EJNMMI Research

Table 2 In vitro and in vivo pharmacological parameters of GluN2B ligands

From: Candidate 3-benzazepine-1-ol type GluN2B receptor radioligands (¹¹C-NR2B-Me enantiomers) have high binding in cerebellum but not to σ1 receptors

Ligand	K_i for GluN2B (nM)	ED₅₀ in rat whole brain in vivo
		¹¹C-(S)-NR2B-SMe^a	¹¹C-(−)-NR2B-Me	¹¹C-(+)-NR2B-Me	¹⁸F-FTC146
		(nmol/kg)
NR2B-SMe	2.0	9.5			1064
Ro-25-6981	9.0	29	34	45
CO101,244	43	74		41

^aRef. [26]
^bRef. [36]
^cRef. [37]

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