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  1. Galectin-3 is a ß-galactoside-binding lectin expressed in most of tissues in normal conditions and overexpressed in myocardium from early stages of heart failure (HF). It is an established biomarker associated...

    Authors: Teresa Arias, Artiom Petrov, Jiqiu Chen, Hans de Haas, Carlos Pérez-Medina, Gustav J Strijkers, Roger J Hajjar, Zahi A Fayad, Valentín Fuster and Jagat Narula

    Citation: EJNMMI Research 2014 4:75

    Content type: Original research

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  2. The ability to quantify the capacity of a central nervous system (CNS) drug to cross the human blood-brain barrier (BBB) provides valuable information for de-risking drug development of new molecules. Here, we...

    Authors: Khanum Ridler, Vincent Cunningham, Mickael Huiban, Laurent Martarello, Sabina Pampols-Maso, Jan Passchier, Roger N Gunn, Graham Searle, Anissa Abi-Dargham, Mark Slifstein, Jeanette Watson, Marc Laruelle and Eugenii A Rabiner

    Citation: EJNMMI Research 2014 4:66

    Content type: Original research

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  3. We have explored the possibility that the serotonin 1B receptor radioligand [11C]AZ10419369 is a substrate for adenosine triphosphate (ATP)-binding cassette (ABC) transporters, such as P-glycoprotein (P-gp), Mrp4...

    Authors: Miklós Tóth, Jenny Häggkvist, Andrea Varrone, Sjoerd J Finnema, Janine Doorduin, Masaki Tokunaga, Makoto Higuchi, Balázs Gulyás and Christer Halldin

    Citation: EJNMMI Research 2014 4:64

    Content type: Original research

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  4. The serotonin precursor 5-hydroxy-l-[β-11C]tryptophan ([11C]HTP) is in clinical use for localization of neuroendocrine tumors and has been suggested as a proxy marker for pancreatic islet cells. However, degradat...

    Authors: Jonas Eriksson, Ola Åberg, Ram Kumar Selvaraju, Gunnar Antoni, Lars Johansson and Olof Eriksson

    Citation: EJNMMI Research 2014 4:62

    Content type: Original research

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  5. Due to its high expression in prostate cancer, PSMA (prostate-specific membrane antigen) represents an ideal target for both diagnostic imaging and endoradiotherapeutic approaches. Based on a previously publis...

    Authors: Martina Weineisen, Jakub Simecek, Margret Schottelius, Markus Schwaiger and Hans-Jürgen Wester

    Citation: EJNMMI Research 2014 4:63

    Content type: Original research

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  6. Three-dimensional (3D) hydrogel-based stem cell therapies contribute to enhanced therapeutic efficacy in treating diseases, and determining the optimal mechanical strength of the hydrogel in vivo is important for...

    Authors: Do Won Hwang, Kyung Min Park, Hye-kyung Shim, Yeona Jin, Hyun Jeong Oh, So Won Oh, Song Lee, Hyewon Youn, Yoon Ki Joung, Hong J Lee, Seung U Kim, Ki Dong Park and Dong Soo Lee

    Citation: EJNMMI Research 2014 4:61

    Content type: Original research

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  7. Epithelial ovarian cancer (EOC) is characterized by the overexpression of cancer antigen 125 (CA125), a mucinous glycoprotein that serves as a tumor biomarker. Early diagnosis of EOC is plagued by its asymptom...

    Authors: Sai Kiran Sharma, Melinda Wuest, Monica Wang, Darryl Glubrecht, Bonnie Andrais, Suzanne E Lapi and Frank Wuest

    Citation: EJNMMI Research 2014 4:60

    Content type: Original research

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  8. The kidneys are regarded as one of the main dose-limiting organs in the treatment of neuroendocrine tumours with 177Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate), despite the successful use of kidney uptake bloc...

    Authors: Johanna Dalmo, Emelie Westberg, Lars Barregard, Lisa Svedbom, Martin Johansson, Margareta Törnqvist and Eva Forssell-Aronsson

    Citation: EJNMMI Research 2014 4:59

    Content type: Original research

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  9. Bone Scan Index (BSI) is a quantitative measurement of tumour burden in the skeleton calculated from bone scan images. When analysed at the time of diagnosis,it has been shown to provide prognostic information...

    Authors: Mariana Reza, Anders Bjartell, Mattias Ohlsson, Reza Kaboteh, Per Wollmer, Lars Edenbrandt and Elin Trägårdh

    Citation: EJNMMI Research 2014 4:58

    Content type: Original research

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  10. In vivo bioluminescence, fluorescence, and single-photon emission computed tomography (SPECT) imaging provide complementary information about biological processes. However, to date these signatures are evaluated ...

    Authors: Matthias N van Oosterom, Rob Kreuger, Tessa Buckle, Wendy A Mahn, Anton Bunschoten, Lee Josephson, Fijs WB van Leeuwen and Freek J Beekman

    Citation: EJNMMI Research 2014 4:56

    Content type: Original research

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  11. Hepatic mitochondrial dysfunction has been implicated in pathological conditions leading to non-alcoholic steatohepatitis (NASH). Technetium-99 m-2-methoxyisobutyl-isonitrile (99mTc-MIBI), a lipophilic cationic m...

    Authors: Takemi Rokugawa, Tomoya Uehara, Yusuke Higaki, Shuuichi Matsushima, Atsushi Obata, Yasushi Arano and Kohji Abe

    Citation: EJNMMI Research 2014 4:57

    Content type: Original research

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  12. Radiation treatment with simultaneous integrated boost against suspected lymph node metastases may be a curative therapeutic option in patients with high-risk prostate cancer (>15% estimated risk of pelvic lym...

    Authors: Sara Strandberg, Camilla Thellenberg Karlsson, Torbjörn Sundström, Mattias Ögren, Margareta Ögren, Jan Axelsson and Katrine Riklund

    Citation: EJNMMI Research 2014 4:55

    Content type: Original research

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  13. Dopamine D2/3 receptor (D2/3R) agonist radiopharmaceuticals are considered superior to antagonists to detect dopamine release, e.g. induced by amphetamines. Agonists bind preferentially to the high-affinity state...

    Authors: Jan-Peter van Wieringen, Martin C Michel, Henk M Janssen, Anton G Janssen, Philip H Elsinga and Jan Booij

    Citation: EJNMMI Research 2014 4:53

    Content type: Original research

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  14. Today's standard treatment of advanced-stage ovarian cancer, including surgery followed by a paclitaxel-platinum-based chemotherapy, is limited in efficacy. Recently, we could show that radioimmunotherapy (RIT...

    Authors: Dennis Lindenblatt, Eliane Fischer, Susan Cohrs, Roger Schibli and Jürgen Grünberg

    Citation: EJNMMI Research 2014 4:54

    Content type: Original research

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  15. The aims of this study were to determine the optimal tracer kinetic model for [11C]-meta- hydroxyephedrine ([11C]HED) and to evaluate the performance of several simplified methods.

    Authors: Hendrik J Harms, Stefan de Haan, Paul Knaapen, Cornelis P Allaart, Mischa T Rijnierse, Robert C Schuit, Albert D Windhorst, Adriaan A Lammertsma, Marc C Huisman and Mark Lubberink

    Citation: EJNMMI Research 2014 4:52

    Content type: Original research

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  16. Development of tracers for imaging with positron emission tomography (PET) is often a time-consuming process associated with considerable attrition. In an effort to simplify this process, we herein propose a m...

    Authors: Markus Fridén, Marie Wennerberg, Madeleine Antonsson, Maria Sandberg-Ställ, Lars Farde and Magnus Schou

    Citation: EJNMMI Research 2014 4:50

    Content type: Original research

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  17. Prostate cancer is a leading cause of death in the male population of the western world. Human kallikrein-related peptidase 2 (hK2) is abundantly expressed in malignant prostatic tissue, and its gene, KLK2, is re...

    Authors: Oskar Vilhelmsson Timmermand, David Ulmert, Susan Evans-Axelsson, Kim Pettersson, Anders Bjartell, Hans Lilja, Sven-Erik Strand and Thuy A Tran

    Citation: EJNMMI Research 2014 4:51

    Content type: Original research

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  18. 2-deoxy-2-[18F]fluoro-D-glucose-positron emission tomography (18F-FDG-PET) is applied in the clinic for infection assessment and is under consideration for investigating the inflammatory/immune response in lympho...

    Authors: Svetlana Chefer, Richard C Reba, Christopher Z Leyson, Jurgen Seidel, Reed F Johnson, Joseph E Blaney, Peter B Jahrling and Julie Dyall

    Citation: EJNMMI Research 2014 4:49

    Content type: Preliminary research

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  19. Selective arterial radioembolisation of liver tumours has increased, because of encouraging efficacy reports; however, therapeutic parameters used in external beam therapy are not applicable for understanding ...

    Authors: Jonas Högberg, Magnus Rizell, Ragnar Hultborn, Johanna Svensson, Olof Henrikson, Johan Mölne, Peter Gjertsson and Peter Bernhardt

    Citation: EJNMMI Research 2014 4:48

    Content type: Original research

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  20. Peptide receptor radionuclide therapy (PRRT) is an effective form of treatment for patients with metastatic neuroendocrine tumors (NETs). However, delivering sufficient radiation dose to the tumor to result in...

    Authors: David L Bushnell, Mark T. Madsen, Thomas O'cdorisio, Yusuf Menda, Saima Muzahir, Randi Ryan and M. Sue O'dorisio

    Citation: EJNMMI Research 2014 4:38

    Content type: Original research

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  21. The multitargeting tyrosine kinase inhibitor (TKI) sunitinib is currently the first-line drug therapy for metastasizing renal cell carcinoma (RCC). TKIs have profound effects on tumor angiogenesis, leading to ...

    Authors: David W Chapman, Hans-Sonke Jans, Ivy Ma, John R Mercer, Leonard I Wiebe, Melinda Wuest and Ronald B Moore

    Citation: EJNMMI Research 2014 4:27

    Content type: Original research

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  22. Glioblastoma, the most frequent and aggressive of all astrocytomas, presents a clear predominance in male humans, but the assessment of sexual differences in its tumourigenesis and growth has received little a...

    Authors: Rocío Pérez-Carro, Omar Cauli and Pilar López-Larrubia

    Citation: EJNMMI Research 2014 4:44

    Content type: Original research

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  23. Inhibition of mitogen-activated protein kinase (MEK, also known as MAPK2, MAPKK), a key molecule of the Ras/MAPK (mitogen-activated protein kinase) pathway, has shown promising effects on B-raf-mutated and some R...

    Authors: Tetyana Tegnebratt, Elisabeth Ruge, Sabine Bader, Nobuya Ishii, Satoshi Aida, Yasushi Yoshimura, Chia-Huey Ooi, Li Lu, Nicholas Mitsios, Valerie Meresse, Jan Mulder, Michael Pawlak, Miro Venturi, Jean Tessier and Sharon Stone-Elander

    Citation: EJNMMI Research 2014 4:34

    Content type: Original research

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  24. Targeted radionuclide therapy with high-energy beta-emitters is generally considered suboptimal to cure small tumours (<300 mg). Tumour targeting of the CCK2 receptor-binding minigastrin analogue PP-F11 was de...

    Authors: Mark W. Konijnenberg, Wout A. P. Breeman, Erik de Blois, Ho Sze Chan, Otto C. Boerman, Peter Laverman, Petra Kolenc-Peitl, Marleen Melis and Marion de Jong

    Citation: EJNMMI Research 2014 4:47

    Content type: Original research

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  25. Peptide receptor radionuclide therapy (PRRT) is routinely used for advanced or metastasized neuroendocrine tumours (NET). To prevent nephrotoxicity, positively charged amino acids (AA) are co-infused. The aim ...

    Authors: Constantin Lapa, Rudolf A Werner, Christina Bluemel, Katharina Lückerath, Andreas Schirbel, Alexander Strate, Andreas K Buck and Ken Herrmann

    Citation: EJNMMI Research 2014 4:46

    Content type: Original research

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  26. Staphylococcus epidermidis (S. epidermidis) has emerged as one of the leading pathogens of biomaterial-related infections. Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible endothelial molecule con...

    Authors: Helena Ahtinen, Julia Kulkova, Laura Lindholm, Erkki Eerola, Antti J Hakanen, Niko Moritz, Mirva Söderström, Tiina Saanijoki, Sirpa Jalkanen, Anne Roivainen and Hannu T Aro

    Citation: EJNMMI Research 2014 4:45

    Content type: Original research

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  27. [18F]fluciclatide, a peptide ligand with high affinity for αvβ3/αvβ5 integrins, is a proposed biomarker of tumor angiogenesis. The study rationale was to perform a preliminary evaluation of the relationship betwe...

    Authors: Laura M Kenny, Giampaolo Tomasi, Federico Turkheimer, James Larkin, Martin Gore, Cathryn S Brock, Stephen Mangar and Eric O Aboagye

    Citation: EJNMMI Research 2014 4:30

    Content type: Preliminary research

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  28. The α7 nicotinic acetylcholine receptor (nAChR) is an important molecular target in neuropsychiatry and oncology. Development of applicable highly specific radiotracers has been challenging due to comparably l...

    Authors: Sven Rötering, Winnie Deuther-Conrad, Paul Cumming, Cornelius K Donat, Matthias Scheunemann, Steffen Fischer, Guoming Xiong, Jörg Steinbach, Dan Peters, Osama Sabri, Jan Bucerius and Peter Brust

    Citation: EJNMMI Research 2014 4:43

    Content type: Original research

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  29. The aim of this pilot study was to evaluate whether the uptake of 89Zr-bevacizumab in non-small cell lung cancer (NSCLC) tumors could be visualized and quantified. The correlation between tumor 89Zr-bevacizumab u...

    Authors: Idris Bahce, Marc C Huisman, Eline E Verwer, Rogier Ooijevaar, Firdaouss Boutkourt, Danielle J Vugts, Guus AMS van Dongen, Ronald Boellaard and Egbert F Smit

    Citation: EJNMMI Research 2014 4:35

    Content type: Original research

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  30. The biology of the vulnerable plaque includes increased inflammation and rapid growth of vasa vasorum, processes that are associated with enhanced vascular endothelial growth factor (VEGF)/ imaging receptors f...

    Authors: Yared Tekabe, Maria Kollaros, Adam Zerihoun, Geping Zhang, Marina V Backer, Joseph M Backer and Lynne L Johnson

    Citation: EJNMMI Research 2014 4:41

    Content type: Original research

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  31. The trapping mechanisms of the PET hypoxia imaging agent copper(II)-diacetyl-bis(N4-methylthiosemicarbazone) (64Cu(ATSM)) remain unresolved, although its reduction prior to dissociation may be mediated by intrace...

    Authors: Fiona Shaughnessy, Erika Mariotti, Karen P Shaw, Thomas R Eykyn, Philip J Blower, Richard Siow and Richard Southworth

    Citation: EJNMMI Research 2014 4:40

    Content type: Original research

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  32. Heterogeneous ventilation in lungs of individuals with allergies, cigarette smokers, asthmatics and chronic obstructive pulmonary disease (COPD) patients has been demonstrated using imaging modalities such as ...

    Authors: Pernilla Norberg, Hans Lennart Persson, Birgitta Schmekel, Gudrun Alm Carlsson, Karl Wahlin, Michael Sandborg and Agnetha Gustafsson

    Citation: EJNMMI Research 2014 4:39

    Content type: Original research

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  33. The purpose of the study was to evaluate the applicability of 18 F-labelled amyloid imaging positron emission tomography (PET) agent [ 18 ...

    Authors: Anniina Snellman, Johanna Rokka, Francisco R López-Picón, Olli Eskola, Mario Salmona, Gianluigi Forloni, Mika Scheinin, Olof Solin, Juha O Rinne and Merja Haaparanta-Solin

    Citation: EJNMMI Research 2014 4:37

    Content type: Original research

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  34. With the increasing utilization of 68Ge-68Ga radionuclide generators, 68Ga labelled peptides like DOTATATE are receiving more attention in nuclear medicine. On the one hand, the long half-life of the parent nucli...

    Authors: Ferdinand Sudbrock, Thomas Fischer, Beate Zimmermanns, Mehrab Guliyev, Markus Dietlein, Alexander Drzezga and Klaus Schomäcker

    Citation: EJNMMI Research 2014 4:36

    Content type: Original research

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  35. Abnormal behaviors of young patients after taking the anti-influenza agent oseltamivir (Tamiflu®, F. Hoffmann-La Roche, Ltd., Basel, Switzerland) have been suspected as neuropsychiatric adverse events (NPAEs)....

    Authors: Chie Seki, Arata Oh-Nishi, Yuji Nagai, Takafumi Minamimoto, Shigeru Obayashi, Makoto Higuchi, Makoto Takei, Kenji Furutsuka, Takehito Ito, Ming-Rong Zhang, Hiroshi Ito, Mototsugu Ito, Sumito Ito, Hiroyuki Kusuhara, Yuichi Sugiyama and Tetsuya Suhara

    Citation: EJNMMI Research 2014 4:24

    Content type: Original research

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  36. For yttrium-90 (90Y) radioembolization, the common practice of assuming a standard 1,000-g lung mass for predictive dosimetry is fundamentally incongruent with the modern philosophy of personalized medicine. We r...

    Authors: Yung Hsiang Kao, Butch M Magsombol, Ying Toh, Kiang Hiong Tay, Pierce KH Chow, Anthony SW Goh and David CE Ng

    Citation: EJNMMI Research 2014 4:33

    Content type: Original research

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  37. To combine the sensitivity of bioluminescent imaging (BLI) with the 3D and quantitative properties of pinhole single-photon emission computed tomography (SPECT)/micro-computed tomography (CT) (phSPECT/micro-CT...

    Authors: Lode RY Goethals, Tomas J Bos, Luc Baeyens, Frank De Geeter, Nick Devoogdt and Tony Lahoutte

    Citation: EJNMMI Research 2014 4:32

    Content type: Original research

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  38. Various diseases derive from pathologically altered β-cells. Their function can be increased, leading to hyperinsulinism, or decreased, resulting in diabetes. Non-invasive imaging of the β-cell-specific glucag...

    Authors: Andreas Jodal, Brigitte Lankat-Buttgereit, Maarten Brom, Roger Schibli and Martin Béhé

    Citation: EJNMMI Research 2014 4:31

    Content type: Original research

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  39. Receptor for advanced glycated end product (RAGE) expression is a prominent feature of atherosclerosis. We have previously shown in apoE null mice uptake of a radiolabeled anti-RAGE antibody in atherosclerotic...

    Authors: Lynne L Johnson, Yared Tekabe, Maria Kollaros, George Eng, Ketan Bhatia, Chong Li, Christian G Krueger, Dhanansayan Shanmuganayagam and Ann Marie Schmidt

    Citation: EJNMMI Research 2014 4:26

    Content type: Original research

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  40. Cerebral stroke is a severe and frequent condition that requires rapid and reliable diagnosis. If administered shortly after the first symptoms manifest themselves, IV thrombolysis has been shown to increase t...

    Authors: Maria-Joao Ribeiro, Johnny Vercouillie, Severine Debiais, Jean-Philippe Cottier, Isabelle Bonnaud, Vincent Camus, Samuel Banister, Michael Kassiou, Nicolas Arlicot and Denis Guilloteau

    Citation: EJNMMI Research 2014 4:28

    Content type: Original research

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  41. ROBO1 is a membrane protein that functions in axon guidance. ROBO1 contributes to tumour metastasis and angiogenesis and may have potential as a target protein of immunotherapy because ROBO1 is specifically ex...

    Authors: Kentaro Fujiwara, Keitaro Koyama, Kosuke Suga, Masako Ikemura, Yasutaka Saito, Akihiro Hino, Hiroko Iwanari, Osamu Kusano-Arai, Kenichi Mitsui, Hiroyuki Kasahara, Masashi Fukayama, Tatsuhiko Kodama, Takao Hamakubo and Toshimitsu Momose

    Citation: EJNMMI Research 2014 4:29

    Content type: Original research

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  42. The aim of this study was to investigate the reproducibility of intra- and inter-observer interpretation of [18F]choline positron emission tomography/computed tomography examinations in patients suffering from bi...

    Authors: Clothilde Pegard, Céline Gallazzini-Crépin, Joris Giai, Julien Dubreuil, Cécile Caoduro, Marie-Dominique Desruet, Julie Roux, Alex Calizzano, Daniel Fagret, Chloé Lamesa, Hatem Boulahdour and Jean-Philippe Vuillez

    Citation: EJNMMI Research 2014 4:25

    Content type: Original research

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  43. The ability of recombinant antibodies to adequately penetrate into tumours is a key factor in achieving therapeutic effect; however, the behaviour of antibodies at a cellular level in tumours is poorly underst...

    Authors: Marika Ciprotti, Geoffrey Chong, Hui K Gan, Anthony Chan, Carmel Murone, Duncan MacGregor, Fook-Thean Lee, Terrance G Johns, Joan K Heath, Matthias Ernst, Antony W Burgess and Andrew M Scott

    Citation: EJNMMI Research 2014 4:22

    Content type: Original research

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  44. Previously, we reported on the unexpected development of distant metastases in the subcutaneous rat pancreas CA20948 tumor model after 4.5 weeks of treatment with RAD001-only or in combination with [177Lu-DOTA0,T...

    Authors: Sander M Bison, Stefan E Pool, Stuart J Koelewijn, Linda M van der Graaf, Harald C Groen, Marleen Melis and Marion de Jong

    Citation: EJNMMI Research 2014 4:21

    Content type: Original research

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  45. The utility of 18 F-FDG and 11C-PBR28 to identify aortic wall inflammation associated with abdominal aortic aneurysm (AAA) development was assessed.

    Authors: Sean J English, Jose A Diaz, Xia Shao, David Gordon, Melissa Bevard, Gang Su, Peter K Henke, Virginia E Rogers, Gilbert R Upchurch and Morand Piert

    Citation: EJNMMI Research 2014 4:20

    Content type: Original Research

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  46. This study was designed to explore the feasibility of replacing the conventional peri-/intratumoural ultrasound (US)-guided technetium-99m albumin nanocolloid (99mTc-nanocolloid) administration by an injection of...

    Authors: Bas Pouw, Linda J de Wit-van der Veen, Daan Hellingman, Oscar R Brouwer, Marie-Jeanne TFD Vrancken Peeters, Marcel PM Stokkel and Renato A Valdés Olmos

    Citation: EJNMMI Research 2014 4:19

    Content type: Original research

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  47. Standard uptake values (SUV) as well as tumor-to-blood standard uptake ratios (SUR) measured with [ 18F-]fluorodeoxyglucose (FDG) PET are time dependent. This poses a serious problem for reliable quantification s...

    Authors: Jörg van den Hoff, Alexandr Lougovski, Georg Schramm, Jens Maus, Liane Oehme, Jan Petr, Bettina Beuthien-Baumann, Jörg Kotzerke and Frank Hofheinz

    Citation: EJNMMI Research 2014 4:18

    Content type: Original research

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  48. Vascular endothelial growth factor receptor 2 (VEGFR2) is a crucial mediator of tumour angiogenesis. High expression levels of the receptor have been correlated to poor prognosis in cancer patients. Reliable i...

    Authors: Erik Samén, Li Lu, Jan Mulder, Jan-Olov Thorell, Peter Damberg, Tetyana Tegnebratt, Lars Holmgren, Helene Rundqvist and Sharon Stone-Elander

    Citation: EJNMMI Research 2014 4:17

    Content type: Original research

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