Fig. 1
89Zr-aGPC3 avidly binds to tumor with minimal off-target binding. a, b Tissue biodistribution of 89Zr-aGPC3 and 89Zr-aBHV1 in tumor-bearing mice 4 h (n = 4), 24 h (n = 4), and 144 h (n = 3 for GPC3, n = 6 for BHV1) after injection. c Tumor-to-liver ratio 4 h, 24 h, and 144 h after injection. d Comparative blood clearance profiles in tumor-bearing mice at 5, 15, 30, 60, 120, 240 min, 24 h and 7 days after injection with of 89Zr-aGPC3 or 89Zr-aBHV1 (n = 4/time point). Bar and symbol denote mean, error bar denotes standard deviation