Fig. 1

Fused anterior 3D PET/CT image acquired at 0–30 s and PET images acquired at 1–5 min and 20–50 min show the in vivo biodistribution of [¹⁸F]fluoride in male Sprague Dawley rats (the images present the same rat but from two different imaging sessions). a At 0–30 s, the highest uptakes are observed in the caudal vein, vena cava, heart, and kidneys. b At 1–5 min after the injection, uptake appears in the kidneys, bladder, and epiphyseal regions of long bones, mandible, and costochondral joints. c At 20–50 min, uptake is decreased in the kidneys but elevated in the bones and bladder