In vitro evaluation of (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a positron emission tomography probe for imaging amino acid transporters

EJNMMI Research

Table 1 Properties of tumor-related amino acid transporters

Gene	Alias	Substrates	Inhibitors	PET probes
SLC7A5	LAT1	Leu, Ile, Val, Trp, Tyr, Phe, Met, His	BCH, JPH203	FAMT, FBPA, FACBC, FET, FPhPA
SLC6A14	ATB^0,+	Leu, Ile, Val, Trp, Tyr, Phe, Met, His, Ala, Ser, Cys	α-Methyl-L-Trp	FEMAET, FET
SLC1A5	ASCT2	Ala, Ser, Cys, Thr, Gln, Asn	γ-Glu-p-nitroanilide, Benzylserine	FACBC, FPhPA
SLC7A11	xCT	Cys, Glu	Sulfasalazine, Erastin, Sorafenib	FSPG

PET, positron emission tomography; LAT1, L-type amino acid transporter 1; ATB^0,+, sodium- and chloride-dependent neutral and basic amino acid transporter B(0 +); ASCT2, alanine serine cysteine transporter 2; xCT, cystine/glutamate transporter; BCH, 2-amino-2-norbornanecarboxylic acid; JPH203, (S)-2-amino-3-(4-((5-amino-2-phenylbenzo[d]oxazol-7-yl)methoxy)-3,5-dichloropheyl) propanoic acid; FAMT, L-3-¹⁸F-fluoro-α-methyl tyrosine; FBPA, 4-borono-2-¹⁸F-fluoro-phenylalanine; FACBC, anti-1-amino-3-¹⁸F-fluorocyclobutane-1-carboxylic acid; FET, ¹⁸F-fluoro-ethyl-tyrosine; FPhPA, 2-amino-5-(4-¹⁸F-fluorophenyl)pent-4-ynoic acid; FEMAET, O-2(2-¹⁸F-fluoroethyl)methylamino)ethyltyrosine; FSPG, (4S)-4-(3-¹⁸F-fluoropropyl)-L-glutamate