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Fig. 4 | EJNMMI Research

Fig. 4

From: Candidate 3-benzazepine-1-ol type GluN2B receptor radioligands (11C-NR2B-Me enantiomers) have high binding in cerebellum but not to σ1 receptors

Fig. 4

Blocking of whole brain radioactivity uptake in rat by dosing with the GluN2B ligand Ro-25-6981 before intravenous injection of 11C-(−)-NR2B-Me (A) or 11C-(+)-NR2B-Me (B), and the respective fitted dose–response curves of Ro-25 6981 from 11C-(−)-NR2B-Me, 11C-(+)-NR2B-Me, 11C-(S)-NR2B-SMe (ED50 = 34 nmol/kg, 45 nmol/kg, 29 nmol/kg) (C) and the respective fitted dose–response curves of Ro-25 6981 from 18F-FTC146, 11C-(S)-NR2B-SMe (ED50 = 1064 nmol/kg, 9.5 nmol/kg) (D). Data are for n = 1

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