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  1. Although neurofibrillary tangles (NFTs) mainly accumulate in the medial temporal lobe with human aging, only a few imaging studies have investigated correlations between NFT accumulation and gray matter (GM) v...

    Authors: Yoko Shigemoto, Daichi Sone, Miho Ota, Norihide Maikusa, Masayo Ogawa, Kyoji Okita, Harumasa Takano, Koichi Kato, Yukio Kimura, Emiko Morimoto, Fumio Suzuki, Hiroyuki Fujii, Noriko Sato and Hiroshi Matsuda
    Citation: EJNMMI Research 2019 9:81
  2. Preclinical imaging of endothelial activation and mineralization using both positron emission tomography (PET) and magnetic resonance (MR) remains scarce.

    Authors: Guillaume Rucher, Lucie Cameliere, Jihene Fendri, Antoine Anfray, Ahmed Abbas, Saïd Kamel, Quentin Dupas, Nicolas Delcroix, Ludovic Berger and Alain Manrique
    Citation: EJNMMI Research 2019 9:80
  3. (1) To perform a comprehensive analysis of the time elapsed between the last G-CSF injection and the PET/CT examination on the biodistribution of 18F-FDG, with emphasis on liver, spleen, and bone marrow uptake, a...

    Authors: Magno Oliveira, Charline Lasnon, Catherine Nganoa, Anne-Claire Gac, Gandhi Damaj and Nicolas Aide
    Citation: EJNMMI Research 2019 9:79
  4. Immunotherapies that employ immune checkpoint modulators (ICMs) have emerged as an effective treatment for a variety of solid cancers, as well as a paradigm shift in the treatment of cancers. Despite this brea...

    Authors: Mathieu Sinigaglia, Tarek Assi, Florent L. Besson, Samy Ammari, Myriam Edjlali, Whitney Feltus, Laura Rozenblum-Beddok, Binsheng Zhao, Lawrence H. Schwartz, Fatima-Zohra Mokrane and Laurent Dercle
    Citation: EJNMMI Research 2019 9:78
  5. PET (positron emission tomography) biokinetic modelling relies on accurate quantitative data. One of the main corrections required in PET imaging to obtain high quantitative accuracy is tissue attenuation corr...

    Authors: Jorge Cabello, Mihai Avram, Felix Brandl, Mona Mustafa, Martin Scherr, Claudia Leucht, Stefan Leucht, Christian Sorg and Sibylle I. Ziegler
    Citation: EJNMMI Research 2019 9:77
  6. The bone marrow (BM) is a main risk organ during Lu-177-PSMA ligand therapy of metastasized castration-resistant prostate cancer (mCRPC) patients. So far, BM dosimetry relies on S values, which are pre-computed f...

    Authors: Astrid Gosewisch, Harun Ilhan, Sebastian Tattenberg, Andrea Mairani, Katia Parodi, Julia Brosch, Lena Kaiser, Franz Josef Gildehaus, Andrei Todica, Sibylle Ziegler, Peter Bartenstein and Guido Böning
    Citation: EJNMMI Research 2019 9:76
  7. The development and clinical translation of [68Ga] Pentixafor has substantially promoted the relevance of non-invasive PET imaging of CXCR4 expression in a broad spectrum of diseases, including cancer and inflamm...

    Authors: Margret Schottelius, Marina Ludescher, Frauke Richter, Tobias G. Kapp, Horst Kessler and Hans-Jürgen Wester
    Citation: EJNMMI Research 2019 9:75
  8. In a colorectal cancer xenograft model, we investigated the therapeutic effect of metformin on tumor hypoxia with [18F]flortanidazole ([18F]HX4) small-animal positron emission tomography (μPET). We also assessed ...

    Authors: Sven De Bruycker, Christel Vangestel, Steven Staelens, Leonie wyffels, Jan Detrez, Marlies Verschuuren, Winnok H. De Vos, Patrick Pauwels, Tim Van den Wyngaert and Sigrid Stroobants
    Citation: EJNMMI Research 2019 9:74
  9. To evaluate the optimal tracer uptake time, the minimal amount of radioactivity and the inter-observer agreement for 11C-choline positron emission tomography/computed tomography (PET/CT) in patients with primary ...

    Authors: Milou E. Noltes, Schelto Kruijff, Walter Noordzij, Eef D. Telenga, David Vállez García, Malgorzata Trofimiuk-Müldner, Marta Opalińska, Alicja Hubalewska-Dydejczyk, Gert Luurtsema, Rudi A. J. O. Dierckx, Mostafa El Moumni, Ronald Boellaard and Adrienne H. Brouwers
    Citation: EJNMMI Research 2019 9:73
  10. 18F-fluorocholine (FCH) PET/CT is a promising technique for visualizing hyperfunctioning parathyroid glands in hyperparathyroidism. It is still under debate whether to use this technique as a first-line imaging ....

    Authors: Wouter A. M. Broos, Maurits Wondergem, Remco J. J. Knol and Friso M. van der Zant
    Citation: EJNMMI Research 2019 9:72
  11. Cimbi-36 can be 11C-labeled to form an agonist radioligand used for positron emission tomography (PET) imaging of the 5-HT2A receptor in the brain. In its non-labeled form (25B-NBOMe), it is used as a recreationa...

    Authors: Annette Johansen, Søren Holm, Bente Dall, Sune Keller, Jesper L. Kristensen, Gitte M. Knudsen and Hanne D. Hansen
    Citation: EJNMMI Research 2019 9:71
  12. Whole body [18F]-fluorodihydrotestosterone positron emission tomography ([18F]FDHT PET) imaging directly targets the androgen receptor and is a promising prognostic and predictive biomarker in metastatic castrati...

    Authors: Matthijs C. F. Cysouw, Gerbrand M. Kramer, Dennis Heijtel, Robert C. Schuit, Michael J. Morris, Alfons J. M. van den Eertwegh, Jens Voortman, Otto S. Hoekstra, Daniela E. Oprea-Lager and Ronald Boellaard
    Citation: EJNMMI Research 2019 9:70
  13. For almost a decade, terbium radioisotopes have been explored for their potential theragnostic application in nuclear medicine: 152Tb and 155Tb are the radioisotopes identified for PET or SPECT imaging, while 149

    Authors: Cristina Müller, Aviral Singh, Christoph A. Umbricht, Harshad R. Kulkarni, Karl Johnston, Martina Benešová, Stefan Senftleben, Dirk Müller, Christiaan Vermeulen, Roger Schibli, Ulli Köster, Nicholas P. van der Meulen and Richard P. Baum
    Citation: EJNMMI Research 2019 9:68
  14. Our aim was to present a new data analysis technique for the early detection of tumorous lesions using single-photon emission computed tomography (SPECT) imaging. Beyond standardized uptake value (SUV) and sta...

    Authors: Dániel S. Veres, Domokos Máthé, Nikolett Hegedűs, Ildikó Horváth, Fanni J. Kiss, Gabriella Taba, Edit Tóth-Bodrogi, Tibor Kovács and Krisztián Szigeti
    Citation: EJNMMI Research 2019 9:67
  15. We investigated the whole-body distribution and the radiation dosimetry of [18F]-JK-PSMA-7, a novel 18F-labeled PSMA-ligand for PET/CT imaging of prostate cancer.

    Authors: Melanie Hohberg, Carsten Kobe, Philipp Krapf, Philipp Täger, Jochen Hammes, Felix Dietlein, Boris D. Zlatopolskiy, Heike Endepols, Markus Wild, Stephan Neubauer, Axel Heidenreich, Bernd Neumaier, Alexander Drzezga and Markus Dietlein
    Citation: EJNMMI Research 2019 9:66
  16. The Deauville score (DS) is a clinical tool, based on the comparison between lesion and reference organ uptake of 18F-fluorodeoxyglucose (FDG), used to stratify patients with lymphoma into categories reflecting t...

    Authors: John Ly, David Minarik, Lars Edenbrandt, Per Wollmer and Elin Trägårdh
    Citation: EJNMMI Research 2019 9:65
  17. Block-sequential regularized expectation maximization (BSREM), commercially Q. Clear (GE Healthcare, Milwaukee, WI, USA), is a reconstruction algorithm that allows for a fully convergent iterative reconstructi...

    Authors: Elin Trägårdh, David Minarik, Helén Almquist, Ulrika Bitzén, Sabine Garpered, Erland Hvittfelt, Berit Olsson and Jenny Oddstig
    Citation: EJNMMI Research 2019 9:64
  18. To determine the reliability of visual assessment of [123I]FP-CIT SPECT imaging by non-experts in dopamine transporter (DAT) SPECT imaging in patients with early drug-naive Parkinson’s disease (PD). Also, we expl...

    Authors: Sven R. Suwijn, Constant V. M. Verschuur, Marleen A. Slim, Jan Booij and Rob M. A. de Bie
    Citation: EJNMMI Research 2019 9:63
  19. The aim of this study was to compare predictive and post-treatment dosimetry and analyze the differences, investigating factors related to activity preparation and delivery, imaging modality used, and interven...

    Authors: Marilyne Kafrouni, Carole Allimant, Marjolaine Fourcade, Sébastien Vauclin, Boris Guiu, Denis Mariano-Goulart and Fayçal Ben Bouallègue
    Citation: EJNMMI Research 2019 9:62
  20. The quality of phantom images was previously shown to be higher on digital (Vereos Philips®) compared to analog PET (Ingenuity Philips®) cameras. This study aimed to determine the extent to which this differen...

    Authors: Julien Salvadori, Laetitia Imbert, Mathieu Perrin, Gilles Karcher, Zohra Lamiral, Pierre-Yves Marie and Antoine Verger
    Citation: EJNMMI Research 2019 9:61
  21. To facilitate hypoxia imaging in a clinical setting, we developed 1-(2,2-dihydroxymethyl-3-[18F]-fluoropropyl)-2-nitroimidazole ([18F]DiFA) as a new tracer that targets tumor hypoxia with its lower lipophilicity ...

    Authors: Shiro Watanabe, Tohru Shiga, Kenji Hirata, Keiichi Magota, Shozo Okamoto, Takuya Toyonaga, Kei Higashikawa, Hironobu Yasui, Jun Kobayashi, Ken-ichi Nishijima, Ken Iseki, Hiroki Matsumoto, Yuji Kuge and Nagara Tamaki
    Citation: EJNMMI Research 2019 9:60
  22. In clinical practice, visual assessment of glucose metabolism images is often used for the diagnosis of Alzheimer’s disease (AD) through 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) s...

    Authors: Débora E. Peretti, David Vállez García, Fransje E. Reesink, Janine Doorduin, Bauke M. de Jong, Peter P. De Deyn, Rudi A. J. O. Dierckx and Ronald Boellaard
    Citation: EJNMMI Research 2019 9:59
  23. Non-invasive tumor blood flow (TBF) quantification is a candidate approach for risk stratification and monitoring of prostate cancer patients. Validation data have recently been published on prostate TBF measu...

    Authors: Mads Ryø Jochumsen, Kirsten Bouchelouche, Katrine Bødkergaard Nielsen, Jørgen Frøkiær, Michael Borre, Jens Sörensen and Lars Poulsen Tolbod
    Citation: EJNMMI Research 2019 9:58
  24. Positron emission tomography (PET) is increasingly used to guide local treatment in glioma. The purpose of this study was a direct comparison of two potential tracers for detecting glioma infiltration, O-(2-[18F]...

    Authors: Niels Verburg, Thomas Koopman, Maqsood Yaqub, Otto S. Hoekstra, Adriaan A. Lammertsma, Lothar A. Schwarte, Frederik Barkhof, Petra J. W. Pouwels, Jan J. Heimans, Jaap C. Reijneveld, Annemieke J. M. Rozemuller, William P. Vandertop, Pieter Wesseling, Ronald Boellaard and Philip C. de Witt Hamer
    Citation: EJNMMI Research 2019 9:57
  25. (E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-(3-(2-[18F]-fluoroethoxy)propyl) oxime ([18F]-PSS232) is a new PET tracer for imaging of metabotropic glutamate receptor subtype 5 (mGlu5), and has shown promising re...

    Authors: Bert-Ram Sah, Michael Sommerauer, Linjing Mu, Gloria Pla Gonzalez, Susanne Geistlich, Valerie Treyer, Roger Schibli, Alfred Buck, Geoffrey Warnock and Simon M. Ametamey
    Citation: EJNMMI Research 2019 9:56
  26. This study investigated the noninvasive assessment of tumor vascularization with clinical F-18-fluorodeoxyglucose positron emission tomography/computed tomography and contrast-enhanced computed tomography ([18...

    Authors: Martin Mirus, Sergey V. Tokalov, Andrij Abramyuk, Jessica Heinold, Vincent Prochnow, Klaus Zöphel, Jörg Kotzerke and Nasreddin Abolmaali
    Citation: EJNMMI Research 2019 9:55
  27. 18F-FDG PET/CT has proven to be a reliable tool for therapy monitoring in sarcoidosis. Previous PET studies investigated the SUVmax as a marker for disease activity. Total lung glycolysis (TLuG) is a new tool, q....

    Authors: Milou C. Schimmelpennink, Adriane D. M. Vorselaars, Marcel Veltkamp and Ruth G. M. Keijsers
    Citation: EJNMMI Research 2019 9:54
  28. Biodistribution studies based on organ harvesting represent the gold standard pre-clinical technique for dose extrapolations. However, sequential imaging is becoming increasingly popular as it allows the extra...

    Authors: Francesco Cicone, Silvano Gnesin, Thibaut Denoël, Thierry Stora, Nicholas P. van der Meulen, Cristina Müller, Christiaan Vermeulen, Martina BeneÅ¡ová, Ulli Köster, Karl Johnston, Ernesto Amato, Lucrezia Auditore, George Coukos, Michael Stabin, Niklaus Schaefer, David Viertl…
    Citation: EJNMMI Research 2019 9:53
  29. Prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRP-R) are expressed in prostate cancer and can be targeted with radiolabeled inhibitors and antagonists. Their performances fo...

    Authors: Romain Schollhammer, Henri De Clermont Gallerande, Mokrane Yacoub, Marie-Laure Quintyn Ranty, Nicole Barthe, Delphine Vimont, Elif Hindié, Philippe Fernandez and Clément Morgat
    Citation: EJNMMI Research 2019 9:52
  30. Eribulin, an inhibitor of microtubule dynamics, shows antitumor potency against a variety of solid cancers through its antivascular activity and remodeling of tumor vasculature. 18F-Fluoromisonidazole (18F-FMISO)...

    Authors: Songji Zhao, Wenwen Yu, Naoyuki Ukon, Chengbo Tan, Ken-ichi Nishijima, Yoichi Shimizu, Kei Higashikawa, Tohru Shiga, Hiroko Yamashita, Nagara Tamaki and Yuji Kuge
    Citation: EJNMMI Research 2019 9:51
  31. To evaluate the expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter1 (LAT1) in prostate cancer (PCa) and their impact on uptake of 18F-1-amino-3-fluorocyclobutane-1-carbo...

    Authors: Irena Saarinen, Ivan Jambor, Mai Kim, Anna Kuisma, Jukka Kemppainen, Harri Merisaari, Olli Eskola, Anna-Riina Koskenniemi, Ileana Montoya Perez, Peter Boström, Pekka Taimen and Heikki Minn
    Citation: EJNMMI Research 2019 9:50
  32. Pretargeted imaging allows the use of short-lived radionuclides when imaging the accumulation of slow clearing targeting agents such as antibodies. The biotin-(strept)avidin and the bispecific antibody-hapten ...

    Authors: Patricia E. Edem, Jean-Philippe Sinnes, Stefanie Pektor, Nicole Bausbacher, Raffaella Rossin, Abdolreza Yazdani, Matthias Miederer, Andreas Kjær, John F. Valliant, Marc S. Robillard, Frank Rösch and Matthias M. Herth
    Citation: EJNMMI Research 2019 9:49
  33. The widespread use of 68Ga for positron emission tomography (PET) relies on the development of radiopharmaceutical precursors that can be radiolabelled and dispensed in a simple, quick, and convenient manner. The...

    Authors: Jean-Philippe Sinnes, Johannes Nagel, Bradley P. Waldron, Theodosia Maina, Berthold A. Nock, Ralf K. Bergmann, Martin Ullrich, Jens Pietzsch, Michael Bachmann, Richard P. Baum and Frank Rösch
    Citation: EJNMMI Research 2019 9:48
  34. [11C]methionine ([11C]Met) was used for cancer imaging based on upregulated amino acid transport and protein synthesis in different tumor types. However, the short half-life of 11C decay limited further clinical ...

    Authors: Olga Sergeeva, Yifan Zhang, Jonathan D. Kenyon, Galen A. Miller-Atkins, Chunying Wu, Renuka Iyer, Sandra Sexton, Patrick Wojtylak, Amad Awadallah, Wei Xin, E. Ricky Chan, James K. O’Donnel and Zhenghong Lee
    Citation: EJNMMI Research 2019 9:47
  35. Liposomes are drug nano-carriers that are capable of targeting therapeutics to tumor sites because of enhanced permeability retention (EPR). In several preclinical studies with various tumor-bearing mice models,

    Authors: Shyh-Jen Wang, Wen-Sheng Huang, Chi-Mu Chuang, Chih-Hsien Chang, Te-Wei Lee, Gann Ting, Ming-Huang Chen, Peter Mu-Hsin Chang, Ta-Chung Chao, Hao-Wei Teng, Yee Chao, Yuh-Min Chen, Tzu-Ping Lin, Ya-Jen Chang, Su-Jung Chen, Yuan-Ruei Huang…
    Citation: EJNMMI Research 2019 9:46
  36. Conjugation or fusion to AlbudAbsâ„¢ (albumin-binding domain antibodies) is a novel approach to extend the half-life and alter the tissue distribution of biological and small molecule therapeutics. To understand...

    Authors: Kevin S. Thorneloe, Armin Sepp, Sean Zhang, Laura Galinanes-Garcia, Paul Galette, Wasfi Al-Azzam, Danielle J. Vugts, Guus van Dongen, Phillip Elsinga, Johan Wiegers, Andor W. J. M. Glaudemans, Veena Vincent, Jessica Renaux, Matt Szapacs, Mary Birchler, Matthew Cleveland…
    Citation: EJNMMI Research 2019 9:45
  37. Following publication of the original article [1], the authors flagged the that the Kaplan-Meier curve in Fig. 6 is a duplication of the Kaplan-Meier curve in Fig. 5, which is not correct.

    Authors: Sarah Lindgren Belal, May Sadik, Reza Kaboteh, Nezar Hasani, Olof Enqvist, Linus Svärm, Fredrik Kahl, Jane Simonsen, Mads H. Poulsen, Mattias Ohlsson, Poul F. Høilund-Carlsen, Lars Edenbrandt and Elin Trägårdh
    Citation: EJNMMI Research 2019 9:44

    The original article was published in EJNMMI Research 2017 7:15

  38. Reactive oxygen species (ROS)-induced oxidative stress damages many cellular components such as fatty acids, DNA, and proteins. This damage is implicated in many disease pathologies including cancer and neurod...

    Authors: Kiran Kumar Solingapuram Sai, Nagaraju Bashetti, Xiaofei Chen, Skylar Norman, Justin W. Hines, Omsai Meka, J. V. Shanmukha Kumar, Sriram Devanathan, Gagan Deep, Cristina M. Furdui and Akiva Mintz
    Citation: EJNMMI Research 2019 9:43
  39. In molecular imaging and nuclear medicine, theranostic agents that integrate radionuclide pairs are successfully being used for individualized care, which has led to rapidly growing interest in their continued...

    Authors: C. Shaun Loveless, Lauren L. Radford, Samuel J. Ferran, Stacy L. Queern, Matthew R. Shepherd and Suzanne E. Lapi
    Citation: EJNMMI Research 2019 9:42
  40. Acute allograft rejection is one of the major complications after lung transplantation, and adequate and early recognition is important. Till now, the reference standard to detect acute rejection is the histop...

    Authors: Eef D. Telenga, Wim van der Bij, Erik F. J. de Vries, Erik A. M. Verschuuren, Wim Timens, Gert Luurtsema, Riemer H. J. A. Slart, Alberto Signore and Andor W. J. M. Glaudemans
    Citation: EJNMMI Research 2019 9:41
  41. Positron emission tomography (PET) imaging of 90Y following selective internal radiation therapy (SIRT) is possible, but image quality is poor, and therefore, accurate quantification and dosimetry are challenging...

    Authors: Nathaniel P. Scott and Daniel R. McGowan
    Citation: EJNMMI Research 2019 9:40
  42. While [18F]fluoromisonidazole (FMISO), a representative PET tracer to detect hypoxia, is reported to be able to prospect the prognosis after treatment for various types of cancers, the relation is unclear for pan...

    Authors: Tomohiko Yamane, Masayasu Aikawa, Masanori Yasuda, Kenji Fukushima, Akira Seto, Koujun Okamoto, Isamu Koyama and Ichiei Kuji
    Citation: EJNMMI Research 2019 9:39
  43. Positron emission tomography (PET) can be used for in vivo evaluation of the pathology associated with multiple sclerosis. We investigated the use of longitudinal PET imaging and the 18-kDa translocator protei...

    Authors: S. K. Vainio, A. M. Dickens, J. Tuisku, O. Eskola, O. Solin, E. Löyttyniemi, D. C. Anthony, J. O. Rinne, L. Airas and M. Haaparanta-Solin
    Citation: EJNMMI Research 2019 9:38
  44. The specific uptake size index (SUSI) of striatal FP-CIT uptake is independent of spatial resolution in the SPECT image, in contrast to the specific binding ratio (SBR). This suggests that the SUSI is particul...

    Authors: Ralph Buchert, Catharina Lange, Timo S. Spehl, Ivayla Apostolova, Lars Frings, Cathrine Jonsson, Philipp T. Meyer and Sabine Hellwig
    Citation: EJNMMI Research 2019 9:37
  45. Semi-automated quantitative measurement of metabolic tumor volume (MTV) for prognosis in diffuse large B-Cell lymphoma (DLBCL) has gained considerable interest lately. However, simple tumor volume measures may...

    Authors: Lars C. Gormsen, Mikkel H. Vendelbo, Mette Abildgaard Pedersen, Ate Haraldsen, Karin Hjorthaug, Trond Velde Bogsrud, Lars J. Petersen, Karen Juul Jensen, Rasmus Brøndum and Tarec C. El-Galaly
    Citation: EJNMMI Research 2019 9:36
  46. The goal of targeted radiotherapy (TRT) is to administer radionuclides to tumor cells, while limiting radiation exposure to normal tissues. 3′-Deoxy-3′-[18F]-fluorothymidine (18F-FLT) is able to target tumor cell...

    Authors: Thititip Tippayamontri, Brigitte Guérin, René Ouellet, Otman Sarrhini, Jacques Rousseau, Roger Lecomte, Benoit Paquette and Léon Sanche
    Citation: EJNMMI Research 2019 9:33
  47. A long dynamic scanning protocol may be required to accurately measure longitudinal changes in amyloid load. However, such a protocol results in a lower patient comfort and scanning efficiency compared to stat...

    Authors: Fiona Heeman, Maqsood Yaqub, Isadora Lopes Alves, Kerstin Heurling, Johannes Berkhof, Juan Domingo Gispert, Santiago Bullich, Christopher Foley and Adriaan A. Lammertsma
    Citation: EJNMMI Research 2019 9:32
  48. [11C]-acetate positron emission tomography is used to assess oxidative metabolism in various tissues including the heart, tumor, and brown adipose tissue. For brown adipose tissue, a monoexponential decay model i...

    Authors: Marie Anne Richard, Denis P. Blondin, Christophe Noll, Réjean Lebel, Martin Lepage and André C. Carpentier
    Citation: EJNMMI Research 2019 9:31

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