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EJNMMI Research
Fig. 5 | EJNMMI Research

Fig. 5

From: In vitro evaluation of (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a positron emission tomography probe for imaging amino acid transporters

Fig. 5

Functional analysis of amino acid transporter-overexpressing cell lines. Transporter-mediated 18F-FIMP uptake was measured in the presence ( +) or absence (−) of specific inhibitors (BCH, AMT, GPNA, or SF) in control vector-transfected cells (Mock) and expression vector-transfected cells. Data are presented as the mean ± SD (n = 4–6). *P < 0.01 when compared to mock cells without an inhibitor; †P < 0.01 when compared to the corresponding overexpressing cells without an inhibitor. AMT, α-Me-DL-Trp; BCH, 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid; GPNA, L-γ-glutamyl-p-nitroanilide; SF, sulfasalazine.

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