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Table 4 Sensitivity analysis results for the tumor compartments with area under the concentration–time curve (AUC; 0–24 h) as output parameter

From: A physiologically based pharmacokinetic model for [68Ga]Ga-(HA-)DOTATATE to predict whole-body distribution and tumor sink effects in GEP-NET patients

Compartment

Input parameter

Sensitivity value

Primary tumor

Fraction vascular of primary tumor

0.655

Primary tumor

[68Ga]Ga-DOTATATE dose (µg)

1.03

Liver metastases

[68Ga]Ga-DOTATATE dose (µg)

1.03

Liver metastases

Fraction vascular of liver metastases

0.735

Liver metastases

SA proportionality factor

0.527

Other metastases

[68Ga]Ga-DOTATATE dose (µg)

1.03

Other metastases

Fraction vascular of other metastases

0.575

  1. Only sensitivity values < −0.5 or > 0.5 were reported