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  1. Content type: Original research

    Dopamine D2/3 receptor (D2/3R) agonist radiopharmaceuticals are considered superior to antagonists to detect dopamine release, e.g. induced by amphetamines. Agonists bind preferentially to the high-affinity state...

    Authors: Jan-Peter van Wieringen, Martin C Michel, Henk M Janssen, Anton G Janssen, Philip H Elsinga and Jan Booij

    Citation: EJNMMI Research 2014 4:53

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  2. Content type: Original research

    Today's standard treatment of advanced-stage ovarian cancer, including surgery followed by a paclitaxel-platinum-based chemotherapy, is limited in efficacy. Recently, we could show that radioimmunotherapy (RIT...

    Authors: Dennis Lindenblatt, Eliane Fischer, Susan Cohrs, Roger Schibli and Jürgen Grünberg

    Citation: EJNMMI Research 2014 4:54

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  3. Content type: Original research

    The aims of this study were to determine the optimal tracer kinetic model for [11C]-meta- hydroxyephedrine ([11C]HED) and to evaluate the performance of several simplified methods.

    Authors: Hendrik J Harms, Stefan de Haan, Paul Knaapen, Cornelis P Allaart, Mischa T Rijnierse, Robert C Schuit, Albert D Windhorst, Adriaan A Lammertsma, Marc C Huisman and Mark Lubberink

    Citation: EJNMMI Research 2014 4:52

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  4. Content type: Original research

    Development of tracers for imaging with positron emission tomography (PET) is often a time-consuming process associated with considerable attrition. In an effort to simplify this process, we herein propose a m...

    Authors: Markus Fridén, Marie Wennerberg, Madeleine Antonsson, Maria Sandberg-Ställ, Lars Farde and Magnus Schou

    Citation: EJNMMI Research 2014 4:50

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  5. Content type: Original research

    Prostate cancer is a leading cause of death in the male population of the western world. Human kallikrein-related peptidase 2 (hK2) is abundantly expressed in malignant prostatic tissue, and its gene, KLK2, is re...

    Authors: Oskar Vilhelmsson Timmermand, David Ulmert, Susan Evans-Axelsson, Kim Pettersson, Anders Bjartell, Hans Lilja, Sven-Erik Strand and Thuy A Tran

    Citation: EJNMMI Research 2014 4:51

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  6. Content type: Preliminary research

    2-deoxy-2-[18F]fluoro-D-glucose-positron emission tomography (18F-FDG-PET) is applied in the clinic for infection assessment and is under consideration for investigating the inflammatory/immune response in lympho...

    Authors: Svetlana Chefer, Richard C Reba, Christopher Z Leyson, Jurgen Seidel, Reed F Johnson, Joseph E Blaney, Peter B Jahrling and Julie Dyall

    Citation: EJNMMI Research 2014 4:49

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  7. Content type: Original research

    Selective arterial radioembolisation of liver tumours has increased, because of encouraging efficacy reports; however, therapeutic parameters used in external beam therapy are not applicable for understanding ...

    Authors: Jonas Högberg, Magnus Rizell, Ragnar Hultborn, Johanna Svensson, Olof Henrikson, Johan Mölne, Peter Gjertsson and Peter Bernhardt

    Citation: EJNMMI Research 2014 4:48

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  8. Content type: Original research

    Peptide receptor radionuclide therapy (PRRT) is an effective form of treatment for patients with metastatic neuroendocrine tumors (NETs). However, delivering sufficient radiation dose to the tumor to result in...

    Authors: David L Bushnell, Mark T. Madsen, Thomas O'cdorisio, Yusuf Menda, Saima Muzahir, Randi Ryan and M. Sue O'dorisio

    Citation: EJNMMI Research 2014 4:38

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  9. Content type: Original research

    The multitargeting tyrosine kinase inhibitor (TKI) sunitinib is currently the first-line drug therapy for metastasizing renal cell carcinoma (RCC). TKIs have profound effects on tumor angiogenesis, leading to ...

    Authors: David W Chapman, Hans-Sonke Jans, Ivy Ma, John R Mercer, Leonard I Wiebe, Melinda Wuest and Ronald B Moore

    Citation: EJNMMI Research 2014 4:27

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  10. Content type: Original research

    Glioblastoma, the most frequent and aggressive of all astrocytomas, presents a clear predominance in male humans, but the assessment of sexual differences in its tumourigenesis and growth has received little a...

    Authors: Rocío Pérez-Carro, Omar Cauli and Pilar López-Larrubia

    Citation: EJNMMI Research 2014 4:44

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  11. Content type: Original research

    Inhibition of mitogen-activated protein kinase (MEK, also known as MAPK2, MAPKK), a key molecule of the Ras/MAPK (mitogen-activated protein kinase) pathway, has shown promising effects on B-raf-mutated and some R...

    Authors: Tetyana Tegnebratt, Elisabeth Ruge, Sabine Bader, Nobuya Ishii, Satoshi Aida, Yasushi Yoshimura, Chia-Huey Ooi, Li Lu, Nicholas Mitsios, Valerie Meresse, Jan Mulder, Michael Pawlak, Miro Venturi, Jean Tessier and Sharon Stone-Elander

    Citation: EJNMMI Research 2014 4:34

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  12. Content type: Original research

    Targeted radionuclide therapy with high-energy beta-emitters is generally considered suboptimal to cure small tumours (<300 mg). Tumour targeting of the CCK2 receptor-binding minigastrin analogue PP-F11 was de...

    Authors: Mark W. Konijnenberg, Wout A. P. Breeman, Erik de Blois, Ho Sze Chan, Otto C. Boerman, Peter Laverman, Petra Kolenc-Peitl, Marleen Melis and Marion de Jong

    Citation: EJNMMI Research 2014 4:47

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  13. Content type: Original research

    Peptide receptor radionuclide therapy (PRRT) is routinely used for advanced or metastasized neuroendocrine tumours (NET). To prevent nephrotoxicity, positively charged amino acids (AA) are co-infused. The aim ...

    Authors: Constantin Lapa, Rudolf A Werner, Christina Bluemel, Katharina Lückerath, Andreas Schirbel, Alexander Strate, Andreas K Buck and Ken Herrmann

    Citation: EJNMMI Research 2014 4:46

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  14. Content type: Original research

    Staphylococcus epidermidis (S. epidermidis) has emerged as one of the leading pathogens of biomaterial-related infections. Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible endothelial molecule con...

    Authors: Helena Ahtinen, Julia Kulkova, Laura Lindholm, Erkki Eerola, Antti J Hakanen, Niko Moritz, Mirva Söderström, Tiina Saanijoki, Sirpa Jalkanen, Anne Roivainen and Hannu T Aro

    Citation: EJNMMI Research 2014 4:45

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  15. Content type: Preliminary research

    [18F]fluciclatide, a peptide ligand with high affinity for αvβ3/αvβ5 integrins, is a proposed biomarker of tumor angiogenesis. The study rationale was to perform a preliminary evaluation of the relationship betwe...

    Authors: Laura M Kenny, Giampaolo Tomasi, Federico Turkheimer, James Larkin, Martin Gore, Cathryn S Brock, Stephen Mangar and Eric O Aboagye

    Citation: EJNMMI Research 2014 4:30

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  16. Content type: Original research

    The α7 nicotinic acetylcholine receptor (nAChR) is an important molecular target in neuropsychiatry and oncology. Development of applicable highly specific radiotracers has been challenging due to comparably l...

    Authors: Sven Rötering, Winnie Deuther-Conrad, Paul Cumming, Cornelius K Donat, Matthias Scheunemann, Steffen Fischer, Guoming Xiong, Jörg Steinbach, Dan Peters, Osama Sabri, Jan Bucerius and Peter Brust

    Citation: EJNMMI Research 2014 4:43

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  17. Content type: Original research

    The aim of this pilot study was to evaluate whether the uptake of 89Zr-bevacizumab in non-small cell lung cancer (NSCLC) tumors could be visualized and quantified. The correlation between tumor 89Zr-bevacizumab u...

    Authors: Idris Bahce, Marc C Huisman, Eline E Verwer, Rogier Ooijevaar, Firdaouss Boutkourt, Danielle J Vugts, Guus AMS van Dongen, Ronald Boellaard and Egbert F Smit

    Citation: EJNMMI Research 2014 4:35

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  18. Content type: Original research

    The biology of the vulnerable plaque includes increased inflammation and rapid growth of vasa vasorum, processes that are associated with enhanced vascular endothelial growth factor (VEGF)/ imaging receptors f...

    Authors: Yared Tekabe, Maria Kollaros, Adam Zerihoun, Geping Zhang, Marina V Backer, Joseph M Backer and Lynne L Johnson

    Citation: EJNMMI Research 2014 4:41

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  19. Content type: Original research

    The trapping mechanisms of the PET hypoxia imaging agent copper(II)-diacetyl-bis(N4-methylthiosemicarbazone) (64Cu(ATSM)) remain unresolved, although its reduction prior to dissociation may be mediated by intrace...

    Authors: Fiona Shaughnessy, Erika Mariotti, Karen P Shaw, Thomas R Eykyn, Philip J Blower, Richard Siow and Richard Southworth

    Citation: EJNMMI Research 2014 4:40

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  20. Content type: Original research

    Heterogeneous ventilation in lungs of individuals with allergies, cigarette smokers, asthmatics and chronic obstructive pulmonary disease (COPD) patients has been demonstrated using imaging modalities such as ...

    Authors: Pernilla Norberg, Hans Lennart Persson, Birgitta Schmekel, Gudrun Alm Carlsson, Karl Wahlin, Michael Sandborg and Agnetha Gustafsson

    Citation: EJNMMI Research 2014 4:39

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  21. Content type: Original research

    The purpose of the study was to evaluate the applicability of 18 F-labelled amyloid imaging positron emission tomography (PET) agent [ 18 ...

    Authors: Anniina Snellman, Johanna Rokka, Francisco R López-Picón, Olli Eskola, Mario Salmona, Gianluigi Forloni, Mika Scheinin, Olof Solin, Juha O Rinne and Merja Haaparanta-Solin

    Citation: EJNMMI Research 2014 4:37

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  22. Content type: Original research

    With the increasing utilization of 68Ge-68Ga radionuclide generators, 68Ga labelled peptides like DOTATATE are receiving more attention in nuclear medicine. On the one hand, the long half-life of the parent nucli...

    Authors: Ferdinand Sudbrock, Thomas Fischer, Beate Zimmermanns, Mehrab Guliyev, Markus Dietlein, Alexander Drzezga and Klaus Schomäcker

    Citation: EJNMMI Research 2014 4:36

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  23. Content type: Original research

    Abnormal behaviors of young patients after taking the anti-influenza agent oseltamivir (Tamiflu®, F. Hoffmann-La Roche, Ltd., Basel, Switzerland) have been suspected as neuropsychiatric adverse events (NPAEs)....

    Authors: Chie Seki, Arata Oh-Nishi, Yuji Nagai, Takafumi Minamimoto, Shigeru Obayashi, Makoto Higuchi, Makoto Takei, Kenji Furutsuka, Takehito Ito, Ming-Rong Zhang, Hiroshi Ito, Mototsugu Ito, Sumito Ito, Hiroyuki Kusuhara, Yuichi Sugiyama and Tetsuya Suhara

    Citation: EJNMMI Research 2014 4:24

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  24. Content type: Original research

    For yttrium-90 (90Y) radioembolization, the common practice of assuming a standard 1,000-g lung mass for predictive dosimetry is fundamentally incongruent with the modern philosophy of personalized medicine. We r...

    Authors: Yung Hsiang Kao, Butch M Magsombol, Ying Toh, Kiang Hiong Tay, Pierce KH Chow, Anthony SW Goh and David CE Ng

    Citation: EJNMMI Research 2014 4:33

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  25. Content type: Original research

    To combine the sensitivity of bioluminescent imaging (BLI) with the 3D and quantitative properties of pinhole single-photon emission computed tomography (SPECT)/micro-computed tomography (CT) (phSPECT/micro-CT...

    Authors: Lode RY Goethals, Tomas J Bos, Luc Baeyens, Frank De Geeter, Nick Devoogdt and Tony Lahoutte

    Citation: EJNMMI Research 2014 4:32

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  26. Content type: Original research

    Various diseases derive from pathologically altered β-cells. Their function can be increased, leading to hyperinsulinism, or decreased, resulting in diabetes. Non-invasive imaging of the β-cell-specific glucag...

    Authors: Andreas Jodal, Brigitte Lankat-Buttgereit, Maarten Brom, Roger Schibli and Martin Béhé

    Citation: EJNMMI Research 2014 4:31

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  27. Content type: Original research

    Receptor for advanced glycated end product (RAGE) expression is a prominent feature of atherosclerosis. We have previously shown in apoE null mice uptake of a radiolabeled anti-RAGE antibody in atherosclerotic...

    Authors: Lynne L Johnson, Yared Tekabe, Maria Kollaros, George Eng, Ketan Bhatia, Chong Li, Christian G Krueger, Dhanansayan Shanmuganayagam and Ann Marie Schmidt

    Citation: EJNMMI Research 2014 4:26

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  28. Content type: Original research

    Cerebral stroke is a severe and frequent condition that requires rapid and reliable diagnosis. If administered shortly after the first symptoms manifest themselves, IV thrombolysis has been shown to increase t...

    Authors: Maria-Joao Ribeiro, Johnny Vercouillie, Severine Debiais, Jean-Philippe Cottier, Isabelle Bonnaud, Vincent Camus, Samuel Banister, Michael Kassiou, Nicolas Arlicot and Denis Guilloteau

    Citation: EJNMMI Research 2014 4:28

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  29. Content type: Original research

    ROBO1 is a membrane protein that functions in axon guidance. ROBO1 contributes to tumour metastasis and angiogenesis and may have potential as a target protein of immunotherapy because ROBO1 is specifically ex...

    Authors: Kentaro Fujiwara, Keitaro Koyama, Kosuke Suga, Masako Ikemura, Yasutaka Saito, Akihiro Hino, Hiroko Iwanari, Osamu Kusano-Arai, Kenichi Mitsui, Hiroyuki Kasahara, Masashi Fukayama, Tatsuhiko Kodama, Takao Hamakubo and Toshimitsu Momose

    Citation: EJNMMI Research 2014 4:29

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  30. Content type: Original research

    The aim of this study was to investigate the reproducibility of intra- and inter-observer interpretation of [18F]choline positron emission tomography/computed tomography examinations in patients suffering from bi...

    Authors: Clothilde Pegard, Céline Gallazzini-Crépin, Joris Giai, Julien Dubreuil, Cécile Caoduro, Marie-Dominique Desruet, Julie Roux, Alex Calizzano, Daniel Fagret, Chloé Lamesa, Hatem Boulahdour and Jean-Philippe Vuillez

    Citation: EJNMMI Research 2014 4:25

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  31. Content type: Original research

    The ability of recombinant antibodies to adequately penetrate into tumours is a key factor in achieving therapeutic effect; however, the behaviour of antibodies at a cellular level in tumours is poorly underst...

    Authors: Marika Ciprotti, Geoffrey Chong, Hui K Gan, Anthony Chan, Carmel Murone, Duncan MacGregor, Fook-Thean Lee, Terrance G Johns, Joan K Heath, Matthias Ernst, Antony W Burgess and Andrew M Scott

    Citation: EJNMMI Research 2014 4:22

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  32. Content type: Original research

    Previously, we reported on the unexpected development of distant metastases in the subcutaneous rat pancreas CA20948 tumor model after 4.5 weeks of treatment with RAD001-only or in combination with [177Lu-DOTA0,T...

    Authors: Sander M Bison, Stefan E Pool, Stuart J Koelewijn, Linda M van der Graaf, Harald C Groen, Marleen Melis and Marion de Jong

    Citation: EJNMMI Research 2014 4:21

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  33. Content type: Original Research

    The utility of 18 F-FDG and 11C-PBR28 to identify aortic wall inflammation associated with abdominal aortic aneurysm (AAA) development was assessed.

    Authors: Sean J English, Jose A Diaz, Xia Shao, David Gordon, Melissa Bevard, Gang Su, Peter K Henke, Virginia E Rogers, Gilbert R Upchurch and Morand Piert

    Citation: EJNMMI Research 2014 4:20

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  34. Content type: Original research

    This study was designed to explore the feasibility of replacing the conventional peri-/intratumoural ultrasound (US)-guided technetium-99m albumin nanocolloid (99mTc-nanocolloid) administration by an injection of...

    Authors: Bas Pouw, Linda J de Wit-van der Veen, Daan Hellingman, Oscar R Brouwer, Marie-Jeanne TFD Vrancken Peeters, Marcel PM Stokkel and Renato A Valdés Olmos

    Citation: EJNMMI Research 2014 4:19

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  35. Content type: Original research

    Standard uptake values (SUV) as well as tumor-to-blood standard uptake ratios (SUR) measured with [ 18F-]fluorodeoxyglucose (FDG) PET are time dependent. This poses a serious problem for reliable quantification s...

    Authors: Jörg van den Hoff, Alexandr Lougovski, Georg Schramm, Jens Maus, Liane Oehme, Jan Petr, Bettina Beuthien-Baumann, Jörg Kotzerke and Frank Hofheinz

    Citation: EJNMMI Research 2014 4:18

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  36. Content type: Original research

    Vascular endothelial growth factor receptor 2 (VEGFR2) is a crucial mediator of tumour angiogenesis. High expression levels of the receptor have been correlated to poor prognosis in cancer patients. Reliable i...

    Authors: Erik Samén, Li Lu, Jan Mulder, Jan-Olov Thorell, Peter Damberg, Tetyana Tegnebratt, Lars Holmgren, Helene Rundqvist and Sharon Stone-Elander

    Citation: EJNMMI Research 2014 4:17

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  37. Content type: Original research

    123I-CMICE-013 is a novel radiotracer previously reported to have promising characteristics for single-photon emission computed tomography (SPECT) myocardial perfusion imaging. We evaluated the biokinetics and ra...

    Authors: Yin Duan, Julia Lockwood, Lihui Wei, Chad Hunter, Karen Soueidan, Corinne Bensimon, Pasan Fernando, R Glenn Wells and Terrence D Ruddy

    Citation: EJNMMI Research 2014 4:16

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  38. Content type: Preliminary research

    Cerenkov luminescence imaging (CLI) is an emerging imaging technique where visible light emitted from injected beta-emitting radionuclides is detected with an optical imaging device. CLI research has mostly be...

    Authors: Jeffrey D Steinberg, Anandhkumar Raju, Prashant Chandrasekharan, Chang-Tong Yang, Karen Khoo, Jean-Pierre Abastado, Edward G Robins and David W Townsend

    Citation: EJNMMI Research 2014 4:15

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  39. Content type: Original research

    To date, the majority of protein-based radiopharmaceuticals have been radiolabelled using non-site-specific conjugation methods, with little or no control to ensure retained protein function post-labelling. Th...

    Authors: Adam Badar, Jennifer Williams, Rafael TM de Rosales, Richard Tavaré, Florian Kampmeier, Philip J Blower and Gregory ED Mullen

    Citation: EJNMMI Research 2014 4:14

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  40. Content type: Original research

    Sensitive and specific detection of nodal status, sites of metastases and low-volume recurrent disease could greatly improve management of patients with advanced prostate cancer. Prostate-specific membrane ant...

    Authors: Florian Kampmeier, Jennifer D Williams, John Maher, Gregory E Mullen and Philip J Blower

    Citation: EJNMMI Research 2014 4:13

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  41. Content type: Original research

    The objective of this study is to investigate the feasibility and the additional interest of a parametric imaging (PI) method to monitor the early tumour metabolic response in a prospective series of oesophage...

    Authors: Pierre Vera, Bernard Dubray, Odré Palie, Irène Buvat, Sébastien Hapdey, Romain Modzelewski, Ahmed Benyoucef, Caroline Rousseau, Marc-Etienne Meyer, Stéphane Bardet, Isabelle Gardin, Frederic Di Fiore and Pierre Michel

    Citation: EJNMMI Research 2014 4:12

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  42. Content type: Original research

    Patients with squamous cell carcinoma in the head and neck region (HNSCC) offer a diagnostic challenge due to difficulties to detect small tumours and metastases. Imaging methods available are not sufficient, ...

    Authors: Anna-Karin Haylock, Diana Spiegelberg, Johan Nilvebrant, Karl Sandström and Marika Nestor

    Citation: EJNMMI Research 2014 4:11

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  43. Content type: Original research

    4′-[methyl-11C]-thiothymidine (4DST) is a novel positron emission tomography (PET) tracer to assess proliferation of malignancy. The diagnostic abilities of 4DST and 2-deoxy-2-18 F-fluoro-d-glucose (FDG) for dete...

    Authors: Ryogo Minamimoto, Jun Toyohara, Hideyuki Ito, Ayako Seike, Yoko Miyata, Miyako Morooka, Momoko Okasaki, Kazuhiko Nakajima, Kimiteru Ito, Kiichi Ishiwata and Kazuo Kubota

    Citation: EJNMMI Research 2014 4:10

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  44. Content type: Original research

    Neuroendocrine tumors are well vascularized and express specific cell surface markers, such as somatostatin receptors and the glucagon-like peptide-1 receptor (GLP-1R). Using the Rip1Tag2 transgenic mouse mode...

    Authors: Andreas Wicki, Damian Wild, Vincent Prêtre, Rosalba Mansi, Annette Orleth, Jean-Claude Reubi, Christoph Rochlitz, Christoph Mamot, Helmut R Mäcke and Gerhard Christofori

    Citation: EJNMMI Research 2014 4:9

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  45. Content type: Original research

    Positron emission tomography (PET) scanning with [18 F]fluorodeoxyglucose (18 F-FDG) is a useful diagnostic and prediction tool in brain tumors, but its value in childhood diffuse intrinsic pontine glioma (DIPG) ...

    Authors: Marc H A Jansen, Reina W Kloet, Dannis G van Vuurden, Sophie EM Veldhuijzen van Zanten, Birgit I Witte, Serge Goldman, W Peter Vandertop, Emile FI Comans, Otto S Hoekstra, Ronald Boellaard and Gert-Jan JL Kaspers

    Citation: EJNMMI Research 2014 4:8

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  46. Content type: Original research

    Quantitative measures of 11C-raclopride receptor binding can be used as a correlate of postsynaptic D2 receptor density in the striatum, allowing 11C-raclopride positron emission tomography (PET) to be used for t...

    Authors: Felix P Kuhn, Geoffrey I Warnock, Cyrill Burger, Katharina Ledermann, Chantal Martin-Soelch and Alfred Buck

    Citation: EJNMMI Research 2014 4:7

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  47. Content type: Original research

    The purpose of this study was to assess the relationship of CT-perfusion (CTP), 18F-FDG-PET/CT and histological parameters, and the possible added value of CTP to FDG-PET/CT in the initial staging of lung cancer.

    Authors: Martin W Huellner, Timothy D Collen, Philipp Gut, Ralph Winterhalder, Chantal Pauli, Joachim Diebold, Burkhardt Seifert, Klaus Strobel and Patrick Veit-Haibach

    Citation: EJNMMI Research 2014 4:6

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  48. Content type: Original research

    In an effort to reduce necessary acquisition time to perform molecular breast imaging (MBI), we compared diagnostic performance of MBI performed with standard 10-min-per-view acquisitions and half-time 5-min-p...

    Authors: Carrie B Hruska, Amy Lynn Conners, Katie N Jones, Amanda L Weinmann, Ravi K Lingineni, Rickey E Carter, Deborah J Rhodes and Michael K O’Connor

    Citation: EJNMMI Research 2014 4:5

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