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  1. In order to better understand the concept of mechanical dyssynchrony, a promising hallmark of cardiac resynchronization therapy (CRT) response, we investigated its effect on regional myocardial metabolism and ...

    Authors: Ganna Degtiarova, Piet Claus, Jürgen Duchenne, Marta Cvijic, Georg Schramm, Johan Nuyts, Jens-Uwe Voigt and Olivier Gheysens

    Citation: EJNMMI Research 2019 9:105

    Content type: Original research

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  2. We investigated the prognostic predictive value of the combination of fluorodeoxyglucose (FDG)- and fluoromisonidazole (FMISO)-PET in patients with non-small cell lung carcinoma (NSCLC) treated with stereotact...

    Authors: Shiro Watanabe, Tetsuya Inoue, Shozo Okamoto, Keiichi Magota, Ayumi Takayanagi, Jun Sakakibara-Konishi, Norio Katoh, Kenji Hirata, Osamu Manabe, Takuya Toyonaga, Yuji Kuge, Hiroki Shirato, Nagara Tamaki and Tohru Shiga

    Citation: EJNMMI Research 2019 9:104

    Content type: Original research

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  3. The aim of this analysis was to investigate whether the standardized uptake value (SUV) normalized by lean body mass (SUL) is a more appropriate quantitative parameter compared to the commonly used SUV normali...

    Authors: Andrei Gafita, Jeremie Calais, Charlott Franz, Isabel Rauscher, Hui Wang, Andrew Roberstson, Johannes Czernin, Wolfgang A. Weber and Matthias Eiber

    Citation: EJNMMI Research 2019 9:103

    Content type: Original research

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  4. Preclinical biodistribution and dosimetric analysis of [177Lu]Lu-DOTAZOL suggest the bisphosphonate zoledronate as a promising new radiopharmaceutical for therapy of bone metastases. We evaluated biodistribution ...

    Authors: Ambreen Khawar, Elisabeth Eppard, Frank Roesch, Hojjat Ahmadzadehfar, Stefan Kürpig, Michael Meisenheimer, Florian. C. Gaertner, Markus Essler and Ralph. A. Bundschuh

    Citation: EJNMMI Research 2019 9:102

    Content type: Original research

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  5. Vagus nerve activation impacts inflammation. Therefore, we hypothesized that vagal nerve stimulation (VNS) influenced arterial wall inflammation as measured by 18F-FDG uptake.

    Authors: Ellen Boswijk, Renee Franssen, Guy H. E. J. Vijgen, Roel Wierts, Jochem A. J. van der Pol, Alma M. A. Mingels, Erwin M. J. Cornips, Marian H. J. M. Majoie, Wouter D. van Marken Lichtenbelt, Felix M. Mottaghy, Joachim E. Wildberger and Jan Bucerius

    Citation: EJNMMI Research 2019 9:101

    Content type: Original research

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  6. Over the last decade, a few radioligands have been developed for PET imaging of brain 5-HT1B receptors. The 5-HT1B receptor is a G-protein-coupled receptor (GPCR) that exists in two different agonist affinity sta...

    Authors: Anton Lindberg, Ryosuke Arakawa, Tsuyoshi Nogami, Sangram Nag, Magnus Schou, Charles S. Elmore, Lars Farde, Victor W. Pike and Christer Halldin

    Citation: EJNMMI Research 2019 9:100

    Content type: Original research

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  7. Despite the widespread use of F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in the diagnosis and response assessment of patients with lymphoma, few studies have assessed...

    Authors: Hye Lim Park, Joo Hyun O, Sonya Youngju Park, Seung-Eun Jung, Gyeongsin Park, Byung-Ock Choi, Sung Hoon Kim, Young-Woo Jeon, Seok-Goo Cho and Suk-Woo Yang

    Citation: EJNMMI Research 2019 9:99

    Content type: Original research

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  8. Combining modalities using dual-labeled antibodies may allow preoperative and intraoperative tumor localization and could be used in image-guided surgery to improve complete tumor resection. Trastuzumab is a m...

    Authors: Marion M. Deken, Desirée L. Bos, Willemieke S. F. J. Tummers, Taryn L. March, Cornelis J. H. van de Velde, Mark Rijpkema and Alexander L. Vahrmeijer

    Citation: EJNMMI Research 2019 9:98

    Content type: Original research

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  9. The linkage between the genetic and phenotypic heterogeneity of the tumor has not been thoroughly evaluated. Herein, we investigated how the genetic and metabolic heterogeneity features of the tumor are associ...

    Authors: Jinyeong Choi, Jeong-An Gim, Chiwoo Oh, Seunggyun Ha, Howard Lee, Hongyoon Choi and Hyung-Jun Im

    Citation: EJNMMI Research 2019 9:97

    Content type: Original research

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  10. This letter aims at explaining that adjusting the performance of PET/CT systems to a new standard also requires updating of interpretation criteria. Simply changing one aspect of the imaging procedure, i.e., P...

    Authors: Ronald Boellaard, Terez Sera, Andres Kaalep, Otto S. Hoekstra, Sally F. Barrington and Josée M. Zijlstra

    Citation: EJNMMI Research 2019 9:95

    Content type: Letter to the Editor

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  11. Selective removal of initially tumor-positive axillary lymph nodes in breast cancer patients who underwent neoadjuvant systemic treatment (NST) improves the accuracy of nodal staging and provides the opportuni...

    Authors: Daan Hellingman, Maarten L. Donswijk, Gonneke A. O. Winter-Warnars, Petra de Koekkoek-Doll, Marilyn Pinas, Yvonne Budde-van Namen, Johan Westerga, Marie-Jeanne T. F. D. Vrancken Peeters, Nikola Kimmings and Marcel P. M. Stokkel

    Citation: EJNMMI Research 2019 9:94

    Content type: Original research

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  12. Prostate-specific membrane antigen (PSMA) is overexpressed on the endothelial cells of tumor neo-vessels of several solid malignancies, including differentiated thyroid cancer (DTC). We aimed to test the poten...

    Authors: Martina Sollini, Luca di Tommaso, Margarita Kirienko, Chiara Piombo, Marco Erreni, Andrea Gerardo Lania, Paola Anna Erba, Lidija Antunovic and Arturo Chiti

    Citation: EJNMMI Research 2019 9:93

    Content type: Original research

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  13. Methamphetamine (METH)-associated alterations in the striatal dopamine (DA) system or dopamine transport (DAT) have been identified in clinical and preclinical studies with positron emission tomography (PET) i...

    Authors: Wen-Sheng Huang, Guann-Juh Chen, Tung-Han Tsai, Chen-Yi Cheng, Chyng-Yann Shiue, Kuo-Hsing Ma and Skye Hsin-Hsien Yeh

    Citation: EJNMMI Research 2019 9:92

    Content type: Original research

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  14. Amyloid PET plays a vital role in detecting the accumulation of in vivo amyloid-β (Aβ). The quantification of Aβ accumulation has been widely performed using the region of interest (ROI)-based mean cortical st...

    Authors: Go Akamatsu, Yasuhiko Ikari, Akihito Ohnishi, Keiichi Matsumoto, Hiroyuki Nishida, Yasuji Yamamoto and Michio Senda

    Citation: EJNMMI Research 2019 9:91

    Content type: Original research

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  15. Overall, 40% of patients with a locally advanced head and neck cancer (LAHNC) treated by chemoradiotherapy (CRT) present local recurrence within 2 years after the treatment. The aims of this study were to char...

    Authors: J. Beaumont, O. Acosta, A. Devillers, X. Palard-Novello, E. Chajon, R. de Crevoisier and J. Castelli

    Citation: EJNMMI Research 2019 9:90

    Content type: Original research

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  16. The aim of this study was to evaluate the prognostic value of positron emission tomography (PET) parameters and the PET texture features of fluorine 18-fluorodeoxyglucose ([18F]FDG) uptake on pretreatment PET/com...

    Authors: Wen-Jie Wu, Zhen-Yu Li, Shuang Dong, Shu-Ming Liu, Lei Zheng, Ming-Wei Huang and Jian-Guo Zhang

    Citation: EJNMMI Research 2019 9:89

    Content type: Original research

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  17. An efficient and cost-effective synthesis of the metal chelating agents that couple to tumor-targeting peptides is required to enhance the process of preclinical research toward the clinical translation of mol...

    Authors: Subhani M. Okarvi and Ibrahim AlJammaz

    Citation: EJNMMI Research 2019 9:88

    Content type: Original research

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  18. Rheumatoid arthritis (RA) is one of the most common rheumatic diseases. Joint inflammation and pathological growth of joint cartilage cause swollen and painful joints, which severely diminishes the patients’ l...

    Authors: Johannes Notni, Florian T. Gassert, Katja Steiger, Peter Sommer, Wilko Weichert, Ernst J. Rummeny, Markus Schwaiger, Horst Kessler, Reinhard Meier and Melanie A. Kimm

    Citation: EJNMMI Research 2019 9:87

    Content type: Original research

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  19. Lung cancer is one of the most common cancers in the world. Early detection and correct staging are fundamental for treatment and prognosis. Positron emission tomography with computed tomography (PET/CT) is re...

    Authors: Johan Economou Lundeberg, Jenny Oddstig, Ulrika Bitzén and Elin Trägårdh

    Citation: EJNMMI Research 2019 9:35

    Content type: Original research

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  20. Image-guided surgery may improve surgical outcome for colorectal cancer patients. Here, we evaluated the feasibility of a pretargeting strategy for multimodal imaging in colorectal cancer using an anti-carcino...

    Authors: Fortuné M. K. Elekonawo, Susanne Lütje, Gerben M. Franssen, Desirée L. Bos, David M. Goldenberg, Otto C. Boerman and Mark Rijpkema

    Citation: EJNMMI Research 2019 9:86

    Content type: Original research

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  21. A cerebrospinal fluid (CSF)-mask algorithm has been developed to reduce the adverse influence of CSF-low-counts on the diagnostic utility of the specific binding ratio (SBR) index calculated with Southampton m...

    Authors: Yu Iwabuchi, Tadaki Nakahara, Masashi Kameyama, Yohji Matsusaka, Yasuhiro Minami, Daisuke Ito, Hajime Tabuchi, Yoshitake Yamada and Masahiro Jinzaki

    Citation: EJNMMI Research 2019 9:85

    Content type: Original research

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  22. The aim of the current study was to assess whether and to what extent monitoring response to treatment using prostate-specific membrane antigen (PSMA)-based positron-emitting tomography/computerized tomography...

    Authors: Jonathan Kuten, David Sarid, Ofer Yossepowitch, Nicola J. Mabjeesh and Einat Even-Sapir

    Citation: EJNMMI Research 2019 9:84

    Content type: Original research

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  23. Positron emission tomography/magnetic resonance imaging (PET/MRI) is a promising diagnostic imaging tool for the diagnosis of dementia, as PET can add complementary information to the routine imaging examinati...

    Authors: Silje Kjærnes Øen, Thomas Morten Keil, Erik Magnus Berntsen, Joel Fredrik Aanerud, Thomas Schwarzlmüller, Claes Nøhr Ladefoged, Anna Maria Karlberg and Live Eikenes

    Citation: EJNMMI Research 2019 9:83

    Content type: Original research

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  24. The use of 16α-[18F]fluoro-17β-estradiol (FES) positron emission tomography (PET) in clinical dilemmas and for therapy decision-making in lesions expressing estrogen receptors is growing. However, on a considerab...

    Authors: C. M. Venema, E. F. J. de Vries, S. J. van der Veen, M. D. Dorrius, M. van Kruchten, C. P. Schröder, G. A. P. Hospers and A. W. J. M. Glaudemans

    Citation: EJNMMI Research 2019 9:82

    Content type: Original research

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  25. Although neurofibrillary tangles (NFTs) mainly accumulate in the medial temporal lobe with human aging, only a few imaging studies have investigated correlations between NFT accumulation and gray matter (GM) v...

    Authors: Yoko Shigemoto, Daichi Sone, Miho Ota, Norihide Maikusa, Masayo Ogawa, Kyoji Okita, Harumasa Takano, Koichi Kato, Yukio Kimura, Emiko Morimoto, Fumio Suzuki, Hiroyuki Fujii, Noriko Sato and Hiroshi Matsuda

    Citation: EJNMMI Research 2019 9:81

    Content type: Short communication

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  26. Preclinical imaging of endothelial activation and mineralization using both positron emission tomography (PET) and magnetic resonance (MR) remains scarce.

    Authors: Guillaume Rucher, Lucie Cameliere, Jihene Fendri, Antoine Anfray, Ahmed Abbas, Saïd Kamel, Quentin Dupas, Nicolas Delcroix, Ludovic Berger and Alain Manrique

    Citation: EJNMMI Research 2019 9:80

    Content type: Original research

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  27. (1) To perform a comprehensive analysis of the time elapsed between the last G-CSF injection and the PET/CT examination on the biodistribution of 18F-FDG, with emphasis on liver, spleen, and bone marrow uptake, a...

    Authors: Magno Oliveira, Charline Lasnon, Catherine Nganoa, Anne-Claire Gac, Gandhi Damaj and Nicolas Aide

    Citation: EJNMMI Research 2019 9:79

    Content type: Original research

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  28. Immunotherapies that employ immune checkpoint modulators (ICMs) have emerged as an effective treatment for a variety of solid cancers, as well as a paradigm shift in the treatment of cancers. Despite this brea...

    Authors: Mathieu Sinigaglia, Tarek Assi, Florent L. Besson, Samy Ammari, Myriam Edjlali, Whitney Feltus, Laura Rozenblum-Beddok, Binsheng Zhao, Lawrence H. Schwartz, Fatima-Zohra Mokrane and Laurent Dercle

    Citation: EJNMMI Research 2019 9:78

    Content type: Review

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  29. PET (positron emission tomography) biokinetic modelling relies on accurate quantitative data. One of the main corrections required in PET imaging to obtain high quantitative accuracy is tissue attenuation corr...

    Authors: Jorge Cabello, Mihai Avram, Felix Brandl, Mona Mustafa, Martin Scherr, Claudia Leucht, Stefan Leucht, Christian Sorg and Sibylle I. Ziegler

    Citation: EJNMMI Research 2019 9:77

    Content type: Original research

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  30. The bone marrow (BM) is a main risk organ during Lu-177-PSMA ligand therapy of metastasized castration-resistant prostate cancer (mCRPC) patients. So far, BM dosimetry relies on S values, which are pre-computed f...

    Authors: Astrid Gosewisch, Harun Ilhan, Sebastian Tattenberg, Andrea Mairani, Katia Parodi, Julia Brosch, Lena Kaiser, Franz Josef Gildehaus, Andrei Todica, Sibylle Ziegler, Peter Bartenstein and Guido Böning

    Citation: EJNMMI Research 2019 9:76

    Content type: Original research

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  31. The development and clinical translation of [68Ga] Pentixafor has substantially promoted the relevance of non-invasive PET imaging of CXCR4 expression in a broad spectrum of diseases, including cancer and inflamm...

    Authors: Margret Schottelius, Marina Ludescher, Frauke Richter, Tobias G. Kapp, Horst Kessler and Hans-Jürgen Wester

    Citation: EJNMMI Research 2019 9:75

    Content type: Short communication

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  32. In a colorectal cancer xenograft model, we investigated the therapeutic effect of metformin on tumor hypoxia with [18F]flortanidazole ([18F]HX4) small-animal positron emission tomography (μPET). We also assessed ...

    Authors: Sven De Bruycker, Christel Vangestel, Steven Staelens, Leonie wyffels, Jan Detrez, Marlies Verschuuren, Winnok H. De Vos, Patrick Pauwels, Tim Van den Wyngaert and Sigrid Stroobants

    Citation: EJNMMI Research 2019 9:74

    Content type: Original research

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  33. To evaluate the optimal tracer uptake time, the minimal amount of radioactivity and the inter-observer agreement for 11C-choline positron emission tomography/computed tomography (PET/CT) in patients with primary ...

    Authors: Milou E. Noltes, Schelto Kruijff, Walter Noordzij, Eef D. Telenga, David Vállez García, Malgorzata Trofimiuk-Müldner, Marta Opalińska, Alicja Hubalewska-Dydejczyk, Gert Luurtsema, Rudi A. J. O. Dierckx, Mostafa El Moumni, Ronald Boellaard and Adrienne H. Brouwers

    Citation: EJNMMI Research 2019 9:73

    Content type: Original research

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  34. 18F-fluorocholine (FCH) PET/CT is a promising technique for visualizing hyperfunctioning parathyroid glands in hyperparathyroidism. It is still under debate whether to use this technique as a first-line imaging ....

    Authors: Wouter A. M. Broos, Maurits Wondergem, Remco J. J. Knol and Friso M. van der Zant

    Citation: EJNMMI Research 2019 9:72

    Content type: Original research

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  35. Cimbi-36 can be 11C-labeled to form an agonist radioligand used for positron emission tomography (PET) imaging of the 5-HT2A receptor in the brain. In its non-labeled form (25B-NBOMe), it is used as a recreationa...

    Authors: Annette Johansen, Søren Holm, Bente Dall, Sune Keller, Jesper L. Kristensen, Gitte M. Knudsen and Hanne D. Hansen

    Citation: EJNMMI Research 2019 9:71

    Content type: Original research

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  36. Whole body [18F]-fluorodihydrotestosterone positron emission tomography ([18F]FDHT PET) imaging directly targets the androgen receptor and is a promising prognostic and predictive biomarker in metastatic castrati...

    Authors: Matthijs C. F. Cysouw, Gerbrand M. Kramer, Dennis Heijtel, Robert C. Schuit, Michael J. Morris, Alfons J. M. van den Eertwegh, Jens Voortman, Otto S. Hoekstra, Daniela E. Oprea-Lager and Ronald Boellaard

    Citation: EJNMMI Research 2019 9:70

    Content type: Original research

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  37. For almost a decade, terbium radioisotopes have been explored for their potential theragnostic application in nuclear medicine: 152Tb and 155Tb are the radioisotopes identified for PET or SPECT imaging, while 149

    Authors: Cristina Müller, Aviral Singh, Christoph A. Umbricht, Harshad R. Kulkarni, Karl Johnston, Martina Benešová, Stefan Senftleben, Dirk Müller, Christiaan Vermeulen, Roger Schibli, Ulli Köster, Nicholas P. van der Meulen and Richard P. Baum

    Citation: EJNMMI Research 2019 9:68

    Content type: Original research

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  38. Our aim was to present a new data analysis technique for the early detection of tumorous lesions using single-photon emission computed tomography (SPECT) imaging. Beyond standardized uptake value (SUV) and sta...

    Authors: Dániel S. Veres, Domokos Máthé, Nikolett Hegedűs, Ildikó Horváth, Fanni J. Kiss, Gabriella Taba, Edit Tóth-Bodrogi, Tibor Kovács and Krisztián Szigeti

    Citation: EJNMMI Research 2019 9:67

    Content type: Original research

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  39. We investigated the whole-body distribution and the radiation dosimetry of [18F]-JK-PSMA-7, a novel 18F-labeled PSMA-ligand for PET/CT imaging of prostate cancer.

    Authors: Melanie Hohberg, Carsten Kobe, Philipp Krapf, Philipp Täger, Jochen Hammes, Felix Dietlein, Boris D. Zlatopolskiy, Heike Endepols, Markus Wild, Stephan Neubauer, Axel Heidenreich, Bernd Neumaier, Alexander Drzezga and Markus Dietlein

    Citation: EJNMMI Research 2019 9:66

    Content type: Original research

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  40. The Deauville score (DS) is a clinical tool, based on the comparison between lesion and reference organ uptake of 18F-fluorodeoxyglucose (FDG), used to stratify patients with lymphoma into categories reflecting t...

    Authors: John Ly, David Minarik, Lars Edenbrandt, Per Wollmer and Elin Trägårdh

    Citation: EJNMMI Research 2019 9:65

    Content type: Original research

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  41. Block-sequential regularized expectation maximization (BSREM), commercially Q. Clear (GE Healthcare, Milwaukee, WI, USA), is a reconstruction algorithm that allows for a fully convergent iterative reconstructi...

    Authors: Elin Trägårdh, David Minarik, Helén Almquist, Ulrika Bitzén, Sabine Garpered, Erland Hvittfelt, Berit Olsson and Jenny Oddstig

    Citation: EJNMMI Research 2019 9:64

    Content type: Original research

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  42. To determine the reliability of visual assessment of [123I]FP-CIT SPECT imaging by non-experts in dopamine transporter (DAT) SPECT imaging in patients with early drug-naive Parkinson’s disease (PD). Also, we expl...

    Authors: Sven R. Suwijn, Constant V. M. Verschuur, Marleen A. Slim, Jan Booij and Rob M. A. de Bie

    Citation: EJNMMI Research 2019 9:63

    Content type: Short communication

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  43. The aim of this study was to compare predictive and post-treatment dosimetry and analyze the differences, investigating factors related to activity preparation and delivery, imaging modality used, and interven...

    Authors: Marilyne Kafrouni, Carole Allimant, Marjolaine Fourcade, Sébastien Vauclin, Boris Guiu, Denis Mariano-Goulart and Fayçal Ben Bouallègue

    Citation: EJNMMI Research 2019 9:62

    Content type: Original research

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  44. The quality of phantom images was previously shown to be higher on digital (Vereos Philips®) compared to analog PET (Ingenuity Philips®) cameras. This study aimed to determine the extent to which this differen...

    Authors: Julien Salvadori, Laetitia Imbert, Mathieu Perrin, Gilles Karcher, Zohra Lamiral, Pierre-Yves Marie and Antoine Verger

    Citation: EJNMMI Research 2019 9:61

    Content type: Original research

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  45. To facilitate hypoxia imaging in a clinical setting, we developed 1-(2,2-dihydroxymethyl-3-[18F]-fluoropropyl)-2-nitroimidazole ([18F]DiFA) as a new tracer that targets tumor hypoxia with its lower lipophilicity ...

    Authors: Shiro Watanabe, Tohru Shiga, Kenji Hirata, Keiichi Magota, Shozo Okamoto, Takuya Toyonaga, Kei Higashikawa, Hironobu Yasui, Jun Kobayashi, Ken-ichi Nishijima, Ken Iseki, Hiroki Matsumoto, Yuji Kuge and Nagara Tamaki

    Citation: EJNMMI Research 2019 9:60

    Content type: Original research

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  46. In clinical practice, visual assessment of glucose metabolism images is often used for the diagnosis of Alzheimer’s disease (AD) through 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) s...

    Authors: Débora E. Peretti, David Vállez García, Fransje E. Reesink, Janine Doorduin, Bauke M. de Jong, Peter P. De Deyn, Rudi A. J. O. Dierckx and Ronald Boellaard

    Citation: EJNMMI Research 2019 9:59

    Content type: Original research

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  47. Non-invasive tumor blood flow (TBF) quantification is a candidate approach for risk stratification and monitoring of prostate cancer patients. Validation data have recently been published on prostate TBF measu...

    Authors: Mads Ryø Jochumsen, Kirsten Bouchelouche, Katrine Bødkergaard Nielsen, Jørgen Frøkiær, Michael Borre, Jens Sörensen and Lars Poulsen Tolbod

    Citation: EJNMMI Research 2019 9:58

    Content type: Original research

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  48. Positron emission tomography (PET) is increasingly used to guide local treatment in glioma. The purpose of this study was a direct comparison of two potential tracers for detecting glioma infiltration, O-(2-[18F]...

    Authors: Niels Verburg, Thomas Koopman, Maqsood Yaqub, Otto S. Hoekstra, Adriaan A. Lammertsma, Lothar A. Schwarte, Frederik Barkhof, Petra J. W. Pouwels, Jan J. Heimans, Jaap C. Reijneveld, Annemieke J. M. Rozemuller, William P. Vandertop, Pieter Wesseling, Ronald Boellaard and Philip C. de Witt Hamer

    Citation: EJNMMI Research 2019 9:57

    Content type: Original research

    Published on: