Semi-quantitative indices of 2-[18F]FDG PET/CT in assessing cardiovascular and non-cardiovascular manifestations of IgG4-related disease and treatment response

EJNMMI Research

Table 5 Comparisons of semi-quantitative parameters and radiological findings before and after treatment

	Before therapy		During therapy		One-tailed p value
	Mean	Variance	Mean	Variance	One-tailed p value
TLG
Total	1066.61	1,778,964.88	53.24	1699.45	0.019
Cardiovascular subgroup	1974.15	1,926,531.95	67.00	1978.97	0.019
Non-cardiovascular subgroup	159.08	17,094.12	39.48	1371.45	0.037
SUVmax
Total	8.74	23.80	2.96	3.56	0.001
Cardiovascular subgroup	9.46	46.61	2.60	1.31	0.035
Non-cardiovascular subgroup	8.02	5.65	3.32	6.37	0.004
MTV
Total	321.56	147,654.62	30.40	571.32	0.019
Cardiovascular subgroup	589.66	150,410.42	36.12	578.80	0.017
Non-cardiovascular subgroup	159.08	17,094.12	39.48	1371.45	0.037
Number of lesions
Total	4.60	7.16	1.40	0.49	0.002
Cardiovascular subgroup	6.00	10.00	1.40	0.30	0.012
Non-cardiovascular subgroup	3.20	1.20	1.40	0.80	0.027
TBR
Cardiovascular subgroup	3.00	0.0956	1.524	0.066	0.002

Out of 10 patients with pre-treatment and post-treatment 2-[¹⁸F]FDG PET/CT scans, there were significant decreases in TLG, SUVmax, MTV, and number of lesions, but no significant decrease in total IgG and ESR. There was also statistically significant difference in TBR for the cardiovascular subgroup