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Table 2 Comparison of metabolic parameters and quantitative serum tumor markers between EGFR wild-type and mutant-type male patients with NSCLC

From: Identification of EGFR mutation status in male patients with non-small-cell lung cancer: role of 18F-FDG PET/CT and serum tumor markers CYFRA21-1 and SCC-Ag

Factors

Total

EGFR

P value

Wild-type

Mutant-type

Metabolic parameters (median [IQR])

    

 pSUVmax

11.69 [7.63–15.74]

13.01 [8.84–16.44]

8.68 [4.98–21.70]

 < 0.001*

 nSUVmax

8.90 [5.93–14.15]

8.93 [5.97–12.76]

8.41 [5.45–15.77]

0.798

 mSUVmax

9.60 [6.05–13.12]

10.78 [5.94–13.93]

8.80 [5.96–11.63]

0.365

Serum tumor markers (median [IQR])

    

 CEA (ng/mL)

3.06 [1.65–8.77]

2.66 [1.66–8.48]

4.18 [1.73–13.95]

0.286

 Ferritin (ng/mL)

205.9 [128.3–387.7]

184.6 [125.1–356.0]

260.6 [135.5–394.9]

0.248

 CA50 (U/mL)

9.51 [6.10–14.33]

10.54 [6.49–15.33]

8.73 [4.88–12.13]

0.103

 CA125 (U/mL)

12.70 [6.95–32.55]

13.70 [7.25–33.72]

11.40 [5.90–34.20]

0.622

 CA72-4 (U/mL)

1.82 [1.00–4.04]

1.94 [1.07–5.98]

1.36 [1.00–2.77]

0.065

 NSE (ng/mL)

9.38 [6.72–12.06]

9.38 [6.72–11.51]

9.30 [6.72–12.26]

0.828

 SCC-Ag (ng/mL)

0.92 [0.56–1.71]

1.05 [0.63–2.31]

0.67 [0.48–1.44]

0.006*

 CYFRA 21-1 (ng/mL)

3.35 [2.39–6.74]

4.01 [2.67–8.16]

2.65 [1.93–4.45]

0.002*

  1. *Indicates significant differences between the comparison groups