Ligand | Ki for σ1 | Refs | Ki for σ2 | ED50 in vivo versusa: | |
---|
| | | | 11C-(−)-NR2B-Me | 11C-(+)-NR2B-Me |
---|
| (nM)b | | (nM)c | (nmol/kg) | |
---|
TC1 | 10 | [40] | 370 | 48 | 64 |
SA4503 | 17.4 | [41, 42] | 1784 | 43 | 41 |
| 4.6 | [38, 43] | 63 | | |
(+)-Pentazocine | 13.7 | [41, 44] | 2875 | > 1000 | |
( ±)-PPCC | 1.5 | [45] | 50.8 | > 1000 | |
PRE-084 | 44 | [46, 47] | | > 1000 | |
(+)-SKF10047 | 48 | [48] | 625 | > 1000 | |
- aIn rat whole brain
- bReference radioligand: 3H-pentazocine
- cReference radioligand: 3H-DTG