Impact of framing scheme optimization and smoking status on binding potential analysis in dynamic PET with [11C]ABP688

EJNMMI Research

Table 3 Results of the normalized BP_ND in the comparison between the HC and SZ groups separated by framing scheme

Brain region	Constant 5 min framing			Constant true counts framing
Brain region	F test	P-value**	η²p*	F test	P-value**	η²p*
Whole Brain GM	1.401	0.247	0.048	0.326	0.572	0.012
Frontal left	12.036	0.002**	0.301	6.445	0.017	0.187
Frontal right	10.679	0.003**	0.276	2.469	0.127	0.081
Orbitofrontal cortex middle	0.710	0.407	0.025	2.556	0.121	0.084
Parietal left	10.712	0.003**	0.277	4.091	0.053	0.127
Parietal right	16.636	< 0.001**	0.373	5.205	0.030	0.157
Primary auditory	1.072	0.309	0.037	0.910	0.348	0.031
ACC	4.525	0.042	0.139	3.690	0.065	0.116
PCC	4.708	0.039	0.144	3.112	0.089	0.100
Caudate	0.044	0.835	0.002	0.253	0.619	0.009
Putamen	1.632	0.212	0.055	1.561	0.222	0.053
Thalamus	1.351	0.255	0.046	0.271	0.607	0.010
Motor cortex	10.829	0.003**	0.279	4.127	0.052	0.128
White matter	1.366	0.252	0.047	0.278	0.602	0.010

*Effect size, **Significance P ≤ 0.003 after Bonferroni correction are highlighted in bold italic
Table 3 Samples balanced by smoking status, age, gender and education for the analysis of normalized BP_ND based on different framing schemes. All brain regions with statistical analysis results were reported from a pairwise analysis between groups