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  1. Content type: Original research

    The biology of the vulnerable plaque includes increased inflammation and rapid growth of vasa vasorum, processes that are associated with enhanced vascular endothelial growth factor (VEGF)/ imaging receptors f...

    Authors: Yared Tekabe, Maria Kollaros, Adam Zerihoun, Geping Zhang, Marina V Backer, Joseph M Backer and Lynne L Johnson

    Citation: EJNMMI Research 2014 4:41

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  2. Content type: Original research

    Heterogeneous ventilation in lungs of individuals with allergies, cigarette smokers, asthmatics and chronic obstructive pulmonary disease (COPD) patients has been demonstrated using imaging modalities such as ...

    Authors: Pernilla Norberg, Hans Lennart Persson, Birgitta Schmekel, Gudrun Alm Carlsson, Karl Wahlin, Michael Sandborg and Agnetha Gustafsson

    Citation: EJNMMI Research 2014 4:39

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  3. Content type: Original research

    The purpose of the study was to evaluate the applicability of 18 F-labelled amyloid imaging positron emission tomography (PET) agent [ 18 ...

    Authors: Anniina Snellman, Johanna Rokka, Francisco R López-Picón, Olli Eskola, Mario Salmona, Gianluigi Forloni, Mika Scheinin, Olof Solin, Juha O Rinne and Merja Haaparanta-Solin

    Citation: EJNMMI Research 2014 4:37

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  4. Content type: Original research

    With the increasing utilization of 68Ge-68Ga radionuclide generators, 68Ga labelled peptides like DOTATATE are receiving more attention in nuclear medicine. On the one hand, the long half-life of the parent nucli...

    Authors: Ferdinand Sudbrock, Thomas Fischer, Beate Zimmermanns, Mehrab Guliyev, Markus Dietlein, Alexander Drzezga and Klaus Schomäcker

    Citation: EJNMMI Research 2014 4:36

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  5. Content type: Original research

    Abnormal behaviors of young patients after taking the anti-influenza agent oseltamivir (Tamiflu®, F. Hoffmann-La Roche, Ltd., Basel, Switzerland) have been suspected as neuropsychiatric adverse events (NPAEs)....

    Authors: Chie Seki, Arata Oh-Nishi, Yuji Nagai, Takafumi Minamimoto, Shigeru Obayashi, Makoto Higuchi, Makoto Takei, Kenji Furutsuka, Takehito Ito, Ming-Rong Zhang, Hiroshi Ito, Mototsugu Ito, Sumito Ito, Hiroyuki Kusuhara, Yuichi Sugiyama and Tetsuya Suhara

    Citation: EJNMMI Research 2014 4:24

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  6. Content type: Original research

    For yttrium-90 (90Y) radioembolization, the common practice of assuming a standard 1,000-g lung mass for predictive dosimetry is fundamentally incongruent with the modern philosophy of personalized medicine. We r...

    Authors: Yung Hsiang Kao, Butch M Magsombol, Ying Toh, Kiang Hiong Tay, Pierce KH Chow, Anthony SW Goh and David CE Ng

    Citation: EJNMMI Research 2014 4:33

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  7. Content type: Original research

    To combine the sensitivity of bioluminescent imaging (BLI) with the 3D and quantitative properties of pinhole single-photon emission computed tomography (SPECT)/micro-computed tomography (CT) (phSPECT/micro-CT...

    Authors: Lode RY Goethals, Tomas J Bos, Luc Baeyens, Frank De Geeter, Nick Devoogdt and Tony Lahoutte

    Citation: EJNMMI Research 2014 4:32

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  8. Content type: Original research

    Various diseases derive from pathologically altered β-cells. Their function can be increased, leading to hyperinsulinism, or decreased, resulting in diabetes. Non-invasive imaging of the β-cell-specific glucag...

    Authors: Andreas Jodal, Brigitte Lankat-Buttgereit, Maarten Brom, Roger Schibli and Martin Béhé

    Citation: EJNMMI Research 2014 4:31

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  9. Content type: Original research

    Receptor for advanced glycated end product (RAGE) expression is a prominent feature of atherosclerosis. We have previously shown in apoE null mice uptake of a radiolabeled anti-RAGE antibody in atherosclerotic...

    Authors: Lynne L Johnson, Yared Tekabe, Maria Kollaros, George Eng, Ketan Bhatia, Chong Li, Christian G Krueger, Dhanansayan Shanmuganayagam and Ann Marie Schmidt

    Citation: EJNMMI Research 2014 4:26

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  10. Content type: Original research

    Cerebral stroke is a severe and frequent condition that requires rapid and reliable diagnosis. If administered shortly after the first symptoms manifest themselves, IV thrombolysis has been shown to increase t...

    Authors: Maria-Joao Ribeiro, Johnny Vercouillie, Severine Debiais, Jean-Philippe Cottier, Isabelle Bonnaud, Vincent Camus, Samuel Banister, Michael Kassiou, Nicolas Arlicot and Denis Guilloteau

    Citation: EJNMMI Research 2014 4:28

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  11. Content type: Original research

    ROBO1 is a membrane protein that functions in axon guidance. ROBO1 contributes to tumour metastasis and angiogenesis and may have potential as a target protein of immunotherapy because ROBO1 is specifically ex...

    Authors: Kentaro Fujiwara, Keitaro Koyama, Kosuke Suga, Masako Ikemura, Yasutaka Saito, Akihiro Hino, Hiroko Iwanari, Osamu Kusano-Arai, Kenichi Mitsui, Hiroyuki Kasahara, Masashi Fukayama, Tatsuhiko Kodama, Takao Hamakubo and Toshimitsu Momose

    Citation: EJNMMI Research 2014 4:29

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  12. Content type: Original research

    The aim of this study was to investigate the reproducibility of intra- and inter-observer interpretation of [18F]choline positron emission tomography/computed tomography examinations in patients suffering from bi...

    Authors: Clothilde Pegard, Céline Gallazzini-Crépin, Joris Giai, Julien Dubreuil, Cécile Caoduro, Marie-Dominique Desruet, Julie Roux, Alex Calizzano, Daniel Fagret, Chloé Lamesa, Hatem Boulahdour and Jean-Philippe Vuillez

    Citation: EJNMMI Research 2014 4:25

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  13. Content type: Original research

    The ability of recombinant antibodies to adequately penetrate into tumours is a key factor in achieving therapeutic effect; however, the behaviour of antibodies at a cellular level in tumours is poorly underst...

    Authors: Marika Ciprotti, Geoffrey Chong, Hui K Gan, Anthony Chan, Carmel Murone, Duncan MacGregor, Fook-Thean Lee, Terrance G Johns, Joan K Heath, Matthias Ernst, Antony W Burgess and Andrew M Scott

    Citation: EJNMMI Research 2014 4:22

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  14. Content type: Original research

    Previously, we reported on the unexpected development of distant metastases in the subcutaneous rat pancreas CA20948 tumor model after 4.5 weeks of treatment with RAD001-only or in combination with [177Lu-DOTA0,T...

    Authors: Sander M Bison, Stefan E Pool, Stuart J Koelewijn, Linda M van der Graaf, Harald C Groen, Marleen Melis and Marion de Jong

    Citation: EJNMMI Research 2014 4:21

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  15. Content type: Original Research

    The utility of 18 F-FDG and 11C-PBR28 to identify aortic wall inflammation associated with abdominal aortic aneurysm (AAA) development was assessed.

    Authors: Sean J English, Jose A Diaz, Xia Shao, David Gordon, Melissa Bevard, Gang Su, Peter K Henke, Virginia E Rogers, Gilbert R Upchurch and Morand Piert

    Citation: EJNMMI Research 2014 4:20

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  16. Content type: Original research

    This study was designed to explore the feasibility of replacing the conventional peri-/intratumoural ultrasound (US)-guided technetium-99m albumin nanocolloid (99mTc-nanocolloid) administration by an injection of...

    Authors: Bas Pouw, Linda J de Wit-van der Veen, Daan Hellingman, Oscar R Brouwer, Marie-Jeanne TFD Vrancken Peeters, Marcel PM Stokkel and Renato A Valdés Olmos

    Citation: EJNMMI Research 2014 4:19

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  17. Content type: Original research

    Standard uptake values (SUV) as well as tumor-to-blood standard uptake ratios (SUR) measured with [ 18F-]fluorodeoxyglucose (FDG) PET are time dependent. This poses a serious problem for reliable quantification s...

    Authors: Jörg van den Hoff, Alexandr Lougovski, Georg Schramm, Jens Maus, Liane Oehme, Jan Petr, Bettina Beuthien-Baumann, Jörg Kotzerke and Frank Hofheinz

    Citation: EJNMMI Research 2014 4:18

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  18. Content type: Original research

    Vascular endothelial growth factor receptor 2 (VEGFR2) is a crucial mediator of tumour angiogenesis. High expression levels of the receptor have been correlated to poor prognosis in cancer patients. Reliable i...

    Authors: Erik Samén, Li Lu, Jan Mulder, Jan-Olov Thorell, Peter Damberg, Tetyana Tegnebratt, Lars Holmgren, Helene Rundqvist and Sharon Stone-Elander

    Citation: EJNMMI Research 2014 4:17

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  19. Content type: Original research

    123I-CMICE-013 is a novel radiotracer previously reported to have promising characteristics for single-photon emission computed tomography (SPECT) myocardial perfusion imaging. We evaluated the biokinetics and ra...

    Authors: Yin Duan, Julia Lockwood, Lihui Wei, Chad Hunter, Karen Soueidan, Corinne Bensimon, Pasan Fernando, R Glenn Wells and Terrence D Ruddy

    Citation: EJNMMI Research 2014 4:16

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  20. Content type: Preliminary research

    Cerenkov luminescence imaging (CLI) is an emerging imaging technique where visible light emitted from injected beta-emitting radionuclides is detected with an optical imaging device. CLI research has mostly be...

    Authors: Jeffrey D Steinberg, Anandhkumar Raju, Prashant Chandrasekharan, Chang-Tong Yang, Karen Khoo, Jean-Pierre Abastado, Edward G Robins and David W Townsend

    Citation: EJNMMI Research 2014 4:15

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  21. Content type: Original research

    To date, the majority of protein-based radiopharmaceuticals have been radiolabelled using non-site-specific conjugation methods, with little or no control to ensure retained protein function post-labelling. Th...

    Authors: Adam Badar, Jennifer Williams, Rafael TM de Rosales, Richard Tavaré, Florian Kampmeier, Philip J Blower and Gregory ED Mullen

    Citation: EJNMMI Research 2014 4:14

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  22. Content type: Original research

    Sensitive and specific detection of nodal status, sites of metastases and low-volume recurrent disease could greatly improve management of patients with advanced prostate cancer. Prostate-specific membrane ant...

    Authors: Florian Kampmeier, Jennifer D Williams, John Maher, Gregory E Mullen and Philip J Blower

    Citation: EJNMMI Research 2014 4:13

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  23. Content type: Original research

    The objective of this study is to investigate the feasibility and the additional interest of a parametric imaging (PI) method to monitor the early tumour metabolic response in a prospective series of oesophage...

    Authors: Pierre Vera, Bernard Dubray, Odré Palie, Irène Buvat, Sébastien Hapdey, Romain Modzelewski, Ahmed Benyoucef, Caroline Rousseau, Marc-Etienne Meyer, Stéphane Bardet, Isabelle Gardin, Frederic Di Fiore and Pierre Michel

    Citation: EJNMMI Research 2014 4:12

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  24. Content type: Original research

    Patients with squamous cell carcinoma in the head and neck region (HNSCC) offer a diagnostic challenge due to difficulties to detect small tumours and metastases. Imaging methods available are not sufficient, ...

    Authors: Anna-Karin Haylock, Diana Spiegelberg, Johan Nilvebrant, Karl Sandström and Marika Nestor

    Citation: EJNMMI Research 2014 4:11

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  25. Content type: Original research

    4′-[methyl-11C]-thiothymidine (4DST) is a novel positron emission tomography (PET) tracer to assess proliferation of malignancy. The diagnostic abilities of 4DST and 2-deoxy-2-18 F-fluoro-d-glucose (FDG) for dete...

    Authors: Ryogo Minamimoto, Jun Toyohara, Hideyuki Ito, Ayako Seike, Yoko Miyata, Miyako Morooka, Momoko Okasaki, Kazuhiko Nakajima, Kimiteru Ito, Kiichi Ishiwata and Kazuo Kubota

    Citation: EJNMMI Research 2014 4:10

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  26. Content type: Original research

    Neuroendocrine tumors are well vascularized and express specific cell surface markers, such as somatostatin receptors and the glucagon-like peptide-1 receptor (GLP-1R). Using the Rip1Tag2 transgenic mouse mode...

    Authors: Andreas Wicki, Damian Wild, Vincent Prêtre, Rosalba Mansi, Annette Orleth, Jean-Claude Reubi, Christoph Rochlitz, Christoph Mamot, Helmut R Mäcke and Gerhard Christofori

    Citation: EJNMMI Research 2014 4:9

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  27. Content type: Original research

    Positron emission tomography (PET) scanning with [18 F]fluorodeoxyglucose (18 F-FDG) is a useful diagnostic and prediction tool in brain tumors, but its value in childhood diffuse intrinsic pontine glioma (DIPG) ...

    Authors: Marc H A Jansen, Reina W Kloet, Dannis G van Vuurden, Sophie EM Veldhuijzen van Zanten, Birgit I Witte, Serge Goldman, W Peter Vandertop, Emile FI Comans, Otto S Hoekstra, Ronald Boellaard and Gert-Jan JL Kaspers

    Citation: EJNMMI Research 2014 4:8

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  28. Content type: Original research

    Quantitative measures of 11C-raclopride receptor binding can be used as a correlate of postsynaptic D2 receptor density in the striatum, allowing 11C-raclopride positron emission tomography (PET) to be used for t...

    Authors: Felix P Kuhn, Geoffrey I Warnock, Cyrill Burger, Katharina Ledermann, Chantal Martin-Soelch and Alfred Buck

    Citation: EJNMMI Research 2014 4:7

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  29. Content type: Original research

    The purpose of this study was to assess the relationship of CT-perfusion (CTP), 18F-FDG-PET/CT and histological parameters, and the possible added value of CTP to FDG-PET/CT in the initial staging of lung cancer.

    Authors: Martin W Huellner, Timothy D Collen, Philipp Gut, Ralph Winterhalder, Chantal Pauli, Joachim Diebold, Burkhardt Seifert, Klaus Strobel and Patrick Veit-Haibach

    Citation: EJNMMI Research 2014 4:6

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  30. Content type: Original research

    In an effort to reduce necessary acquisition time to perform molecular breast imaging (MBI), we compared diagnostic performance of MBI performed with standard 10-min-per-view acquisitions and half-time 5-min-p...

    Authors: Carrie B Hruska, Amy Lynn Conners, Katie N Jones, Amanda L Weinmann, Ravi K Lingineni, Rickey E Carter, Deborah J Rhodes and Michael K O’Connor

    Citation: EJNMMI Research 2014 4:5

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  31. Content type: Preliminary research

    Florbetapir is one of several 18F-labeled amyloid plaque imaging tracers for positron emission tomography (PET). As the bio-distribution and radiation dose of PET tracers in human research are important for estim...

    Authors: Abhinay D Joshi, Michael J Pontecorvo, Lee Adler, Michael G Stabin, Daniel M Skovronsky, Alan P Carpenter and Mark A Mintun

    Citation: EJNMMI Research 2014 4:4

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  32. Content type: Original research

    We observed a disproportional 18 F-fluorothymidine (F-FLT) uptake in follicular lymphoma (FL) relative to its low cell proliferation. We tested the hypothesis that the ‘excess’ uptake of 18 F-FLT in FL is rela...

    Authors: Marielle J Wondergem, Ken Herrmann, Sergei Syrbu, Josée M Zijlstra, Nikie Hoetjes, Otto S Hoekstra, Saskia AGM Cillessen, Laura M Moesbergen, Andreas K Buck, Julie M Vose and Malik E Juweid

    Citation: EJNMMI Research 2014 4:3

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  33. Content type: Original research

    The lupus-associated (La)-specific murine monoclonal antibody DAB4 (APOMAB®) specifically binds dead cancer cells. Using DAB4, we examined La expression in human lung cancer samples to assess its suitability a...

    Authors: Alexander H Staudacher, Fares Al-Ejeh, Cara K Fraser, Jocelyn M Darby, David M Roder, Andrew Ruszkiewicz, Jim Manavis and Michael P Brown

    Citation: EJNMMI Research 2014 4:2

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  34. Content type: Original research

    F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising modality for detecting active lesions of cardiac sarcoidosis (CS). However, determining whether 18F-FDG uptake in the myocardium is phy...

    Authors: Miyako Morooka, Masao Moroi, Kimiichi Uno, Kimiteru Ito, Jin Wu, Takashi Nakagawa, Kazuo Kubota, Ryogo Minamimoto, Yoko Miyata, Momoko Okasaki, Osamu Okazaki, Yoshihito Yamada, Tetsuo Yamaguchi and Michiaki Hiroe

    Citation: EJNMMI Research 2014 4:1

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  35. Content type: Original research

    While non-rigid fusion is by definition expected to alter the information of positron emission tomography (PET) data, we assessed whether rigid transformation also influences metabolic tumor volume (MTV) deter...

    Authors: Ingo G Steffen, Frank Hofheinz, Julian MM Rogasch, Christian Furth, Holger Amthauer and Juri Ruf

    Citation: EJNMMI Research 2013 3:85

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  36. Content type: Original research

    We present a method for extracting arterial input functions from dynamic [18F]FLT PET images of the head and neck, directly accounting for the partial volume effect. The method uses two blood samples, for which t...

    Authors: Sara L Hackett, Dan Liu, Anastasia Chalkidou, Paul Marsden, David Landau and John D Fenwick

    Citation: EJNMMI Research 2013 3:84

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  37. Content type: Original research

    Artificial neural network (ANN)-based bone scan index (BSI), a marker of the amount of bone metastasis, has been shown to enhance diagnostic accuracy and reproducibility but is potentially affected by training...

    Authors: Kenichi Nakajima, Yasuo Nakajima, Hiroyuki Horikoshi, Munehisa Ueno, Hiroshi Wakabayashi, Tohru Shiga, Mana Yoshimura, Eiji Ohtake, Yoshifumi Sugawara, Hideyasu Matsuyama and Lars Edenbrandt

    Citation: EJNMMI Research 2013 3:83

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  38. Content type: Original research

    Peptide receptor radionuclide therapy (PRRT) with 177Lu-[DOTA0,Tyr3]octreotate (177Lu-octreotate) is generally performed using a fixed activity of 7.4 GBq (200 mCi) per course bound to 180 to 300 μg of the peptid...

    Authors: Amir Sabet, James Nagarajah, Ahmet Semih Dogan, Hans-Jürgen Biersack, Amin Sabet, Stefan Guhlke and Samer Ezziddin

    Citation: EJNMMI Research 2013 3:82

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  39. Content type: Original research

    Circumferential pulmonary vein isolation (PVI) is the cornerstone of the current state-of-the-art management of atrial fibrillation (AF). However, the precise mechanisms behind AF relapses post PVI are still u...

    Authors: Christian Wenning, Philipp S Lange, Christoph Schülke, Alexis Vrachimis, Gerold Mönnig, Otmar Schober, Lars Eckardt and Michael Schäfers

    Citation: EJNMMI Research 2013 3:81

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  40. Content type: Original research

    Sigma2 (σ2) receptors are highly expressed in cancer cell lines and in tumours. Two novel selective 18F-phthalimido σ2 ligands, 18F-SIG343 and 18F-SIG353, were prepared and characterised for their potential tumou...

    Authors: Vu H Nguyen, Tien Pham, Chris Fookes, Paula Berghofer, Ivan Greguric, Andrew Arthur, Filomena Mattner, Gita Rahardjo, Emma Davis, Nicholas Howell, Marie-Claude Gregoire, Andrew Katsifis and Rachael Shepherd

    Citation: EJNMMI Research 2013 3:80

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  41. Content type: Original research

    The aim of this randomised pilot study was to investigate the haemodynamic effects measured by oxygen-15 positron emission tomography (PET) of interventional treatment consisting of either endarterectomy or en...

    Authors: Suzanne Persoon, Bart NM van Berckel, Jochem P Bremmer, Ronald Boellaard, Ale Algra, Gert Jan de Borst, Adriaan A Lammertsma, L Jaap Kappelle and Catharina JM Klijn

    Citation: EJNMMI Research 2013 3:79

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  42. Content type: Original research

    [11C]Befloxatone measures the density of the enzyme monoamine oxidase A (MAO-A) in the brain. MAO-A is responsible for the degradation of different neurotransmitters and is implicated in several neurologic and ps...

    Authors: Paolo Zanotti-Fregonara, Claire Leroy, Dimitri Roumenov, Christian Trichard, Jean-Luc Martinot and Michel Bottlaender

    Citation: EJNMMI Research 2013 3:78

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  43. Content type: Original research

    The standard uptake value (SUV) approach in oncological positron emission tomography has known shortcomings, all of which affect the reliability of the SUV as a surrogate of the targeted quantity, the metaboli...

    Authors: Jörg van den Hoff, Liane Oehme, Georg Schramm, Jens Maus, Alexandr Lougovski, Jan Petr, Bettina Beuthien-Baumann and Frank Hofheinz

    Citation: EJNMMI Research 2013 3:77

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  44. Content type: Original research

    Recently, we reported an information density theory and an analysis of three-parameter plus shorter scan than conventional method (3P+) for the amyloid-binding ligand [11C]Pittsburgh compound B (PIB) as an exampl...

    Authors: Koichi Sato, Kiyoshi Fukushi, Hitoshi Shinotoh, Hitoshi Shimada, Shigeki Hirano, Noriko Tanaka, Tetsuya Suhara, Toshiaki Irie and Hiroshi Ito

    Citation: EJNMMI Research 2013 3:76

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  45. Content type: Original research

    Image-based diagnosis of tumours can be advanced and improved by targeted strategies addressing malignant molecular structures. A promising molecular target is the cholecystokinin-2-receptor (CCK2R) which can ...

    Authors: Susanne Kossatz, Rosalba Mansi, Martin Béhé, Peter Czerney and Ingrid Hilger

    Citation: EJNMMI Research 2013 3:75

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  46. Content type: Original research

    The Langendorff perfused heart is a physiologically relevant and controllable model with potential for assessing the pharmacokinetics of new radiotracers under a range of pathophysiological conditions.. We ass...

    Authors: Erika Mariotti, Mattia Veronese, Joel T Dunn, Rodolfo A Medina, Philip J Blower, Richard Southworth and Thomas R Eykyn

    Citation: EJNMMI Research 2013 3:74

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  47. Content type: Original research

    The radiopharmaceutical 131I-metaiodobenzylguanidine (131I-MIBG) is used for the targeted radiotherapy of noradrenaline transporter (NAT)-expressing neuroblastoma. Enhancement of 131I-MIBG's efficacy is achieved ...

    Authors: Colin Rae, Mathias Tesson, John W Babich, Marie Boyd and Robert J Mairs

    Citation: EJNMMI Research 2013 3:73

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  48. Content type: Original research

    Stem cell therapy has a promising potential for the curing of various degenerative diseases, including congestive heart failure (CHF). In this study, we determined the efficacy of different delivery methods fo...

    Authors: Esmat Elhami, Bryson Dietz, Bo Xiang, Jixian Deng, Fei Wang, Chao Chi, Andrew L Goertzen, Shadreck Mzengeza, Darren Freed, Rakesh C Arora and Ganghong Tian

    Citation: EJNMMI Research 2013 3:72

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