fatiha Maskali, Sylvain Poussier, Jennifer Zangrando, Pierre-Yves Marie, Henri Boutley, Renaud Fay, Gilles Karcher, Daniel R Wagner and Yvan Devaux

    Citation: EJNMMI Research 2013 3:65

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  8. Content type: Original research

    The objective of this study was firstly to develop and evaluate an automated method for the detection of new lesions and changes in bone scan index (BSI) in serial bone scans and secondly to evaluate the progn...

    Authors: Reza Kaboteh, Peter Gjertsson, Håkan Leek, Milan Lomsky, Mattias Ohlsson, Karl Sjöstrand and Lars Edenbrandt

    Citation: EJNMMI Research 2013 3:64

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  9. Content type: Original research

    The European Association of Nuclear Medicine procedure guidelines for whole-body fluorodeoxyglucose positron-emission tomography (FDG-PET) scanning prescribe a dose proportional to the patient’s body mass. How...

    Authors: Eleonore H de Groot, Nieky Post, Ronald Boellaard, Nils RL Wagenaar, Antoon TM Willemsen and Jorn A van Dalen

    Citation: EJNMMI Research 2013 3:63

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  10. Content type: Original research

    The purpose of the present study was to quantify renal cell injury after ischemia and reperfusion in a pig model using 99mTc-lactadherin as a marker of apoptosis and 99mTc-sestamibi as a marker of mitochondrial d...

    Authors: Stine S Pedersen, Anna K Keller, Marie K Nielsen, Bente Jespersen, Lise Falborg, Jan T Rasmussen, Christian W Heegaard and Michael Rehling

    Citation: EJNMMI Research 2013 3:62

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  11. Content type: Original research

    Kinetic modeling of brain glucose metabolism in small rodents from positron emission tomography (PET) data using 2-deoxy-2-[18 F]fluoro-d-glucose (FDG) has been highly inconsistent, due to different modeling para...

    Authors: Malte F Alf, Marianne I Martić-Kehl, Roger Schibli and Stefanie D Krämer

    Citation: EJNMMI Research 2013 3:61

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  12. Content type: Original research

    Gastrointestinal (GI) disorders are commonly associated with chronic conditions such as diabetes, obesity, and hypertension. Direct consequences are obstipation or diarrhea as opposite aspects of the irritable...

    Authors: Parasuraman Padmanabhan, Johannes Grosse, Abu Bakar Md Ali Asad, George K Radda and Xavier Golay

    Citation: EJNMMI Research 2013 3:60

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  13. Content type: Original research

    Preclinical and histological data show overexpression of the type 1 cannabinoid receptor (CB1R) in prostate carcinoma (PCa). In a prospective study, the feasibility of 18F-MK-9470 positron emission tomography (PE...

    Authors: Kimy M Emonds, Michel Koole, Cindy Casteels, Laura Van den Bergh, Guy M Bormans, Filip Claus, Liesbeth De Wever, Evelyne Lerut, Hendrik Van Poppel, Steven Joniau, Herlinde Dumez, Karin Haustermans, Luc Mortelmans, Karolien Goffin, Koen Van Laere, Christophe M Deroose…

    Citation: EJNMMI Research 2013 3:59

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  14. Content type: Original research

    Stress myocardial perfusion scintigraphy (MPS) is widely regarded as a useful imaging modality for diagnosing patients with suspected ischemic heart disease. Current European guidelines recommend stress study ...

    Authors: Lars Edenbrandt, Mattias Ohlsson and Elin Trägårdh

    Citation: EJNMMI Research 2013 3:58

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  15. Content type: Original research

    Coincidence imaging of low-abundance yttrium-90 (90Y) internal pair production by positron emission tomography with integrated computed tomography (PET/CT) achieves high-resolution imaging of post-radioembolizati...

    Authors: Yung-Hsiang Kao, Jeffrey D Steinberg, Young-Soon Tay, Gabriel KY Lim, Jianhua Yan, David W Townsend, Charley A Budgeon, Jan A Boucek, Roslyn J Francis, Timothy ST Cheo, Mark C Burgmans, Farah G Irani, Richard HG Lo, Kiang-Hiong Tay, Bien-Soo Tan, Pierce KH Chow…

    Citation: EJNMMI Research 2013 3:57

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  16. Content type: Original research

    Yttrium-90 (90Y) positron emission tomography with integrated computed tomography (PET/CT) represents a technological leap from 90Y bremsstrahlung single-photon emission computed tomography with integrated comput...

    Authors: Yung-Hsiang Kao, Jeffrey D Steinberg, Young-Soon Tay, Gabriel KY Lim, Jianhua Yan, David W Townsend, Angela Takano, Mark C Burgmans, Farah G Irani, Terence KB Teo, Tow-Non Yeow, Apoorva Gogna, Richard HG Lo, Kiang-Hiong Tay, Bien-Soo Tan, Pierce KH Chow…

    Citation: EJNMMI Research 2013 3:56

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  17. Content type: Original research

    Infectious diseases are the second leading cause of death worldwide. In order to better understand and treat them, an accurate evaluation using multi-modal imaging techniques for anatomical and functional char...

    Authors: Ulas Bagci, Brent Foster, Kirsten Miller-Jaster, Brian Luna, Bappaditya Dey, William R Bishai, Colleen B Jonsson, Sanjay Jain and Daniel J Mollura

    Citation: EJNMMI Research 2013 3:55

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  18. Content type: Original research

    Metabotropic glutamate 7 (mGlu7) receptor is a crucial target protein for the development of pharmaceuticals against central nervous system disorders. In the present study, we synthesized [11C]MMPIP, a putative r...

    Authors: Tomoteru Yamasaki, Katsushi Kumata, Joji Yui, Masayuki Fujinaga, Kenji Furutsuka, Akiko Hatori, Lin Xie, Masanao Ogawa, Nobuki Nengaki, Kazunori Kawamura and Ming-Rong Zhang

    Citation: EJNMMI Research 2013 3:54

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  19. Content type: Original research

    Many automated radiosynthesizers for producing positron emission tomography (PET) probes provide a means for the operator to create custom synthesis programs. The programming interfaces are typically designed ...

    Authors: Shane B Claggett, Kevin M Quinn, Mark Lazari, Melissa D Moore and R Michael van Dam

    Citation: EJNMMI Research 2013 3:53

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  20. Content type: Original research

    Automated radiosynthesizers are vital for routine production of positron-emission tomography tracers to minimize radiation exposure to operators and to ensure reproducible synthesis yields. The recent trend in...

    Authors: Mark Lazari, Kevin M Quinn, Shane B Claggett, Jeffrey Collins, Gaurav J Shah, Henry E Herman, Brandon Maraglia, Michael E Phelps, Melissa D Moore and R Michael van Dam

    Citation: EJNMMI Research 2013 3:52

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  21. Content type: Original research

    Many biological factors of 2-[18 F]fluoro-2-deoxy-d-glucose (18 F-FDG) in blood can affect 18 F-FDG uptake in tumors. In this study, longitudinal 18 F-FDG positron emission tomography (PET) studies were performed...

    Authors: Wei Sha, Hu Ye, Keisuke S Iwamoto, Koon-Pong Wong, Moses Quinn Wilks, David Stout, William McBride and Sung-Cheng Huang

    Citation: EJNMMI Research 2013 3:51

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  22. Content type: Original research

    The influence of the blood glucose level on the tracer uptake of normal tissues at [18F]-2-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) was retrospectively studied in examinations in clinical...

    Authors: Henry Lindholm, Fredrik Brolin, Cathrine Jonsson and Hans Jacobsson

    Citation: EJNMMI Research 2013 3:50

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  23. Content type: Original research

    Care providers use complementary information from multiple imaging modalities to identify and characterize metastatic tumors in early stages and perform surveillance for cancer recurrence. These tasks require ...

    Authors: Ulas Bagci, Gabriela Kramer-Marek and Daniel J Mollura

    Citation: EJNMMI Research 2013 3:49

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  24. Content type: Original research

    The cardiac PRKAG2 mutation in the γ2-subunit of adenosine monophosphate activated kinase (AMPK) is characterized by excessive glycogen deposition, hypertrophy, frequent arrhythmias, and progressive conduction...

    Authors: Stephanie L Thorn, Michael H Gollob, Mary-Ellen Harper, Rob S Beanlands, Robert A deKemp and Jean N DaSilva

    Citation: EJNMMI Research 2013 3:48

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  25. Content type: Original research

    A recent study from our laboratory demonstrated that 11C-LY2428703, a new positron emission tomographic radioligand for metabotropic glutamate receptor 1 (mGluR1), has promising in vitro properties and excellent

    Authors: Paolo Zanotti-Fregonara, Vanessa N Barth, Sami S Zoghbi, Jeih-San Liow, Eric Nisenbaum, Edward Siuda, Robert L Gladding, Denise Rallis-Frutos, Cheryl Morse, Johannes Tauscher, Victor W Pike and Robert B Innis

    Citation: EJNMMI Research 2013 3:47

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  26. Content type: Original research

    6-Hydroxydopamine (6-OHDA) is widely used in pre-clinical animal studies to induce degeneration of midbrain dopamine neurons to create animal models of Parkinson's disease. The aim of our study was to evaluate...

    Authors: Susanne Bäck, Mari Raki, Raimo K Tuominen, Atso Raasmaja, Kim Bergström and Pekka T Männistö

    Citation: EJNMMI Research 2013 3:46

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  27. Content type: Original research

    Although the treatment of Parkinson’s disease (PD) is very effective, in the course of the disease, 40% to 60% of patients develop dyskinesias. The pathophysiology of dyskinesias is still unclear. Results of p...

    Authors: Sven R Suwijn, Henk W Berendse, Constant VM Verschuur, Ania Winogrodzka, Rob MA de Bie and Jan Booij

    Citation: EJNMMI Research 2013 3:44

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  28. Content type: Original research

    Florbetapir (AV-45) has been shown to be a reliable tool to assess amyloid load in patients with Alzheimer's disease (AD) at demential stages. Longitudinal studies also suggest that AV-45 has the ability to bi...

    Authors: Laure Saint-Aubert, Emmanuel J Barbeau, Patrice Péran, Federico Nemmi, Celine Vervueren, Helene Mirabel, Pierre Payoux, Anne Hitzel, Fabrice Bonneville, Raluca Gramada, Mathieu Tafani, Christian Vincent, Michele Puel, Sophie Dechaumont, Francois Chollet and Jeremie Pariente

    Citation: EJNMMI Research 2013 3:43

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  29. Content type: Original research

    Hypoxia within solid tumors confers radiation resistance and a poorer prognosis. 124I-iodoazomycin galactopyranoside (124I-IAZGP) has shown promise as a hypoxia radiotracer in animal models. We performed a clinic...

    Authors: Joseph A O’Donoghue, José G Guillem, Heiko Schöder, Nancy Y Lee, Chaitanya R Divgi, Jeannine A Ruby, John L Humm, Steven A Lee-Kong, Eva M Burnazi, Shangde Cai, Sean D Carlin, Tobias Leibold, Pat B Zanzonico and C Clifton Ling

    Citation: EJNMMI Research 2013 3:42

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  30. Content type: Original research

    Quantification of cerebral blood flow (CBF) is important for the understanding of normal and pathologic brain physiology. Positron emission tomography (PET) with H2 15O (or C15O2) can quantify CBF and apply kinet...

    Authors: Nobuyuki Kudomi, Yukito Maeda, Yasuhiro Sasakawa, Toshihide Monden, Yuka Yamamoto, Nobuyuki Kawai, Hidehiro Iida and Yoshihiro Nishiyama

    Citation: EJNMMI Research 2013 3:41

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  31. Content type: Short communication

    Since proteoglycans (PGs) appear as key partners in chondrosarcoma biology, PG-targeted imaging using the radiotracer 99mTc-N-(triethylammonium)-3-propyl-[15]ane-N5 (99mTc-NTP 15-5) developed by our group was pre...

    Authors: Elisabeth Miot-Noirault, Emmanuelle David, Aurélien Vidal, Caroline Peyrode, Sophie Besse, Marie-Mélanie Dauplat, Marie-Françoise Heymann, François Gouin, Jean-Michel Chezal, Dominique Heymann and Françoise Rédini

    Citation: EJNMMI Research 2013 3:40

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  32. Content type: Original research

    Mesolimbic and nigrostriatal dopaminergic pathways play important roles in both the rewarding and conditioning effects of drugs. The dopamine transporter (DAT) is of central importance in regulating dopaminerg...

    Authors: Gerda Thomsen, Gitte Moos Knudsen, Peter S Jensen, Morten Ziebell, Klaus K Holst, Susanne Asenbaum, Jan Booij, Jacques Darcourt, John C Dickson, Özlem L Kapucu, Flavio Nobili, Osama Sabri, Terez Sera, Klaus Tatsch, Livia Tossici-Bolt, Koen Van Laere…

    Citation: EJNMMI Research 2013 3:39

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  33. Content type: Original research

    Expression of αvβ3 integrin is increased after myocardial infarction as part of the repair process. Increased expression of αvβ3 has been shown by molecular imaging with 18F-galacto-RGD in a rat model. The 68Ga-l...

    Authors: Iina Laitinen, Johannes Notni, Karolin Pohle, Martina Rudelius, Eliane Farrell, Stephan G Nekolla, Gjermund Henriksen, Stefanie Neubauer, Horst Kessler, Hans-Jürgen Wester and Markus Schwaiger

    Citation: EJNMMI Research 2013 3:38

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  34. Content type: Review

    Targeted agents are increasingly used for treating cancer and other diseases, but patients may need to be carefully selected to maximize the potential for therapeutic benefit. One way to select patients is to ...

    Authors: William J McBride, Robert M Sharkey and David M Goldenberg

    Citation: EJNMMI Research 2013 3:36

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  35. Content type: Original research

    [18F]UCB-H was developed as a novel radiotracer with a high affinity for synaptic vesicle protein 2A, the binding site for the antiepileptic levetiracetam. The objectives of this study were to evaluate the radiat...

    Authors: Florian Bretin, Geoffrey Warnock, Mohamed Ali Bahri, Joël Aerts, Nathalie Mestdagh, Tim Buchanan, Anne Valade, Frédéric Mievis, Fabrice Giacomelli, Christian Lemaire, André Luxen, Eric Salmon, Alain Seret and Alain Plenevaux

    Citation: EJNMMI Research 2013 3:35

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  36. Content type: Original research

    Serotonergic neurons in the rodent hypothalamus are implicated in key neuroendocrine and metabolic functions, including circadian rhythmicity. However, the assessment of the serotonergic system in the human hy...

    Authors: Anke J Borgers, Anneke Alkemade, Elsmarieke M Van de Giessen, Madeleine L Drent, Jan Booij, Peter H Bisschop and Eric Fliers

    Citation: EJNMMI Research 2013 3:34

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  37. Content type: Original research

    We propose a new approach to facilitate sentinel node biopsy examination by multimodality imaging in which radioactive and near-infrared (NIR) fluorescent nanoparticles depict deeply situated sentinel nodes an...

    Authors: Makoto Tsuchimochi, Kazuhide Hayama, Michio Toyama, Ichiro Sasagawa and Norio Tsubokawa

    Citation: EJNMMI Research 2013 3:33

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  38. Content type: Original research

    The biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe ([18F] FACT) was investigated in humans.

    Authors: Miho Shidahara, Manabu Tashiro, Nobuyuki Okamura, Shozo Furumoto, Katsutoshi Furukawa, Shoichi Watanuki, Kotaro Hiraoka, Masayasu Miyake, Ren Iwata, Hajime Tamura, Hiroyuki Arai, Yukitsuka Kudo and Kazuhiko Yanai

    Citation: EJNMMI Research 2013 3:32

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  39. Content type: Original research

    Androgen deprivation (AD) is generally used as a first-line palliative treatment in prostate cancer (PCa) patients with rising prostate-specific antigen (PSA) after primary therapy. To acquire an accurate dete...

    Authors: Kimy M Emonds, Johannes V Swinnen, Evelyne Lerut, Michel Koole, Luc Mortelmans and Felix M Mottaghy

    Citation: EJNMMI Research 2013 3:31

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  40. Content type: Original research

    The activation of microglia, in general, and the upregulation of the translocator protein (18 kDa) (TSPO) system, in particular, are key features of neuroinflammation, of which the in vivo visualization and quant...

    Authors: Akihiro Takano, Fredrik Piehl, Jan Hillert, Andrea Varrone, Sangram Nag, Balázs Gulyás, Per Stenkrona, Victor L Villemagne, Christopher C Rowe, Richard Macdonell, Nabil Al Tawil, Thomas Kucinski, Torsten Zimmermann, Marcus Schultze-Mosgau, Andrea Thiele, Anja Hoffmann…

    Citation: EJNMMI Research 2013 3:30

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  41. Content type: Original research

    Respiratory gating and gate optimization strategies present solutions for overcoming image degradation caused by respiratory motion in PET and traditionally utilize hardware systems and/or employ complex proce...

    Authors: Adam Leon Kesner, Galith Abourbeh, Eyal Mishani, Roland Chisin, Sagi Tshori and Nanette Freedman

    Citation: EJNMMI Research 2013 3:29

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  42. Content type: Original research

    Reduced ventilation in lung regions affected by chronic obstructive pulmonary disease (COPD), reflected as inhomogeneities in the single-photon emission computed tomography (SPECT) lung image, is correlated to...

    Authors: Pernilla Norberg, Hans Lennart Persson, Gudrun Alm Carlsson, Björn Bake, Magnus Kentson, Michael Sandborg and Agnetha Gustafsson

    Citation: EJNMMI Research 2013 3:28

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  43. Content type: Original research

    [11C]methionine (MET) has been used to monitor amino acid metabolism in tumors, the pancreas, liver, and myocardium. The aim of the present study was to standardize [11C]MET positron emission tomography (PET) by ...

    Authors: Kayako Isohashi, Eku Shimosegawa, Hiroki Kato, Yasukazu Kanai, Sadahiro Naka, Koichi Fujino, Hiroshi Watabe and Jun Hatazawa

    Citation: EJNMMI Research 2013 3:27

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  44. Content type: Original research

    A kinetic model analysis was recently proposed to estimate the 18F-fluorodeoxyglucose (18F-FDG) integrated activity in an arbitrary tissue that uses tracer uptake and release rate constants. The aim of the curren...

    Authors: Eric Laffon, Manuel Bardiès, Jacques Barbet and Roger Marthan

    Citation: EJNMMI Research 2013 3:26

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  45. Content type: Original research

    Previous studies showed that radiolabeled murine monoclonal antibody (mAb) 14C5 and its Fab and F(ab')2 fragments, targeting αvβ5 integrin, have promising properties for diagnostic and therapeutic applications in...

    Authors: Caroline Dumolyn, Steve Schoonooghe, Lieselotte Moerman, Sara Neyt, Jurgen Haustraete and Filip De Vos

    Citation: EJNMMI Research 2013 3:25

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  46. Content type: Original research

    Serotonin 5-HT4 receptor (5-HT4-R) agonists are potential therapeutic agents for enterokinetic and cognitive disorders and are marketed for treatment of constipation. The aim of this study was to develop an agoni...

    Authors: Hans JC Buiter, Albert D Windhorst, Marc C Huisman, Joris H De Maeyer, Jan AJ Schuurkes, Adriaan A Lammertsma and Josée E Leysen

    Citation: EJNMMI Research 2013 3:24

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  47. Content type: Original research

    Most carcinomas are prone to metastasize despite successful treatment of the primary tumor. One way to address this clinical challenge may be targeted therapy with α-emitting radionuclides such as astatine-211 (2...

    Authors: Sophie E Eriksson, Tom Bäck, Erika Elgström, Holger Jensen, Rune Nilsson, Sture Lindegren and Jan Tennvall

    Citation: EJNMMI Research 2013 3:23

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  48. Content type: Original research

    Functional brain changes induced by chemotherapy are still not well characterized. We used a novel approach with a multivariate technique to analyze brain resting state [18 F]FDG-PET in patients with lymphoma, to...

    Authors: Federico D'Agata, Tommaso Costa, Paola Caroppo, Bruno Baudino, Franco Cauda, Matteo Manfredi, Giuliano Geminiani, Paolo Mortara, Lorenzo Pinessi, Giancarlo Castellano and Gianni Bisi

    Citation: EJNMMI Research 2013 3:22

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